UniProtKB - P53041 (PPP5_HUMAN)
Serine/threonine-protein phosphatase 5
PPP5C
Functioni
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359).
Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359).
Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835).
Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700).
Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity).
Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity).
Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549).
May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750).
Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861).
Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity).
Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359).
By similarity16 PublicationsCatalytic activityi
- EC:3.1.3.167 PublicationsThis reaction proceeds in the forward7 Publications direction.
- EC:3.1.3.166 PublicationsThis reaction proceeds in the forward6 Publications direction.
Cofactori
Activity regulationi
Kineticsi
- KM=1.847 µM for CSNK1E (at 30 degrees Celsius)2 Publications
- KM=13.2 µM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius)2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 242 | Manganese 1Combined sources3 Publications | 1 | |
Metal bindingi | 244 | Manganese 1; via tele nitrogenCombined sources3 Publications | 1 | |
Binding sitei | 244 | Substrate1 Publication | 1 | |
Metal bindingi | 271 | Manganese 1Combined sources3 Publications | 1 | |
Metal bindingi | 271 | Manganese 2Combined sources3 Publications | 1 | |
Binding sitei | 275 | Substrate1 Publication | 1 | |
Metal bindingi | 303 | Manganese 2Combined sources3 Publications | 1 | |
Active sitei | 304 | Proton donor/acceptor1 Publication | 1 | |
Metal bindingi | 352 | Manganese 2; via tele nitrogenCombined sources3 Publications | 1 | |
Binding sitei | 400 | Substrate1 Publication | 1 | |
Metal bindingi | 427 | Manganese 2; via pros nitrogenCombined sources3 Publications | 1 | |
Binding sitei | 427 | Substrate1 Publication | 1 |
GO - Molecular functioni
- ADP binding Source: MGI
- ATP binding Source: MGI
- Hsp90 protein binding Source: CAFA
- identical protein binding Source: IntAct
- lipid binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- phosphatase activity Source: ARUK-UCL
- phosphoprotein phosphatase activity Source: UniProtKB
- protein serine/threonine phosphatase activity Source: UniProtKB
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
- RNA binding Source: Ensembl
- tau protein binding Source: ARUK-UCL
GO - Biological processi
- double-strand break repair Source: Reactome
- MAPK cascade Source: Reactome
- mitotic cell cycle Source: ProtInc
- peptidyl-serine dephosphorylation Source: UniProtKB
- peptidyl-threonine dephosphorylation Source: ARUK-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- protein dephosphorylation Source: ProtInc
- response to arachidonic acid Source: ARUK-UCL
- response to lead ion Source: ARUK-UCL
- response to morphine Source: Ensembl
- transcription, DNA-templated Source: ProtInc
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | DNA damage, DNA repair |
Ligand | Lipid-binding, Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 |
PathwayCommonsi | P53041 |
Reactomei | R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-8939211, ESR-mediated signaling |
SABIO-RKi | P53041 |
SignaLinki | P53041 |
SIGNORi | P53041 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 5 (EC:3.1.3.167 Publications)Short name: PP5 Alternative name(s): Protein phosphatase T Short name: PP-T Short name: PPT |
Gene namesi | Name:PPP5C Synonyms:PPP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9322, PPP5C |
MIMi | 600658, gene |
neXtProti | NX_P53041 |
VEuPathDBi | HostDB:ENSG00000011485 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Nucleus
- Nucleus 1 Publication
Note: Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726).2 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- chaperone complex Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Amyloid, Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 32 | K → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. 1 Publication | 1 | |
Mutagenesisi | 74 | R → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. 1 Publication | 1 | |
Mutagenesisi | 83 | G → N: No effect on interaction with HSP90AA1. 1 Publication | 1 | |
Mutagenesisi | 93 | K → E: Decreases interaction with RAC1 and translocation to the membrane in presence of active RAC1. 1 Publication | 1 | |
Mutagenesisi | 97 | K → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. Loss of interaction with RAF1. 2 Publications | 1 | |
Mutagenesisi | 101 | R → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. 1 Publication | 1 | |
Mutagenesisi | 304 | H → Q: Catalytically inactive; no effect on interaction with CRY2 but increases the stability of the interaction with CSNK1E. No effect on RAF1 phosphorylation. 3 Publications | 1 |
Keywords - Diseasei
Alzheimer disease, Amyloidosis, NeurodegenerationOrganism-specific databases
DisGeNETi | 5536 |
OpenTargetsi | ENSG00000011485 |
PharmGKBi | PA33686 |
Miscellaneous databases
Pharosi | P53041, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3425389 |
DrugBanki | DB00171, ATP |
Genetic variation databases
BioMutai | PPP5C |
DMDMi | 1709744 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000058894 | 2 – 499 | Serine/threonine-protein phosphatase 5Add BLAST | 498 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
AcetylationProteomic databases
EPDi | P53041 |
jPOSTi | P53041 |
MassIVEi | P53041 |
MaxQBi | P53041 |
PaxDbi | P53041 |
PeptideAtlasi | P53041 |
PRIDEi | P53041 |
ProteomicsDBi | 56568 |
PTM databases
DEPODi | PPP5C |
GlyGeni | P53041, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P53041 |
MetOSitei | P53041 |
PhosphoSitePlusi | P53041 |
SwissPalmi | P53041 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000011485, Expressed in frontal cortex and 177 other tissues |
ExpressionAtlasi | P53041, baseline and differential |
Genevisiblei | P53041, HS |
Organism-specific databases
HPAi | ENSG00000011485, Low tissue specificity |
Interactioni
Subunit structurei
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155).
Part of a complex with HSP90/HSP90AA1 and steroid receptors (By similarity).
Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226). Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid (PubMed:15383005).
Interacts with CPNE1 (via VWFA domain) (By similarity).
Interacts with CDC16, CDC27 (PubMed:9405394).
Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5 (PubMed:23102700).
Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity (PubMed:14871926).
Interacts with RAD17; reduced by DNA damage (PubMed:14871926).
Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities (By similarity).
Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions (PubMed:22399290).
Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels (PubMed:22781750).
Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 down-regulates the phosphatase activity on CSNK1E (PubMed:16790549).
Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane (PubMed:19948726).
Interacts with FLCN (PubMed:27353360).
By similarity12 PublicationsBinary interactionsi
P53041
GO - Molecular functioni
- Hsp90 protein binding Source: CAFA
- identical protein binding Source: IntAct
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 111528, 140 interactors |
DIPi | DIP-29043N |
IntActi | P53041, 70 interactors |
MINTi | P53041 |
STRINGi | 9606.ENSP00000012443 |
Chemistry databases
BindingDBi | P53041 |
Miscellaneous databases
RNActi | P53041, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P53041 |
SMRi | P53041 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53041 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 28 – 61 | TPR 1Add BLAST | 34 | |
Repeati | 62 – 95 | TPR 2Add BLAST | 34 | |
Repeati | 96 – 129 | TPR 3Add BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 184 – 499 | CatalyticAdd BLAST | 316 | |
Regioni | 303 – 304 | Substrate binding1 Publication | 2 | |
Regioni | 495 – 499 | Required for autoinhibitionBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 23 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0376, Eukaryota |
GeneTreei | ENSGT00940000158785 |
InParanoidi | P53041 |
OMAi | NHFFMSR |
OrthoDBi | 671536at2759 |
PhylomeDBi | P53041 |
TreeFami | TF105562 |
Family and domain databases
CDDi | cd07417, MPP_PP5_C, 1 hit |
DisProti | DP00365 |
Gene3Di | 1.25.40.10, 1 hit 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041753, PP5_C IPR013235, PPP_dom IPR006186, Ser/Thr-sp_prot-phosphatase IPR011236, Ser/Thr_PPase_5 IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
PANTHERi | PTHR45668:SF5, PTHR45668:SF5, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit PF08321, PPP5, 1 hit PF00515, TPR_1, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit SSF56300, SSF56300, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit PS50005, TPR, 3 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF
60 70 80 90 100
YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY
110 120 130 140 150
RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER
160 170 180 190 200
AIAGDEHKRS VVDSLDIESM TIEDEYSGPK LEDGKVTISF MKELMQWYKD
210 220 230 240 250
QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC GDTHGQFYDL
260 270 280 290 300
LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL
310 320 330 340 350
RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI
360 370 380 390 400
MHGGLFSEDG VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR
410 420 430 440 450
GVSCQFGPDV TKAFLEENNL DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN
460 470 480 490
YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP HPNVKPMAYA NTLLQLGMM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YDU8 | H0YDU8_HUMAN | Serine/threonine-protein phosphatas... | PPP5C | 485 | Annotation score: | ||
A8MU39 | A8MU39_HUMAN | Serine/threonine-protein phosphatas... | PPP5C | 371 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 403 | S → T in AAB60384 (PubMed:8666404).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007275 mRNA Translation: AAP35939.1 X89416 mRNA Translation: CAA61595.1 U25174 mRNA Translation: AAB60384.1 AC007193 Genomic DNA Translation: AAD22669.1 CH471126 Genomic DNA Translation: EAW57416.1 BC001970 mRNA Translation: AAH01970.1 X92121 mRNA Translation: CAA63089.1 |
CCDSi | CCDS12684.1 |
PIRi | S52570 |
RefSeqi | NP_006238.1, NM_006247.3 |
Genome annotation databases
Ensembli | ENST00000012443; ENSP00000012443; ENSG00000011485 |
GeneIDi | 5536 |
KEGGi | hsa:5536 |
MANE-Selecti | ENST00000012443.9; ENSP00000012443.4; NM_006247.4; NP_006238.1 |
UCSCi | uc002pem.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007275 mRNA Translation: AAP35939.1 X89416 mRNA Translation: CAA61595.1 U25174 mRNA Translation: AAB60384.1 AC007193 Genomic DNA Translation: AAD22669.1 CH471126 Genomic DNA Translation: EAW57416.1 BC001970 mRNA Translation: AAH01970.1 X92121 mRNA Translation: CAA63089.1 |
CCDSi | CCDS12684.1 |
PIRi | S52570 |
RefSeqi | NP_006238.1, NM_006247.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A17 | X-ray | 2.45 | A | 16-181 | [»] | |
1S95 | X-ray | 1.60 | A/B | 169-499 | [»] | |
1WAO | X-ray | 2.90 | 1/2/3/4 | 23-499 | [»] | |
2BUG | NMR | - | A | 19-147 | [»] | |
3H60 | X-ray | 2.00 | A/B | 176-490 | [»] | |
3H61 | X-ray | 1.45 | A/D | 176-490 | [»] | |
3H62 | X-ray | 1.40 | B/C | 176-490 | [»] | |
3H63 | X-ray | 1.30 | A/C | 176-490 | [»] | |
3H64 | X-ray | 1.90 | A/D | 176-490 | [»] | |
3H66 | X-ray | 2.59 | A/B | 176-490 | [»] | |
3H67 | X-ray | 1.65 | A/D | 176-490 | [»] | |
3H68 | X-ray | 1.50 | A/D | 176-490 | [»] | |
3H69 | X-ray | 2.10 | A/D | 176-490 | [»] | |
4ZVZ | X-ray | 2.00 | A/B/C/D | 169-499 | [»] | |
4ZX2 | X-ray | 1.23 | A | 169-499 | [»] | |
5HPE | X-ray | 2.27 | A | 175-499 | [»] | |
5UI1 | X-ray | 1.96 | A/B/C/D | 169-499 | [»] | |
5WG8 | X-ray | 1.65 | A | 169-499 | [»] | |
BMRBi | P53041 | |||||
SMRi | P53041 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111528, 140 interactors |
DIPi | DIP-29043N |
IntActi | P53041, 70 interactors |
MINTi | P53041 |
STRINGi | 9606.ENSP00000012443 |
Chemistry databases
BindingDBi | P53041 |
ChEMBLi | CHEMBL3425389 |
DrugBanki | DB00171, ATP |
PTM databases
DEPODi | PPP5C |
GlyGeni | P53041, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P53041 |
MetOSitei | P53041 |
PhosphoSitePlusi | P53041 |
SwissPalmi | P53041 |
Genetic variation databases
BioMutai | PPP5C |
DMDMi | 1709744 |
Proteomic databases
EPDi | P53041 |
jPOSTi | P53041 |
MassIVEi | P53041 |
MaxQBi | P53041 |
PaxDbi | P53041 |
PeptideAtlasi | P53041 |
PRIDEi | P53041 |
ProteomicsDBi | 56568 |
Protocols and materials databases
Antibodypediai | 31446, 677 antibodies from 32 providers |
DNASUi | 5536 |
Genome annotation databases
Ensembli | ENST00000012443; ENSP00000012443; ENSG00000011485 |
GeneIDi | 5536 |
KEGGi | hsa:5536 |
MANE-Selecti | ENST00000012443.9; ENSP00000012443.4; NM_006247.4; NP_006238.1 |
UCSCi | uc002pem.4, human |
Organism-specific databases
CTDi | 5536 |
DisGeNETi | 5536 |
GeneCardsi | PPP5C |
HGNCi | HGNC:9322, PPP5C |
HPAi | ENSG00000011485, Low tissue specificity |
MIMi | 600658, gene |
neXtProti | NX_P53041 |
OpenTargetsi | ENSG00000011485 |
PharmGKBi | PA33686 |
VEuPathDBi | HostDB:ENSG00000011485 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0376, Eukaryota |
GeneTreei | ENSGT00940000158785 |
InParanoidi | P53041 |
OMAi | NHFFMSR |
OrthoDBi | 671536at2759 |
PhylomeDBi | P53041 |
TreeFami | TF105562 |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 |
PathwayCommonsi | P53041 |
Reactomei | R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-8939211, ESR-mediated signaling |
SABIO-RKi | P53041 |
SignaLinki | P53041 |
SIGNORi | P53041 |
Miscellaneous databases
BioGRID-ORCSi | 5536, 19 hits in 1052 CRISPR screens |
ChiTaRSi | PPP5C, human |
EvolutionaryTracei | P53041 |
GeneWikii | PPP5C |
GenomeRNAii | 5536 |
Pharosi | P53041, Tbio |
PROi | PR:P53041 |
RNActi | P53041, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011485, Expressed in frontal cortex and 177 other tissues |
ExpressionAtlasi | P53041, baseline and differential |
Genevisiblei | P53041, HS |
Family and domain databases
CDDi | cd07417, MPP_PP5_C, 1 hit |
DisProti | DP00365 |
Gene3Di | 1.25.40.10, 1 hit 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041753, PP5_C IPR013235, PPP_dom IPR006186, Ser/Thr-sp_prot-phosphatase IPR011236, Ser/Thr_PPase_5 IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
PANTHERi | PTHR45668:SF5, PTHR45668:SF5, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit PF08321, PPP5, 1 hit PF00515, TPR_1, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit SSF56300, SSF56300, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit PS50005, TPR, 3 hits PS50293, TPR_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PPP5_HUMAN | |
Accessioni | P53041Primary (citable) accession number: P53041 Secondary accession number(s): Q16722, Q53XV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 227 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families