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Entry version 140 (10 Feb 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Vitamin B6 transporter TPN1

Gene

TPN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.39.2.2, the nucleobase:cation symporter-1 (ncs1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitamin B6 transporter TPN1
Alternative name(s):
Transport of pyridoxine protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPN1
Ordered Locus Names:YGL186C
ORF Names:G1370
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003154, TPN1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGL186C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 122ExtracellularSequence analysis3
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 157CytoplasmicSequence analysisAdd BLAST14
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 198ExtracellularSequence analysisAdd BLAST20
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 221CytoplasmicSequence analysis2
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 274ExtracellularSequence analysisAdd BLAST32
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 302CytoplasmicSequence analysis7
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 362ExtracellularSequence analysisAdd BLAST39
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 394CytoplasmicSequence analysisAdd BLAST11
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 421ExtracellularSequence analysis6
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 519CytoplasmicSequence analysisAdd BLAST77
Transmembranei520 – 540HelicalSequence analysisAdd BLAST21
Topological domaini541 – 545ExtracellularSequence analysis5
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 579CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001979291 – 579Vitamin B6 transporter TPN1Add BLAST579

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53099

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53099

PRoteomics IDEntifications database

More...
PRIDEi
P53099

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53099

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33069, 60 interactors

Protein interaction database and analysis system

More...
IntActi
P53099, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YGL186C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53099, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR29, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176331

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026016_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P53099

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAYRWIP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012681, NCS1
IPR001248, Pur-cyt_permease
IPR026030, Pur-cyt_permease_Fcy2/21/22
IPR038271, Pur-cyt_permease_sf
IPR030175, Tpn1

The PANTHER Classification System

More...
PANTHERi
PTHR31806, PTHR31806, 1 hit
PTHR31806:SF8, PTHR31806:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002744, Pur-cyt_permease, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00800, ncs1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53099-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRDNMDTTK RKEDHTKHTT DVIEFYEEGT AASSLNIATE KANSSPSILR
60 70 80 90 100
RIINRAAWLS KKVDAMGVES TGIQRISPYE RGTSKKQFLH VAGLWLSATG
110 120 130 140 150
GLSSMSSFLL GPLLFGLSFR ESVASSLISV TIGCLIAAYC SIMGPQSGCR
160 170 180 190 200
QMVTARYLFG WWFVKLVALA SIIGVMGWSV VNSVVGGEML AAISNDKVPL
210 220 230 240 250
WVGIVIVTVC SFLVAIFGIK QVIKVETYLS VPVLTAFLLL YISSSDKYSF
260 270 280 290 300
VNAYVSKGNL DSSTRKGNWM SFFSLCYSIT ATWGSITADY YILFPEDTPY
310 320 330 340 350
IQIFCLTFFG TFLPTCFVGI LGLLLASVAM SYKPWSVEYD SHGMGGLLWA
360 370 380 390 400
GFQRWNGFGK FCVVVLVFSL VSNNIINTYS AAFSIQLSSV FCAKIPRWFW
410 420 430 440 450
SIVCTIICLV CALIGRNHFS TILGNFLPMI GYWISMYFIL LFEENLVFRR
460 470 480 490 500
FFLHLYTKEF PTVTGEINGP ELVGSSKEVE KDAVTNIHLL KRKHKVTKHR
510 520 530 540 550
YNWDKWEDYE VLTHGYAATF AFIVGVAGVV VGMAQAYWIG PIAAKFGEYG
560 570
GDVAMWLSMA FSGVVYPPCR YLELRKFGR
Length:579
Mass (Da):64,546
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26686199D1FD8522
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X91489 Genomic DNA Translation: CAA62788.1
Z72708 Genomic DNA Translation: CAA96898.1
BK006941 Genomic DNA Translation: DAA07929.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61131

NCBI Reference Sequences

More...
RefSeqi
NP_011329.1, NM_001181051.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL186C_mRNA; YGL186C; YGL186C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL186C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91489 Genomic DNA Translation: CAA62788.1
Z72708 Genomic DNA Translation: CAA96898.1
BK006941 Genomic DNA Translation: DAA07929.1
PIRiS61131
RefSeqiNP_011329.1, NM_001181051.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33069, 60 interactors
IntActiP53099, 1 interactor
STRINGi4932.YGL186C

Protein family/group databases

TCDBi2.A.39.2.2, the nucleobase:cation symporter-1 (ncs1) family

PTM databases

iPTMnetiP53099

Proteomic databases

MaxQBiP53099
PaxDbiP53099
PRIDEiP53099

Genome annotation databases

EnsemblFungiiYGL186C_mRNA; YGL186C; YGL186C
GeneIDi852689
KEGGisce:YGL186C

Organism-specific databases

SGDiS000003154, TPN1
VEuPathDBiFungiDB:YGL186C

Phylogenomic databases

eggNOGiENOG502QR29, Eukaryota
GeneTreeiENSGT00940000176331
HOGENOMiCLU_026016_2_1_1
InParanoidiP53099
OMAiFAYRWIP

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53099
RNActiP53099, protein

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681, NCS1
IPR001248, Pur-cyt_permease
IPR026030, Pur-cyt_permease_Fcy2/21/22
IPR038271, Pur-cyt_permease_sf
IPR030175, Tpn1
PANTHERiPTHR31806, PTHR31806, 1 hit
PTHR31806:SF8, PTHR31806:SF8, 1 hit
PfamiView protein in Pfam
PF02133, Transp_cyt_pur, 1 hit
PIRSFiPIRSF002744, Pur-cyt_permease, 1 hit
TIGRFAMsiTIGR00800, ncs1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPN1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53099
Secondary accession number(s): D6VTW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 10, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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