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UniProtKB - P53048 (MAL11_YEAST)
Protein
General alpha-glucoside permease
Gene
MAL11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system).
3 PublicationsGO - Molecular functioni
- alpha-glucoside:proton symporter activity Source: SGD
- carbohydrate:proton symporter activity Source: GO_Central
- maltose:proton symporter activity Source: SGD
- trehalose transmembrane transporter activity Source: SGD
GO - Biological processi
- alpha-glucoside transport Source: UniProtKB
- carbohydrate transport Source: GO_Central
- disaccharide catabolic process Source: SGD
- maltose metabolic process Source: UniProtKB-KW
- maltose transport Source: SGD
- trehalose transport Source: SGD
Keywordsi
Biological process | Maltose metabolism, Sugar transport, Symport, Transport |
Protein family/group databases
TCDBi | 2.A.1.1.11, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: General alpha-glucoside permeaseAlternative name(s): Maltose permease MAL11 Maltose transport protein MAL11 |
Gene namesi | Name:MAL11 Synonyms:AGT1, MAL1T, MTP1 Ordered Locus Names:YGR289C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003521, MAL11 |
VEuPathDBi | FungiDB:YGR289C |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 115 | CytoplasmicSequence analysisAdd BLAST | 115 | |
Transmembranei | 116 – 136 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 137 – 150 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 151 – 171 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 172 – 186 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 187 – 207 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 208 | ExtracellularSequence analysis | 1 | |
Transmembranei | 209 – 229 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 242 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 243 – 263 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 264 – 278 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 279 – 299 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 300 – 370 | CytoplasmicSequence analysisAdd BLAST | 71 | |
Transmembranei | 371 – 391 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 392 – 404 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 405 – 425 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 433 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 434 – 454 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 455 – 466 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 467 – 487 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 488 – 499 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 500 – 520 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 521 – 532 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 533 – 553 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 554 – 616 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050425 | 1 – 616 | General alpha-glucoside permeaseAdd BLAST | 616 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 523 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P53048 |
Expressioni
Inductioni
Interactioni
Protein-protein interaction databases
BioGRIDi | 33539, 113 interactors |
DIPi | DIP-5567N |
IntActi | P53048, 2 interactors |
MINTi | P53048 |
STRINGi | 4932.YGR289C |
Miscellaneous databases
RNActi | P53048, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 40 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 587 – 616 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 594 – 609 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000176341 |
HOGENOMi | CLU_001265_11_5_1 |
InParanoidi | P53048 |
OMAi | NNTLMPR |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P53048-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF
60 70 80 90 100
ELDHLEFTTN SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL
110 120 130 140 150
LKYPKAALWS ILVSTTLVME GYDTALLSAL YALPVFQRKF GTLNGEGSYE
160 170 180 190 200
ITSQWQIGLN MCVLCGEMIG LQITTYMVEF MGNRYTMITA LGLLTAYIFI
210 220 230 240 250
LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL RYYMTSYSNI
260 270 280 290 300
CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE
310 320 330 340 350
SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL
360 370 380 390 400
ASKSGSFFNC FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA
410 420 430 440 450
TDKAFTFSLI QYCLGLAGTL CSWVISGRVG RWTILTYGLA FQMVCLFIIG
460 470 480 490 500
GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG AVVYCIVAEI PSAELRTKTI
510 520 530 540 550
VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF TAVTLAWVII
560 570 580 590 600
DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS
610
QSSSIKQREL NAADKC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 396 – 398 | RAG → KKQV in AAB07600 (PubMed:8594329).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L47346 Genomic DNA Translation: AAB07600.1 Z73074 Genomic DNA Translation: CAA97322.1 BK006941 Genomic DNA Translation: DAA08377.1 |
PIRi | S64624 |
RefSeqi | NP_011805.3, NM_001181418.3 |
Genome annotation databases
EnsemblFungii | YGR289C_mRNA; YGR289C; YGR289C |
GeneIDi | 853207 |
KEGGi | sce:YGR289C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L47346 Genomic DNA Translation: AAB07600.1 Z73074 Genomic DNA Translation: CAA97322.1 BK006941 Genomic DNA Translation: DAA08377.1 |
PIRi | S64624 |
RefSeqi | NP_011805.3, NM_001181418.3 |
3D structure databases
SMRi | P53048 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33539, 113 interactors |
DIPi | DIP-5567N |
IntActi | P53048, 2 interactors |
MINTi | P53048 |
STRINGi | 4932.YGR289C |
Protein family/group databases
TCDBi | 2.A.1.1.11, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P53048 |
Genome annotation databases
EnsemblFungii | YGR289C_mRNA; YGR289C; YGR289C |
GeneIDi | 853207 |
KEGGi | sce:YGR289C |
Organism-specific databases
SGDi | S000003521, MAL11 |
VEuPathDBi | FungiDB:YGR289C |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000176341 |
HOGENOMi | CLU_001265_11_5_1 |
InParanoidi | P53048 |
OMAi | NNTLMPR |
Miscellaneous databases
PROi | PR:P53048 |
RNActi | P53048, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MAL11_YEAST | |
Accessioni | P53048Primary (citable) accession number: P53048 Secondary accession number(s): D6VV66 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families