UniProtKB - P52961 (NAR1_HUMAN)
Protein
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Gene
ART1
Organism
Homo sapiens (Human)
Status
Functioni
Has ADP-ribosyltransferase activity toward GLP1R.1 Publication
Catalytic activityi
- EC:2.4.2.31
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 121 | NADBy similarity | 1 | |
Binding sitei | 179 | NADBy similarity | 1 | |
Binding sitei | 233 | NADBy similarity | 1 | |
Active sitei | 247 | By similarity | 1 |
GO - Molecular functioni
- NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: Reactome
- NAD+ ADP-ribosyltransferase activity Source: GO_Central
- NAD+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC
- NADP+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- peptidyl-arginine ADP-ribosylation Source: GO_Central
- protein ADP-ribosylation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Ligand | NAD, NADP |
Enzyme and pathway databases
PathwayCommonsi | P52961 |
Reactomei | R-HSA-1462054, Alpha-defensins |
Names & Taxonomyi
Protein namesi | Recommended name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC:2.4.2.31)Alternative name(s): ADP-ribosyltransferase C2 and C3 toxin-like 1 Short name: ARTC1 Mono(ADP-ribosyl)transferase 1 CD_antigen: CD296 |
Gene namesi | Name:ART1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:723, ART1 |
MIMi | 601625, gene |
neXtProti | NX_P52961 |
VEuPathDBi | HostDB:ENSG00000129744.2 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: Ensembl
Keywords - Cellular componenti
Membrane, Sarcoplasmic reticulumPathology & Biotechi
Organism-specific databases
DisGeNETi | 417 |
OpenTargetsi | ENSG00000129744 |
PharmGKBi | PA25014 |
Miscellaneous databases
Pharosi | P52961, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2158 |
DrugBanki | DB01854, 5-Bromonicotinamide |
Genetic variation databases
BioMutai | ART1 |
DMDMi | 206729882 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000019311 | 23 – 295 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1Add BLAST | 273 | |
PropeptideiPRO_0000019312 | 296 – 327 | Removed in mature formSequence analysisAdd BLAST | 32 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 277 | By similarity | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 174 ↔ 224 | By similarity | ||
Glycosylationi | 253 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 295 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
MassIVEi | P52961 |
PaxDbi | P52961 |
PeptideAtlasi | P52961 |
PRIDEi | P52961 |
ProteomicsDBi | 56565 |
PTM databases
GlyGeni | P52961, 2 sites |
PhosphoSitePlusi | P52961 |
Expressioni
Gene expression databases
Bgeei | ENSG00000129744, Expressed in muscle of leg and 86 other tissues |
Genevisiblei | P52961, HS |
Organism-specific databases
HPAi | ENSG00000129744, Group enriched (skeletal muscle, tongue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 106910, 6 interactors |
STRINGi | 9606.ENSP00000250693 |
Miscellaneous databases
RNActi | P52961, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Arg-specific ADP-ribosyltransferase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUE9, Eukaryota |
GeneTreei | ENSGT01010000222513 |
HOGENOMi | CLU_059744_1_0_1 |
InParanoidi | P52961 |
OMAi | NSAMGQG |
OrthoDBi | 963174at2759 |
PhylomeDBi | P52961 |
TreeFami | TF335356 |
Family and domain databases
InterProi | View protein in InterPro IPR000768, ART |
Pfami | View protein in Pfam PF01129, ART, 1 hit |
PRINTSi | PR00970, RIBTRNSFRASE |
PROSITEi | View protein in PROSITE PS01291, ART, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P52961-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY
60 70 80 90 100
AGCAAAMTAA LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP
110 120 130 140 150
TRPSPPPLGF RDEHGVALLA YTANSPLHKE FNAAVREAGR SRAHYLHHFS
160 170 180 190 200
FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG VHGLRFRPAG PRATVRLGGF
210 220 230 240 250
ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE VLIPPFETFQ
260 270 280 290 300
VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS
310 320
PLSAVWSLLL LLWFLVVRAF PDGPGLL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034125 | 105 | P → L. Corresponds to variant dbSNP:rs35123761Ensembl. | 1 | |
Natural variantiVAR_034126 | 126 | P → R. Corresponds to variant dbSNP:rs35619488Ensembl. | 1 | |
Natural variantiVAR_053526 | 257 | L → P1 PublicationCorresponds to variant dbSNP:rs2280134Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S74683 mRNA Translation: AAB32387.1 CH471158 Genomic DNA Translation: EAX02559.1 BC069102 mRNA Translation: AAH69102.1 BC111729 mRNA Translation: AAI11730.1 AJ291430 mRNA Translation: CAC69964.1 |
CCDSi | CCDS7744.1 |
PIRi | A55966 |
RefSeqi | NP_004305.2, NM_004314.2 XP_011518416.1, XM_011520114.2 XP_016873252.1, XM_017017763.1 |
Genome annotation databases
Ensembli | ENST00000250693; ENSP00000250693; ENSG00000129744 |
GeneIDi | 417 |
KEGGi | hsa:417 |
UCSCi | uc001lye.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S74683 mRNA Translation: AAB32387.1 CH471158 Genomic DNA Translation: EAX02559.1 BC069102 mRNA Translation: AAH69102.1 BC111729 mRNA Translation: AAI11730.1 AJ291430 mRNA Translation: CAC69964.1 |
CCDSi | CCDS7744.1 |
PIRi | A55966 |
RefSeqi | NP_004305.2, NM_004314.2 XP_011518416.1, XM_011520114.2 XP_016873252.1, XM_017017763.1 |
3D structure databases
SMRi | P52961 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106910, 6 interactors |
STRINGi | 9606.ENSP00000250693 |
Chemistry databases
ChEMBLi | CHEMBL2158 |
DrugBanki | DB01854, 5-Bromonicotinamide |
PTM databases
GlyGeni | P52961, 2 sites |
PhosphoSitePlusi | P52961 |
Genetic variation databases
BioMutai | ART1 |
DMDMi | 206729882 |
Proteomic databases
MassIVEi | P52961 |
PaxDbi | P52961 |
PeptideAtlasi | P52961 |
PRIDEi | P52961 |
ProteomicsDBi | 56565 |
Protocols and materials databases
Antibodypediai | 23357, 206 antibodies |
Genome annotation databases
Ensembli | ENST00000250693; ENSP00000250693; ENSG00000129744 |
GeneIDi | 417 |
KEGGi | hsa:417 |
UCSCi | uc001lye.1, human |
Organism-specific databases
CTDi | 417 |
DisGeNETi | 417 |
GeneCardsi | ART1 |
HGNCi | HGNC:723, ART1 |
HPAi | ENSG00000129744, Group enriched (skeletal muscle, tongue) |
MIMi | 601625, gene |
neXtProti | NX_P52961 |
OpenTargetsi | ENSG00000129744 |
PharmGKBi | PA25014 |
VEuPathDBi | HostDB:ENSG00000129744.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUE9, Eukaryota |
GeneTreei | ENSGT01010000222513 |
HOGENOMi | CLU_059744_1_0_1 |
InParanoidi | P52961 |
OMAi | NSAMGQG |
OrthoDBi | 963174at2759 |
PhylomeDBi | P52961 |
TreeFami | TF335356 |
Enzyme and pathway databases
PathwayCommonsi | P52961 |
Reactomei | R-HSA-1462054, Alpha-defensins |
Miscellaneous databases
BioGRID-ORCSi | 417, 1 hit in 871 CRISPR screens |
ChiTaRSi | ART1, human |
GenomeRNAii | 417 |
Pharosi | P52961, Tbio |
PROi | PR:P52961 |
RNActi | P52961, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129744, Expressed in muscle of leg and 86 other tissues |
Genevisiblei | P52961, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000768, ART |
Pfami | View protein in Pfam PF01129, ART, 1 hit |
PRINTSi | PR00970, RIBTRNSFRASE |
PROSITEi | View protein in PROSITE PS01291, ART, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAR1_HUMAN | |
Accessioni | P52961Primary (citable) accession number: P52961 Secondary accession number(s): Q6NTD2, Q96KT9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries