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Entry version 151 (25 May 2022)
Sequence version 1 (01 Oct 1996)
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Protein

Putative flavin carrier protein 3

Gene

FLC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative flavin carrier protein 3
Alternative name(s):
FAD transporter 3
TRP-like ion channel FLC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLC3
Ordered Locus Names:YGL139W
ORF Names:G2812
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003107, FLC3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGL139W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 169LumenalSequence analysisAdd BLAST141
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 200CytoplasmicSequence analysis10
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 229LumenalSequence analysis8
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 255CytoplasmicSequence analysis5
Transmembranei256 – 278HelicalSequence analysisAdd BLAST23
Topological domaini279 – 323LumenalSequence analysisAdd BLAST45
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 377CytoplasmicSequence analysisAdd BLAST33
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 405LumenalSequence analysis7
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 467CytoplasmicSequence analysisAdd BLAST41
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Topological domaini489 – 495LumenalSequence analysis7
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 525CytoplasmicSequence analysis9
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21
Topological domaini547 – 557LumenalSequence analysisAdd BLAST11
Transmembranei558 – 578HelicalSequence analysisAdd BLAST21
Topological domaini579 – 802CytoplasmicSequence analysisAdd BLAST224

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020273829 – 802Putative flavin carrier protein 3Add BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei616PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei779PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53121

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53121

PRoteomics IDEntifications database

More...
PRIDEi
P53121

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53121

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33113, 43 interactors

Database of interacting proteins

More...
DIPi
DIP-5496N

STRING: functional protein association networks

More...
STRINGi
4932.YGL139W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53121, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P53121

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni629 – 802DisorderedSequence analysisAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi644 – 673Polar residuesSequence analysisAdd BLAST30
Compositional biasi699 – 788Polar residuesSequence analysisAdd BLAST90

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSVZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010226_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53121

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIMGWVF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N

The PANTHER Classification System

More...
PANTHERi
PTHR31145, PTHR31145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06011, TRP, 1 hit
PF14558, TRP_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01320, TRP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P53121-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFLQVYKSS ALIGLIILLA SKVNLAEAKR KLVATSLVTC MENSQLSANS
60 70 80 90 100
FDVVFNPDDR SLHYDLDMST QIDSYIFADI DVYAYGFKII TKNVDLCSIN
110 120 130 140 150
WKQFCPVHPG NIQIDSIEYI SSEYVNEIPG IAYQVPDIDA YARVKITNNV
160 170 180 190 200
SEYLACIQIY FSNGKTVSQI GVKWATAVVA GIGLLLSAIL STFGNSTAAS
210 220 230 240 250
HISANTMSLF LYFQSVVVVA MQHVHRVPPI AAAWAENLVW SMGLIRISFM
260 270 280 290 300
QRIFRWYVQS TGGTPSLYLT STSMSVLAQR SWQYLMELPL IKRATNVLYG
310 320 330 340 350
NANTLIFRGI KRLGYKMGIE NTSIVCTGFT FFVLCGYVLA GFIIVFKCCV
360 370 380 390 400
ELATRLGWIQ KARFWEFRKQ WRMILKGALL RYIYIGFVQL TILSFWEFTE
410 420 430 440 450
RDSPAVIVIA CLFILLSCGL MLWAAWRTVF FARRSVALYN NPAALLYGDE
460 470 480 490 500
YVLHKYGFFY TMFNANHYWW NIVLLSYIFV KSLLVGFAQA SGQTQVLFMF
510 520 530 540 550
ILDLFYFVAI IYYKPYLDRP TNIMNILIAT VTVVNSFLFM FFSDLFNQSY
560 570 580 590 600
KVAAIMGWIF FIMNAAFSFI LLMMILAFAG MMLFSKNPDL RFKPAKDDRT
610 620 630 640 650
SFQRNTMKPE GTVNRSVANE LLALGNVAKD HDDNSDYESN DTGVNDELKQ
660 670 680 690 700
AQDETTPTTV TSSDDNKPTF SEKILSKFSR PKNENASTDA LRVEAPKQQT
710 720 730 740 750
FPHNLTNLSR ENLSTLGSKP YPGHTRSQSD AHNGLINSFE EEDTSSNTDP
760 770 780 790 800
FHDSTEGDLL DTSSSDGGFR SQNYVRDDSI NSLGNNKQPL RKPPGFFDEG

FM
Length:802
Mass (Da):90,761
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BA13714AD912295
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X99960 Genomic DNA Translation: CAA68223.1
Z72661 Genomic DNA Translation: CAA96851.1
Z72660 Genomic DNA Translation: CAA96850.1
X92670 Genomic DNA Translation: CAA63357.1
BK006941 Genomic DNA Translation: DAA07971.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64153

NCBI Reference Sequences

More...
RefSeqi
NP_011376.3, NM_001181004.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL139W_mRNA; YGL139W; YGL139W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL139W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99960 Genomic DNA Translation: CAA68223.1
Z72661 Genomic DNA Translation: CAA96851.1
Z72660 Genomic DNA Translation: CAA96850.1
X92670 Genomic DNA Translation: CAA63357.1
BK006941 Genomic DNA Translation: DAA07971.1
PIRiS64153
RefSeqiNP_011376.3, NM_001181004.3

3D structure databases

AlphaFoldDBiP53121
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi33113, 43 interactors
DIPiDIP-5496N
STRINGi4932.YGL139W

PTM databases

iPTMnetiP53121

Proteomic databases

MaxQBiP53121
PaxDbiP53121
PRIDEiP53121

Genome annotation databases

EnsemblFungiiYGL139W_mRNA; YGL139W; YGL139W
GeneIDi852738
KEGGisce:YGL139W

Organism-specific databases

SGDiS000003107, FLC3
VEuPathDBiFungiDB:YGL139W

Phylogenomic databases

eggNOGiENOG502QSVZ, Eukaryota
GeneTreeiENSGT00940000176312
HOGENOMiCLU_010226_0_0_1
InParanoidiP53121
OMAiSIMGWVF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53121
RNActiP53121, protein

Family and domain databases

InterProiView protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N
PANTHERiPTHR31145, PTHR31145, 1 hit
PfamiView protein in Pfam
PF06011, TRP, 1 hit
PF14558, TRP_N, 1 hit
SMARTiView protein in SMART
SM01320, TRP_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLC3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53121
Secondary accession number(s): D6VU10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 25, 2022
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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