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Protein

Homeobox protein DBX1

Gene

Dbx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 240HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription by RNA polymerase II Source: MGI
  • ventral spinal cord interneuron specification Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:Dbx1
Synonyms:Dbx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:94867 Dbx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488641 – 335Homeobox protein DBX1Add BLAST335

Proteomic databases

PaxDbiP52950
PRIDEiP52950

PTM databases

iPTMnetiP52950
PhosphoSitePlusiP52950

Expressioni

Developmental stagei

During early and mid-gestation, dbx expression is restricted to the telencephalon, diencephalon, dorsal mesencephalon and spinal cord. At later gestational stages, dbx expression continues in the dorsal mesencephalon and diencephalon, in which expression is more restricted than at the earlier stages.

Gene expression databases

BgeeiENSMUSG00000030507 Expressed in 72 organ(s), highest expression level in head
CleanExiMM_DBX1
GenevisibleiP52950 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032717

Structurei

3D structure databases

ProteinModelPortaliP52950
SMRiP52950
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi319 – 331Asp/Glu-rich (highly acidic)Add BLAST13

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000112172
HOVERGENiHBG005454
InParanoidiP52950
OMAiMMFPSLI
OrthoDBiEOG091G0MGV
PhylomeDBiP52950
TreeFamiTF350735

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52950-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PTYLSRSIPA ASLSPPSQEA PAALADSGTS DLGSPGSGSR RGSSPQTALS
110 120 130 140 150
PASEPTFLKF GVNAILSSAP RRETSPALLQ SPPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKTF
210 220 230 240 250
QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGDEEEDN PGARLAYHAP ADPRHLLEGP
310 320 330
LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
Length:335
Mass (Da):36,334
Last modified:October 1, 1996 - v1
Checksum:i06312CD41F03F369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75837 mRNA Translation: AAB33013.1
BC082541 mRNA Translation: AAH82541.1
AK134473 mRNA Translation: BAE22155.1
CCDSiCCDS21306.1
PIRiE41606
RefSeqiNP_001005232.1, NM_001005232.1
UniGeneiMm.307176

Genome annotation databases

EnsembliENSMUST00000032717; ENSMUSP00000032717; ENSMUSG00000030507
GeneIDi13172
KEGGimmu:13172
UCSCiuc009hbn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75837 mRNA Translation: AAB33013.1
BC082541 mRNA Translation: AAH82541.1
AK134473 mRNA Translation: BAE22155.1
CCDSiCCDS21306.1
PIRiE41606
RefSeqiNP_001005232.1, NM_001005232.1
UniGeneiMm.307176

3D structure databases

ProteinModelPortaliP52950
SMRiP52950
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032717

PTM databases

iPTMnetiP52950
PhosphoSitePlusiP52950

Proteomic databases

PaxDbiP52950
PRIDEiP52950

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032717; ENSMUSP00000032717; ENSMUSG00000030507
GeneIDi13172
KEGGimmu:13172
UCSCiuc009hbn.1 mouse

Organism-specific databases

CTDi120237
MGIiMGI:94867 Dbx1

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000112172
HOVERGENiHBG005454
InParanoidiP52950
OMAiMMFPSLI
OrthoDBiEOG091G0MGV
PhylomeDBiP52950
TreeFamiTF350735

Miscellaneous databases

PROiPR:P52950
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030507 Expressed in 72 organ(s), highest expression level in head
CleanExiMM_DBX1
GenevisibleiP52950 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDBX1_MOUSE
AccessioniPrimary (citable) accession number: P52950
Secondary accession number(s): Q3UYQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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