ART1

Functionⁱ

Has ADP-ribosyltransferase activity toward GLP1R.1 Publication

Catalytic activityⁱ

NAD⁺ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	121	NADBy similarity	1
Binding siteⁱ	179	NADBy similarity	1
Binding siteⁱ	233	NADBy similarity	1
Active siteⁱ	247	By similarity	1

GO - Molecular functionⁱ

NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: Reactome
NAD+ ADP-ribosyltransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

peptidyl-arginine ADP-ribosylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein ADP-ribosylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	NAD, NADP

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1462054 Alpha-defensins

Reactomeⁱ

R-HSA-1462054 Alpha-defensins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC:2.4.2.31) Alternative name(s): ADP-ribosyltransferase C2 and C3 toxin-like 1 Short name: ARTC1 Mono(ADP-ribosyl)transferase 1 CD_antigen: CD296
Gene namesⁱ	Name:ART1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129744.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:723 ART1
MIMⁱ	601625 gene
neXtProtⁱ	NX_P52961

Keywords - Cellular componentⁱ

Membrane, Sarcoplasmic reticulum

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	417
Open Targets More...OpenTargetsⁱ	ENSG00000129744
PharmGKBⁱ	PA25014

Chemistry databases

ChEMBLⁱ	CHEMBL2158
Drug and drug target database More...DrugBankⁱ	DB01854 5-Bromonicotinamide

Polymorphism and mutation databases

BioMutaⁱ	ART1
DMDMⁱ	206729882

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST	22
ChainⁱPRO_0000019311	23 – 295	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1Add BLAST	273
PropeptideⁱPRO_0000019312	296 – 327	Removed in mature formSequence analysisAdd BLAST	32

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	53 ↔ 277	By similarity
Glycosylationⁱ	65	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	174 ↔ 224	By similarity
Glycosylationⁱ	253	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	295	GPI-anchor amidated serineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbⁱ	P52961
PeptideAtlas More...PeptideAtlasⁱ	P52961
PRIDEⁱ	P52961
ProteomicsDBⁱ	56565

PTM databases

PhosphoSitePlusⁱ	P52961

PhosphoSitePlusⁱ

P52961

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000129744 Expressed in 65 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_ART1
Genevisibleⁱ	P52961 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051148

HPAⁱ

HPA051148

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	106910, 6 interactors
STRINGⁱ	9606.ENSP00000250693

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52961
SMRⁱ	P52961
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Arg-specific ADP-ribosyltransferase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IGR0 Eukaryota ENOG4111WZG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062975
HOGENOMⁱ	HOG000273888
HOVERGENⁱ	HBG004464
InParanoidⁱ	P52961
KEGG Orthology (KO) More...KOⁱ	K06716
OMAⁱ	PASFDDQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BSN
PhylomeDBⁱ	P52961
TreeFamⁱ	TF335356

Family and domain databases

InterProⁱ	View protein in InterPro IPR000768 ART
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01129 ART, 1 hit
PRINTSⁱ	PR00970 RIBTRNSFRASE
PROSITEⁱ	View protein in PROSITE PS01291 ART, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P52961-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY 
        60         70         80         90        100
AGCAAAMTAA LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP 
       110        120        130        140        150
TRPSPPPLGF RDEHGVALLA YTANSPLHKE FNAAVREAGR SRAHYLHHFS 
       160        170        180        190        200
FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG VHGLRFRPAG PRATVRLGGF 
       210        220        230        240        250
ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE VLIPPFETFQ 
       260        270        280        290        300
VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS 
       310        320 
PLSAVWSLLL LLWFLVVRAF PDGPGLL

Length:327

Mass (Da):36,335

Last modified:September 23, 2008 - v2

Checksum:ⁱ8FDC568197031EA5

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034125	105	P → L. Corresponds to variant dbSNP:rs35123761Ensembl.	1
Natural variantⁱVAR_034126	126	P → R. Corresponds to variant dbSNP:rs35619488Ensembl.	1
Natural variantⁱVAR_053526	257	L → P1 PublicationCorresponds to variant dbSNP:rs2280134Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S74683 mRNA Translation: AAB32387.1 CH471158 Genomic DNA Translation: EAX02559.1 BC069102 mRNA Translation: AAH69102.1 BC111729 mRNA Translation: AAI11730.1 AJ291430 mRNA Translation: CAC69964.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7744.1
PIRⁱ	A55966
NCBI Reference Sequences More...RefSeqⁱ	NP_004305.2, NM_004314.2 XP_011518416.1, XM_011520114.2 XP_016873252.1, XM_017017763.1
UniGeneⁱ	Hs.382188

Genome annotation databases

Ensemblⁱ	ENST00000250693; ENSP00000250693; ENSG00000129744
GeneIDⁱ	417
KEGGⁱ	hsa:417
UCSC genome browser More...UCSCⁱ	uc001lye.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52961	NAD(P)(+)--arginine ADP-ribosyltransferase		PANTR		327	UniRef90_P52961
NAD(P)(+)--arginine ADP-ribosyltransferase		PANPA		327
NAD(P)(+)--arginine ADP-ribosyltransferase		SAIBB		327
NAD(P)(+)--arginine ADP-ribosyltransferase		CALJA		327
NAD(P)(+)--arginine ADP-ribosyltransferase		Cebus capucinus imitator		327
+5

Protein	Similar proteins		Species	Score	Length	Source
P52961	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1		MOUSE		325	UniRef50_P52961
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1		RABIT		327
NAD(P)(+)--arginine ADP-ribosyltransferase		PANTR		327
NAD(P)(+)--arginine ADP-ribosyltransferase		PANPA		327
NAD(P)(+)--arginine ADP-ribosyltransferase		Cebus capucinus imitator		327
+160

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S74683 mRNA Translation: AAB32387.1 CH471158 Genomic DNA Translation: EAX02559.1 BC069102 mRNA Translation: AAH69102.1 BC111729 mRNA Translation: AAI11730.1 AJ291430 mRNA Translation: CAC69964.1
CCDSⁱ	CCDS7744.1
PIRⁱ	A55966
RefSeqⁱ	NP_004305.2, NM_004314.2 XP_011518416.1, XM_011520114.2 XP_016873252.1, XM_017017763.1
UniGeneⁱ	Hs.382188

3D structure databases

ProteinModelPortalⁱ	P52961
SMRⁱ	P52961
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106910, 6 interactors
STRINGⁱ	9606.ENSP00000250693

Chemistry databases

ChEMBLⁱ	CHEMBL2158
DrugBankⁱ	DB01854 5-Bromonicotinamide

PTM databases

PhosphoSitePlusⁱ	P52961

PhosphoSitePlusⁱ

P52961

Polymorphism and mutation databases

BioMutaⁱ	ART1
DMDMⁱ	206729882

Proteomic databases

PaxDbⁱ	P52961
PeptideAtlasⁱ	P52961
PRIDEⁱ	P52961
ProteomicsDBⁱ	56565

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000250693; ENSP00000250693; ENSG00000129744
GeneIDⁱ	417
KEGGⁱ	hsa:417
UCSCⁱ	uc001lye.1 human

Organism-specific databases

CTDⁱ	417
DisGeNETⁱ	417
EuPathDBⁱ	HostDB:ENSG00000129744.2
GeneCardsⁱ	ART1
H-InvDBⁱ	HIX0035913
HGNCⁱ	HGNC:723 ART1
HPAⁱ	HPA051148
MIMⁱ	601625 gene
neXtProtⁱ	NX_P52961
OpenTargetsⁱ	ENSG00000129744
PharmGKBⁱ	PA25014
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGR0 Eukaryota ENOG4111WZG LUCA
GeneTreeⁱ	ENSGT00530000062975
HOGENOMⁱ	HOG000273888
HOVERGENⁱ	HBG004464
InParanoidⁱ	P52961
KOⁱ	K06716
OMAⁱ	PASFDDQ
OrthoDBⁱ	EOG091G0BSN
PhylomeDBⁱ	P52961
TreeFamⁱ	TF335356

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1462054 Alpha-defensins

Reactomeⁱ

R-HSA-1462054 Alpha-defensins

Miscellaneous databases

GenomeRNAiⁱ	417
Protein Ontology More...PROⁱ	PR:P52961
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129744 Expressed in 65 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_ART1
Genevisibleⁱ	P52961 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000768 ART
Pfamⁱ	View protein in Pfam PF01129 ART, 1 hit
PRINTSⁱ	PR00970 RIBTRNSFRASE
PROSITEⁱ	View protein in PROSITE PS01291 ART, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAR1_HUMAN
Accessionⁱ	P52961Primary (citable) accession number: P52961 Secondary accession number(s): Q6NTD2, Q96KT9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	September 23, 2008
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P52961 (NAR1_HUMAN)

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GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ