The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P53094 (MDS3_YEAST)
Protein
Negative regulator of sporulation MDS3
Gene
MDS3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Negatively regulates early sporulation-specific genes. Seems to exert its function by positively regulating the Ras/cAMP pathway. Required for growth under alkaline conditions. Acts synergetically with PMD1.
2 PublicationsMiscellaneous
Present with 396 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- meiotic cell cycle Source: UniProtKB-KW
- negative regulation of ascospore formation Source: SGD
- pseudohyphal growth Source: SGD
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
- TOR signaling Source: SGD
Keywordsi
Biological process | Meiosis, Sporulation |
Enzyme and pathway databases
Reactomei | R-SCE-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Negative regulator of sporulation MDS3Alternative name(s): MCK1 dosage suppressor 3 |
Gene namesi | Name:MDS3 Ordered Locus Names:YGL197W ORF Names:G1307 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003165, MDS3 |
VEuPathDBi | FungiDB:YGL197W |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119137 | 1 – 1487 | Negative regulator of sporulation MDS3Add BLAST | 1487 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 472 | PhosphoserineCombined sources | 1 | |
Modified residuei | 475 | PhosphoserineCombined sources | 1 | |
Modified residuei | 621 | PhosphoserineCombined sources | 1 | |
Modified residuei | 639 | PhosphoserineCombined sources | 1 | |
Modified residuei | 693 | PhosphoserineCombined sources | 1 | |
Modified residuei | 698 | PhosphoserineCombined sources | 1 | |
Modified residuei | 744 | PhosphoserineCombined sources | 1 | |
Modified residuei | 747 | PhosphoserineCombined sources | 1 | |
Modified residuei | 756 | PhosphoserineCombined sources | 1 | |
Modified residuei | 757 | PhosphoserineCombined sources | 1 | |
Modified residuei | 781 | PhosphoserineCombined sources | 1 | |
Modified residuei | 785 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 787 | PhosphoserineCombined sources | 1 | |
Modified residuei | 900 | PhosphoserineCombined sources | 1 | |
Modified residuei | 904 | PhosphoserineCombined sources | 1 | |
Modified residuei | 930 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1187 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53094 |
PaxDbi | P53094 |
PRIDEi | P53094 |
PTM databases
iPTMneti | P53094 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33060, 157 interactors |
DIPi | DIP-6381N |
IntActi | P53094, 25 interactors |
MINTi | P53094 |
STRINGi | 4932.YGL197W |
Miscellaneous databases
RNActi | P53094, protein |
Structurei
3D structure databases
AlphaFoldDBi | P53094 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 171 – 226 | Kelch 1Add BLAST | 56 | |
Repeati | 234 – 287 | Kelch 2Add BLAST | 54 | |
Repeati | 371 – 419 | Kelch 3Add BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 639 – 720 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 772 – 796 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 810 – 986 | DisorderedSequence analysisAdd BLAST | 177 | |
Regioni | 1134 – 1169 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1189 – 1214 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1263 – 1283 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1308 – 1341 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 639 – 678 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 695 – 720 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 781 – 796 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 810 – 855 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 868 – 882 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 883 – 932 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 943 – 986 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 1135 – 1169 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1189 – 1211 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QSQ9, Eukaryota |
GeneTreei | ENSGT00940000176594 |
HOGENOMi | CLU_252311_0_0_1 |
InParanoidi | P53094 |
OMAi | SGGMVFR |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR015915, Kelch-typ_b-propeller |
SUPFAMi | SSF117281, SSF117281, 1 hit |
i Sequence
Sequence statusi: Complete.
P53094-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLLQPSTCF CYPLKLPPLP LTSDSNEFDE CARKRLTLDY RTGSAVTLTR
60 70 80 90 100
SNIFVHGGLT IPLNLPVVNS MQLQKELILF FAKEKNNGSS FRNLNEWISK
110 120 130 140 150
ETFFLDLMSR TWYRVKTSFD QRTEELLKAE SSSAKADNDT NEIRTDIKKG
160 170 180 190 200
KSLESPLKER LFHSLCYLDG CLYIFGGLTV SPQSGYELIA TNELWKLDLN
210 220 230 240 250
TKKWSLLSDD PQIARRFNHT MHVKNENNDN RDTKLIIVGG LNNMDQPVKK
260 270 280 290 300
IDIYNISQNC WQSETIPKQP MEITTNVNGI PLALSKDQNF SILVENNEAN
310 320 330 340 350
VPALAFYMRS DQIDEYLGKD SSKIKENSPI VALPLLSESQ GIRMPSNPAL
360 370 380 390 400
PKKLLNVPYE LLAPTGDYFG FNIIIGGFHP NYQSSNFHCF IYDINSGKWS
410 420 430 440 450
RVATACPDCD INKHRFWRVF VWKSHHQTIL LGTKTDDYYS PSVQRFDHLS
460 470 480 490 500
TFGLPLVNIF NKTIQLPHHK ISASSLPIPI ENFAKHKDTP LKKVSFTSSA
510 520 530 540 550
TSQFENYIRY IAPPLEMSSI QSVFPPYAMV LGKDALEIYG KPLSDFEFIT
560 570 580 590 600
SEGDSIGIPC YLLRKRWGRY FDMLLSQSYT KVCADYETTD TQSTLIKFSP
610 620 630 640 650
HSSRNSSKAV RQEGRLSSSG SLDNYFEKNF PIFARTSVSE AQNTQPQVAN
660 670 680 690 700
ADAKAPNTPS TSDEPSSSSS SDLYSTPHYQ RNNDEEDDED PVSPKPVSKS
710 720 730 740 750
NSIYRPIRKT ESSSTTSSSN GMIFRVPFKE KAAVTSNTEA LLESNLSLQE
760 770 780 790 800
LSRRRSSLMS IPSGELLRSS ISEAEHQRRA SHPLTSSPLF EDSGTPCGKQ
810 820 830 840 850
LQQLQQHTIQ NPHNHLSPRR FSRSARSSIS YVSSSSDRRG NSISSRSTSD
860 870 880 890 900
SFGTPPVLGV LNVPLPPQTR EPNEPPPPCP AMSTGSNTRR SNTLTDYMHS
910 920 930 940 950
NKASPFSSRR SSHIGRRSST PETENAFSAT PRASLDGQML GKSLKEGSTS
960 970 980 990 1000
QYTQPRMNSF PKANETIQTP TSSNNEWSRQ SVTSNTDSFD SLQSNFALEL
1010 1020 1030 1040 1050
EPLLTPRSLY MPWPTSTVRA FAEFFYTGQV NSKWLLAPVA LDLLVMAKIY
1060 1070 1080 1090 1100
EIPLLYKLIL EVLYSILAKK EESLSLICTS LMETFRTKTL NSYKGDEEKT
1110 1120 1130 1140 1150
NTYLTSNDNY QELLKLKVSL ENIDNGYYDP DLLRKQSRAQ SSSTQESSGS
1160 1170 1180 1190 1200
ANGEKTATGA GSLETSSTNV PTVFAGGPRD SHNSVGSIGF PNSMNIQGSR
1210 1220 1230 1240 1250
RSTSGFSPRV KMKSSLSKEI DPKTFYEEYE PKEGKSFDDN DDQQTNIGSF
1260 1270 1280 1290 1300
NLHLFDMNYG SISSSSTNSI SSSDLEEKEE QEQLQDLLEI EREDSAEILD
1310 1320 1330 1340 1350
ARFRNKEDDK VTKDISNDKK RNYLPHEKNN LKAKEGKETR DVREEEEEFD
1360 1370 1380 1390 1400
FGLGMLSLNK IKREAKHVDK VDDSVDPLFK SSAFPQSPIR AYGSTTRTSS
1410 1420 1430 1440 1450
ASGKPFRDNR SFNAFSVLTL ENMASANALP PVDYVIKSIY RTTVLVNDIR
1460 1470 1480
LMVRCMDCIE LSKNLRALKK KTMEDISKLK GISKPSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 262 – 264 | QSE → HPK in CAA62947 (PubMed:9046087).Curated | 3 | |
Sequence conflicti | 262 – 264 | QSE → HPK in CAA96909 (PubMed:9169869).Curated | 3 | |
Sequence conflicti | 403 | A → R in CAA62947 (PubMed:9046087).Curated | 1 | |
Sequence conflicti | 403 | A → R in CAA96909 (PubMed:9169869).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91837 Genomic DNA Translation: CAA62947.1 Z72719 Genomic DNA Translation: CAA96909.1 BK006941 Genomic DNA Translation: DAA07917.2 |
PIRi | S62048 |
RefSeqi | NP_011318.2, NM_001181062.2 |
Genome annotation databases
EnsemblFungii | YGL197W_mRNA; YGL197W; YGL197W |
GeneIDi | 852678 |
KEGGi | sce:YGL197W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91837 Genomic DNA Translation: CAA62947.1 Z72719 Genomic DNA Translation: CAA96909.1 BK006941 Genomic DNA Translation: DAA07917.2 |
PIRi | S62048 |
RefSeqi | NP_011318.2, NM_001181062.2 |
3D structure databases
AlphaFoldDBi | P53094 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33060, 157 interactors |
DIPi | DIP-6381N |
IntActi | P53094, 25 interactors |
MINTi | P53094 |
STRINGi | 4932.YGL197W |
PTM databases
iPTMneti | P53094 |
Proteomic databases
MaxQBi | P53094 |
PaxDbi | P53094 |
PRIDEi | P53094 |
Genome annotation databases
EnsemblFungii | YGL197W_mRNA; YGL197W; YGL197W |
GeneIDi | 852678 |
KEGGi | sce:YGL197W |
Organism-specific databases
SGDi | S000003165, MDS3 |
VEuPathDBi | FungiDB:YGL197W |
Phylogenomic databases
eggNOGi | ENOG502QSQ9, Eukaryota |
GeneTreei | ENSGT00940000176594 |
HOGENOMi | CLU_252311_0_0_1 |
InParanoidi | P53094 |
OMAi | SGGMVFR |
Enzyme and pathway databases
Reactomei | R-SCE-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P53094 |
RNActi | P53094, protein |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR015915, Kelch-typ_b-propeller |
SUPFAMi | SSF117281, SSF117281, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDS3_YEAST | |
Accessioni | P53094Primary (citable) accession number: P53094 Secondary accession number(s): D6VTV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 21, 2011 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names