PDX1

Functionⁱ

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Miscellaneous

According to PubMed:16141209, it may be methylated by SETD7 in vitro. However, the relevance of methylation is unsure in vivo.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	146 – 205	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription factor activity
Source: BHF-UCL
Traceable author statementⁱ
- 17941991
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 8988180
detection of glucose Source: BHF-UCL
digestive tract development Source: Ensembl
exocrine pancreas development Source: Ensembl
generation of precursor metabolites and energy
Source: ProtInc
Traceable author statementⁱ
- 8954967
glucose homeostasis Source: Ensembl
glucose metabolic process Source: Ensembl
insulin secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 17941991
liver development Source: Ensembl
morphogenesis of embryonic epithelium Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
negative regulation of type B pancreatic cell apoptotic process Source: Ensembl
nitric oxide mediated signal transduction
Source: BHF-UCL
Inferred from direct assayⁱ
- 17941991
positive regulation of cell proliferation Source: Ensembl
positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: BHF-UCL
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8954967
type B pancreatic cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 12124776

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
SignaLinkⁱ	P52945
SIGNORⁱ	P52945

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pancreas/duodenum homeobox protein 1 Short name: PDX-1 Alternative name(s): Glucose-sensitive factor Short name: GSF Insulin promoter factor 1 Short name: IPF-1 Insulin upstream factor 1 Short name: IUF-1 Islet/duodenum homeobox-1 Short name: IDX-1 Somatostatin-transactivating factor 1 Short name: STF-1
Gene namesⁱ	Name:PDX1 Synonyms:IPF1, STF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139515.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6107 PDX1
MIMⁱ	600733 gene
neXtProtⁱ	NX_P52945

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Pancreatic agenesis 1 (PAGEN1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by isolated hypoplasia or agenesis of the pancreas, pancreatic beta-cell failure resulting in neonatal insulin-dependent diabetes mellitus, and exocrine pancreatic insufficiency.

Diabetes mellitus, non-insulin-dependent (NIDDM)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Maturity-onset diabetes of the young 4 (MODY4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3651
GeneReviewsⁱ	PDX1
MalaCards human disease database More...MalaCardsⁱ	PDX1
MIMⁱ	125853 phenotype 260370 phenotype 606392 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000139515
Orphanetⁱ	552 MODY 2805 Partial pancreatic agenesis 99885 Permanent neonatal diabetes mellitus
PharmGKBⁱ	PA162399173

Polymorphism and mutation databases

BioMutaⁱ	PDX1
DMDMⁱ	1708540

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049147	1 – 283	Pancreas/duodenum homeobox protein 1Add BLAST		283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	151	Phosphothreonine; by PASKBy similarity		1
Modified residueⁱ	268	Phosphoserine; by HIPK21 Publication		1

Post-translational modificationⁱ

Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P52945
PeptideAtlas More...PeptideAtlasⁱ	P52945
PRIDEⁱ	P52945
ProteomicsDBⁱ	56554

PTM databases

iPTMnetⁱ	P52945
PhosphoSitePlusⁱ	P52945

Expressionⁱ

Tissue specificityⁱ

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

Gene expression databases

Bgeeⁱ	ENSG00000139515 Expressed in 19 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PDX1
Genevisibleⁱ	P52945 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025873 HPA059146

HPAⁱ

CAB025873
HPA059146

Interactionⁱ

Subunit structureⁱ

Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b complex.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	109860, 9 interactors
ELMⁱ	P52945
IntActⁱ	P52945, 2 interactors
Molecular INTeraction database More...MINTⁱ	P52945
STRINGⁱ	9606.ENSP00000370421

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52945
SMRⁱ	P52945
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	13 – 73	Transactivation domainBy similarityAdd BLAST		61

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	118 – 123	Antp-type hexapeptide		6
Motifⁱ	197 – 203	Nuclear localization signalBy similarity		7

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	42 – 51	Poly-Pro	10
Compositional biasⁱ	216 – 219	Poly-Gly	4
Compositional biasⁱ	239 – 244	Poly-Pro	6

Domainⁱ

The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter.By similarity

The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).By similarity

Sequence similaritiesⁱ

Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144005
HOGENOMⁱ	HOG000115484
HOVERGENⁱ	HBG004525
InParanoidⁱ	P52945
KEGG Orthology (KO) More...KOⁱ	K07594
OMAⁱ	PPPCLYM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GVH
PhylomeDBⁱ	P52945
TreeFamⁱ	TF326223

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P52945-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF 
        60         70         80         90        100
PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF 
       110        120        130        140        150
PEGAEPGVLE EPNRVQLPFP WMKSTKAHAW KGQWAGGAYA AEPEENKRTR 
       160        170        180        190        200
TAYTRAQLLE LEKEFLFNKY ISRPRRVELA VMLNLTERHI KIWFQNRRMK 
       210        220        230        240        250
WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP PPPPGGAVPP 
       260        270        280 
AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR

Length:283

Mass (Da):30,771

Last modified:October 1, 1996 - v1

Checksum:ⁱ5D48EC8D3289F72B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	56	A → S in AAC05157 (PubMed:9252422).Curated	1
Sequence conflictⁱ	116	Q → H in AAC05157 (PubMed:9252422).Curated	1
Sequence conflictⁱ	210 – 211	GG → SS in AAC05157 (PubMed:9252422).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_009309	18	C → R Rare polymorphism; risk factor for type 2 diabetes. 1 PublicationCorresponds to variant dbSNP:rs137852785EnsemblClinVar.	1
Natural variantⁱVAR_009310	59	Q → L Polymorphism; risk factor for type 2 diabetes. 1 PublicationCorresponds to variant dbSNP:rs137852784EnsemblClinVar.	1
Natural variantⁱVAR_009311	76	D → N Polymorphism; risk factor for type 2 diabetes. 2 PublicationsCorresponds to variant dbSNP:rs137852783EnsemblClinVar.	1
Natural variantⁱVAR_009312	197	R → H Polymorphism; risk factor for type 2 diabetes. 1 PublicationCorresponds to variant dbSNP:rs137852786EnsemblClinVar.	1
Natural variantⁱVAR_009313	243	P → PP Polymorphism; risk factor for type 2 diabetes. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35632 mRNA Translation: AAA88820.1 S82178, S82168 Genomic DNA Translation: AAB47101.1 U30329 mRNA Translation: AAA74012.1 X99894 mRNA Translation: CAA68169.1 AF035260, AF035259 Genomic DNA Translation: AAB88463.1 AF049893 mRNA Translation: AAC05157.1 AL353195 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08420.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9327.1
PIRⁱ	G01926
NCBI Reference Sequences More...RefSeqⁱ	NP_000200.1, NM_000209.3
UniGeneⁱ	Hs.32938

Genome annotation databases

Ensemblⁱ	ENST00000381033; ENSP00000370421; ENSG00000139515
GeneIDⁱ	3651
KEGGⁱ	hsa:3651
UCSC genome browser More...UCSCⁱ	uc001urt.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52945	Pancreas/duodenum homeobox protein 1		GORGO		284	UniRef90_P52945
Pancreas/duodenum homeobox protein 1	)	MESAU		283
Pancreas/duodenum homeobox protein 1		PANPA		283
Pancreas/duodenum homeobox protein 1		PANTR		283
pancreas/duodenum homeobox protein 1		DELLE		289
+73

Protein	Similar proteins		Species	Score	Length	Source
P52945	Pancreas/duodenum homeobox protein 1		GORGO		284	UniRef50_P52945
Pancreas/duodenum homeobox protein 1	)	MESAU		283
Pancreas/duodenum homeobox protein 1		PANPA		283
Pancreas/duodenum homeobox protein 1		PANTR		283
pancreas/duodenum homeobox protein 1		DELLE		289
+101

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35632 mRNA Translation: AAA88820.1 S82178, S82168 Genomic DNA Translation: AAB47101.1 U30329 mRNA Translation: AAA74012.1 X99894 mRNA Translation: CAA68169.1 AF035260, AF035259 Genomic DNA Translation: AAB88463.1 AF049893 mRNA Translation: AAC05157.1 AL353195 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08420.1
CCDSⁱ	CCDS9327.1
PIRⁱ	G01926
RefSeqⁱ	NP_000200.1, NM_000209.3
UniGeneⁱ	Hs.32938

3D structure databases

ProteinModelPortalⁱ	P52945
SMRⁱ	P52945
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109860, 9 interactors
ELMⁱ	P52945
IntActⁱ	P52945, 2 interactors
MINTⁱ	P52945
STRINGⁱ	9606.ENSP00000370421

PTM databases

iPTMnetⁱ	P52945
PhosphoSitePlusⁱ	P52945

Polymorphism and mutation databases

BioMutaⁱ	PDX1
DMDMⁱ	1708540

Proteomic databases

PaxDbⁱ	P52945
PeptideAtlasⁱ	P52945
PRIDEⁱ	P52945
ProteomicsDBⁱ	56554

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3651
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000381033; ENSP00000370421; ENSG00000139515
GeneIDⁱ	3651
KEGGⁱ	hsa:3651
UCSCⁱ	uc001urt.3 human

Organism-specific databases

CTDⁱ	3651
DisGeNETⁱ	3651
EuPathDBⁱ	HostDB:ENSG00000139515.5
GeneCardsⁱ	PDX1
GeneReviewsⁱ	PDX1
HGNCⁱ	HGNC:6107 PDX1
HPAⁱ	CAB025873 HPA059146
MalaCardsⁱ	PDX1
MIMⁱ	125853 phenotype 260370 phenotype 600733 gene 606392 phenotype
neXtProtⁱ	NX_P52945
OpenTargetsⁱ	ENSG00000139515
Orphanetⁱ	552 MODY 2805 Partial pancreatic agenesis 99885 Permanent neonatal diabetes mellitus
PharmGKBⁱ	PA162399173
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000144005
HOGENOMⁱ	HOG000115484
HOVERGENⁱ	HBG004525
InParanoidⁱ	P52945
KOⁱ	K07594
OMAⁱ	PPPCLYM
OrthoDBⁱ	EOG091G0GVH
PhylomeDBⁱ	P52945
TreeFamⁱ	TF326223

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
SignaLinkⁱ	P52945
SIGNORⁱ	P52945

Miscellaneous databases

GeneWikiⁱ	PDX1
GenomeRNAiⁱ	3651
Protein Ontology More...PROⁱ	PR:P52945
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139515 Expressed in 19 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PDX1
Genevisibleⁱ	P52945 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDX1_HUMAN
Accessionⁱ	P52945Primary (citable) accession number: P52945 Secondary accession number(s): O60594, Q5VYW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - P52945 (PDX1_HUMAN)

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Pancreas/duodenum homeobox protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Diabetes mellitus, non-insulin-dependent (NIDDM)

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ