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Entry version 153 (13 Feb 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Imitation switch two complex protein 1

Gene

ITC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. ITC1 is required for nucleosome-stimulated ATPase activity and chromatin-remodeling activity of the complex. Required for the repression of MATa a-specific genes.6 Publications

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-30628-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Imitation switch two complex protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITC1
Ordered Locus Names:YGL133W
ORF Names:G2842
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YGL133W

Saccharomyces Genome Database

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SGDi
S000003101 ITC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842701 – 1264Imitation switch two complex protein 1Add BLAST1264

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P53125

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P53125

PRoteomics IDEntifications database

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PRIDEi
P53125

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53125

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ISW2 complex, which at least consists of ISW2, ITC1, DLS1 and DPB4. May form a stable subcomplex with ISW2.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ISW2Q087732EBI-23967,EBI-31118

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
33119, 267 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-728 ISW2 chromatin remodeling complex
CPX-734 ISW2 chromatin remodeling complex variant 2

Database of interacting proteins

More...
DIPi
DIP-6737N

Protein interaction database and analysis system

More...
IntActi
P53125, 36 interactors

Molecular INTeraction database

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MINTi
P53125

STRING: functional protein association networks

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STRINGi
4932.YGL133W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P53125

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P53125

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 130WACPROSITE-ProRule annotationAdd BLAST108
Domaini423 – 483DDTPROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000176599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065973

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P53125

Identification of Orthologs from Complete Genome Data

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OMAi
VARFLHF

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018501 DDT_dom
IPR028941 WHIM2_dom
IPR013136 WSTF_Acf1_Cbp146

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02791 DDT, 1 hit
PF10537 WAC_Acf1_DNA_bd, 1 hit
PF15613 WSD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00571 DDT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50827 DDT, 1 hit
PS51136 WAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53125-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLYKRKPIL LPDPKPLPLD LNVQVWHIEE TGEWFSSYEE FLERFDFYTR
60 70 80 90 100
HHFTCEITGT SCLTFFQALD SEETQFKYVE DRFPLKLREP VARFLHFNGI
110 120 130 140 150
RRLDALVEKV YARFKNDFFP GEVVYLRKQK DSSTTSSNSQ QSTPQPDDMV
160 170 180 190 200
EINSVGNPGL PQYQYQRRYV IKEKVQFNAT INPESREIVM PAHTKYMLIE
210 220 230 240 250
EAASSNKSFI VDQGQIYRDR STFTKHLIKC FFKITLQRAS SKMGAPWCVK
260 270 280 290 300
PEYLAMYGLT MEWPKDMLKY KEDEPVVARR SNSANVSSPE SEKNKRQSKS
310 320 330 340 350
SGKSNTSNDA SNKKETKKKR KPTEVNDSEN NSSEEDKKKG QNVTSETHSK
360 370 380 390 400
KRKKEANEEP NTENVESVPT PANAEPQAVT ITSIMDDLAL PYQHPPNIFP
410 420 430 440 450
NLTYYNEKLE CISLGSTKLS RPFDSFGKLL QAYQFLNTFG SKICLSHFSL
460 470 480 490 500
DQFITSLKCT DPYELKGEVV LVNIRTQTSK EQEIENNGLP MKNKAETTTE
510 520 530 540 550
EDSENPSDWQ RNSFIRDMIM KRNSDKVEYK IVHDDPASDD ILDNINHNGS
560 570 580 590 600
ALLIEVFTAL LRLFINEEGD WSCIVVENWI IDDKGVLMER KDERGEGEAK
610 620 630 640 650
QKRNAHGYFL QDKEKIDNLK DTLKENATEV QKESDAKNET NSESDSKSDS
660 670 680 690 700
DSEERDPKLE KCLNYRNVNW IERLTKRQFN NSYWLIILLG VLEDCRHLPM
710 720 730 740 750
YTEFIDSFIE KIIPKDISAT QLPKQLWRNF CRKLSFSDKV NALWILVDLV
760 770 780 790 800
SHFSPDIKAA VDDSMELCGQ IRSERFKVAR ELKTEAAVLS NLQGDLQAIQ
810 820 830 840 850
EKLNKTDENT PSADGADKKD DSESNSEPID LIIIEKKQKL IEEQDKKVQA
860 870 880 890 900
LQSDKNFLDN CLFENDLQRL KPLGLDRYGN RYFWLDHNGV PFPQYPAGMN
910 920 930 940 950
ETPKSNNSLS YHSGRLLIQG PKASSAKFFL NVSDEQLSNW QKIRNSEGIS
960 970 980 990 1000
EATREVFGIS KTSSGSYNYV ENGIEVELLD SNDRVNPLIE LTPIQKKIMD
1010 1020 1030 1040 1050
ETPSRLLLSP DQWYCIDKLE DLSRIMDWLD NWGRKEHDLL RQIRPIMERI
1060 1070 1080 1090 1100
KSSLSLRDHA LSLTAFTKNE EKLLKELENN EFTENELNVD SMDVDDKNSG
1110 1120 1130 1140 1150
VKSEVDVQVD AEEKREAVID EKLEVIADEL MKLDDSSKTR NVLNRIQELE
1160 1170 1180 1190 1200
DQRDELLEQK KSIINSQRPG ARILARSERK RTKISRGNKV NKQIEILTDL
1210 1220 1230 1240 1250
VNYRHFKAME DVIAWKNVLA NSIWGSSLRK NASGNKRSGV IETVDDKLKD
1260
IVGQTSRTVT PAPN
Length:1,264
Mass (Da):145,643
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45E4CF8835C7C746
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z72655 Genomic DNA Translation: CAA96844.1
BK006941 Genomic DNA Translation: DAA07977.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64146

NCBI Reference Sequences

More...
RefSeqi
NP_011382.1, NM_001180998.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL133W_mRNA; YGL133W_mRNA; YGL133W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852744

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL133W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72655 Genomic DNA Translation: CAA96844.1
BK006941 Genomic DNA Translation: DAA07977.1
PIRiS64146
RefSeqiNP_011382.1, NM_001180998.1

3D structure databases

ProteinModelPortaliP53125
SMRiP53125
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33119, 267 interactors
ComplexPortaliCPX-728 ISW2 chromatin remodeling complex
CPX-734 ISW2 chromatin remodeling complex variant 2
DIPiDIP-6737N
IntActiP53125, 36 interactors
MINTiP53125
STRINGi4932.YGL133W

PTM databases

iPTMnetiP53125

Proteomic databases

MaxQBiP53125
PaxDbiP53125
PRIDEiP53125

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL133W_mRNA; YGL133W_mRNA; YGL133W
GeneIDi852744
KEGGisce:YGL133W

Organism-specific databases

EuPathDBiFungiDB:YGL133W
SGDiS000003101 ITC1

Phylogenomic databases

GeneTreeiENSGT00940000176599
HOGENOMiHOG000065973
InParanoidiP53125
OMAiVARFLHF

Enzyme and pathway databases

BioCyciYEAST:G3O-30628-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53125

Family and domain databases

InterProiView protein in InterPro
IPR018501 DDT_dom
IPR028941 WHIM2_dom
IPR013136 WSTF_Acf1_Cbp146
PfamiView protein in Pfam
PF02791 DDT, 1 hit
PF10537 WAC_Acf1_DNA_bd, 1 hit
PF15613 WSD, 1 hit
SMARTiView protein in SMART
SM00571 DDT, 1 hit
PROSITEiView protein in PROSITE
PS50827 DDT, 1 hit
PS51136 WAC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITC1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53125
Secondary accession number(s): D6VU16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 13, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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