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Protein

Nucleoporin SEH1

Gene

SEH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis. It is also required for normal nuclear morphology. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.4 Publications

Miscellaneous

Present with 952 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nucleocytoplasmic transport Source: SGD
  • positive regulation of TORC1 signaling Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30600-MONOMER

Protein family/group databases

TCDBi1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin SEH1
Alternative name(s):
Nuclear pore protein SEH1
SEC13 homolog 1
Gene namesi
Name:SEH1
Ordered Locus Names:YGL100W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL100W
SGDiS000003068 SEH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512151 – 349Nucleoporin SEH1Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53011
PaxDbiP53011
PRIDEiP53011

PTM databases

iPTMnetiP53011

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. SEH1 is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1). Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33149, 378 interactors
ComplexPortaliCPX-3231 SEA complex
CPX-824 Nuclear pore complex
DIPiDIP-4193N
IntActiP53011, 51 interactors
MINTiP53011
STRINGi4932.YGL100W

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 17Combined sources6
Beta strandi19 – 28Combined sources10
Beta strandi31 – 38Combined sources8
Beta strandi40 – 42Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi58 – 63Combined sources6
Helixi66 – 68Combined sources3
Beta strandi70 – 76Combined sources7
Beta strandi77 – 79Combined sources3
Beta strandi81 – 86Combined sources6
Beta strandi97 – 104Combined sources8
Beta strandi111 – 116Combined sources6
Helixi119 – 121Combined sources3
Beta strandi123 – 129Combined sources7
Beta strandi133 – 138Combined sources6
Beta strandi149 – 156Combined sources8
Beta strandi163 – 165Combined sources3
Beta strandi169 – 173Combined sources5
Beta strandi177 – 179Combined sources3
Beta strandi182 – 187Combined sources6
Beta strandi190 – 196Combined sources7
Beta strandi202 – 207Combined sources6
Beta strandi215 – 220Combined sources6
Beta strandi227 – 235Combined sources9
Beta strandi240 – 247Combined sources8
Beta strandi291 – 300Combined sources10
Beta strandi307 – 312Combined sources6
Beta strandi314 – 316Combined sources3
Beta strandi319 – 323Combined sources5
Beta strandi328 – 333Combined sources6
Beta strandi339 – 345Combined sources7

3D structure databases

ProteinModelPortaliP53011
SMRiP53011
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53011

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 46WD 1Add BLAST40
Repeati53 – 94WD 2Add BLAST42
Repeati106 – 147WD 3Add BLAST42
Repeati153 – 192WD 4Add BLAST40
Repeati210 – 253WD 5Add BLAST44
Repeati302 – 341WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat SEC13 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00550000074999
HOGENOMiHOG000216896
InParanoidiP53011
KOiK14299
OMAiIYEAPDI
OrthoDBiEOG092C2Z2A

Family and domain databases

InterProiView protein in InterPro
IPR037597 Nucleoporin_Seh1
IPR037363 Sec13/Seh1_fam
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11024 PTHR11024, 1 hit
PTHR11024:SF3 PTHR11024:SF3, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P53011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPFDSGHDD LVHDVVYDFY GRHVATCSSD QHIKVFKLDK DTSNWELSDS
60 70 80 90 100
WRAHDSSIVA IDWASPEYGR IIASASYDKT VKLWEEDPDQ EECSGRRWNK
110 120 130 140 150
LCTLNDSKGS LYSVKFAPAH LGLKLACLGN DGILRLYDAL EPSDLRSWTL
160 170 180 190 200
TSEMKVLSIP PANHLQSDFC LSWCPSRFSP EKLAVSALEQ AIIYQRGKDG
210 220 230 240 250
KLHVAAKLPG HKSLIRSISW APSIGRWYQL IATGCKDGRI RIFKITEKLS
260 270 280 290 300
PLASEESLTN SNMFDNSADV DMDAQGRSDS NTEEKAELQS NLQVELLSEH
310 320 330 340
DDHNGEVWSV SWNLTGTILS SAGDDGKVRL WKATYSNEFK CMSVITAQQ
Length:349
Mass (Da):39,123
Last modified:October 1, 1996 - v1
Checksum:iEAF75B9DE074106B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90994 Genomic DNA Translation: CAA62480.1
Z72622 Genomic DNA Translation: CAA96806.1
AY558497 Genomic DNA Translation: AAS56823.1
BK006941 Genomic DNA Translation: DAA08006.1
PIRiS62137
RefSeqiNP_011415.1, NM_001180965.1

Genome annotation databases

EnsemblFungiiYGL100W; YGL100W; YGL100W
GeneIDi852778
KEGGisce:YGL100W

Similar proteinsi

Entry informationi

Entry nameiSEH1_YEAST
AccessioniPrimary (citable) accession number: P53011
Secondary accession number(s): D6VU45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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