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UniProtKB - P53121 (FLC3_YEAST)
Protein
Putative flavin carrier protein 3
Gene
FLC3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.
By similarityGO - Molecular functioni
- FAD transmembrane transporter activity Source: SGD
GO - Biological processi
- FAD transport Source: SGD
- fungal-type cell wall biogenesis Source: GO_Central
- sphingolipid biosynthetic process Source: SGD
- transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Putative flavin carrier protein 3Alternative name(s): FAD transporter 3 TRP-like ion channel FLC3 |
Gene namesi | Name:FLC3 Ordered Locus Names:YGL139W ORF Names:G2812 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003107, FLC3 |
VEuPathDBi | FungiDB:YGL139W |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 169 | LumenalSequence analysisAdd BLAST | 141 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 191 – 200 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 222 – 229 | LumenalSequence analysis | 8 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 251 – 255 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 256 – 278 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 279 – 323 | LumenalSequence analysisAdd BLAST | 45 | |
Transmembranei | 324 – 344 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 345 – 377 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 378 – 398 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 399 – 405 | LumenalSequence analysis | 7 | |
Transmembranei | 406 – 426 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 427 – 467 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 468 – 488 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 489 – 495 | LumenalSequence analysis | 7 | |
Transmembranei | 496 – 516 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 517 – 525 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 526 – 546 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 547 – 557 | LumenalSequence analysisAdd BLAST | 11 | |
Transmembranei | 558 – 578 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 579 – 802 | CytoplasmicSequence analysisAdd BLAST | 224 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000202738 | 29 – 802 | Putative flavin carrier protein 3Add BLAST | 774 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 149 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 321 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 616 | PhosphoserineCombined sources | 1 | |
Modified residuei | 635 | PhosphoserineCombined sources | 1 | |
Modified residuei | 779 | PhosphoserineCombined sources | 1 | |
Modified residuei | 782 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P53121 |
PaxDbi | P53121 |
PRIDEi | P53121 |
PTM databases
iPTMneti | P53121 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33113, 43 interactors |
DIPi | DIP-5496N |
STRINGi | 4932.YGL139W |
Miscellaneous databases
RNActi | P53121, protein |
Structurei
3D structure databases
AlphaFoldDBi | P53121 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 629 – 802 | DisorderedSequence analysisAdd BLAST | 174 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 644 – 673 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 699 – 788 | Polar residuesSequence analysisAdd BLAST | 90 |
Sequence similaritiesi
Belongs to the transient receptor potential (TRP) ion channel family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSVZ, Eukaryota |
GeneTreei | ENSGT00940000176312 |
HOGENOMi | CLU_010226_0_0_1 |
InParanoidi | P53121 |
OMAi | SIMGWVF |
Family and domain databases
InterProi | View protein in InterPro IPR010308, TRP_C IPR040241, TRP_Flc/Pkd2-like IPR032800, TRP_N |
PANTHERi | PTHR31145, PTHR31145, 1 hit |
Pfami | View protein in Pfam PF06011, TRP, 1 hit PF14558, TRP_N, 1 hit |
SMARTi | View protein in SMART SM01320, TRP_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P53121-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFLQVYKSS ALIGLIILLA SKVNLAEAKR KLVATSLVTC MENSQLSANS
60 70 80 90 100
FDVVFNPDDR SLHYDLDMST QIDSYIFADI DVYAYGFKII TKNVDLCSIN
110 120 130 140 150
WKQFCPVHPG NIQIDSIEYI SSEYVNEIPG IAYQVPDIDA YARVKITNNV
160 170 180 190 200
SEYLACIQIY FSNGKTVSQI GVKWATAVVA GIGLLLSAIL STFGNSTAAS
210 220 230 240 250
HISANTMSLF LYFQSVVVVA MQHVHRVPPI AAAWAENLVW SMGLIRISFM
260 270 280 290 300
QRIFRWYVQS TGGTPSLYLT STSMSVLAQR SWQYLMELPL IKRATNVLYG
310 320 330 340 350
NANTLIFRGI KRLGYKMGIE NTSIVCTGFT FFVLCGYVLA GFIIVFKCCV
360 370 380 390 400
ELATRLGWIQ KARFWEFRKQ WRMILKGALL RYIYIGFVQL TILSFWEFTE
410 420 430 440 450
RDSPAVIVIA CLFILLSCGL MLWAAWRTVF FARRSVALYN NPAALLYGDE
460 470 480 490 500
YVLHKYGFFY TMFNANHYWW NIVLLSYIFV KSLLVGFAQA SGQTQVLFMF
510 520 530 540 550
ILDLFYFVAI IYYKPYLDRP TNIMNILIAT VTVVNSFLFM FFSDLFNQSY
560 570 580 590 600
KVAAIMGWIF FIMNAAFSFI LLMMILAFAG MMLFSKNPDL RFKPAKDDRT
610 620 630 640 650
SFQRNTMKPE GTVNRSVANE LLALGNVAKD HDDNSDYESN DTGVNDELKQ
660 670 680 690 700
AQDETTPTTV TSSDDNKPTF SEKILSKFSR PKNENASTDA LRVEAPKQQT
710 720 730 740 750
FPHNLTNLSR ENLSTLGSKP YPGHTRSQSD AHNGLINSFE EEDTSSNTDP
760 770 780 790 800
FHDSTEGDLL DTSSSDGGFR SQNYVRDDSI NSLGNNKQPL RKPPGFFDEG
FM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99960 Genomic DNA Translation: CAA68223.1 Z72661 Genomic DNA Translation: CAA96851.1 Z72660 Genomic DNA Translation: CAA96850.1 X92670 Genomic DNA Translation: CAA63357.1 BK006941 Genomic DNA Translation: DAA07971.1 |
PIRi | S64153 |
RefSeqi | NP_011376.3, NM_001181004.3 |
Genome annotation databases
EnsemblFungii | YGL139W_mRNA; YGL139W; YGL139W |
GeneIDi | 852738 |
KEGGi | sce:YGL139W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99960 Genomic DNA Translation: CAA68223.1 Z72661 Genomic DNA Translation: CAA96851.1 Z72660 Genomic DNA Translation: CAA96850.1 X92670 Genomic DNA Translation: CAA63357.1 BK006941 Genomic DNA Translation: DAA07971.1 |
PIRi | S64153 |
RefSeqi | NP_011376.3, NM_001181004.3 |
3D structure databases
AlphaFoldDBi | P53121 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33113, 43 interactors |
DIPi | DIP-5496N |
STRINGi | 4932.YGL139W |
PTM databases
iPTMneti | P53121 |
Proteomic databases
MaxQBi | P53121 |
PaxDbi | P53121 |
PRIDEi | P53121 |
Genome annotation databases
EnsemblFungii | YGL139W_mRNA; YGL139W; YGL139W |
GeneIDi | 852738 |
KEGGi | sce:YGL139W |
Organism-specific databases
SGDi | S000003107, FLC3 |
VEuPathDBi | FungiDB:YGL139W |
Phylogenomic databases
eggNOGi | ENOG502QSVZ, Eukaryota |
GeneTreei | ENSGT00940000176312 |
HOGENOMi | CLU_010226_0_0_1 |
InParanoidi | P53121 |
OMAi | SIMGWVF |
Miscellaneous databases
PROi | PR:P53121 |
RNActi | P53121, protein |
Family and domain databases
InterProi | View protein in InterPro IPR010308, TRP_C IPR040241, TRP_Flc/Pkd2-like IPR032800, TRP_N |
PANTHERi | PTHR31145, PTHR31145, 1 hit |
Pfami | View protein in Pfam PF06011, TRP, 1 hit PF14558, TRP_N, 1 hit |
SMARTi | View protein in SMART SM01320, TRP_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FLC3_YEAST | |
Accessioni | P53121Primary (citable) accession number: P53121 Secondary accession number(s): D6VU10 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families