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Entry version 206 (11 Dec 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Homeobox protein Nkx-2.5

Gene

NKX2-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi138 – 197HomeoboxPROSITE-ProRule annotation2 PublicationsAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-5578768 Physiological factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P52952

SIGNOR Signaling Network Open Resource

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SIGNORi
P52952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Nkx-2.5
Alternative name(s):
Cardiac-specific homeobox
Homeobox protein CSX
Homeobox protein NK-2 homolog E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NKX2-5
Synonyms:CSX, NKX2.5, NKX2E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000183072.9

Human Gene Nomenclature Database

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HGNCi
HGNC:2488 NKX2-5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600584 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52952

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Atrial septal defect 7, with or without atrioventricular conduction defects (ASD7)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria, and atrioventricular conduction defects in some cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0382127L → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_03821315K → I in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs387906773EnsemblClinVar.1
Natural variantiVAR_03821419N → S in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_03821521E → Q in TOF and ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893904EnsemblClinVar.1
Natural variantiVAR_03821622Q → P in ASD7 and TOF. 2 PublicationsCorresponds to variant dbSNP:rs201442000EnsemblClinVar.1
Natural variantiVAR_01011625R → C in ASD7, TOF, CHNG5, HLHS2 and CTHM; unknown pathological significance; exhibits significant functional impairment with reduction of transactivation properties and dominant-negative effect; the mutant protein activity on the DIO2, TG and TPO promoters is significantly impaired. 7 PublicationsCorresponds to variant dbSNP:rs28936670EnsemblClinVar.1
Natural variantiVAR_03821745S → P in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs779548360Ensembl.1
Natural variantiVAR_03821851F → L in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs753937287Ensembl.1
Natural variantiVAR_03821963A → V in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs530270916Ensembl.1
Natural variantiVAR_03822069L → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_03822177P → L in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038222114C → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038223114C → S in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038224118K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038225124K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038226126E → V in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038227127A → E in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs387906774EnsemblClinVar.1
Natural variantiVAR_038228133P → S in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1184594159Ensembl.1
Natural variantiVAR_038229135A → T in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038230142R → C in ASD7. 1 Publication1
Natural variantiVAR_038231144L → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_003752178T → M in ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893900EnsemblClinVar.1
Natural variantiVAR_038232183K → E in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs137852686EnsemblClinVar.1
Natural variantiVAR_038233187Q → H in ASD7. 1 Publication1
Natural variantiVAR_010117188N → K in ASD7. 2 Publications1
Natural variantiVAR_010118189R → G in ASD7. 2 Publications1
Natural variantiVAR_038234190R → C in ASD7. 1 PublicationCorresponds to variant dbSNP:rs104893906EnsemblClinVar.1
Natural variantiVAR_010119191Y → C in ASD7. 2 Publications1
Natural variantiVAR_038235192K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038236192K → T in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038237194K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038238205V → E in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038239216R → C in TOF and ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893905EnsemblClinVar.1
Natural variantiVAR_038240219A → V in ASD7 and TOF; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs104893902EnsemblClinVar.1
Natural variantiVAR_038241226D → N in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760528062Ensembl.1
Natural variantiVAR_038242248Y → H in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038243275P → T in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs368366482Ensembl.1
Natural variantiVAR_038244279S → F in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1223599871Ensembl.1
Natural variantiVAR_038245279S → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038246281A → V in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038247286A → V in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038248294N → H in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038249299D → G in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs137852683EnsemblClinVar.1
Natural variantiVAR_038250305S → G in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038251320G → S in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038252322R → Q in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038253323A → T in ASD7 and TOF. 2 Publications1
Tetralogy of Fallot (TOF)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03821521E → Q in TOF and ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893904EnsemblClinVar.1
Natural variantiVAR_03821622Q → P in ASD7 and TOF. 2 PublicationsCorresponds to variant dbSNP:rs201442000EnsemblClinVar.1
Natural variantiVAR_038239216R → C in TOF and ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893905EnsemblClinVar.1
Natural variantiVAR_038240219A → V in ASD7 and TOF; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs104893902EnsemblClinVar.1
Natural variantiVAR_038253323A → T in ASD7 and TOF. 2 Publications1
Conotruncal heart malformations (CTHM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01011625R → C in ASD7, TOF, CHNG5, HLHS2 and CTHM; unknown pathological significance; exhibits significant functional impairment with reduction of transactivation properties and dominant-negative effect; the mutant protein activity on the DIO2, TG and TPO promoters is significantly impaired. 7 PublicationsCorresponds to variant dbSNP:rs28936670EnsemblClinVar.1
Hypothyroidism, congenital, non-goitrous, 5 (CHNG5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-autoimmune condition characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG5 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047869119A → S in CHNG5; exhibits a significant functional impairment with reduction of transactivation properties and dominant-negative effect which was associated with reduced DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852684EnsemblClinVar.1
Natural variantiVAR_047870161R → P in CHNG5; exhibits a significant functional impairment with reduction of transactivation properties and dominant-negative effect which was associated with reduced DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852685EnsemblClinVar.1
Ventricular septal defect 3 (VSD3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06758659P → A in VSD3; significantly reduced activation of NPPA gene compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387906775EnsemblClinVar.1
Natural variantiVAR_067587283P → Q in VSD3. 1 PublicationCorresponds to variant dbSNP:rs375086983EnsemblClinVar.1
Hypoplastic left heart syndrome 2 (HLHS2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome due to defective development of the aorta proximal to the entrance of the ductus arteriosus, and hypoplasia of the left ventricle and mitral valve. As a result of the abnormal circulation, the ductus arteriosus and foramen ovale are patent and the right atrium, right ventricle, and pulmonary artery are enlarged.
Related information in OMIM

Keywords - Diseasei

Atrial septal defect, Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
1482

MalaCards human disease database

More...
MalaCardsi
NKX2-5
MIMi108900 phenotype
187500 phenotype
217095 phenotype
225250 phenotype
614432 phenotype
614435 phenotype

Open Targets

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OpenTargetsi
ENSG00000183072

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
95713 Athyreosis
99103 Atrial septal defect, ostium secundum type
1479 Atrial septal defect-atrioventricular conduction defects syndrome
1627 Deletion 5q35
334 Familial atrial fibrillation
402075 Familial bicuspid aortic valve
101351 Familial isolated congenital asplenia
871 Familial progressive cardiac conduction defect
2248 Hypoplastic left heart syndrome
1480 NON RARE IN EUROPE: Ventricular septal defect
3303 Tetralogy of Fallot
95712 Thyroid ectopia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24202

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P52952 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NKX2-5

Domain mapping of disease mutations (DMDM)

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DMDMi
1708211

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000489371 – 324Homeobox protein Nkx-2.5Add BLAST324

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P52952

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P52952

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P52952

PeptideAtlas

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PeptideAtlasi
P52952

PRoteomics IDEntifications database

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PRIDEi
P52952

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
19299
56562 [P52952-1]
56563 [P52952-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P52952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P52952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in the heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000183072 Expressed in 63 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P52952 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P52952 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA065034

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via the homeobox); binds DNA as homodimer (PubMed:22849347).

Interacts (via the homeobox) with TBX5 (via the T-box); this complex binds DNA (PubMed:26926761).

Interacts with HIPK1 and HIPK2, but not HIPK3.

Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain.

Also interacts with JARID2 which represses its ability to activate transcription of ANF.

Interacts with FBLIM1.

Interacts with TBX18 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107864, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-61 NKX2-5 homodimer complex

Protein interaction database and analysis system

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IntActi
P52952, 18 interactors

Molecular INTeraction database

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MINTi
P52952

STRING: functional protein association networks

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STRINGi
9606.ENSP00000327758

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P52952 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52952

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 108Ala/Pro-richAdd BLAST67
Compositional biasi208 – 282Ala/Pro-richAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The homeobox domain binds to double-stranded DNA (PubMed:22849347).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0842 Eukaryota
ENOG410XR21 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231923

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P52952

KEGG Orthology (KO)

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KOi
K09345

Identification of Orthologs from Complete Genome Data

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OMAi
DKKELCA

Database of Orthologous Groups

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OrthoDBi
1124079at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P52952

TreeFam database of animal gene trees

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TreeFami
TF351204

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR033629 NKX-2.5

The PANTHER Classification System

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PANTHERi
PTHR24340:SF28 PTHR24340:SF28, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00024 HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P52952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPSPALTPT PFSVKDILNL EQQQRSLAAA GELSARLEAT LAPSSCMLAA
60 70 80 90 100
FKPEAYAGPE AAAPGLPELR AELGRAPSPA KCASAFPAAP AFYPRAYSDP
110 120 130 140 150
DPAKDPRAEK KELCALQKAV ELEKTEADNA ERPRARRRRK PRVLFSQAQV
160 170 180 190 200
YELERRFKQQ RYLSAPERDQ LASVLKLTST QVKIWFQNRR YKCKRQRQDQ
210 220 230 240 250
TLELVGLPPP PPPPARRIAV PVLVRDGKPC LGDSAPYAPA YGVGLNPYGY
260 270 280 290 300
NAYPAYPGYG GAACSPGYSC TAAYPAGPSP AQPATAAANN NFVNFGVGDL
310 320
NAVQSPGIPQ SNSGVSTLHG IRAW
Length:324
Mass (Da):34,918
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACCC9C2F9C292586
GO
Isoform 2 (identifier: P52952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-151: ELCALQKAVE...RVLFSQAQVY → GCELPRGQRP...CRWLPVHLAE
     152-324: Missing.

Show »
Length:151
Mass (Da):16,102
Checksum:iFFBDEE031AFCB6AF
GO
Isoform 3 (identifier: P52952-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-112: E → A
     113-324: Missing.

Show »
Length:112
Mass (Da):11,681
Checksum:i1DED387CB9297E28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH49E5RH49_HUMAN
Homeobox protein Nkx-2.5
NKX2-5
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0382127L → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_03821315K → I in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs387906773EnsemblClinVar.1
Natural variantiVAR_04958116D → A. Corresponds to variant dbSNP:rs17052019Ensembl.1
Natural variantiVAR_03821419N → S in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_03821521E → Q in TOF and ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893904EnsemblClinVar.1
Natural variantiVAR_03821622Q → P in ASD7 and TOF. 2 PublicationsCorresponds to variant dbSNP:rs201442000EnsemblClinVar.1
Natural variantiVAR_01011625R → C in ASD7, TOF, CHNG5, HLHS2 and CTHM; unknown pathological significance; exhibits significant functional impairment with reduction of transactivation properties and dominant-negative effect; the mutant protein activity on the DIO2, TG and TPO promoters is significantly impaired. 7 PublicationsCorresponds to variant dbSNP:rs28936670EnsemblClinVar.1
Natural variantiVAR_03821745S → P in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs779548360Ensembl.1
Natural variantiVAR_03821851F → L in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs753937287Ensembl.1
Natural variantiVAR_06758659P → A in VSD3; significantly reduced activation of NPPA gene compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387906775EnsemblClinVar.1
Natural variantiVAR_03821963A → V in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs530270916Ensembl.1
Natural variantiVAR_03822069L → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_06905874G → D1 PublicationCorresponds to variant dbSNP:rs201362118Ensembl.1
Natural variantiVAR_03822177P → L in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038222114C → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038223114C → S in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038224118K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_047869119A → S in CHNG5; exhibits a significant functional impairment with reduction of transactivation properties and dominant-negative effect which was associated with reduced DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852684EnsemblClinVar.1
Natural variantiVAR_038225124K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038226126E → V in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038227127A → E in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs387906774EnsemblClinVar.1
Natural variantiVAR_038228133P → S in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1184594159Ensembl.1
Natural variantiVAR_038229135A → T in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038230142R → C in ASD7. 1 Publication1
Natural variantiVAR_038231144L → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_047870161R → P in CHNG5; exhibits a significant functional impairment with reduction of transactivation properties and dominant-negative effect which was associated with reduced DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852685EnsemblClinVar.1
Natural variantiVAR_003752178T → M in ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893900EnsemblClinVar.1
Natural variantiVAR_038232183K → E in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs137852686EnsemblClinVar.1
Natural variantiVAR_038233187Q → H in ASD7. 1 Publication1
Natural variantiVAR_010117188N → K in ASD7. 2 Publications1
Natural variantiVAR_010118189R → G in ASD7. 2 Publications1
Natural variantiVAR_038234190R → C in ASD7. 1 PublicationCorresponds to variant dbSNP:rs104893906EnsemblClinVar.1
Natural variantiVAR_010119191Y → C in ASD7. 2 Publications1
Natural variantiVAR_038235192K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038236192K → T in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038237194K → R in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038238205V → E in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038239216R → C in TOF and ASD7. 3 PublicationsCorresponds to variant dbSNP:rs104893905EnsemblClinVar.1
Natural variantiVAR_038240219A → V in ASD7 and TOF; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs104893902EnsemblClinVar.1
Natural variantiVAR_038241226D → N in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760528062Ensembl.1
Natural variantiVAR_069590236P → H Found in patients with isolated congenital asplenia; unknown pathological significance; does not affect DNA binding; impairs transactivation activity. 1 PublicationCorresponds to variant dbSNP:rs397515399EnsemblClinVar.1
Natural variantiVAR_038242248Y → H in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038243275P → T in ASD7. 2 PublicationsCorresponds to variant dbSNP:rs368366482Ensembl.1
Natural variantiVAR_038244279S → F in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1223599871Ensembl.1
Natural variantiVAR_038245279S → P in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038246281A → V in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_067587283P → Q in VSD3. 1 PublicationCorresponds to variant dbSNP:rs375086983EnsemblClinVar.1
Natural variantiVAR_038247286A → V in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_067588291Missing in CTMH. 1 Publication1
Natural variantiVAR_038248294N → H in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038249299D → G in ASD7; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs137852683EnsemblClinVar.1
Natural variantiVAR_038250305S → G in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038251320G → S in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038252322R → Q in ASD7; somatic mutation. 1 Publication1
Natural variantiVAR_038253323A → T in ASD7 and TOF. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043492112 – 151ELCAL…QAQVY → GCELPRGQRPPVLFSSALSQ PDFLQMLSETCRWLPVHLAE in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_045481112E → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_045482113 – 324Missing in isoform 3. 1 PublicationAdd BLAST212
Alternative sequenceiVSP_043493152 – 324Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U34962 mRNA Translation: AAC50470.1
AB021133 mRNA Translation: BAA35181.1
AK297844 mRNA Translation: BAG60178.1
AK290615 mRNA Translation: BAF83304.1
AK309495 mRNA No translation available.
AC008412 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61404.1
BC025711 mRNA Translation: AAH25711.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4387.1 [P52952-1]
CCDS54949.1 [P52952-2]
CCDS54950.1 [P52952-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001159647.1, NM_001166175.1 [P52952-3]
NP_001159648.1, NM_001166176.1 [P52952-2]
NP_004378.1, NM_004387.3 [P52952-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329198; ENSP00000327758; ENSG00000183072 [P52952-1]
ENST00000424406; ENSP00000395378; ENSG00000183072 [P52952-3]
ENST00000521848; ENSP00000427906; ENSG00000183072 [P52952-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1482

UCSC genome browser

More...
UCSCi
uc003mcm.3 human [P52952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34962 mRNA Translation: AAC50470.1
AB021133 mRNA Translation: BAA35181.1
AK297844 mRNA Translation: BAG60178.1
AK290615 mRNA Translation: BAF83304.1
AK309495 mRNA No translation available.
AC008412 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61404.1
BC025711 mRNA Translation: AAH25711.1
CCDSiCCDS4387.1 [P52952-1]
CCDS54949.1 [P52952-2]
CCDS54950.1 [P52952-3]
RefSeqiNP_001159647.1, NM_001166175.1 [P52952-3]
NP_001159648.1, NM_001166176.1 [P52952-2]
NP_004378.1, NM_004387.3 [P52952-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RKQX-ray1.70A/B138-192[»]
4S0HX-ray2.82B/F142-192[»]
SMRiP52952
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107864, 20 interactors
ComplexPortaliCPX-61 NKX2-5 homodimer complex
IntActiP52952, 18 interactors
MINTiP52952
STRINGi9606.ENSP00000327758

PTM databases

iPTMnetiP52952
PhosphoSitePlusiP52952

Polymorphism and mutation databases

BioMutaiNKX2-5
DMDMi1708211

Proteomic databases

jPOSTiP52952
MassIVEiP52952
PaxDbiP52952
PeptideAtlasiP52952
PRIDEiP52952
ProteomicsDBi19299
56562 [P52952-1]
56563 [P52952-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1482

Genome annotation databases

EnsembliENST00000329198; ENSP00000327758; ENSG00000183072 [P52952-1]
ENST00000424406; ENSP00000395378; ENSG00000183072 [P52952-3]
ENST00000521848; ENSP00000427906; ENSG00000183072 [P52952-2]
GeneIDi1482
KEGGihsa:1482
UCSCiuc003mcm.3 human [P52952-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1482
DisGeNETi1482
EuPathDBiHostDB:ENSG00000183072.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NKX2-5
HGNCiHGNC:2488 NKX2-5
HPAiHPA065034
MalaCardsiNKX2-5
MIMi108900 phenotype
187500 phenotype
217095 phenotype
225250 phenotype
600584 gene
614432 phenotype
614435 phenotype
neXtProtiNX_P52952
OpenTargetsiENSG00000183072
Orphaneti95713 Athyreosis
99103 Atrial septal defect, ostium secundum type
1479 Atrial septal defect-atrioventricular conduction defects syndrome
1627 Deletion 5q35
334 Familial atrial fibrillation
402075 Familial bicuspid aortic valve
101351 Familial isolated congenital asplenia
871 Familial progressive cardiac conduction defect
2248 Hypoplastic left heart syndrome
1480 NON RARE IN EUROPE: Ventricular septal defect
3303 Tetralogy of Fallot
95712 Thyroid ectopia
PharmGKBiPA24202

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00940000158996
HOGENOMiHOG000231923
InParanoidiP52952
KOiK09345
OMAiDKKELCA
OrthoDBi1124079at2759
PhylomeDBiP52952
TreeFamiTF351204

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-5578768 Physiological factors
SignaLinkiP52952
SIGNORiP52952

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NKX2-5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1482
PharosiP52952 Tbio

Protein Ontology

More...
PROi
PR:P52952
RNActiP52952 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183072 Expressed in 63 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiP52952 baseline and differential
GenevisibleiP52952 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR033629 NKX-2.5
PANTHERiPTHR24340:SF28 PTHR24340:SF28, 1 hit
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNKX25_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52952
Secondary accession number(s): A8K3K0, B4DNB6, E9PBU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2019
This is version 206 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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