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UniProtKB - P53041 (PPP5_HUMAN)

Entry version 224 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Serine/threonine-protein phosphatase 5

Gene

PPP5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359).By similarity16 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+, Mn2+Note: Binds 2 Mg2+ or Mn2+ cations per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.6 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.847 µM for CSNK1E (at 30 degrees Celsius)2 Publications
  2. KM=13.2 µM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius)2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi242Manganese 1Combined sources3 Publications1
    Metal bindingi244Manganese 1; via tele nitrogenCombined sources3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei244Substrate1 Publication1
    Metal bindingi271Manganese 1Combined sources3 Publications1
    Metal bindingi271Manganese 2Combined sources3 Publications1
    Binding sitei275Substrate1 Publication1
    Metal bindingi303Manganese 2Combined sources3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei304Proton donor/acceptor1 Publication1
    Metal bindingi352Manganese 2; via tele nitrogenCombined sources3 Publications1
    Binding sitei400Substrate1 Publication1
    Metal bindingi427Manganese 2; via pros nitrogenCombined sources3 Publications1
    Binding sitei427Substrate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protein phosphatase
    Biological processDNA damage, DNA repair
    LigandLipid-binding, Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.1.3.16, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P53041

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-5675221, Negative regulation of MAPK pathway
    R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
    R-HSA-8939211, ESR-mediated signaling

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P53041

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...    SignaLinki    		P53041

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P53041

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 5 (EC:3.1.3.167 Publications)
    Short name:
    PP5
    Alternative name(s):
    Protein phosphatase T
    Short name:
    PP-T
    Short name:
    PPT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PPP5C
    Synonyms:PPP5
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:9322, PPP5C

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		600658, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P53041

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000011485.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Amyloid, Cell membrane, Cytoplasm, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32K → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. 1 Publication1
    Mutagenesisi74R → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. 1 Publication1
    Mutagenesisi83G → N: No effect on interaction with HSP90AA1. 1 Publication1
    Mutagenesisi93K → E: Decreases interaction with RAC1 and translocation to the membrane in presence of active RAC1. 1 Publication1
    Mutagenesisi97K → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. Loss of interaction with RAF1. 2 Publications1
    Mutagenesisi101R → A: Loss of interaction with HSP90AA1. No effect on interaction with S100A1, S100A2 and S100A6. 1 Publication1
    Mutagenesisi304H → Q: Catalytically inactive; no effect on interaction with CRY2 but increases the stability of the interaction with CSNK1E. No effect on RAF1 phosphorylation. 3 Publications1

    Keywords - Diseasei

    Alzheimer disease, Amyloidosis, Neurodegeneration

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		5536

    Open Targets

    More...    OpenTargetsi    		ENSG00000011485

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA33686

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P53041, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3425389

    Drug and drug target database

    More...    DrugBanki    		DB00171, ATP

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		PPP5C

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		1709744

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000588942 – 499Serine/threonine-protein phosphatase 5Add BLAST498

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P53041

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P53041

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P53041

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P53041

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P53041

    PeptideAtlas

    More...    PeptideAtlasi    		P53041

    PRoteomics IDEntifications database

    More...    PRIDEi    		P53041

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		56568

    PTM databases

    DEPOD human dephosphorylation database

    More...    DEPODi    		PPP5C

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P53041

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		P53041

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P53041

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P53041

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000011485, Expressed in frontal cortex and 176 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P53041, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P53041, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000011485, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155).

    Part of a complex with HSP90/HSP90AA1 and steroid receptors (By similarity).

    Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226). Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid (PubMed:15383005).

    Interacts with CPNE1 (via VWFA domain) (By similarity).

    Interacts with CDC16, CDC27 (PubMed:9405394).

    Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5 (PubMed:23102700).

    Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity (PubMed:14871926).

    Interacts with RAD17; reduced by DNA damage (PubMed:14871926).

    Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities (By similarity).

    Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions (PubMed:22399290).

    Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels (PubMed:22781750).

    Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 downregulates the phosphatase activity on CSNK1E (PubMed:16790549).

    Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane (PubMed:19948726).

    Interacts with FLCN (PubMed:27353360).

    By similarity12 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		111528, 129 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-29043N

    Protein interaction database and analysis system

    More...    IntActi    		P53041, 70 interactors

    Molecular INTeraction database

    More...    MINTi    		P53041

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000012443

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P53041

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P53041, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1499
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Biological Magnetic Resonance Data Bank

    More...    BMRBi    		P53041

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P53041

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P53041

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati28 – 61TPR 1Add BLAST34
    Repeati62 – 95TPR 2Add BLAST34
    Repeati96 – 129TPR 3Add BLAST34

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 499CatalyticAdd BLAST316
    Regioni303 – 304Substrate binding1 Publication2
    Regioni495 – 499Required for autoinhibitionBy similarity5

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0376, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000158785

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P53041

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		AHMSLGK

    Database of Orthologous Groups

    More...    OrthoDBi    		671536at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P53041

    TreeFam database of animal gene trees

    More...    TreeFami    		TF105562

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd07417, MPP_PP5_C, 1 hit

    Database of protein disorder

    More...    DisProti    		DP00365

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.25.40.10, 1 hit
    3.60.21.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR004843, Calcineurin-like_PHP_ApaH
    IPR029052, Metallo-depent_PP-like
    IPR041753, PP5_C
    IPR013235, PPP_dom
    IPR006186, Ser/Thr-sp_prot-phosphatase
    IPR011236, Ser/Thr_PPase_5
    IPR013026, TPR-contain_dom
    IPR011990, TPR-like_helical_dom_sf
    IPR001440, TPR_1
    IPR019734, TPR_repeat

    The PANTHER Classification System

    More...    PANTHERi    		PTHR45668:SF5, PTHR45668:SF5, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00149, Metallophos, 1 hit
    PF08321, PPP5, 1 hit
    PF00515, TPR_1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00114, STPHPHTASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00156, PP2Ac, 1 hit
    SM00028, TPR, 3 hits

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48452, SSF48452, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00125, SER_THR_PHOSPHATASE, 1 hit
    PS50005, TPR, 3 hits
    PS50293, TPR_REGION, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    P53041-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF 
            60         70         80         90        100
    YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY 
           110        120        130        140        150
    RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER 
           160        170        180        190        200
    AIAGDEHKRS VVDSLDIESM TIEDEYSGPK LEDGKVTISF MKELMQWYKD 
           210        220        230        240        250
    QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC GDTHGQFYDL 
           260        270        280        290        300
    LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 
           310        320        330        340        350
    RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI 
           360        370        380        390        400
    MHGGLFSEDG VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR 
           410        420        430        440        450
    GVSCQFGPDV TKAFLEENNL DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN 
           460        470        480        490 
    YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP HPNVKPMAYA NTLLQLGMM
    Length:499
    Mass (Da):56,879
    Last modified:October 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB3B2090D8658BB3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H0YDU8H0YDU8_HUMAN
    Serine/threonine-protein phosphatas...
    PPP5C
    		485Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A8MU39A8MU39_HUMAN
    Serine/threonine-protein phosphatas...
    PPP5C
    		371Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti403S → T in AAB60384 (PubMed:8666404).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		BT007275 mRNA Translation: AAP35939.1
    X89416 mRNA Translation: CAA61595.1
    U25174 mRNA Translation: AAB60384.1
    AC007193 Genomic DNA Translation: AAD22669.1
    CH471126 Genomic DNA Translation: EAW57416.1
    BC001970 mRNA Translation: AAH01970.1
    X92121 mRNA Translation: CAA63089.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12684.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		S52570

    NCBI Reference Sequences

    More...    RefSeqi    		NP_006238.1, NM_006247.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000012443; ENSP00000012443; ENSG00000011485

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		5536

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:5536

    UCSC genome browser

    More...    UCSCi    		uc002pem.4, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		BT007275 mRNA Translation: AAP35939.1
    X89416 mRNA Translation: CAA61595.1
    U25174 mRNA Translation: AAB60384.1
    AC007193 Genomic DNA Translation: AAD22669.1
    CH471126 Genomic DNA Translation: EAW57416.1
    BC001970 mRNA Translation: AAH01970.1
    X92121 mRNA Translation: CAA63089.1
    CCDSiCCDS12684.1
    PIRiS52570
    RefSeqiNP_006238.1, NM_006247.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1A17X-ray2.45A16-181[»]
    1S95X-ray1.60A/B169-499[»]
    1WAOX-ray2.901/2/3/423-499[»]
    2BUGNMR-A19-147[»]
    3H60X-ray2.00A/B176-490[»]
    3H61X-ray1.45A/D176-490[»]
    3H62X-ray1.40B/C176-490[»]
    3H63X-ray1.30A/C176-490[»]
    3H64X-ray1.90A/D176-490[»]
    3H66X-ray2.59A/B176-490[»]
    3H67X-ray1.65A/D176-490[»]
    3H68X-ray1.50A/D176-490[»]
    3H69X-ray2.10A/D176-490[»]
    4ZVZX-ray2.00A/B/C/D169-499[»]
    4ZX2X-ray1.23A169-499[»]
    5HPEX-ray2.27A175-499[»]
    5UI1X-ray1.96A/B/C/D169-499[»]
    5WG8X-ray1.65A169-499[»]
    BMRBiP53041
    SMRiP53041
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi111528, 129 interactors
    DIPiDIP-29043N
    IntActiP53041, 70 interactors
    MINTiP53041
    STRINGi9606.ENSP00000012443

    Chemistry databases

    BindingDBiP53041
    ChEMBLiCHEMBL3425389
    DrugBankiDB00171, ATP

    PTM databases

    DEPODiPPP5C
    iPTMnetiP53041
    MetOSiteiP53041
    PhosphoSitePlusiP53041
    SwissPalmiP53041

    Genetic variation databases

    BioMutaiPPP5C
    DMDMi1709744

    Proteomic databases

    EPDiP53041
    jPOSTiP53041
    MassIVEiP53041
    MaxQBiP53041
    PaxDbiP53041
    PeptideAtlasiP53041
    PRIDEiP53041
    ProteomicsDBi56568

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		31446, 667 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		5536

    Genome annotation databases

    EnsembliENST00000012443; ENSP00000012443; ENSG00000011485
    GeneIDi5536
    KEGGihsa:5536
    UCSCiuc002pem.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		5536
    DisGeNETi5536

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		PPP5C
    HGNCiHGNC:9322, PPP5C
    HPAiENSG00000011485, Low tissue specificity
    MIMi600658, gene
    neXtProtiNX_P53041
    OpenTargetsiENSG00000011485
    PharmGKBiPA33686
    VEuPathDBiHostDB:ENSG00000011485.14

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0376, Eukaryota
    GeneTreeiENSGT00940000158785
    InParanoidiP53041
    OMAiAHMSLGK
    OrthoDBi671536at2759
    PhylomeDBiP53041
    TreeFamiTF105562

    Enzyme and pathway databases

    BRENDAi3.1.3.16, 2681
    PathwayCommonsiP53041
    ReactomeiR-HSA-5675221, Negative regulation of MAPK pathway
    R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
    R-HSA-8939211, ESR-mediated signaling
    SABIO-RKiP53041
    SignaLinkiP53041
    SIGNORiP53041

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		5536, 19 hits in 1000 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		PPP5C, human
    EvolutionaryTraceiP53041

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		PPP5C

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		5536
    PharosiP53041, Tbio

    Protein Ontology

    More...    PROi    		PR:P53041
    RNActiP53041, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000011485, Expressed in frontal cortex and 176 other tissues
    ExpressionAtlasiP53041, baseline and differential
    GenevisibleiP53041, HS

    Family and domain databases

    CDDicd07417, MPP_PP5_C, 1 hit
    DisProtiDP00365
    Gene3Di1.25.40.10, 1 hit
    3.60.21.10, 1 hit
    InterProiView protein in InterPro
    IPR004843, Calcineurin-like_PHP_ApaH
    IPR029052, Metallo-depent_PP-like
    IPR041753, PP5_C
    IPR013235, PPP_dom
    IPR006186, Ser/Thr-sp_prot-phosphatase
    IPR011236, Ser/Thr_PPase_5
    IPR013026, TPR-contain_dom
    IPR011990, TPR-like_helical_dom_sf
    IPR001440, TPR_1
    IPR019734, TPR_repeat
    PANTHERiPTHR45668:SF5, PTHR45668:SF5, 1 hit
    PfamiView protein in Pfam
    PF00149, Metallophos, 1 hit
    PF08321, PPP5, 1 hit
    PF00515, TPR_1, 1 hit
    PRINTSiPR00114, STPHPHTASE
    SMARTiView protein in SMART
    SM00156, PP2Ac, 1 hit
    SM00028, TPR, 3 hits
    SUPFAMiSSF48452, SSF48452, 1 hit
    PROSITEiView protein in PROSITE
    PS00125, SER_THR_PHOSPHATASE, 1 hit
    PS50005, TPR, 3 hits
    PS50293, TPR_REGION, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPP5_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53041
    Secondary accession number(s): Q16722, Q53XV2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: April 7, 2021
    This is version 224 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
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