Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear pore complex protein Nup98-Nup96

Gene

NUP98

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei881Nucleophile2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • nuclear localization sequence binding Source: GO_Central
  • promoter-specific chromatin binding Source: UniProtKB
  • RNA binding Source: GO_Central
  • serine-type peptidase activity Source: UniProtKB-KW
  • structural constituent of nuclear pore Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processHost-virus interaction, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P52948

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S59.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup98-Nup96 (EC:3.4.21.-2 Publications)
Cleaved into the following 2 chains:
Alternative name(s):
98 kDa nucleoporin
Nucleoporin Nup98
Short name:
Nup98
Alternative name(s):
96 kDa nucleoporin
Nucleoporin Nup96
Short name:
Nup96
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP98
Synonyms:ADAR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110713.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8068 NUP98

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601021 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52948

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23.1 Publication
A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1.1 Publication
A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1.1 Publication
A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1.1 Publication
A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.1 Publication
A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi808K → A: No effect on autoprocessing. Severe loss of autoprocessing; when associated with A-879. 1 Publication1
Mutagenesisi816N → A: Slight reduction in autoprocessing. 1 Publication1
Mutagenesisi879H → A or Q: Moderate reduction in autoprocessing. 1 Publication1
Mutagenesisi880 – 883FSKY → SSKR: Loss of processing. Loss of nuclear membrane localization. 1 Publication4
Mutagenesisi881S → A: Loss of autoprocessing. Loss of nuclear membrane localization. 2 Publications1
Mutagenesisi882K → A: No effect in autoprocessing. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei531 – 532Breakpoint for translocation to form NUP98-CCDC28A2
Sitei531 – 532Breakpoint for translocation to form NUP98-PHF23 oncogene2

Organism-specific databases

DisGeNET

More...
DisGeNETi
4928

Open Targets

More...
OpenTargetsi
ENSG00000110713

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31856

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUP98

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153660

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000199291 – 880Nuclear pore complex protein Nup98Add BLAST880
ChainiPRO_0000019930881 – 1817Nuclear pore complex protein Nup96Add BLAST937

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei524PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki563Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei603N6-acetyllysine; alternateCombined sources1
Cross-linki603Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei608PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei618PhosphoserineCombined sources1
Modified residuei623PhosphoserineCombined sources1
Modified residuei625PhosphoserineCombined sources1
Modified residuei653PhosphoserineBy similarity1
Cross-linki665Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei670PhosphothreonineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei683PhosphoserineCombined sources1
Modified residuei839PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1
Modified residuei934PhosphoserineCombined sources1
Modified residuei1000PhosphothreonineCombined sources1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1043PhosphoserineCombined sources1
Modified residuei1060PhosphoserineCombined sources1
Modified residuei1064PhosphoserineBy similarity1
Modified residuei1070PhosphothreonineCombined sources1
Modified residuei1329PhosphoserineBy similarity1
Modified residuei1772PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, PubMed:20407419, PubMed:12191480, PubMed:18287282). Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:20407419, PubMed:12191480).4 Publications
Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei880 – 881Cleavage; by autolysis3 Publications2

Keywords - PTMi

Acetylation, Autocatalytic cleavage, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P52948

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52948

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52948

PeptideAtlas

More...
PeptideAtlasi
P52948

PRoteomics IDEntifications database

More...
PRIDEi
P52948

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56555
56556 [P52948-2]
56557 [P52948-3]
56558 [P52948-4]
56559 [P52948-5]
56560 [P52948-6]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1578

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52948

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52948

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P52948

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110713 Expressed in 225 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52948 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52948 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA074810

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (NPC) (PubMed:15229283, PubMed:18287282). Interacts directly with NUP96 (PubMed:12191480). Part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and NUP96; this complex plays a role in RNA export and in tethering NUP98 and NUP153 to the nucleus (PubMed:11684705). Interacts with RAE1 (PubMed:10209021, PubMed:20498086). Does not interact with TPR (PubMed:11684705). Interacts directly with NUP88 and NUP214, subunits of the cytoplasmic filaments of the NPC (By similarity). Interacts (via N-terminus) with DHX9 (via DRBM, OB-fold and RGG domains); this interaction occurs in a RNA-dependent manner and stimulates DHX9-mediated ATPase activity (PubMed:28221134).By similarity7 Publications
(Microbial infection) Interacts with vesicular stomatitis virus protein M (PubMed:11106761).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RAE1P784067EBI-295727,EBI-724495

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110982, 102 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P52948

Database of interacting proteins

More...
DIPi
DIP-32484N

Protein interaction database and analysis system

More...
IntActi
P52948, 53 interactors

Molecular INTeraction database

More...
MINTi
P52948

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316032

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11817
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P52948

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P52948

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P52948

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini738 – 880Peptidase S59PROSITE-ProRule annotationAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 156FG repeats 1Add BLAST156
Regioni157 – 213GLEBS; interaction with RAE11 PublicationAdd BLAST57
Regioni214 – 480FG repeats 2Add BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 480Gly/Thr-richAdd BLAST474
Compositional biasi890 – 894Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin GLFG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0845 Eukaryota
ENOG410XPV4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074799

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052702

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52948

KEGG Orthology (KO)

More...
KOi
K14297

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHKMQLM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00HN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52948

TreeFam database of animal gene trees

More...
TreeFami
TF343335

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1610.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037665 Nucleoporin_S59-like
IPR021967 Nup96
IPR037637 NUP98-NUP96
IPR007230 Peptidase_S59
IPR036903 Peptidase_S59_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23198 PTHR23198, 2 hits
PTHR23198:SF6 PTHR23198:SF6, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04096 Nucleoporin2, 1 hit
PF12110 Nup96, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82215 SSF82215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51434 NUP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52948-1) [UniParc]FASTAAdd to basket
Also known as: Nup98-Nup96 precursor

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG
60 70 80 90 100
LFGNSQTKPG GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS
110 120 130 140 150
LFSSQNNAFA QNKPTGFGNF GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP
160 170 180 190 200
SSFTAAPTGT TIKFNPPTGT DTMVKAGVST NISTKHQCIT AMKEYESKSL
210 220 230 240 250
EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL FSSSTTNSGF
260 270 280 290 300
AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF
310 320 330 340 350
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF
360 370 380 390 400
GQTNTGFGAV GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGNKPTLTLG
410 420 430 440 450
TNTNTSNFGF GTNTSGNSIF GSKPAPGTLG TGLGAGFGTA LGAGQASLFG
460 470 480 490 500
NNQPKIGGPL GTGAFGAPGF NTTTATLGFG APQAPVALTD PNASAAQQAV
510 520 530 540 550
LQQHINSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA QKALTTPTHY
560 570 580 590 600
KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL
610 620 630 640 650
VLKNLNNSNL FSPVNRDSEN LASPSEYPEN GERFSFLSKP VDENHQQDGD
660 670 680 690 700
EDSLVSHFYT NPIAKPIPQT PESAGNKHSN SNSVDDTIVA LNMRAALRNG
710 720 730 740 750
LEGSSEETSF HDESLQDDRE EIENNSYHMH PAGIILTKVG YYTIPSMDDL
760 770 780 790 800
AKITNEKGEC IVSDFTIGRK GYGSIYFEGD VNLTNLNLDD IVHIRRKEVV
810 820 830 840 850
VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP DRLADINYEG
860 870 880 890 900
RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPSKTS
910 920 930 940 950
TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM
960 970 980 990 1000
VDITQEPVLD TMLEESMPED QEPVSASTHI ASSLGINPHV LQIMKASLLT
1010 1020 1030 1040 1050
DEEDVDMALD QRFSRLPSKA DTSQEICSPR LPISASHSSK TRSLVGGLLQ
1060 1070 1080 1090 1100
SKFTSGAFLS PSVSVQECRT PRAASLMNIP STSSWSVPPP LTSVFTMPSP
1110 1120 1130 1140 1150
APEVPLKTVG TRRQLGLVPR EKSVTYGKGK LLMDMALFMG RSFRVGWGPN
1160 1170 1180 1190 1200
WTLANSGEQL NGSHELENHQ IADSMEFGFL PNPVAVKPLT ESPFKVHLEK
1210 1220 1230 1240 1250
LSLRQRKPDE DMKLYQTPLE LKLKHSTVHV DELCPLIVPN LGVAVIHDYA
1260 1270 1280 1290 1300
DWVKEASGDL PEAQIVKHWS LTWTLCEALW GHLKELDSQL NEPREYIQIL
1310 1320 1330 1340 1350
ERRRAFSRWL SCTATPQIEE EVSLTQKNSP VEAVFSYLTG KRISEACSLA
1360 1370 1380 1390 1400
QQSGDHRLAL LLSQFVGSQS VRELLTMQLV DWHQLQADSF IQDERLRIFA
1410 1420 1430 1440 1450
LLAGKPVWQL SEKKQINVCS QLDWKRSLAI HLWYLLPPTA SISRALSMYE
1460 1470 1480 1490 1500
EAFQNTSDSD RYACSPLPSY LEGSGCVIAE EQNSQTPLRD VCFHLLKLYS
1510 1520 1530 1540 1550
DRHYDLNQLL EPRSITADPL DYRLSWHLWE VLRALNYTHL SAQCEGVLQA
1560 1570 1580 1590 1600
SYAGQLESEG LWEWAIFVLL HIDNSGIREK AVRELLTRHC QLLETPESWA
1610 1620 1630 1640 1650
KETFLTQKLR VPAKWIHEAK AVRAHMESDK HLEALCLFKA EHWNRCHKLI
1660 1670 1680 1690 1700
IRHLASDAII NENYDYLKGF LEDLAPPERS SLIQDWETSG LVYLDYIRVI
1710 1720 1730 1740 1750
EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD RLAQSDMAKR
1760 1770 1780 1790 1800
VANLLRVVLS LHHPPDRTSD STPDPQRVPL RLLAPHIGRL PMPEDYAMDE
1810
LRSLTQSYLR ELAVGSL
Length:1,817
Mass (Da):197,579
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC60E5456B936C79
GO
Isoform 2 (identifier: P52948-2) [UniParc]FASTAAdd to basket
Also known as: Nup98-Nup96 precursor splice variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     393-409: Missing.
     1502-1576: RHYDLNQLLE...FVLLHIDNSG → S

Show »
Length:1,726
Mass (Da):187,199
Checksum:i0F92C34F9FD7DC92
GO
Isoform 3 (identifier: P52948-3) [UniParc]FASTAAdd to basket
Also known as: Nup98-specific 1

The sequence of this isoform differs from the canonical sequence as follows:
     932-937: SQSPEV → VEKKGQ
     938-1817: Missing.

Show »
Length:937
Mass (Da):97,836
Checksum:i2CB6CE36734F0B82
GO
Isoform 4 (identifier: P52948-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-409: Missing.
     932-937: SQSPEV → VEKKGQ
     938-1817: Missing.

Show »
Length:920
Mass (Da):96,075
Checksum:i129DABAFB69253AD
GO
Isoform 5 (identifier: P52948-5) [UniParc]FASTAAdd to basket
Also known as: Nup196, ADIR2

The sequence of this isoform differs from the canonical sequence as follows:
     393-409: Missing.

Show »
Length:1,800
Mass (Da):195,817
Checksum:i4BCA483C2E9E1A8E
GO
Isoform 6 (identifier: P52948-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1085-1188: WSVPPPLTSV...FLPNPVAVKP → C

Show »
Length:1,714
Mass (Da):186,268
Checksum:i158300FBC47A0C0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3P6H7C3P6_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
753Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEN4H0YEN4_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCR0H0YCR0_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDF4H0YDF4_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCT1H0YCT1_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDA1H0YDA1_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYP8H7BYP8_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNN0E9PNN0_HUMAN
Nuclear pore complex protein Nup98-...
NUP98
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD22395 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence AAD22396 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence AAF19342 differs from that shown. Reason: Frameshift at position 1551.Curated
The sequence AAF19342 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti318L → S in AAH41136 (PubMed:15489334).Curated1
Sequence conflicti376S → G in AAH41136 (PubMed:15489334).Curated1
Sequence conflicti756 – 757EK → VF in AAD22395 (PubMed:10087256).Curated2
Sequence conflicti756 – 757EK → VF in AAD22396 (PubMed:10087256).Curated2
Sequence conflicti1281G → A in AAD22395 (PubMed:10087256).Curated1
Sequence conflicti1281G → A in AAD22396 (PubMed:10087256).Curated1
Sequence conflicti1281G → A in AAL56659 (Ref. 4) Curated1
Sequence conflicti1534 – 1536ALN → DLK in AAD22395 (PubMed:10087256).Curated3
Sequence conflicti1594E → D in AAF19342 (Ref. 7) Curated1
Sequence conflicti1598S → T in AAL56659 (Ref. 4) Curated1
Sequence conflicti1639K → N in AAF19342 (Ref. 7) Curated1
Sequence conflicti1680S → T in AAF19342 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0358591669G → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003619393 – 409Missing in isoform 2, isoform 4 and isoform 5. 7 PublicationsAdd BLAST17
Alternative sequenceiVSP_007942932 – 937SQSPEV → VEKKGQ in isoform 3 and isoform 4. 3 Publications6
Alternative sequenceiVSP_007943938 – 1817Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST880
Alternative sequenceiVSP_0383281085 – 1188WSVPP…VAVKP → C in isoform 6. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_0079441502 – 1576RHYDL…IDNSG → S in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U41815 mRNA Translation: AAC50366.1
AB040538 mRNA Translation: BAB18537.1
AF071076 mRNA Translation: AAD22395.1 Sequence problems.
AF071077 mRNA Translation: AAD22396.1 Sequence problems.
AF231130 mRNA Translation: AAL56659.1
AC060812 Genomic DNA No translation available.
AC090587 Genomic DNA No translation available.
BC041136 mRNA Translation: AAH41136.1
BC012906 mRNA Translation: AAH12906.2
AF116074 mRNA Translation: AAF19342.1 Sequence problems.
BT007349 mRNA Translation: AAP36013.1
AL133601 mRNA Translation: CAB63736.1
AL137613 mRNA Translation: CAB70842.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31347.1 [P52948-2]
CCDS41605.1 [P52948-3]
CCDS41606.1 [P52948-4]
CCDS7746.1 [P52948-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T43443

NCBI Reference Sequences

More...
RefSeqi
NP_005378.4, NM_005387.6 [P52948-3]
NP_057404.2, NM_016320.4 [P52948-5]
NP_624357.1, NM_139131.4 [P52948-4]
NP_624358.2, NM_139132.3 [P52948-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.524750

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324932; ENSP00000316032; ENSG00000110713 [P52948-5]
ENST00000355260; ENSP00000347404; ENSG00000110713 [P52948-2]
ENST00000359171; ENSP00000352091; ENSG00000110713 [P52948-1]
ENST00000397004; ENSP00000380199; ENSG00000110713 [P52948-4]
ENST00000397007; ENSP00000380202; ENSG00000110713 [P52948-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4928

UCSC genome browser

More...
UCSCi
uc001lyh.3 human [P52948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41815 mRNA Translation: AAC50366.1
AB040538 mRNA Translation: BAB18537.1
AF071076 mRNA Translation: AAD22395.1 Sequence problems.
AF071077 mRNA Translation: AAD22396.1 Sequence problems.
AF231130 mRNA Translation: AAL56659.1
AC060812 Genomic DNA No translation available.
AC090587 Genomic DNA No translation available.
BC041136 mRNA Translation: AAH41136.1
BC012906 mRNA Translation: AAH12906.2
AF116074 mRNA Translation: AAF19342.1 Sequence problems.
BT007349 mRNA Translation: AAP36013.1
AL133601 mRNA Translation: CAB63736.1
AL137613 mRNA Translation: CAB70842.1
CCDSiCCDS31347.1 [P52948-2]
CCDS41605.1 [P52948-3]
CCDS41606.1 [P52948-4]
CCDS7746.1 [P52948-5]
PIRiT43443
RefSeqiNP_005378.4, NM_005387.6 [P52948-3]
NP_057404.2, NM_016320.4 [P52948-5]
NP_624357.1, NM_139131.4 [P52948-4]
NP_624358.2, NM_139132.3 [P52948-2]
UniGeneiHs.524750

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KO6X-ray3.00A/C695-880[»]
B/D881-941[»]
2Q5XX-ray1.90A733-887[»]
2Q5YX-ray2.30A/C729-880[»]
3MMYX-ray1.65B/D/F/H158-213[»]
4OWRX-ray3.15B157-213[»]
5A9Qelectron microscopy23.005/E/N/W881-1817[»]
6BZMelectron microscopy0.90A/B116-123[»]
ProteinModelPortaliP52948
SMRiP52948
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110982, 102 interactors
CORUMiP52948
DIPiDIP-32484N
IntActiP52948, 53 interactors
MINTiP52948
STRINGi9606.ENSP00000316032

Protein family/group databases

MEROPSiS59.001

PTM databases

GlyConnecti1578
iPTMnetiP52948
PhosphoSitePlusiP52948

Polymorphism and mutation databases

BioMutaiNUP98
DMDMi308153660

Proteomic databases

EPDiP52948
MaxQBiP52948
PaxDbiP52948
PeptideAtlasiP52948
PRIDEiP52948
ProteomicsDBi56555
56556 [P52948-2]
56557 [P52948-3]
56558 [P52948-4]
56559 [P52948-5]
56560 [P52948-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324932; ENSP00000316032; ENSG00000110713 [P52948-5]
ENST00000355260; ENSP00000347404; ENSG00000110713 [P52948-2]
ENST00000359171; ENSP00000352091; ENSG00000110713 [P52948-1]
ENST00000397004; ENSP00000380199; ENSG00000110713 [P52948-4]
ENST00000397007; ENSP00000380202; ENSG00000110713 [P52948-3]
GeneIDi4928
KEGGihsa:4928
UCSCiuc001lyh.3 human [P52948-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4928
DisGeNETi4928
EuPathDBiHostDB:ENSG00000110713.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NUP98
HGNCiHGNC:8068 NUP98
HPAiHPA074810
MIMi601021 gene
neXtProtiNX_P52948
OpenTargetsiENSG00000110713
PharmGKBiPA31856

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0845 Eukaryota
ENOG410XPV4 LUCA
GeneTreeiENSGT00550000074799
HOVERGENiHBG052702
InParanoidiP52948
KOiK14297
OMAiPHKMQLM
OrthoDBiEOG091G00HN
PhylomeDBiP52948
TreeFamiTF343335

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase
SIGNORiP52948

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUP98 human
EvolutionaryTraceiP52948

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NUP98

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4928
PMAP-CutDBiP52948

Protein Ontology

More...
PROi
PR:P52948

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110713 Expressed in 225 organ(s), highest expression level in testis
ExpressionAtlasiP52948 baseline and differential
GenevisibleiP52948 HS

Family and domain databases

Gene3Di3.30.1610.10, 1 hit
InterProiView protein in InterPro
IPR037665 Nucleoporin_S59-like
IPR021967 Nup96
IPR037637 NUP98-NUP96
IPR007230 Peptidase_S59
IPR036903 Peptidase_S59_sf
PANTHERiPTHR23198 PTHR23198, 2 hits
PTHR23198:SF6 PTHR23198:SF6, 2 hits
PfamiView protein in Pfam
PF04096 Nucleoporin2, 1 hit
PF12110 Nup96, 1 hit
SUPFAMiSSF82215 SSF82215, 1 hit
PROSITEiView protein in PROSITE
PS51434 NUP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP98_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52948
Secondary accession number(s): Q8IUT2
, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 204 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again