UniProtKB - P52927 (HMGA2_MOUSE)
Protein
High mobility group protein HMGI-C
Gene
Hmga2
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (PubMed:27446912).2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 24 – 34 | A.T hook 1Add BLAST | 11 | |
DNA bindingi | 44 – 54 | A.T hook 2Add BLAST | 11 | |
DNA bindingi | 71 – 82 | A.T hook 3Add BLAST | 12 |
GO - Molecular functioni
- 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
- C2H2 zinc finger domain binding Source: UniProtKB
- cAMP response element binding Source: UniProtKB
- DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB
- DNA binding, bending Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- enzyme binding Source: MGI
- MH1 domain binding Source: UniProtKB
- MH2 domain binding Source: UniProtKB
- minor groove of adenine-thymine-rich DNA binding Source: MGI
- nucleosomal DNA binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- adipose tissue development Source: MGI
- adrenal gland development Source: MGI
- base-excision repair Source: UniProtKB
- cell division Source: UniProtKB-KW
- cell proliferation in forebrain Source: MGI
- chondrocyte differentiation Source: UniProtKB
- chondrocyte proliferation Source: UniProtKB
- chromosome breakage Source: UniProtKB
- chromosome condensation Source: UniProtKB-KW
- DNA damage response, detection of DNA damage Source: UniProtKB
- endodermal cell differentiation Source: UniProtKB
- epithelial to mesenchymal transition Source: UniProtKB
- epithelial tube branching involved in lung morphogenesis Source: MGI
- fat cell differentiation Source: UniProtKB
- fat pad development Source: MGI
- heterochromatin assembly Source: UniProtKB
- histone H2A-S139 phosphorylation Source: UniProtKB
- lung epithelium development Source: MGI
- male gonad development Source: MGI
- meiotic cell cycle Source: UniProtKB-KW
- mesenchymal cell differentiation Source: UniProtKB
- mesodermal cell differentiation Source: UniProtKB
- mesodermal-endodermal cell signaling Source: UniProtKB
- mitotic G2 DNA damage checkpoint Source: UniProtKB
- negative regulation by host of viral transcription Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of astrocyte differentiation Source: MGI
- negative regulation of cellular senescence Source: BHF-UCL
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
- negative regulation of intracellular steroid hormone receptor signaling pathway Source: MGI
- negative regulation of receptor signaling pathway via JAK-STAT Source: MGI
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of Wnt signaling pathway Source: MGI
- oncogene-induced cell senescence Source: UniProtKB
- pituitary gland development Source: MGI
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cell cycle arrest Source: UniProtKB
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cell proliferation in bone marrow Source: BHF-UCL
- positive regulation of cellular response to X-ray Source: UniProtKB
- positive regulation of cellular senescence Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: MGI
- positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
- positive regulation of gene expression Source: UniProtKB
- positive regulation of multicellular organism growth Source: MGI
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
- positive regulation of response to DNA damage stimulus Source: UniProtKB
- positive regulation of stem cell proliferation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell cycle process Source: UniProtKB
- regulation of cellular response to drug Source: UniProtKB
- regulation of growth hormone secretion Source: MGI
- regulation of peptide hormone secretion Source: MGI
- regulation of stem cell population maintenance Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- senescence-associated heterochromatin focus assembly Source: UniProtKB
- signal transduction Source: MGI
- somatic stem cell population maintenance Source: MGI
- spermatogenesis Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, Cell division, DNA condensation, Growth regulation, Meiosis, Mitosis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Names & Taxonomyi
Protein namesi | Recommended name: High mobility group protein HMGI-CAlternative name(s): High mobility group AT-hook protein 2 |
Gene namesi | Name:Hmga2 Synonyms:Hmgic |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101761, Hmga2 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear chromosome Source: MGI
- nucleus Source: MGI
Other locations
- protein-DNA complex Source: UniProtKB
- senescence-associated heterochromatin focus Source: UniProtKB
- SMAD protein complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000206712 | 2 – 108 | High mobility group protein HMGI-CAdd BLAST | 107 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 40 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 44 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 | |
Modified residuei | 104 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P52927 |
PaxDbi | P52927 |
PeptideAtlasi | P52927 |
PRIDEi | P52927 |
PTM databases
iPTMneti | P52927 |
PhosphoSitePlusi | P52927 |
Expressioni
Tissue specificityi
Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level) (PubMed:14668482). Expressed in embryonic myogenic progenitor cells (PubMed:27446912).2 Publications
Developmental stagei
Expressed predominantly during embryogenesis. In myogenic progenitor cells, expressed during early myogenic development (11.5 dpc) to be gradually down-regulated during the fetal stages (17.5 dpc) (PubMed:27446912).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000056758, Expressed in undifferentiated genital tubercle and 247 other tissues |
Genevisiblei | P52927, MM |
Interactioni
Subunit structurei
Interacts with E4F1 (By similarity).
Interacts with NEK2 (PubMed:14668482).
By similarity1 PublicationBinary interactionsi
P52927
With | #Exp. | IntAct |
---|---|---|
RB1 [P06400] from Homo sapiens. | 5 | EBI-912574,EBI-491274 |
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: UniProtKB
- enzyme binding Source: MGI
- MH1 domain binding Source: UniProtKB
- MH2 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200341, 8 interactors |
IntActi | P52927, 476 interactors |
MINTi | P52927 |
STRINGi | 10090.ENSMUSP00000072556 |
Miscellaneous databases
RNActi | P52927, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 44 – 63 | Interaction with E4F1By similarityAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the HMGA family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S80S, Eukaryota |
GeneTreei | ENSGT00940000163109 |
HOGENOMi | CLU_138888_1_0_1 |
InParanoidi | P52927 |
OMAi | KPIGIRR |
PhylomeDBi | P52927 |
TreeFami | TF351623 |
Family and domain databases
InterProi | View protein in InterPro IPR017956, AT_hook_DNA-bd_motif IPR000116, HMGA |
Pfami | View protein in Pfam PF02178, AT_hook, 3 hits |
PRINTSi | PR00929, ATHOOK PR00930, HIGHMOBLTYIY |
SMARTi | View protein in SMART SM00384, AT_hook, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P52927-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSARGEGAGQ PSTSAQGQPA APVPQKRGRG RPRKQQQEPT CEPSPKRPRG
60 70 80 90 100
RPKGSKNKSP SKAAQKKAET IGEKRPRGRP RKWPQQVVQK KPAQETEETS
SQESAEED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6NSP9 | Q6NSP9_MOUSE | High mobility group protein HMGI-C | Hmga2 | 129 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41621 , L41617, L41618, L41619, L41620 Genomic DNA Translation: AAC69244.1 X58380 mRNA Translation: CAA41270.1 X99915 , X99916, X99917, X99918, X99919 Genomic DNA Translation: CAA68187.1 AK028346 mRNA Translation: BAC25896.1 AK142059 mRNA Translation: BAE24928.1 BC052158 mRNA Translation: AAH52158.1 BC085085 mRNA Translation: AAH85085.1 |
CCDSi | CCDS36073.1 |
PIRi | JC4575 |
RefSeqi | NP_001334099.1, NM_001347170.1 NP_034571.1, NM_010441.3 |
Genome annotation databases
Ensembli | ENSMUST00000072777; ENSMUSP00000072556; ENSMUSG00000056758 |
GeneIDi | 15364 |
KEGGi | mmu:15364 |
UCSCi | uc007hfb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41621 , L41617, L41618, L41619, L41620 Genomic DNA Translation: AAC69244.1 X58380 mRNA Translation: CAA41270.1 X99915 , X99916, X99917, X99918, X99919 Genomic DNA Translation: CAA68187.1 AK028346 mRNA Translation: BAC25896.1 AK142059 mRNA Translation: BAE24928.1 BC052158 mRNA Translation: AAH52158.1 BC085085 mRNA Translation: AAH85085.1 |
CCDSi | CCDS36073.1 |
PIRi | JC4575 |
RefSeqi | NP_001334099.1, NM_001347170.1 NP_034571.1, NM_010441.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 200341, 8 interactors |
IntActi | P52927, 476 interactors |
MINTi | P52927 |
STRINGi | 10090.ENSMUSP00000072556 |
PTM databases
iPTMneti | P52927 |
PhosphoSitePlusi | P52927 |
Proteomic databases
MaxQBi | P52927 |
PaxDbi | P52927 |
PeptideAtlasi | P52927 |
PRIDEi | P52927 |
Genome annotation databases
Ensembli | ENSMUST00000072777; ENSMUSP00000072556; ENSMUSG00000056758 |
GeneIDi | 15364 |
KEGGi | mmu:15364 |
UCSCi | uc007hfb.1, mouse |
Organism-specific databases
CTDi | 8091 |
MGIi | MGI:101761, Hmga2 |
Phylogenomic databases
eggNOGi | ENOG502S80S, Eukaryota |
GeneTreei | ENSGT00940000163109 |
HOGENOMi | CLU_138888_1_0_1 |
InParanoidi | P52927 |
OMAi | KPIGIRR |
PhylomeDBi | P52927 |
TreeFami | TF351623 |
Enzyme and pathway databases
Reactomei | R-MMU-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Miscellaneous databases
BioGRID-ORCSi | 15364, 0 hits in 17 CRISPR screens |
ChiTaRSi | Hmga2, mouse |
PROi | PR:P52927 |
RNActi | P52927, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000056758, Expressed in undifferentiated genital tubercle and 247 other tissues |
Genevisiblei | P52927, MM |
Family and domain databases
InterProi | View protein in InterPro IPR017956, AT_hook_DNA-bd_motif IPR000116, HMGA |
Pfami | View protein in Pfam PF02178, AT_hook, 3 hits |
PRINTSi | PR00929, ATHOOK PR00930, HIGHMOBLTYIY |
SMARTi | View protein in SMART SM00384, AT_hook, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMGA2_MOUSE | |
Accessioni | P52927Primary (citable) accession number: P52927 Secondary accession number(s): Q3UQW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families