UniProtKB - P53052 (CPDB_YEREN)
Protein
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
Gene
cpdB
Organism
Yersinia enterocolitica
Status
Functioni
This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate (By similarity).By similarity
Catalytic activityi
Cofactori
a divalent metal cationBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 36 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 38 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 81 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 81 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 121 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 230 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 262 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 264 | Divalent metal cation 1By similarity | 1 | |
Binding sitei | 445 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Source: UniProtKB-EC
- 3'-nucleotidase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- nucleotide binding Source: UniProtKB-KW
GO - Biological processi
- nucleotide catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Multifunctional enzyme |
Ligand | Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.16, 6741 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cpdB |
Organismi | Yersinia enterocolitica |
Taxonomic identifieri | 630 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Yersinia |
Subcellular locationi
GO - Cellular componenti
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000000038 | 25 – 652 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidaseAdd BLAST | 628 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 549 – 555 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Belongs to the 5'-nucleotidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG0737, Bacteria |
Family and domain databases
CDDi | cd07410, MPP_CpdB_N, 1 hit |
Gene3Di | 3.60.21.10, 1 hit 3.90.780.10, 1 hit |
InterProi | View protein in InterPro IPR008334, 5'-Nucleotdase_C IPR036907, 5'-Nucleotdase_C_sf IPR006146, 5'-Nucleotdase_CS IPR006179, 5_nucleotidase/apyrase IPR004843, Calcineurin-like_PHP_ApaH IPR041827, CpdB_N IPR006294, Cyc_nuc_PDE_nucleotidase IPR029052, Metallo-depent_PP-like |
PANTHERi | PTHR11575, PTHR11575, 1 hit |
Pfami | View protein in Pfam PF02872, 5_nucleotid_C, 1 hit PF00149, Metallophos, 1 hit |
PRINTSi | PR01607, APYRASEFAMLY |
SUPFAMi | SSF55816, SSF55816, 1 hit |
TIGRFAMsi | TIGR01390, CycNucDiestase, 1 hit |
PROSITEi | View protein in PROSITE PS00785, 5_NUCLEOTIDASE_1, 1 hit PS00786, 5_NUCLEOTIDASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P53052-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFKRPLTLSL LASLIALTTS TAQAATVDLR VLETTDLHSN MMDFDYYKDK
60 70 80 90 100
PTEKFGLVRT ASLIEAARQQ ATNSVLVDNG DLIQGSPLGD YMAAKGLKAG
110 120 130 140 150
EIHPVYKAMN TLDYAVGNIG NHEFNYGLDY LKKSLAGAKF PYVNANVIDV
160 170 180 190 200
KTGKPLFQPY LIVDTPVKDR DGKNHNLRIG YIGFGPPQVM IWDKANLTGK
210 220 230 240 250
VTVDDITETA KKWVPEMRKQ GANLVVAIPH SGLSSDPYKT MAENSVYYLS
260 270 280 290 300
QVPGIDAIMF GHAHAVFPSK DFATIKGADI AQGTLNGIPA VMPGQWGDHL
310 320 330 340 350
GVVDFVLNND QGQWQVTQAK AEARPIFDKA TQKSLAAENA NLMKVLAADH
360 370 380 390 400
QGTRDFVSQP IGTASDNMYS YLSLIQDDPT VQIVNNAQRA YTEHFIQGDP
410 420 430 440 450
DLADLPVLSA AAPFKAGGRK NDPASFVEVE KGELTFRNAA DLYLYPNTLV
460 470 480 490 500
VVKASGADVK QWLECSAAQF NQIDVNSSKP QSLINWDSFR TYNFDVIDGV
510 520 530 540 550
NYEIDVSQPA RYDGECALIN DKAERIKNLT FNGKPIDPQA TFLIGTNNYR
560 570 580 590 600
AYSGKFAGTG DSHIAFASPD ENRAVLSAYI SAETKKHGQV TPQADNNWRL
610 620 630 640 650
ATLNSQQPLD IRFETSPSTK AAEFIKQKAQ YPMKAMGTDE IGFAVFKIDL
QK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85742 Genomic DNA Translation: CAA59745.1 |
PIRi | S52695 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85742 Genomic DNA Translation: CAA59745.1 |
PIRi | S52695 |
3D structure databases
SMRi | P53052 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 1443113.LC20_04778 |
Phylogenomic databases
eggNOGi | COG0737, Bacteria |
Enzyme and pathway databases
BRENDAi | 3.1.4.16, 6741 |
Family and domain databases
CDDi | cd07410, MPP_CpdB_N, 1 hit |
Gene3Di | 3.60.21.10, 1 hit 3.90.780.10, 1 hit |
InterProi | View protein in InterPro IPR008334, 5'-Nucleotdase_C IPR036907, 5'-Nucleotdase_C_sf IPR006146, 5'-Nucleotdase_CS IPR006179, 5_nucleotidase/apyrase IPR004843, Calcineurin-like_PHP_ApaH IPR041827, CpdB_N IPR006294, Cyc_nuc_PDE_nucleotidase IPR029052, Metallo-depent_PP-like |
PANTHERi | PTHR11575, PTHR11575, 1 hit |
Pfami | View protein in Pfam PF02872, 5_nucleotid_C, 1 hit PF00149, Metallophos, 1 hit |
PRINTSi | PR01607, APYRASEFAMLY |
SUPFAMi | SSF55816, SSF55816, 1 hit |
TIGRFAMsi | TIGR01390, CycNucDiestase, 1 hit |
PROSITEi | View protein in PROSITE PS00785, 5_NUCLEOTIDASE_1, 1 hit PS00786, 5_NUCLEOTIDASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CPDB_YEREN | |
Accessioni | P53052Primary (citable) accession number: P53052 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | August 12, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |