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Protein

PHO85 cyclin-10

Gene

PCL10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL8, negatively controls glycogen accumulation under favorable growth conditions. The PCL10-PHO85 cyclin-CDK holoenzyme has glycogen synthase kinase activity and phosphorylates and negatively regulates glycogen synthase GSY2. Also has minor GLC8 kinase activity.3 Publications

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • glycogen metabolic process Source: UniProtKB-KW
  • negative regulation of glycogen biosynthetic process Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-30629-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
PHO85 cyclin-10
Gene namesi
Name:PCL10
Ordered Locus Names:YGL134W
ORF Names:G2838
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL134W
SGDiS000003102 PCL10

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002027401 – 433PHO85 cyclin-10Add BLAST433

Proteomic databases

MaxQBiP53124
PaxDbiP53124
PRIDEiP53124

PTM databases

iPTMnetiP53124

Interactioni

Subunit structurei

Forms a cyclin-CDK complex with PHO85. Interacts with GSY2, independent of the presence of PHO85.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PHO85P171576EBI-23973,EBI-13327

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33118, 52 interactors
ComplexPortaliCPX-1692 PCL10-PHO85 kinase complex
DIPiDIP-1494N
IntActiP53124, 17 interactors
MINTiP53124
STRINGi4932.YGL134W

Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi246 – 248Combined sources3
Helixi262 – 280Combined sources19
Helixi291 – 298Combined sources8
Helixi310 – 321Combined sources12
Helixi325 – 339Combined sources15
Beta strandi340 – 342Combined sources3
Beta strandi348 – 350Combined sources3
Helixi356 – 358Combined sources3
Helixi359 – 374Combined sources16
Helixi381 – 388Combined sources8
Helixi392 – 406Combined sources15
Helixi415 – 429Combined sources15

3D structure databases

ProteinModelPortaliP53124
SMRiP53124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. PHO80 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00530000067900
InParanoidiP53124
OrthoDBiEOG092C2G1V

Family and domain databases

InterProiView protein in InterPro
IPR013922 Cyclin_PHO80-like
PfamiView protein in Pfam
PF08613 Cyclin, 1 hit

Sequencei

Sequence statusi: Complete.

P53124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMTKNHTTD TEEFDDGDIR PVSLGIVDDY NASFELPLKP KFLQSENFSD
60 70 80 90 100
LTSEWDQSRS NTPGLAEGKT EKAQPCGTTD SSKNRIHVEQ LLESANEMNN
110 120 130 140 150
YLAQNIENIN NFQVGLLNGG KGLYSSMGDD SSACINGTNF SSTSNFELSD
160 170 180 190 200
DELEDTTGCT SSIFDKDLFH QQNGLSIPRR RSPLFKSPTA SFEIGDATDV
210 220 230 240 250
EEQDIDDSIF SECSSITSFD MGGLHISLPH DEEEDQEKTK SESENPLLHG
260 270 280 290 300
IPVDVEVPHI SVDEALANFK ETIELLLKLS GNRKCTGFNT RVEKKEYSNF
310 320 330 340 350
YMKSKPTLSS ADFLKRIQDK CEYQPTVYLV ATFLIDTLFL TRDGNNILQL
360 370 380 390 400
KLNLQEKEVH RMIIAAVRLS TKLLEDFVHS HEYFSKVCGI SKRLLTKLEV
410 420 430
SLLICVCNTK LMVSNRKLAA SKLLLNELRS FCV
Length:433
Mass (Da):48,584
Last modified:October 1, 1996 - v1
Checksum:iDE6608A34BDBDF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72656 Genomic DNA Translation: CAA96845.1
BK006941 Genomic DNA Translation: DAA07976.1
PIRiS64147
RefSeqiNP_011381.1, NM_001180999.1

Genome annotation databases

EnsemblFungiiYGL134W; YGL134W; YGL134W
GeneIDi852743
KEGGisce:YGL134W

Similar proteinsi

Entry informationi

Entry nameiPCL10_YEAST
AccessioniPrimary (citable) accession number: P53124
Secondary accession number(s): D6VU15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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