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Protein

Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial

Gene

E1 ALPHA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Enzyme regulationi

E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciARA:AT1G59900-MONOMER
ReactomeiR-ATH-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-ATH-5362517 Signaling by Retinoic Acid
R-ATH-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-A
Gene namesi
Name:E1 ALPHA
Ordered Locus Names:At1g59900
ORF Names:F23H11.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G59900
TAIRilocus:2025966 AT1G59900

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionSequence analysisAdd BLAST32
ChainiPRO_000002045333 – 389Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrialAdd BLAST357

Proteomic databases

PaxDbiP52901
PRIDEiP52901

2D gel databases

SWISS-2DPAGEiP52901

PTM databases

iPTMnetiP52901

Expressioni

Tissue specificityi

Expressed in roots, rosettes and flowers.1 Publication

Inductioni

Induced by cadmium.1 Publication

Gene expression databases

ExpressionAtlasiP52901 differential
GenevisibleiP52901 AT

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

BioGridi27509, 5 interactors
IntActiP52901, 1 interactor
STRINGi3702.AT1G59900.1

Structurei

3D structure databases

ProteinModelPortaliP52901
SMRiP52901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0225 Eukaryota
COG1071 LUCA
HOGENOMiHOG000281336
InParanoidiP52901
KOiK00161
OMAiDANAQRM
OrthoDBiEOG09360B4J
PhylomeDBiP52901

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSRLSSRS NIITRPFSAA FSRLISTDTT PITIETSLPF TAHLCDPPSR
60 70 80 90 100
SVESSSQELL DFFRTMALMR RMEIAADSLY KAKLIRGFCH LYDGQEAVAI
110 120 130 140 150
GMEAAITKKD AIITAYRDHC IFLGRGGSLH EVFSELMGRQ AGCSKGKGGS
160 170 180 190 200
MHFYKKESSF YGGHGIVGAQ VPLGCGIAFA QKYNKEEAVT FALYGDGAAN
210 220 230 240 250
QGQLFEALNI SALWDLPAIL VCENNHYGMG TAEWRAAKSP SYYKRGDYVP
260 270 280 290 300
GLKVDGMDAF AVKQACKFAK QHALEKGPII LEMDTYRYHG HSMSDPGSTY
310 320 330 340 350
RTRDEISGVR QERDPIERIK KLVLSHDLAT EKELKDMEKE IRKEVDDAIA
360 370 380
KAKDCPMPEP SELFTNVYVK GFGTESFGPD RKEVKASLP
Length:389
Mass (Da):43,059
Last modified:January 10, 2003 - v2
Checksum:i637E5BE5E86DCCAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83 – 84KL → NV in AAA86507 (PubMed:7590338).Curated2
Sequence conflicti362E → D in AAK26016 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21214 mRNA Translation: AAA86507.1
AC007258 Genomic DNA Translation: AAD39331.1
CP002684 Genomic DNA Translation: AEE33638.1
AF360306 mRNA Translation: AAK26016.1
BT000974 mRNA Translation: AAN41374.1
AY087667 mRNA Translation: AAM65205.1
PIRiB96623
JC4358
RefSeqiNP_176198.1, NM_104682.3
UniGeneiAt.23186

Genome annotation databases

EnsemblPlantsiAT1G59900.1; AT1G59900.1; AT1G59900
GeneIDi842284
GrameneiAT1G59900.1; AT1G59900.1; AT1G59900
KEGGiath:AT1G59900

Similar proteinsi

Entry informationi

Entry nameiODPA1_ARATH
AccessioniPrimary (citable) accession number: P52901
Secondary accession number(s): Q9C5E3, Q9SXC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 10, 2003
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

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