We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P53112 (PEX14_YEAST)
Protein
Peroxisomal membrane protein PEX14
Gene
PEX14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.
Miscellaneous
Present with 2570 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- protein-macromolecule adaptor activity Source: SGD
- signaling receptor binding Source: GO_Central
GO - Biological processi
- protein import into peroxisome matrix, docking Source: SGD
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-SCE-9033241, Peroxisomal protein import R-SCE-9603798, Class I peroxisomal membrane protein import |
Protein family/group databases
TCDBi | 3.A.20.1.5, the peroxisomal protein importer (ppi) family |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal membrane protein PEX14Alternative name(s): Peroxin-14 |
Gene namesi | Name:PEX14 Ordered Locus Names:YGL153W ORF Names:G1870 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003121, PEX14 |
VEuPathDBi | FungiDB:YGL153W |
Subcellular locationi
Peroxisome
Peroxisome
- peroxisomal membrane Source: SGD
Other locations
- peroxisomal importomer complex Source: SGD
Keywords - Cellular componenti
Membrane, PeroxisomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 87 – 90 | PTLP → ATLA: Loss of interaction with SH3 domain of PEX13. No effect on membrane association. 1 Publication | 4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000058329 | 2 – 341 | Peroxisomal membrane protein PEX14Add BLAST | 340 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P53112 |
PaxDbi | P53112 |
PRIDEi | P53112 |
PTM databases
iPTMneti | P53112 |
Interactioni
Subunit structurei
Binary interactionsi
P53112
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 33101, 211 interactors |
ComplexPortali | CPX-1904, Peroxisomal PEX13-PEX14-PEX17 docking complex |
DIPi | DIP-1749N |
ELMi | P53112 |
IntActi | P53112, 31 interactors |
MINTi | P53112 |
STRINGi | 4932.YGL153W |
Miscellaneous databases
RNActi | P53112, protein |
Structurei
3D structure databases
AlphaFoldDBi | P53112 |
SMRi | P53112 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53112 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 276 – 341 | DisorderedSequence analysisAdd BLAST | 66 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 86 – 94 | SH3-binding1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 276 – 300 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 306 – 341 | Polar residuesSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the peroxin-14 family.Curated
Phylogenomic databases
eggNOGi | KOG2629, Eukaryota |
GeneTreei | ENSGT00390000015047 |
HOGENOMi | CLU_045718_0_1_1 |
InParanoidi | P53112 |
OMAi | LYGAYEV |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR025655, PEX14 IPR006785, Pex14_N IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR23058, PTHR23058, 1 hit |
Pfami | View protein in Pfam PF04695, Pex14_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P53112-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDVVSKDRK ALFDSAVSFL KDESIKDAPL LKKIEFLKSK GLTEKEIEIA
60 70 80 90 100
MKEPKKDGIV GDEVSKKIGS TENRASQDMY LYEAMPPTLP HRDWKDYFVM
110 120 130 140 150
ATATAGLLYG AYEVTRRYVI PNILPEAKSK LEGDKKEIDD QFSKIDTVLN
160 170 180 190 200
AIEAEQAEFR KKESETLKEL SDTIAELKQA LVQTTRSREK IEDEFRIVKL
210 220 230 240 250
EVVNMQNTID KFVSDNDGMQ ELNNIQKEME SLKSLMNNRM ESGNAQDNRL
260 270 280 290 300
FSISPNGIPG IDTIPSASEI LAKMGMQEES DKEKENGSDA NKDDNAVPAW
310 320 330 340
KKAREQTIDS NASIPEWQKN TAANEISVPD WQNGQVEDSI P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48618 Genomic DNA No translation available. Z72675 Genomic DNA Translation: CAA96864.1 AY558503 Genomic DNA Translation: AAS56829.1 BK006941 Genomic DNA Translation: DAA07959.1 |
PIRi | S60431 |
RefSeqi | NP_011362.3, NM_001181018.3 |
Genome annotation databases
EnsemblFungii | YGL153W_mRNA; YGL153W; YGL153W |
GeneIDi | 852724 |
KEGGi | sce:YGL153W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48618 Genomic DNA No translation available. Z72675 Genomic DNA Translation: CAA96864.1 AY558503 Genomic DNA Translation: AAS56829.1 BK006941 Genomic DNA Translation: DAA07959.1 |
PIRi | S60431 |
RefSeqi | NP_011362.3, NM_001181018.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N5Z | X-ray | 2.70 | P/Q | 83-96 | [»] | |
2V1R | X-ray | 2.10 | P/Q/R | 83-96 | [»] | |
AlphaFoldDBi | P53112 | |||||
SMRi | P53112 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33101, 211 interactors |
ComplexPortali | CPX-1904, Peroxisomal PEX13-PEX14-PEX17 docking complex |
DIPi | DIP-1749N |
ELMi | P53112 |
IntActi | P53112, 31 interactors |
MINTi | P53112 |
STRINGi | 4932.YGL153W |
Protein family/group databases
TCDBi | 3.A.20.1.5, the peroxisomal protein importer (ppi) family |
PTM databases
iPTMneti | P53112 |
Proteomic databases
MaxQBi | P53112 |
PaxDbi | P53112 |
PRIDEi | P53112 |
Genome annotation databases
EnsemblFungii | YGL153W_mRNA; YGL153W; YGL153W |
GeneIDi | 852724 |
KEGGi | sce:YGL153W |
Organism-specific databases
SGDi | S000003121, PEX14 |
VEuPathDBi | FungiDB:YGL153W |
Phylogenomic databases
eggNOGi | KOG2629, Eukaryota |
GeneTreei | ENSGT00390000015047 |
HOGENOMi | CLU_045718_0_1_1 |
InParanoidi | P53112 |
OMAi | LYGAYEV |
Enzyme and pathway databases
Reactomei | R-SCE-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-SCE-9033241, Peroxisomal protein import R-SCE-9603798, Class I peroxisomal membrane protein import |
Miscellaneous databases
EvolutionaryTracei | P53112 |
PROi | PR:P53112 |
RNActi | P53112, protein |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR025655, PEX14 IPR006785, Pex14_N IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR23058, PTHR23058, 1 hit |
Pfami | View protein in Pfam PF04695, Pex14_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PEX14_YEAST | |
Accessioni | P53112Primary (citable) accession number: P53112 Secondary accession number(s): D6VTZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families