UniProtKB - P53127 (SNT2_YEAST)
E3 ubiquitin-protein ligase SNT2
SNT2
Functioni
Transcriptional regulator that, together with ECM5, recruits histone deacetylase RPD3 to a small number of promoters of stress-response genes in response to oxidative stress (PubMed:23878396).
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702).
2 PublicationsCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 317 – 369 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 1038 – 1097 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 1041 – 1095 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 55 | |
Zinc fingeri | 1105 – 1153 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 49 | |
Zinc fingeri | 1177 – 1231 | PHD-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 55 |
GO - Molecular functioni
- chromatin binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: SGD
- ubiquitin-protein transferase activity Source: GO_Central
GO - Biological processi
- histone catabolic process Source: SGD
- histone ubiquitination Source: SGD
- regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: SGD
- response to oxidative stress Source: ComplexPortal
Keywordsi
Molecular function | Transferase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase SNT21 Publication (EC:2.3.2.271 Publication)Alternative name(s): Histone E3 ligase SNT21 Publication RING-type E3 ubiquitin transferase SNT2Curated SANT domain-containing protein 21 Publication |
Gene namesi | Name:SNT21 Publication Ordered Locus Names:YGL131CImported ORF Names:G2850 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003099, SNT2 |
VEuPathDBi | FungiDB:YGL131C |
Subcellular locationi
Nucleus
- Lid2 complex Source: GO_Central
- nucleus Source: SGD
- Snt2C complex Source: ComplexPortal
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202742 | 1 – 1403 | E3 ubiquitin-protein ligase SNT2Add BLAST | 1403 |
Proteomic databases
MaxQBi | P53127 |
PaxDbi | P53127 |
PRIDEi | P53127 |
PTM databases
iPTMneti | P53127 |
Interactioni
Subunit structurei
Component of the Snt2C complex composed of SNT2, ECM5 and RPD3.
Interacts with the E2 ubiquitin-conjugating enzyme UBC4 and histones H3 and H4. Binding is enhanced to methylated histone H3K36me3.
4 PublicationsProtein-protein interaction databases
BioGRIDi | 33120, 52 interactors |
ComplexPortali | CPX-1372, SNT2C histone deacetylase complex |
DIPi | DIP-6540N |
IntActi | P53127, 17 interactors |
MINTi | P53127 |
STRINGi | 4932.YGL131C |
Miscellaneous databases
RNActi | P53127, protein |
Structurei
3D structure databases
AlphaFoldDBi | P53127 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 258 | BAHPROSITE-ProRule annotationAdd BLAST | 138 | |
Domaini | 555 – 606 | SANTPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 40 – 62 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 59 | Polar residuesSequence analysisAdd BLAST | 20 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 317 – 369 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 1038 – 1097 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 1041 – 1095 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 55 | |
Zinc fingeri | 1105 – 1153 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 49 | |
Zinc fingeri | 1177 – 1231 | PHD-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 55 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0955, Eukaryota |
HOGENOMi | CLU_001514_2_0_1 |
InParanoidi | P53127 |
OMAi | FHVGCAH |
Family and domain databases
Gene3Di | 2.30.30.490, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR034732, EPHD IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR029617, Snt2 IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR47672, PTHR47672, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF00628, PHD, 2 hits |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM00249, PHD, 3 hits SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57903, SSF57903, 2 hits |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51805, EPHD, 1 hit PS51293, SANT, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPKEEDFQLP RRREAAKNVN YNEMEIDTKL VQQIQIAEKS GAKTKGSNSQ
60 70 80 90 100
TPRNCKRTSN PASRNEKFKY QKFLHDKNTC WNFIPTLPPS FRKNSRFSNI
110 120 130 140 150
LDLDDAMIDL KKMSLFNTES VLLSANDTIY MISEPAGEPY YVGRVVNFVS
160 170 180 190 200
KPEFSNTIHE AIKTTSVFPA KFFQVRMNWF YRPRDIQEHV NTFNPRLVYA
210 220 230 240 250
SLHQDICPIS SYRGKCSIFH KDEVFDVLPN EKECIIRPNI FYFDELFDRY
260 270 280 290 300
TLKYYKVYST DKILNKWNSK SPFLYVLNRR FRYIYTEPKY PLENVLKKYV
310 320 330 340 350
FHELEVNELS PADYQWDKRC QFCKEWCIQK ESLSCDECGV CAHLYCMDPP
360 370 380 390 400
LDRKPNKDVV WTCFSCLQKQ QGTKDSHVRF LEEQALELDF IRSVRQKIEE
410 420 430 440 450
ISSKAIKENV GYNTENCWFQ YLGIYSISHI GDALNDSMFF PYPFKPSRVG
460 470 480 490 500
VKYQWNGCNH NVPWRRNSYI SANSEEERGS TKTSELAWVL DASKITTRKL
510 520 530 540 550
SEYIEQCKSE ICPILNVRGE TCNFIDVVLK NLLFTNYDTA EAFKKCKREL
560 570 580 590 600
SRKFLKEPSF TAVEIRKFEE AVEKFGSELR PVCEYVGTQP MSMIVRFYYN
610 620 630 640 650
WKKTERGLTV RGKLSKLSKN KRKKEIANHE NDVETKYIDD SSFDTEKLSL
660 670 680 690 700
AESSFQCMFC KTDYSPMWYR VTGGSDDEKI KIRMQTGVNE KTEISEKSPA
710 720 730 740 750
HSKKNEKLGA LCIRCARMWR RYAIKWVPPL ETLRKITGTC QNSFYSAIEG
760 770 780 790 800
IIEENNTNKF TLSPFQAHNK LLEWELVQDS ELIIRQRMKV YKNPNSFVKM
810 820 830 840 850
KRYSMTFHTQ LYKMAVRSYR KNEFHPETMQ RDLELFIEDN KEVRKAIPEQ
860 870 880 890 900
KPERAKNTKD EFPVNIIRQS PGTIKTSDTS RNRKCNDVFI EKASNNNIPK
910 920 930 940 950
ITNASNDLIE ISIKTGGSSS GSVSVDKGFK FVKFDNKTFQ RLRNSLKLVN
960 970 980 990 1000
NKLPKYNEPS TKKIKMINDI ALSNPLNEPN GASYNYTVIS HSKETSVALE
1010 1020 1030 1040 1050
KYHDGNKPSK MLEKDMILKH TKNKPKNPDT AWANNSARTF CSVCKEKFND
1060 1070 1080 1090 1100
NDNYEVVCGN CGLTVHYFCY AIKLPKDMKK NTNLKTFKWL CDPCSNDLNP
1110 1120 1130 1140 1150
IISTTYQCSM CPTKDYDYDR YRSQSFKICP DALKCTSLGT WVHLVCSLFN
1160 1170 1180 1190 1200
EDIKYGNGQS MQPALNTTAV LIKHSRFTCG VCRINGGGLV KCNKCQYRYH
1210 1220 1230 1240 1250
ITCAQNSSNF KLMFEKKNMS VDTTLPCIKD VKLNDTYTLR PILICDRHDI
1260 1270 1280 1290 1300
SLEGNELYPL SYKPQHTLSY IEQYCRYYKC ESDHSLVELR YFEQLRLRHG
1310 1320 1330 1340 1350
EMPGNSHDSA IKPKIYVLPF ERTCPHCGTN KSLYWYEDII CHSCNLRSGA
1360 1370 1380 1390 1400
QELDFDSASA NISNDNGLPV EITQQLMEGI EPAMFDIDIS EAGTDKNTHP
SSQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72654 Genomic DNA Translation: CAA96843.1 Z72652 Genomic DNA Translation: CAA96841.1 BK006941 Genomic DNA Translation: DAA07978.1 |
PIRi | S64142 |
RefSeqi | NP_011384.1, NM_001180996.1 |
Genome annotation databases
EnsemblFungii | YGL131C_mRNA; YGL131C; YGL131C |
GeneIDi | 852746 |
KEGGi | sce:YGL131C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72654 Genomic DNA Translation: CAA96843.1 Z72652 Genomic DNA Translation: CAA96841.1 BK006941 Genomic DNA Translation: DAA07978.1 |
PIRi | S64142 |
RefSeqi | NP_011384.1, NM_001180996.1 |
3D structure databases
AlphaFoldDBi | P53127 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33120, 52 interactors |
ComplexPortali | CPX-1372, SNT2C histone deacetylase complex |
DIPi | DIP-6540N |
IntActi | P53127, 17 interactors |
MINTi | P53127 |
STRINGi | 4932.YGL131C |
PTM databases
iPTMneti | P53127 |
Proteomic databases
MaxQBi | P53127 |
PaxDbi | P53127 |
PRIDEi | P53127 |
Genome annotation databases
EnsemblFungii | YGL131C_mRNA; YGL131C; YGL131C |
GeneIDi | 852746 |
KEGGi | sce:YGL131C |
Organism-specific databases
SGDi | S000003099, SNT2 |
VEuPathDBi | FungiDB:YGL131C |
Phylogenomic databases
eggNOGi | KOG0955, Eukaryota |
HOGENOMi | CLU_001514_2_0_1 |
InParanoidi | P53127 |
OMAi | FHVGCAH |
Miscellaneous databases
PROi | PR:P53127 |
RNActi | P53127, protein |
Family and domain databases
Gene3Di | 2.30.30.490, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR034732, EPHD IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR029617, Snt2 IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR47672, PTHR47672, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF00628, PHD, 2 hits |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM00249, PHD, 3 hits SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57903, SSF57903, 2 hits |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51805, EPHD, 1 hit PS51293, SANT, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SNT2_YEAST | |
Accessioni | P53127Primary (citable) accession number: P53127 Secondary accession number(s): D6VU17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names