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Entry version 157 (12 Aug 2020)
Sequence version 2 (21 Sep 2011)
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Protein

RHO1 GDP-GTP exchange protein 1

Gene

ROM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30783-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RHO1 GDP-GTP exchange protein 1
Alternative name(s):
Protein kinase C suppressor SKC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROM1
Synonyms:SKC1
Ordered Locus Names:YGR070W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YGR070W

Saccharomyces Genome Database

More...
SGDi
S000003302, ROM1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809681 – 1155RHO1 GDP-GTP exchange protein 1Add BLAST1155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei180PhosphothreonineCombined sources1
Modified residuei433PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53046

PRoteomics IDEntifications database

More...
PRIDEi
P53046

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53046

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33313, 60 interactors

Database of interacting proteins

More...
DIPi
DIP-6270N

Protein interaction database and analysis system

More...
IntActi
P53046, 2 interactors

Molecular INTeraction database

More...
MINTi
P53046

STRING: functional protein association networks

More...
STRINGi
4932.YGR070W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53046, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53046

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini464 – 651DHPROSITE-ProRule annotationAdd BLAST188
Domaini842 – 1137CNHPROSITE-ProRule annotationAdd BLAST296

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4305, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001251_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53046

KEGG Orthology (KO)

More...
KOi
K19842

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMINWEG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180, CNH_dom
IPR035899, DBL_dom_sf
IPR000591, DEP_dom
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR041675, PH_5
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF00610, DEP, 1 hit
PF15405, PH_5, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036, CNH, 1 hit
SM00049, DEP, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219, CNH, 1 hit
PS50010, DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53046-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSNELDLRN KYFYEIFGKK RKSDTSTPTQ LFSGSKVQTN INEISITNDE
60 70 80 90 100
DEDSTEDENK ASLKDYTLGH DTGARYRIAP DCSSHQLKAS PVLHISTNLN
110 120 130 140 150
SSPQSFTGDQ ISPTNKKISI NDSTRQDKGN SCTTTSSPSQ KRSNVLLPHV
160 170 180 190 200
RKHSSPSLLS FSKNSGSHMG DPNQLSTPPT PKSAGHTMEL HSSFNGKHSS
210 220 230 240 250
SSTSSLFALE SLKTQNRRSS NSSNHSSQYR RHTNQHQRHH SRSKSSPVSL
260 270 280 290 300
TEISMIKGTP LVYPALLSLI AIKFKQTIKL STHKKMGLLY RDSFTGKQAI
310 320 330 340 350
DTLCLIIGSL DRNLGMLIGK SLEAQKLFHD VLYDHGVRDS VLEIYELSSE
360 370 380 390 400
SIFMAHQSQS STSIANTFSS SSSSVNSLRT KTEIYGVFVP LTHCYSSTCS
410 420 430 440 450
LEKLCYSISC PNRLQQQANL HLKLGGGLKR NISLALDKED DERISWTNSV
460 470 480 490 500
PKSVWESLSK QQIKRQEAIY ELFTTEKKFV KSLEIIRDTF MKKLLETNII
510 520 530 540 550
PSDVRINFVK HVFAHINEIY SVNREFLKAL AQRQSLSPIC PGIADIFLQY
560 570 580 590 600
LPFFDPFLSY IASRPYAKYL IETQRSVNPN FARFDDEVSN SSLRHGIDSF
610 620 630 640 650
LSQGVSRPGR YSLLVREIIH FSDPVTDKDD LQMLMKVQDL LKDLMKRIDR
660 670 680 690 700
ASGAAQDRYD VKVLKQKILF KNEYVNLGLN NEKRKIKHEG LLSRKDVNKT
710 720 730 740 750
DASFSGDIQF YLLDNMLLFL KSKAVNKWHQ HTVFQRPIPL PLLFICPAED
760 770 780 790 800
MPPIKRYVTE NPNCSAGVLL PQYQTSNPKN AIVFAYYGTK QQYQVTLYAP
810 820 830 840 850
QPAGLQTLIE KVKQEQKRLL DETKHITFKQ MVGQFFHSYI NTNRVNDVLI
860 870 880 890 900
CHAGKILLVA TNMGLFVLNY ATSINQKPVH LLHKISISQI SVLEEYKVMI
910 920 930 940 950
LLIDKKLYGC PLDVIDDAEN ADFLFRKNSK VLFKYVAMFK DGFCNGKRII
960 970 980 990 1000
MIAHHFLHAV QLLIVNPLIF DFNSGNFKKN LKAGLVDFSV DSEPLSFSFL
1010 1020 1030 1040 1050
ENKICIGCKK NIKILNVPEV CDKNGFKMRE LLNLHDNKVL ANMYKETFKV
1060 1070 1080 1090 1100
VSMFPIKNST FACFPELCFF LNKQGKREET KGCFHWEGEP EQFACSYPYI
1110 1120 1130 1140 1150
VAINSNFIEI RHIENGELVR CVLGNKIRML KSYAKKILYC YEDPQGFEII

ELLNF
Length:1,155
Mass (Da):131,420
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7289DE418BA7A64
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214T → P in AAA99813 (Ref. 1) Curated1
Sequence conflicti214T → P in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti250L → V in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti279 – 281KLS → QLG in BAA11827 (PubMed:8641285).Curated3
Sequence conflicti385Y → N in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti515H → Y in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti557F → L in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti844R → C in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti852H → S in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti897K → N in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti959A → T in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti960V → A in CAA97072 (PubMed:9169869).Curated1
Sequence conflicti961Q → K in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti1037N → D in BAA11827 (PubMed:8641285).Curated1
Sequence conflicti1151E → G in BAA11827 (PubMed:8641285).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U55000 Genomic DNA Translation: AAA99813.1
Z72855 Genomic DNA Translation: CAA97072.1
D83171 Genomic DNA Translation: BAA11827.1
BK006941 Genomic DNA Translation: DAA08164.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S64365

NCBI Reference Sequences

More...
RefSeqi
NP_011584.2, NM_001181199.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGR070W_mRNA; YGR070W; YGR070W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGR070W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55000 Genomic DNA Translation: AAA99813.1
Z72855 Genomic DNA Translation: CAA97072.1
D83171 Genomic DNA Translation: BAA11827.1
BK006941 Genomic DNA Translation: DAA08164.2
PIRiS64365
RefSeqiNP_011584.2, NM_001181199.2

3D structure databases

SMRiP53046
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33313, 60 interactors
DIPiDIP-6270N
IntActiP53046, 2 interactors
MINTiP53046
STRINGi4932.YGR070W

PTM databases

iPTMnetiP53046

Proteomic databases

PaxDbiP53046
PRIDEiP53046

Genome annotation databases

EnsemblFungiiYGR070W_mRNA; YGR070W; YGR070W
GeneIDi852961
KEGGisce:YGR070W

Organism-specific databases

EuPathDBiFungiDB:YGR070W
SGDiS000003302, ROM1

Phylogenomic databases

eggNOGiKOG4305, Eukaryota
GeneTreeiENSGT00940000176600
HOGENOMiCLU_001251_0_0_1
InParanoidiP53046
KOiK19842
OMAiWMINWEG

Enzyme and pathway databases

BioCyciYEAST:G3O-30783-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53046
RNActiP53046, protein

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001180, CNH_dom
IPR035899, DBL_dom_sf
IPR000591, DEP_dom
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR041675, PH_5
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF00610, DEP, 1 hit
PF15405, PH_5, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SM00049, DEP, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS50010, DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROM1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53046
Secondary accession number(s): Q92326
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 21, 2011
Last modified: August 12, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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