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Protein

Transcription factor jun-D

Gene

Jund

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cellular response to calcium ion Source: Ensembl
  • cellular response to hormone stimulus Source: GO_Central
  • circadian rhythm Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: GO_Central
  • osteoblast development Source: Ensembl
  • positive regulation of cell differentiation Source: GO_Central
  • positive regulation of osteoblast differentiation Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • regulation of cell cycle Source: GO_Central
  • regulation of cell death Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • regulation of transcription, DNA-templated Source: RGD
  • response to cAMP Source: GO_Central
  • response to cytokine Source: GO_Central
  • response to drug Source: GO_Central
  • response to light stimulus Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • transcription by RNA polymerase II Source: RGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:Jund
Synonyms:Jun-d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2945 Jund

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764441 – 341Transcription factor jun-DAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52909
PRIDEiP52909

PTM databases

iPTMnetiP52909
PhosphoSitePlusiP52909

Expressioni

Gene expression databases

BgeeiENSRNOG00000019568
GenevisibleiP52909 RN

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with MEN1.By similarity

GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • ligand-dependent nuclear receptor binding Source: RGD
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi246673, 1 interactor
STRINGi10116.ENSRNOP00000026470

Structurei

3D structure databases

ProteinModelPortaliP52909
SMRiP52909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 325bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni262 – 289Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni290 – 318Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOVERGENiHBG001722
InParanoidiP52909
KOiK04449
OMAiAPVYANL
OrthoDBiEOG091G0N0L
PhylomeDBiP52909

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR029823 JunD
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR11462:SF7 PTHR11462:SF7, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P52909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPFYGEEA LSGLAAGASS VAGAAGAPGG GGFAPPGRAF PGAPPTSSML
60 70 80 90 100
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA
210 220 230 240 250
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP
260 270 280 290 300
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ
310 320 330 340
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y
Length:341
Mass (Da):34,875
Last modified:October 1, 1996 - v1
Checksum:i2D9BF82313101988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26307 Genomic DNA Translation: BAA05369.1
BC062053 mRNA Translation: AAH62053.1
PIRiJC4051
RefSeqiNP_001273895.1, NM_001286966.1
NP_620230.1, NM_138875.4
UniGeneiRn.46225

Genome annotation databases

EnsembliENSRNOT00000026470; ENSRNOP00000026470; ENSRNOG00000019568
GeneIDi24518
KEGGirno:24518
UCSCiRGD:2945 rat

Similar proteinsi

Entry informationi

Entry nameiJUND_RAT
AccessioniPrimary (citable) accession number: P52909
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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