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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

SIT4-associating protein SAP4

Gene

SAP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the SIT4 phosphatase in a cell cycle dependent manner. May be directly or indirectly involved in SIT4-dependent functions in budding and in normal G1 cyclin expression (By similarity).By similarity

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30703-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-204005, COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SIT4-associating protein SAP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAP4
Ordered Locus Names:YGL229C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YGL229C

Saccharomyces Genome Database

More...
SGDi
S000003198, SAP4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975851 – 818SIT4-associating protein SAP4Add BLAST818

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hyperphosphorylated in the absence of SIT4.By similarity

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53036

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53036

PRoteomics IDEntifications database

More...
PRIDEi
P53036

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53036

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33010, 73 interactors

Database of interacting proteins

More...
DIPi
DIP-1604N

Protein interaction database and analysis system

More...
IntActi
P53036, 16 interactors

Molecular INTeraction database

More...
MINTi
P53036

STRING: functional protein association networks

More...
STRINGi
4932.YGL229C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53036, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2073, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003676_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53036

KEGG Orthology (KO)

More...
KOi
K15457

Identification of Orthologs from Complete Genome Data

More...
OMAi
INIILFQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007587, SAPS

The PANTHER Classification System

More...
PANTHERi
PTHR12634, PTHR12634, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04499, SAPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53036-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLWPFGETL SHSGIDSILE EYYLIFRSLE GNETSSTDDK KNEPSMESES
60 70 80 90 100
EFGTESRDRS DLNQSFIDRI LLETALLDEL NGAANDRLVD FICLGYFYDD
110 120 130 140 150
RSQQVRHMDY LVDMLMAYLK DIDRTGYRTP FLLENSFHQT GEYEDQDDED
160 170 180 190 200
PMLYVNIISS IFCSKSAPIV EALVQNTPFL SSLFEVFQFE NIEAENCPIL
210 220 230 240 250
AVFLKINETL LFEQTSSYLE FFKSQPNIVD KFLYHIEVSP LVEFLIKIML
260 270 280 290 300
TDQVESPTNI IDFLYHQDLI PKCLNLLENS KYSPGIQNSS GELLKALISI
310 320 330 340 350
STNFKLDTLW IGPNRLTRQL ASPQYVDQLI NIILFQRGHA MGVAVSIIIE
360 370 380 390 400
LIRKNNSDYD EVDLLSTTIV DNPPSQRDPV YLGHLLYELT MHMEDFYALL
410 420 430 440 450
IKLENDDDDD HDTASKALPS VKHHLLENQL HESFRPLGFE RVKITELISE
460 470 480 490 500
MLHCSNMGLM NSKRGEKIAR TRDKCRDTLD QNSLEKAMKN LNINDNTITS
510 520 530 540 550
NTLEDKCNNN DSNDSNDNQK QKKNIKKKFH DNELYSTFDT SDDNIDDDDD
560 570 580 590 600
MSFEIPYVSE TQNLKIRKNP TIGDLFKIKL HDLGFFPKFL QLFLRYPWNN
610 620 630 640 650
FWHNIVFDII QQIFNGRMDF SYNSFLVYSL FDFKKSTRFI PKPLYGSNQK
660 670 680 690 700
LPVKDFHIIS DFILQGHKDS FEFYEKEKTN LGYMGQLVLI AEEIAKYSKI
710 720 730 740 750
YKTDLIAPDI YAFLQDEVWM SYSSDILNET RTMCSIILGG GQFCAESDEN
760 770 780 790 800
TNQDFLEKAD MSKPAHPSTM DENEIVHEED VKLHDKVAEL IDELGQLTEL
810
DIHDKIKDVI VDHHSDLN
Length:818
Mass (Da):94,729
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB6E4FC06E4DD3FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U50562 Genomic DNA Translation: AAC49305.1
Z72751 Genomic DNA Translation: CAA96947.1
Z72750 Genomic DNA Translation: CAA96946.1
BK006941 Genomic DNA Translation: DAA07889.1

Protein sequence database of the Protein Information Resource

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PIRi
S64251

NCBI Reference Sequences

More...
RefSeqi
NP_011285.1, NM_001181095.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL229C_mRNA; YGL229C; YGL229C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL229C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50562 Genomic DNA Translation: AAC49305.1
Z72751 Genomic DNA Translation: CAA96947.1
Z72750 Genomic DNA Translation: CAA96946.1
BK006941 Genomic DNA Translation: DAA07889.1
PIRiS64251
RefSeqiNP_011285.1, NM_001181095.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33010, 73 interactors
DIPiDIP-1604N
IntActiP53036, 16 interactors
MINTiP53036
STRINGi4932.YGL229C

PTM databases

iPTMnetiP53036

Proteomic databases

MaxQBiP53036
PaxDbiP53036
PRIDEiP53036

Genome annotation databases

EnsemblFungiiYGL229C_mRNA; YGL229C; YGL229C
GeneIDi852622
KEGGisce:YGL229C

Organism-specific databases

EuPathDBiFungiDB:YGL229C
SGDiS000003198, SAP4

Phylogenomic databases

eggNOGiKOG2073, Eukaryota
GeneTreeiENSGT00390000009899
HOGENOMiCLU_003676_2_1_1
InParanoidiP53036
KOiK15457
OMAiINIILFQ

Enzyme and pathway databases

BioCyciYEAST:G3O-30703-MONOMER
ReactomeiR-SCE-204005, COPII-mediated vesicle transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53036
RNActiP53036, protein

Family and domain databases

InterProiView protein in InterPro
IPR007587, SAPS
PANTHERiPTHR12634, PTHR12634, 3 hits
PfamiView protein in Pfam
PF04499, SAPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAP4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53036
Secondary accession number(s): D6VVA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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