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Entry version 182 (10 Apr 2019)
Sequence version 2 (10 Oct 2002)
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Protein

Biliverdin reductase A

Gene

BLVRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.

Miscellaneous

Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protoheme degradation

This protein is involved in the pathway protoheme degradation, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway protoheme degradation and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei98NAD or NADP; via carbonyl oxygen1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi280ZincSequence analysis1
Metal bindingi281ZincSequence analysis1
Metal bindingi292ZincSequence analysis1
Metal bindingi293ZincSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi15 – 20NAD or NADP6
Nucleotide bindingi44 – 46NAD or NADP3
Nucleotide bindingi77 – 80NAD or NADP4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • biliverdin reductase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • heme catabolic process Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS02928-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.24 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189483 Heme degradation

SIGNOR Signaling Network Open Resource

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SIGNORi
P53004

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00684

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Biliverdin reductase A (EC:1.3.1.24)
Short name:
BVR A
Alternative name(s):
Biliverdin-IX alpha-reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BLVRA
Synonyms:BLVR, BVR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000106605.10

Human Gene Nomenclature Database

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HGNCi
HGNC:1062 BLVRA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
109750 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P53004

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperbiliverdinemia (HBLVD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis.
See also OMIM:614156

Organism-specific databases

DisGeNET

More...
DisGeNETi
644

MalaCards human disease database

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MalaCardsi
BLVRA
MIMi614156 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000106605

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
276405 Hyperbiliverdinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25373

Chemistry databases

Drug and drug target database

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DrugBanki
DB00157 NADH

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BLVRA

Domain mapping of disease mutations (DMDM)

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DMDMi
23830892

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000108521 – 22 Publications2
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000108533 – 296Biliverdin reductase A1 PublicationAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei174PhosphothreonineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei248N6-acetyllysineCombined sources1
Modified residuei253N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P53004

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P53004

MaxQB - The MaxQuant DataBase

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MaxQBi
P53004

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P53004

PeptideAtlas

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PeptideAtlasi
P53004

PRoteomics IDEntifications database

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PRIDEi
P53004

ProteomicsDB human proteome resource

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ProteomicsDBi
56566

2D gel databases

USC-OGP 2-DE database

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OGPi
P53004

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00294158

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P53004

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P53004

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106605 Expressed in 231 organ(s), highest expression level in middle temporal gyrus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P53004 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P53004 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019709
HPA042865
HPA054322

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107113, 25 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P53004

Database of interacting proteins

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DIPi
DIP-42180N

Protein interaction database and analysis system

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IntActi
P53004, 8 interactors

Molecular INTeraction database

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MINTi
P53004

STRING: functional protein association networks

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STRINGi
9606.ENSP00000385757

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H63X-ray2.70A/B/C/D7-296[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P53004

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P53004

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P53004

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 16Poly-Val6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IH7U Eukaryota
ENOG4111FZX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000011072

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231884

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003218

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P53004

KEGG Orthology (KO)

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KOi
K00214

Identification of Orthologs from Complete Genome Data

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OMAi
PMTLSWA

Database of Orthologous Groups

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OrthoDBi
879838at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P53004

TreeFam database of animal gene trees

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TreeFami
TF342889

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017094 Biliverdin_Rdtase_A
IPR015249 Biliverdin_Rdtase_cat
IPR036291 NAD(P)-bd_dom_sf
IPR000683 Oxidoreductase_N

Pfam protein domain database

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Pfami
View protein in Pfam
PF09166 Biliv-reduc_cat, 1 hit
PF01408 GFO_IDH_MocA, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037032 Biliverdin_reductase_A, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD040165 Biliverdin_Rdtase_cat, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P53004-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS
60 70 80 90 100
IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM
110 120 130 140 150
TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL
160 170 180 190 200
LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK
210 220 230 240 250
MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI
260 270 280 290
FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK
Length:296
Mass (Da):33,428
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CF2AA7F1CDDB707
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1E1C9J1E1_HUMAN
Biliverdin reductase A
BLVRA
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121L → S in AAH05902 (PubMed:15489334).Curated1
Sequence conflicti154 – 155AG → SD in CAA63635 (PubMed:8631357).Curated2
Sequence conflicti160E → D in CAA63635 (PubMed:8631357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0192303A → T3 PublicationsCorresponds to variant dbSNP:rs699512Ensembl.1
Natural variantiVAR_01923137L → V1 PublicationCorresponds to variant dbSNP:rs17245918Ensembl.1
Natural variantiVAR_01485156Q → R1 PublicationCorresponds to variant dbSNP:rs1050916Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U34877 mRNA Translation: AAC35588.1
X93086 mRNA Translation: CAA63635.1
AK291862 mRNA Translation: BAF84551.1
AY616754 Genomic DNA Translation: AAT11126.1
AC005189 Genomic DNA No translation available.
AC004939 Genomic DNA Translation: AAD05025.1
AC004985 Genomic DNA Translation: AAP21879.1
BC005902 mRNA Translation: AAH05902.1
BC008456 mRNA Translation: AAH08456.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5472.1

Protein sequence database of the Protein Information Resource

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PIRi
G02066
S62624

NCBI Reference Sequences

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RefSeqi
NP_000703.2, NM_000712.3
NP_001240752.1, NM_001253823.1
XP_011513776.1, XM_011515474.2
XP_016868009.1, XM_017012520.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.488143

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265523; ENSP00000265523; ENSG00000106605
ENST00000402924; ENSP00000385757; ENSG00000106605

Database of genes from NCBI RefSeq genomes

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GeneIDi
644

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:644

UCSC genome browser

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UCSCi
uc003tir.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34877 mRNA Translation: AAC35588.1
X93086 mRNA Translation: CAA63635.1
AK291862 mRNA Translation: BAF84551.1
AY616754 Genomic DNA Translation: AAT11126.1
AC005189 Genomic DNA No translation available.
AC004939 Genomic DNA Translation: AAD05025.1
AC004985 Genomic DNA Translation: AAP21879.1
BC005902 mRNA Translation: AAH05902.1
BC008456 mRNA Translation: AAH08456.1
CCDSiCCDS5472.1
PIRiG02066
S62624
RefSeqiNP_000703.2, NM_000712.3
NP_001240752.1, NM_001253823.1
XP_011513776.1, XM_011515474.2
XP_016868009.1, XM_017012520.1
UniGeneiHs.488143

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H63X-ray2.70A/B/C/D7-296[»]
ProteinModelPortaliP53004
SMRiP53004
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107113, 25 interactors
CORUMiP53004
DIPiDIP-42180N
IntActiP53004, 8 interactors
MINTiP53004
STRINGi9606.ENSP00000385757

Chemistry databases

DrugBankiDB00157 NADH

PTM databases

iPTMnetiP53004
PhosphoSitePlusiP53004

Polymorphism and mutation databases

BioMutaiBLVRA
DMDMi23830892

2D gel databases

OGPiP53004
REPRODUCTION-2DPAGEiIPI00294158

Proteomic databases

EPDiP53004
jPOSTiP53004
MaxQBiP53004
PaxDbiP53004
PeptideAtlasiP53004
PRIDEiP53004
ProteomicsDBi56566

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265523; ENSP00000265523; ENSG00000106605
ENST00000402924; ENSP00000385757; ENSG00000106605
GeneIDi644
KEGGihsa:644
UCSCiuc003tir.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
644
DisGeNETi644
EuPathDBiHostDB:ENSG00000106605.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BLVRA
HGNCiHGNC:1062 BLVRA
HPAiHPA019709
HPA042865
HPA054322
MalaCardsiBLVRA
MIMi109750 gene
614156 phenotype
neXtProtiNX_P53004
OpenTargetsiENSG00000106605
Orphaneti276405 Hyperbiliverdinemia
PharmGKBiPA25373

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH7U Eukaryota
ENOG4111FZX LUCA
GeneTreeiENSGT00390000011072
HOGENOMiHOG000231884
HOVERGENiHBG003218
InParanoidiP53004
KOiK00214
OMAiPMTLSWA
OrthoDBi879838at2759
PhylomeDBiP53004
TreeFamiTF342889

Enzyme and pathway databases

UniPathwayi
UPA00684

BioCyciMetaCyc:HS02928-MONOMER
BRENDAi1.3.1.24 2681
ReactomeiR-HSA-189483 Heme degradation
SIGNORiP53004

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BLVRA human
EvolutionaryTraceiP53004

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
644

Protein Ontology

More...
PROi
PR:P53004

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106605 Expressed in 231 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiP53004 baseline and differential
GenevisibleiP53004 HS

Family and domain databases

InterProiView protein in InterPro
IPR017094 Biliverdin_Rdtase_A
IPR015249 Biliverdin_Rdtase_cat
IPR036291 NAD(P)-bd_dom_sf
IPR000683 Oxidoreductase_N
PfamiView protein in Pfam
PF09166 Biliv-reduc_cat, 1 hit
PF01408 GFO_IDH_MocA, 1 hit
PIRSFiPIRSF037032 Biliverdin_reductase_A, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD040165 Biliverdin_Rdtase_cat, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIEA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53004
Secondary accession number(s): A8K747
, O95019, Q86UX0, Q96QL4, Q9BRW8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 10, 2002
Last modified: April 10, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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