SLC25A1

Functionⁱ

Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate (PubMed:29031613, PubMed:29238895). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate (PubMed:29031613). Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD⁺ for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable).1 Publication2 Publications

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-70263 Gluconeogenesis R-HSA-75105 Fatty acyl-CoA biosynthesis

Reactomeⁱ

R-HSA-70263 Gluconeogenesis
R-HSA-75105 Fatty acyl-CoA biosynthesis

Protein family/group databases

TCDBⁱ	2.A.29.7.2 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.7.2 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tricarboxylate transport protein, mitochondrial Alternative name(s): Citrate transport protein Short name: CTP Solute carrier family 25 member 1 Tricarboxylate carrier protein
Gene namesⁱ	Name:SLC25A1 Synonyms:SLC20A3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10979 SLC25A1
MIMⁱ	190315 gene
neXtProtⁱ	NX_P53007

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	29 – 46	Helical; Name=1Sequence analysisAdd BLAST	18
Transmembraneⁱ	86 – 105	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	129 – 143	Helical; Name=3Sequence analysisAdd BLAST	15
Transmembraneⁱ	183 – 202	Helical; Name=4Sequence analysisAdd BLAST	20
Transmembraneⁱ	224 – 241	Helical; Name=5Sequence analysisAdd BLAST	18
Transmembraneⁱ	278 – 297	Helical; Name=6Sequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Combined D-2- and L-2-hydroxyglutaric aciduria (D2L2AD)7 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive neurometabolic disorder characterized by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor development resulting in early death. Brain imaging shows abnormalities including enlarged ventricles, delayed myelination, and germinal layer cysts.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_081661	28	A → T in D2L2AD; unknown pathological significance; very mild decrease of citrate transport rates. 1 Publication	1
Natural variantⁱVAR_081662	40	I → N in D2L2AD; reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_069490	45	P → L in D2L2AD; severely reduced rates of citrate transport. 3 Publications	1
Natural variantⁱVAR_081663	47	E → K in D2L2AD; unknown pathological significance; severely reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_081664	93	G → D in D2L2AD; severely reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_081665	130	G → D in D2L2AD; severely reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs368647424EnsemblClinVar.	1
Natural variantⁱVAR_069491	144	E → Q in D2L2AD; abolishes citrate transport. 2 Publications	1
Natural variantⁱVAR_069492	167	G → R in D2L2AD. 1 Publication	1
Natural variantⁱVAR_069493	193	S → W in D2L2AD; reduced rates of citrate transport. 3 PublicationsCorresponds to variant dbSNP:rs781925968Ensembl.	1
Natural variantⁱVAR_077511	198	R → H in D2L2AD; severely reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs1331417017Ensembl.	1
Natural variantⁱVAR_069494	202	M → T in D2L2AD; reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs782335811Ensembl.	1
Natural variantⁱVAR_081666	238	N → S in D2L2AD; disease phenotype may include decreased activity of mitochondrial respiratory chain complex V. 1 Publication	1
Natural variantⁱVAR_081668	256 – 311	Missing in D2L2AD; no protein detected by Western blot in patient fibroblasts; severely reduced rates of citrate transport. 2 PublicationsAdd BLAST	56
Natural variantⁱVAR_081669	262	C → R in D2L2AD; reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_069495	282	R → C in D2L2AD; abolishes citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs431905509EnsemblClinVar.	1
Natural variantⁱVAR_069496	282	R → G in D2L2AD; abolishes citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs431905509EnsemblClinVar.	1
Natural variantⁱVAR_081670	282	R → H in D2L2AD; abolishes citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs431905510EnsemblClinVar.	1
Natural variantⁱVAR_069497	297	Y → C in D2L2AD; reduced rates of citrate transport. 2 Publications	1

Myasthenic syndrome, congenital, 23, presynaptic (CMS23)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features include easy fatigability and muscle weakness. CMS23 inheritance is autosomal recessive.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_081667	247	R → Q in CMS23; reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs781908532Ensembl.		1

Keywords - Diseaseⁱ

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6576
GeneReviewsⁱ	SLC25A1
MalaCards human disease database More...MalaCardsⁱ	SLC25A1
MIMⁱ	615182 phenotype 618197 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000100075
Orphanetⁱ	356978 D,L-2-hydroxyglutaric aciduria 98914 Presynaptic congenital myasthenic syndromes
PharmGKBⁱ	PA35855

Miscellaneous databases

Pharosⁱ	P53007

Pharosⁱ

P53007

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB09154 Sodium citrate

DrugBankⁱ

DB09154 Sodium citrate

Polymorphism and mutation databases

BioMutaⁱ	SLC25A1
DMDMⁱ	20141931

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 13	MitochondrionBy similarityAdd BLAST		13
ChainⁱPRO_0000019262	14 – 311	Tricarboxylate transport protein, mitochondrialAdd BLAST		298

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	156	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-586 CPTAC-587
EPDⁱ	P53007
jPOSTⁱ	P53007
MassIVEⁱ	P53007
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53007
PaxDbⁱ	P53007
PeptideAtlas More...PeptideAtlasⁱ	P53007
PRIDEⁱ	P53007
ProteomicsDBⁱ	56567
TopDownProteomicsⁱ	P53007

PTM databases

iPTMnetⁱ	P53007
PhosphoSitePlusⁱ	P53007
SwissPalmⁱ	P53007

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100075 Expressed in 220 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P53007 baseline and differential
Genevisibleⁱ	P53007 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112464, 138 interactors
IntActⁱ	P53007, 60 interactors
Molecular INTeraction database More...MINTⁱ	P53007
STRINGⁱ	9606.ENSP00000215882

Structureⁱ

3D structure databases

SMRⁱ	P53007
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	23 – 111	Solcar 1Add BLAST	89
Repeatⁱ	122 – 208	Solcar 2Add BLAST	87
Repeatⁱ	218 – 303	Solcar 3Add BLAST	86

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0756 Eukaryota ENOG410YAYP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074856
InParanoidⁱ	P53007
KEGG Orthology (KO) More...KOⁱ	K15100
OMAⁱ	NSFVCAA
Database of Orthologous Groups More...OrthoDBⁱ	1523221at2759
PhylomeDBⁱ	P53007
TreeFamⁱ	TF105786

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P53007-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPAPRAPRAL AAAAPASGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK 
        60         70         80         90        100
TQLQLDERSH PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV 
       110        120        130        140        150
RFGMFEFLSN HMRDAQGRLD STRGLLCGLG AGVAEAVVVV CPMETIKVKF 
       160        170        180        190        200
IHDQTSPNPK YRGFFHGVRE IVREQGLKGT YQGLTATVLK QGSNQAIRFF 
       210        220        230        240        250
VMTSLRNWYR GDNPNKPMNP LITGVFGAIA GAASVFGNTP LDVIKTRMQG 
       260        270        280        290        300
LEAHKYRNTW DCGLQILKKE GLKAFYKGTV PRLGRVCLDV AIVFVIYDEV 
       310 
VKLLNKVWKT D

Length:311

Mass (Da):34,013

Last modified:February 11, 2002 - v2

Checksum:ⁱF1341629924953D6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B4DP62	B4DP62_HUMAN		Solute carrier family 25 (Mitochond... Solute carrier family 25 (Mitochondrial carrier citrate transporter), member 1, isoform CRA_b (Tricarboxylate transport protein, mitochondrial) (cDNA FLJ60026, highly similar to Tricarboxylate transport protein, mitochondrial)	SLC25A1 hCG_17246	208	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	26	G → E in AAB08515 (PubMed:8666394).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_081661	28	A → T in D2L2AD; unknown pathological significance; very mild decrease of citrate transport rates. 1 Publication	1
Natural variantⁱVAR_081662	40	I → N in D2L2AD; reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_069490	45	P → L in D2L2AD; severely reduced rates of citrate transport. 3 Publications	1
Natural variantⁱVAR_081663	47	E → K in D2L2AD; unknown pathological significance; severely reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_081664	93	G → D in D2L2AD; severely reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_081665	130	G → D in D2L2AD; severely reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs368647424EnsemblClinVar.	1
Natural variantⁱVAR_069491	144	E → Q in D2L2AD; abolishes citrate transport. 2 Publications	1
Natural variantⁱVAR_069492	167	G → R in D2L2AD. 1 Publication	1
Natural variantⁱVAR_069493	193	S → W in D2L2AD; reduced rates of citrate transport. 3 PublicationsCorresponds to variant dbSNP:rs781925968Ensembl.	1
Natural variantⁱVAR_077511	198	R → H in D2L2AD; severely reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs1331417017Ensembl.	1
Natural variantⁱVAR_069494	202	M → T in D2L2AD; reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs782335811Ensembl.	1
Natural variantⁱVAR_081666	238	N → S in D2L2AD; disease phenotype may include decreased activity of mitochondrial respiratory chain complex V. 1 Publication	1
Natural variantⁱVAR_081667	247	R → Q in CMS23; reduced rates of citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs781908532Ensembl.	1
Natural variantⁱVAR_081668	256 – 311	Missing in D2L2AD; no protein detected by Western blot in patient fibroblasts; severely reduced rates of citrate transport. 2 PublicationsAdd BLAST	56
Natural variantⁱVAR_081669	262	C → R in D2L2AD; reduced rates of citrate transport. 1 Publication	1
Natural variantⁱVAR_069495	282	R → C in D2L2AD; abolishes citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs431905509EnsemblClinVar.	1
Natural variantⁱVAR_069496	282	R → G in D2L2AD; abolishes citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs431905509EnsemblClinVar.	1
Natural variantⁱVAR_081670	282	R → H in D2L2AD; abolishes citrate transport. 2 PublicationsCorresponds to variant dbSNP:rs431905510EnsemblClinVar.	1
Natural variantⁱVAR_069497	297	Y → C in D2L2AD; reduced rates of citrate transport. 2 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25147 mRNA Translation: AAB08515.1 L76134 Genomic DNA Translation: AAL40091.1 L75823 mRNA Translation: AAL40090.1 AK292313 mRNA Translation: BAF85002.1 BC004980 mRNA Translation: AAH04980.1 BC008061 mRNA Translation: AAH08061.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13758.1
PIRⁱ	G01789
NCBI Reference Sequences More...RefSeqⁱ	NP_005975.1, NM_005984.4

Genome annotation databases

Ensemblⁱ	ENST00000215882; ENSP00000215882; ENSG00000100075
GeneIDⁱ	6576
KEGGⁱ	hsa:6576
UCSC genome browser More...UCSCⁱ	uc002zoz.6 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P53007	Solute carrier family 25, member 1 (Fragment)		MUSPF		313	UniRef90_P53007
SLC25A1 isoform 1		PANTR		311
Uncharacterized protein		PANPA		311
Solute carrier family 25 member 1		GORGO		311
tricarboxylate transport protein, mitochondrial		VULVU		308
+15

Protein	Similar proteins		Species	Score	Length	Source
P53007	Tricarboxylate transport protein A, mitochondrial		DANRE		359	UniRef50_P53007
Solute carrier family 25, member 1 (Fragment)		MUSPF		313
SLC25A1 isoform 1		PANTR		311
Uncharacterized protein		PANPA		311
Solute carrier family 25 member 1		GORGO		311
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25147 mRNA Translation: AAB08515.1 L76134 Genomic DNA Translation: AAL40091.1 L75823 mRNA Translation: AAL40090.1 AK292313 mRNA Translation: BAF85002.1 BC004980 mRNA Translation: AAH04980.1 BC008061 mRNA Translation: AAH08061.1
CCDSⁱ	CCDS13758.1
PIRⁱ	G01789
RefSeqⁱ	NP_005975.1, NM_005984.4

3D structure databases

SMRⁱ	P53007
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112464, 138 interactors
IntActⁱ	P53007, 60 interactors
MINTⁱ	P53007
STRINGⁱ	9606.ENSP00000215882

Chemistry databases

DrugBankⁱ	DB09154 Sodium citrate

DrugBankⁱ

DB09154 Sodium citrate

Protein family/group databases

TCDBⁱ	2.A.29.7.2 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.7.2 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	P53007
PhosphoSitePlusⁱ	P53007
SwissPalmⁱ	P53007

Polymorphism and mutation databases

BioMutaⁱ	SLC25A1
DMDMⁱ	20141931

Proteomic databases

CPTACⁱ	CPTAC-586 CPTAC-587
EPDⁱ	P53007
jPOSTⁱ	P53007
MassIVEⁱ	P53007
MaxQBⁱ	P53007
PaxDbⁱ	P53007
PeptideAtlasⁱ	P53007
PRIDEⁱ	P53007
ProteomicsDBⁱ	56567
TopDownProteomicsⁱ	P53007

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6576

DNASUⁱ

6576

Genome annotation databases

Ensemblⁱ	ENST00000215882; ENSP00000215882; ENSG00000100075
GeneIDⁱ	6576
KEGGⁱ	hsa:6576
UCSCⁱ	uc002zoz.6 human

Organism-specific databases

CTDⁱ	6576
DisGeNETⁱ	6576
GeneCardsⁱ	SLC25A1
GeneReviewsⁱ	SLC25A1
HGNCⁱ	HGNC:10979 SLC25A1
MalaCardsⁱ	SLC25A1
MIMⁱ	190315 gene 615182 phenotype 618197 phenotype
neXtProtⁱ	NX_P53007
OpenTargetsⁱ	ENSG00000100075
Orphanetⁱ	356978 D,L-2-hydroxyglutaric aciduria 98914 Presynaptic congenital myasthenic syndromes
PharmGKBⁱ	PA35855
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0756 Eukaryota ENOG410YAYP LUCA
GeneTreeⁱ	ENSGT00550000074856
InParanoidⁱ	P53007
KOⁱ	K15100
OMAⁱ	NSFVCAA
OrthoDBⁱ	1523221at2759
PhylomeDBⁱ	P53007
TreeFamⁱ	TF105786

Enzyme and pathway databases

Reactomeⁱ	R-HSA-70263 Gluconeogenesis R-HSA-75105 Fatty acyl-CoA biosynthesis

Reactomeⁱ

R-HSA-70263 Gluconeogenesis
R-HSA-75105 Fatty acyl-CoA biosynthesis

Miscellaneous databases

ChiTaRSⁱ	SLC25A1 human
GeneWikiⁱ	SLC25A1
GenomeRNAiⁱ	6576
Pharosⁱ	P53007
Protein Ontology More...PROⁱ	PR:P53007
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100075 Expressed in 220 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P53007 baseline and differential
Genevisibleⁱ	P53007 HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TXTP_HUMAN
Accessionⁱ	P53007Primary (citable) accession number: P53007 Secondary accession number(s): A8K8E8, Q9BSK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	February 11, 2002
	Last modified:	October 16, 2019
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - P53007 (TXTP_HUMAN)

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Tricarboxylate transport protein, mitochondrial

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Extracellular region or secreted

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ