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Protein

GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Gene

ART1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has ADP-ribosyltransferase activity toward GLP1R.1 Publication

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121NADBy similarity1
Binding sitei179NADBy similarity1
Binding sitei233NADBy similarity1
Active sitei247By similarity1

GO - Molecular functioni

  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: Reactome
  • NAD+ ADP-ribosyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-HSA-1462054 Alpha-defensins

Names & Taxonomyi

Protein namesi
Recommended name:
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 1
Short name:
ARTC1
Mono(ADP-ribosyl)transferase 1
CD_antigen: CD296
Gene namesi
Name:ART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000129744.2
HGNCiHGNC:723 ART1
MIMi601625 gene
neXtProtiNX_P52961

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi417
OpenTargetsiENSG00000129744
PharmGKBiPA25014

Chemistry databases

ChEMBLiCHEMBL2158
DrugBankiDB01854 5-Bromonicotinamide

Polymorphism and mutation databases

BioMutaiART1
DMDMi206729882

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001931123 – 295GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1Add BLAST273
PropeptideiPRO_0000019312296 – 327Removed in mature formSequence analysisAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 277By similarity
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi174 ↔ 224By similarity
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi295GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP52961
PeptideAtlasiP52961
PRIDEiP52961
ProteomicsDBi56565

PTM databases

PhosphoSitePlusiP52961

Expressioni

Gene expression databases

BgeeiENSG00000129744 Expressed in 65 organ(s), highest expression level in muscle of leg
CleanExiHS_ART1
GenevisibleiP52961 HS

Organism-specific databases

HPAiHPA051148

Interactioni

Protein-protein interaction databases

BioGridi106910, 6 interactors
STRINGi9606.ENSP00000250693

Structurei

3D structure databases

ProteinModelPortaliP52961
SMRiP52961
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGR0 Eukaryota
ENOG4111WZG LUCA
GeneTreeiENSGT00530000062975
HOGENOMiHOG000273888
HOVERGENiHBG004464
InParanoidiP52961
KOiK06716
OMAiPASFDDQ
OrthoDBiEOG091G0BSN
PhylomeDBiP52961
TreeFamiTF335356

Family and domain databases

InterProiView protein in InterPro
IPR000768 ART
PfamiView protein in Pfam
PF01129 ART, 1 hit
PRINTSiPR00970 RIBTRNSFRASE
PROSITEiView protein in PROSITE
PS01291 ART, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52961-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY
60 70 80 90 100
AGCAAAMTAA LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP
110 120 130 140 150
TRPSPPPLGF RDEHGVALLA YTANSPLHKE FNAAVREAGR SRAHYLHHFS
160 170 180 190 200
FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG VHGLRFRPAG PRATVRLGGF
210 220 230 240 250
ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE VLIPPFETFQ
260 270 280 290 300
VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS
310 320
PLSAVWSLLL LLWFLVVRAF PDGPGLL
Length:327
Mass (Da):36,335
Last modified:September 23, 2008 - v2
Checksum:i8FDC568197031EA5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034125105P → L. Corresponds to variant dbSNP:rs35123761Ensembl.1
Natural variantiVAR_034126126P → R. Corresponds to variant dbSNP:rs35619488Ensembl.1
Natural variantiVAR_053526257L → P1 PublicationCorresponds to variant dbSNP:rs2280134Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74683 mRNA Translation: AAB32387.1
CH471158 Genomic DNA Translation: EAX02559.1
BC069102 mRNA Translation: AAH69102.1
BC111729 mRNA Translation: AAI11730.1
AJ291430 mRNA Translation: CAC69964.1
CCDSiCCDS7744.1
PIRiA55966
RefSeqiNP_004305.2, NM_004314.2
XP_011518416.1, XM_011520114.2
XP_016873252.1, XM_017017763.1
UniGeneiHs.382188

Genome annotation databases

EnsembliENST00000250693; ENSP00000250693; ENSG00000129744
GeneIDi417
KEGGihsa:417
UCSCiuc001lye.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74683 mRNA Translation: AAB32387.1
CH471158 Genomic DNA Translation: EAX02559.1
BC069102 mRNA Translation: AAH69102.1
BC111729 mRNA Translation: AAI11730.1
AJ291430 mRNA Translation: CAC69964.1
CCDSiCCDS7744.1
PIRiA55966
RefSeqiNP_004305.2, NM_004314.2
XP_011518416.1, XM_011520114.2
XP_016873252.1, XM_017017763.1
UniGeneiHs.382188

3D structure databases

ProteinModelPortaliP52961
SMRiP52961
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106910, 6 interactors
STRINGi9606.ENSP00000250693

Chemistry databases

ChEMBLiCHEMBL2158
DrugBankiDB01854 5-Bromonicotinamide

PTM databases

PhosphoSitePlusiP52961

Polymorphism and mutation databases

BioMutaiART1
DMDMi206729882

Proteomic databases

PaxDbiP52961
PeptideAtlasiP52961
PRIDEiP52961
ProteomicsDBi56565

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250693; ENSP00000250693; ENSG00000129744
GeneIDi417
KEGGihsa:417
UCSCiuc001lye.1 human

Organism-specific databases

CTDi417
DisGeNETi417
EuPathDBiHostDB:ENSG00000129744.2
GeneCardsiART1
H-InvDBiHIX0035913
HGNCiHGNC:723 ART1
HPAiHPA051148
MIMi601625 gene
neXtProtiNX_P52961
OpenTargetsiENSG00000129744
PharmGKBiPA25014
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGR0 Eukaryota
ENOG4111WZG LUCA
GeneTreeiENSGT00530000062975
HOGENOMiHOG000273888
HOVERGENiHBG004464
InParanoidiP52961
KOiK06716
OMAiPASFDDQ
OrthoDBiEOG091G0BSN
PhylomeDBiP52961
TreeFamiTF335356

Enzyme and pathway databases

ReactomeiR-HSA-1462054 Alpha-defensins

Miscellaneous databases

GenomeRNAii417
PROiPR:P52961
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129744 Expressed in 65 organ(s), highest expression level in muscle of leg
CleanExiHS_ART1
GenevisibleiP52961 HS

Family and domain databases

InterProiView protein in InterPro
IPR000768 ART
PfamiView protein in Pfam
PF01129 ART, 1 hit
PRINTSiPR00970 RIBTRNSFRASE
PROSITEiView protein in PROSITE
PS01291 ART, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAR1_HUMAN
AccessioniPrimary (citable) accession number: P52961
Secondary accession number(s): Q6NTD2, Q96KT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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