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Entry version 155 (13 Feb 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Peroxisome proliferation transcriptional regulator

Gene

PIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. Activity is inhibited by OAF1 under non-inducing conditions. Activity is repressed by glucose.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi25 – 52Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-33833-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferation transcriptional regulator
Alternative name(s):
Oleate-activated transcription factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIP2
Synonyms:OAF2
Ordered Locus Names:YOR363C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YOR363C

Saccharomyces Genome Database

More...
SGDi
S000005890 PIP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149641 – 996Peroxisome proliferation transcriptional regulatorAdd BLAST996

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52960

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52960

PRoteomics IDEntifications database

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PRIDEi
P52960

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52960

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Autoregulated. Induced upon growth on fatty acids.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of PIP2 and OAF1.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34748, 50 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1038 Pip2-Oaf1 transcription factor complex

Database of interacting proteins

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DIPi
DIP-1013N

Protein interaction database and analysis system

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IntActi
P52960, 1 interactor

Molecular INTeraction database

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MINTi
P52960

STRING: functional protein association networks

More...
STRINGi
4932.YOR363C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P52960

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P52960

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi985 – 9939aaTAD9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the 9aaTAD motif (residues 985 to 993) is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000066010

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P52960

Identification of Orthologs from Complete Genome Data

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OMAi
DESSPAM

Family and domain databases

Conserved Domains Database

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CDDi
cd00067 GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00172 Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00066 GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701 SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P52960-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYFTDESSPA MNRVGKKRNR LSFVCQACRK AKTKCDQEKP RCGRCTKQNL
60 70 80 90 100
FCIYDVARQA APRNPNKDAT IARLKKEIRY WRNKTVDLTQ EKKDFYTALK
110 120 130 140 150
RPTEELAARR TCKSLQENSF PISLYKTHPR LIMTKVMKRE INPLSEKYLI
160 170 180 190 200
FQDTFLKTLI ASVLLSCSRN SMIPALNADI SRSRTQPCVK NNVVKMREVL
210 220 230 240 250
LKNSKYESQR KSINEFTDRL LQRKNPEEQI AVNKVISLLY SNRESSYLED
260 270 280 290 300
TCPTENDYSD LLKGYINEIE KTLPPKAIIE QYLSHFFEHI FHLIPFASKE
310 320 330 340 350
MLEESIHTTV QYNELGEVRL SMGTTLIRNK MENLCILLLI LRIAYISLTF
360 370 380 390 400
IEDKIEDYSP YITKEMLEQY PIQSEVIFLA QQILASENWC ACANENTISC
410 420 430 440 450
LLYIWCAFVF SPTEGDFLLE QPSDVIINLV ILIGTSIGLH RDPSDFPALN
460 470 480 490 500
HPEASDKRLL NLRRIQWLSI ISMATLESSL KGRLLVSPLS MIDLFIDVRD
510 520 530 540 550
PNCVEIYKKR VKKDLTGSES DEQLLEIHEI FFHRAQLALF LSDLNNITIS
560 570 580 590 600
YSGSVPMDTL ETLRVKANEL LKNKFQLRSV DINIYDEEKT FQKLTFNSIL
610 620 630 640 650
NSISLSGQIL GKLMMLRASI ALMLYFETLA MERSECLSFF YKYFFQCCAD
660 670 680 690 700
TISLIRFFFL YFNGSYEKVL SSLVCFITTK VIQLAVPTTM FTLLVIIMRV
710 720 730 740 750
ELAKNMLLVK CNECNARGDI SDLPEIKEKI KSLDTIKENF ERLLLEVYLL
760 770 780 790 800
ASQNLRFKYF YIFKMLTLFD VFIQRLRKGQ LFSGLFVKVD KDLTTKKIAT
810 820 830 840 850
MLELTLGINL DKSDHLIDRL KGKNLTVNFT LDQLYQIIKE FDRIKNIGVA
860 870 880 890 900
DPQNSLNPSK PNMKDNTPTI ELLLNSSVEN ESVPPYSSSN DPTNVGNAST
910 920 930 940 950
YSLAHNISNQ NNEENMPPSI GSSESNRAAP NLNFMPINNN YNNSGSNINN
960 970 980 990
NDNVKLPSNF KNYYDPPMSS LDISMDVPDI FGSLDFFDYD LLFQND
Length:996
Mass (Da):114,711
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4E3895746EFCF3E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X91991 Genomic DNA Translation: CAA63046.1
Z75271 Genomic DNA Translation: CAA99692.1
BK006948 Genomic DNA Translation: DAA11124.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S70646

NCBI Reference Sequences

More...
RefSeqi
NP_015008.3, NM_001183783.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR363C_mRNA; YOR363C_mRNA; YOR363C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR363C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91991 Genomic DNA Translation: CAA63046.1
Z75271 Genomic DNA Translation: CAA99692.1
BK006948 Genomic DNA Translation: DAA11124.1
PIRiS70646
RefSeqiNP_015008.3, NM_001183783.3

3D structure databases

ProteinModelPortaliP52960
SMRiP52960
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34748, 50 interactors
ComplexPortaliCPX-1038 Pip2-Oaf1 transcription factor complex
DIPiDIP-1013N
IntActiP52960, 1 interactor
MINTiP52960
STRINGi4932.YOR363C

PTM databases

iPTMnetiP52960

Proteomic databases

MaxQBiP52960
PaxDbiP52960
PRIDEiP52960

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR363C_mRNA; YOR363C_mRNA; YOR363C
GeneIDi854545
KEGGisce:YOR363C

Organism-specific databases

EuPathDBiFungiDB:YOR363C
SGDiS000005890 PIP2

Phylogenomic databases

GeneTreeiENSGT00940000176335
HOGENOMiHOG000066010
InParanoidiP52960
OMAiDESSPAM

Enzyme and pathway databases

BioCyciYEAST:G3O-33833-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P52960

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIP2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52960
Secondary accession number(s): D6W358
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 13, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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