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Protein

Cysteine-rich protein 2

Gene

CRIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • zinc ion binding Source: ProtInc

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiP52943

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Protein ESP1
Gene namesi
Name:CRIP2
Synonyms:CRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000182809.10
HGNCiHGNC:2361 CRIP2
MIMi601183 gene
neXtProtiNX_P52943

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi1397
OpenTargetsiENSG00000182809
PharmGKBiPA26879

Polymorphism and mutation databases

DMDMi1706133

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757101 – 208Cysteine-rich protein 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei138N6-acetyllysineCombined sources1
Modified residuei144N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52943
MaxQBiP52943
PaxDbiP52943
PeptideAtlasiP52943
PRIDEiP52943
ProteomicsDBi56553

PTM databases

iPTMnetiP52943
PhosphoSitePlusiP52943

Expressioni

Tissue specificityi

Widespread tissue expression; highest levels in the heart.

Gene expression databases

BgeeiENSG00000182809 Expressed in 211 organ(s), highest expression level in apex of heart
CleanExiHS_CRIP2
ExpressionAtlasiP52943 baseline and differential
GenevisibleiP52943 HS

Organism-specific databases

HPAiHPA042664

Interactioni

Subunit structurei

Interacts with TGFB1I1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RELAQ042062EBI-947590,EBI-73886

Protein-protein interaction databases

BioGridi107787, 18 interactors
DIPiDIP-49905N
IntActiP52943, 15 interactors
MINTiP52943

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP52943
SMRiP52943
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52943

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini126 – 178LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 73Gly-richAdd BLAST11
Compositional biasi180 – 194Gly-richAdd BLAST15

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410KDR6 Eukaryota
ENOG410XUEW LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111234
HOVERGENiHBG051143
InParanoidiP52943
OMAiEPNVCPR
OrthoDBiEOG091G11RX
PhylomeDBiP52943
TreeFamiTF313758

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52943-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK
60 70 80 90 100
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE
110 120 130 140 150
RKASGPPKGP SRASSVTTFT GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC
160 170 180 190 200
LRCERCGKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDR

DPEGKVQP
Length:208
Mass (Da):22,493
Last modified:October 1, 1996 - v1
Checksum:iD32B99F98D51D3B0
GO
Isoform 2 (identifier: P52943-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MASKCPKCDKTVYF → MPPHHLLPWL...TCLVHQAEGT

Show »
Length:282
Mass (Da):30,221
Checksum:iFF8BB75C7912BE75
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YFA4H0YFA4_HUMAN
Cysteine-rich protein 2
CRIP2
192Annotation score:
H0YHD8H0YHD8_HUMAN
Cysteine-rich protein 2
CRIP2
104Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470741 – 14MASKC…KTVYF → MPPHHLLPWLAQVPSAEGEL VRLVSRAGGRGACFWPAVTM EMAVAAGCVCKGGGCCHREP SQDHHESQEHRGPLVGSQTC LVHQAEGT in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42123 mRNA Translation: BAA07703.1
U36190 mRNA Translation: AAB03194.1
BT019911 mRNA Translation: AAV38714.1
AK300092 mRNA Translation: BAH13206.1
AK315757 mRNA Translation: BAG38110.1
AL928654 Genomic DNA No translation available.
BC000434 mRNA Translation: AAH00434.1
BC001931 mRNA Translation: AAH01931.1
BC034151 mRNA Translation: AAH34151.1
BC128101 mRNA Translation: AAI28102.1
CCDSiCCDS10003.1 [P52943-1]
CCDS59246.1 [P52943-2]
PIRiG02090
RefSeqiNP_001257766.1, NM_001270837.1 [P52943-2]
NP_001257770.1, NM_001270841.1
NP_001303.1, NM_001312.3 [P52943-1]
UniGeneiHs.534309

Genome annotation databases

EnsembliENST00000329146; ENSP00000328521; ENSG00000182809 [P52943-1]
ENST00000483017; ENSP00000426119; ENSG00000182809 [P52943-2]
GeneIDi1397
KEGGihsa:1397
UCSCiuc001yrd.3 human [P52943-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42123 mRNA Translation: BAA07703.1
U36190 mRNA Translation: AAB03194.1
BT019911 mRNA Translation: AAV38714.1
AK300092 mRNA Translation: BAH13206.1
AK315757 mRNA Translation: BAG38110.1
AL928654 Genomic DNA No translation available.
BC000434 mRNA Translation: AAH00434.1
BC001931 mRNA Translation: AAH01931.1
BC034151 mRNA Translation: AAH34151.1
BC128101 mRNA Translation: AAI28102.1
CCDSiCCDS10003.1 [P52943-1]
CCDS59246.1 [P52943-2]
PIRiG02090
RefSeqiNP_001257766.1, NM_001270837.1 [P52943-2]
NP_001257770.1, NM_001270841.1
NP_001303.1, NM_001312.3 [P52943-1]
UniGeneiHs.534309

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CU8NMR-A1-63[»]
ProteinModelPortaliP52943
SMRiP52943
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107787, 18 interactors
DIPiDIP-49905N
IntActiP52943, 15 interactors
MINTiP52943

PTM databases

iPTMnetiP52943
PhosphoSitePlusiP52943

Polymorphism and mutation databases

DMDMi1706133

Proteomic databases

EPDiP52943
MaxQBiP52943
PaxDbiP52943
PeptideAtlasiP52943
PRIDEiP52943
ProteomicsDBi56553

Protocols and materials databases

DNASUi1397
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329146; ENSP00000328521; ENSG00000182809 [P52943-1]
ENST00000483017; ENSP00000426119; ENSG00000182809 [P52943-2]
GeneIDi1397
KEGGihsa:1397
UCSCiuc001yrd.3 human [P52943-1]

Organism-specific databases

CTDi1397
DisGeNETi1397
EuPathDBiHostDB:ENSG00000182809.10
GeneCardsiCRIP2
HGNCiHGNC:2361 CRIP2
HPAiHPA042664
MIMi601183 gene
neXtProtiNX_P52943
OpenTargetsiENSG00000182809
PharmGKBiPA26879
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDR6 Eukaryota
ENOG410XUEW LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111234
HOVERGENiHBG051143
InParanoidiP52943
OMAiEPNVCPR
OrthoDBiEOG091G11RX
PhylomeDBiP52943
TreeFamiTF313758

Enzyme and pathway databases

SIGNORiP52943

Miscellaneous databases

ChiTaRSiCRIP2 human
EvolutionaryTraceiP52943
GeneWikiiCRIP2
GenomeRNAii1397
PROiPR:P52943
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182809 Expressed in 211 organ(s), highest expression level in apex of heart
CleanExiHS_CRIP2
ExpressionAtlasiP52943 baseline and differential
GenevisibleiP52943 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP2_HUMAN
AccessioniPrimary (citable) accession number: P52943
Secondary accession number(s): A1A4U1, B7Z6C0, E9PD13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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