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Protein

Tricarboxylate transport protein, mitochondrial

Gene

SLC25A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in citrate-H+/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • fatty-acyl-CoA biosynthetic process Source: Reactome
  • gluconeogenesis Source: Reactome
  • mitochondrial citrate transmembrane transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70263 Gluconeogenesis
R-HSA-75105 Fatty acyl-CoA biosynthesis

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.7.2 the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tricarboxylate transport protein, mitochondrial
Alternative name(s):
Citrate transport protein
Short name:
CTP
Solute carrier family 25 member 1
Tricarboxylate carrier protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A1
Synonyms:SLC20A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100075.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10979 SLC25A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190315 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P53007

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 46Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei86 – 105Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei129 – 143Helical; Name=3Sequence analysisAdd BLAST15
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei224 – 241Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei278 – 297Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined D-2- and L-2-hydroxyglutaric aciduria (D2L2AD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurometabolic disorder characterized by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor development resulting in early death. Brain imaging shows abnormalities including enlarged ventricles, delayed myelination, and germinal layer cysts.
See also OMIM:615182
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06949045P → L in D2L2AD. 1 Publication1
Natural variantiVAR_069491144E → Q in D2L2AD. 1 Publication1
Natural variantiVAR_069492167G → R in D2L2AD. 1 Publication1
Natural variantiVAR_069493193S → W in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs781925968Ensembl.1
Natural variantiVAR_077511198R → H in D2L2AD. 1 Publication1
Natural variantiVAR_069494202M → T in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs782335811Ensembl.1
Natural variantiVAR_069495282R → C in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs431905509EnsemblClinVar.1
Natural variantiVAR_069496282R → G in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs431905509EnsemblClinVar.1
Natural variantiVAR_069497297Y → C in D2L2AD. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6576

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC25A1

MalaCards human disease database

More...
MalaCardsi
SLC25A1
MIMi615182 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100075

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
356978 D,L-2-hydroxyglutaric aciduria
98914 Presynaptic congenital myasthenic syndromes

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35855

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141931

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 13MitochondrionBy similarityAdd BLAST13
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001926214 – 311Tricarboxylate transport protein, mitochondrialAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei156PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P53007

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53007

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53007

PeptideAtlas

More...
PeptideAtlasi
P53007

PRoteomics IDEntifications database

More...
PRIDEi
P53007

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56567

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P53007

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53007

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P53007

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P53007

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100075 Expressed in 220 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC25A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P53007 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P53007 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112464, 56 interactors

Protein interaction database and analysis system

More...
IntActi
P53007, 55 interactors

Molecular INTeraction database

More...
MINTi
P53007

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215882

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P53007

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53007

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 111Solcar 1Add BLAST89
Repeati122 – 208Solcar 2Add BLAST87
Repeati218 – 303Solcar 3Add BLAST86

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0756 Eukaryota
ENOG410YAYP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074856

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53007

KEGG Orthology (KO)

More...
KOi
K15100

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLRFMWF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0KE7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P53007

TreeFam database of animal gene trees

More...
TreeFami
TF105786

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24089 PTHR24089, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00153 Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00926 MITOCARRIER

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P53007-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPRAPRAL AAAAPASGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK
60 70 80 90 100
TQLQLDERSH PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV
110 120 130 140 150
RFGMFEFLSN HMRDAQGRLD STRGLLCGLG AGVAEAVVVV CPMETIKVKF
160 170 180 190 200
IHDQTSPNPK YRGFFHGVRE IVREQGLKGT YQGLTATVLK QGSNQAIRFF
210 220 230 240 250
VMTSLRNWYR GDNPNKPMNP LITGVFGAIA GAASVFGNTP LDVIKTRMQG
260 270 280 290 300
LEAHKYRNTW DCGLQILKKE GLKAFYKGTV PRLGRVCLDV AIVFVIYDEV
310
VKLLNKVWKT D
Length:311
Mass (Da):34,013
Last modified:February 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1341629924953D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DP62B4DP62_HUMAN
Solute carrier family 25 (Mitochond...
SLC25A1 hCG_17246
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26G → E in AAB08515 (PubMed:8666394).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06949045P → L in D2L2AD. 1 Publication1
Natural variantiVAR_069491144E → Q in D2L2AD. 1 Publication1
Natural variantiVAR_069492167G → R in D2L2AD. 1 Publication1
Natural variantiVAR_069493193S → W in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs781925968Ensembl.1
Natural variantiVAR_077511198R → H in D2L2AD. 1 Publication1
Natural variantiVAR_069494202M → T in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs782335811Ensembl.1
Natural variantiVAR_069495282R → C in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs431905509EnsemblClinVar.1
Natural variantiVAR_069496282R → G in D2L2AD. 1 PublicationCorresponds to variant dbSNP:rs431905509EnsemblClinVar.1
Natural variantiVAR_069497297Y → C in D2L2AD. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25147 mRNA Translation: AAB08515.1
L76134 Genomic DNA Translation: AAL40091.1
L75823 mRNA Translation: AAL40090.1
AK292313 mRNA Translation: BAF85002.1
BC004980 mRNA Translation: AAH04980.1
BC008061 mRNA Translation: AAH08061.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13758.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G01789

NCBI Reference Sequences

More...
RefSeqi
NP_005975.1, NM_005984.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.111024

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215882; ENSP00000215882; ENSG00000100075

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6576

UCSC genome browser

More...
UCSCi
uc002zoz.6 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25147 mRNA Translation: AAB08515.1
L76134 Genomic DNA Translation: AAL40091.1
L75823 mRNA Translation: AAL40090.1
AK292313 mRNA Translation: BAF85002.1
BC004980 mRNA Translation: AAH04980.1
BC008061 mRNA Translation: AAH08061.1
CCDSiCCDS13758.1
PIRiG01789
RefSeqiNP_005975.1, NM_005984.4
UniGeneiHs.111024

3D structure databases

ProteinModelPortaliP53007
SMRiP53007
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112464, 56 interactors
IntActiP53007, 55 interactors
MINTiP53007
STRINGi9606.ENSP00000215882

Protein family/group databases

TCDBi2.A.29.7.2 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiP53007
PhosphoSitePlusiP53007
SwissPalmiP53007

Polymorphism and mutation databases

DMDMi20141931

Proteomic databases

EPDiP53007
MaxQBiP53007
PaxDbiP53007
PeptideAtlasiP53007
PRIDEiP53007
ProteomicsDBi56567
TopDownProteomicsiP53007

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215882; ENSP00000215882; ENSG00000100075
GeneIDi6576
KEGGihsa:6576
UCSCiuc002zoz.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6576
DisGeNETi6576
EuPathDBiHostDB:ENSG00000100075.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC25A1
GeneReviewsiSLC25A1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0040279
HGNCiHGNC:10979 SLC25A1
MalaCardsiSLC25A1
MIMi190315 gene
615182 phenotype
neXtProtiNX_P53007
OpenTargetsiENSG00000100075
Orphaneti356978 D,L-2-hydroxyglutaric aciduria
98914 Presynaptic congenital myasthenic syndromes
PharmGKBiPA35855

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0756 Eukaryota
ENOG410YAYP LUCA
GeneTreeiENSGT00550000074856
HOVERGENiHBG103009
InParanoidiP53007
KOiK15100
OMAiGLRFMWF
OrthoDBiEOG091G0KE7
PhylomeDBiP53007
TreeFamiTF105786

Enzyme and pathway databases

ReactomeiR-HSA-70263 Gluconeogenesis
R-HSA-75105 Fatty acyl-CoA biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC25A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC25A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6576

Protein Ontology

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PROi
PR:P53007

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100075 Expressed in 220 organ(s), highest expression level in liver
CleanExiHS_SLC25A1
ExpressionAtlasiP53007 baseline and differential
GenevisibleiP53007 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTXTP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53007
Secondary accession number(s): A8K8E8, Q9BSK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 11, 2002
Last modified: December 5, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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