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Entry version 191 (16 Oct 2019)
Sequence version 3 (10 May 2002)
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Protein

Aldo-keto reductase family 1 member C2

Gene

AKR1C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by hexestrol with an IC50 of 2.8 µM, 1,10-phenanthroline with an IC50 of 2100 µM, 1,7-phenanthroline with an IC50 of 1500 µM, flufenamic acid with an IC50 of 0.9 µM, indomethacin with an IC50 of 75 µM, ibuprofen with an IC50 of 6.9 µM, lithocholic acid with an IC50 of 0.07 µM, ursodeoxycholic acid with an IC50 of 0.08 µM and chenodeoxycholic acid with an IC50 of 0.13 µM.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=260 µM for (s)-tetralol1 Publication
  2. KM=520 µM for (s)-indan-1-ol1 Publication
  3. KM=5000 µM for benzene dihydrodiol1 Publication
  4. KM=1 µM for 5-beta-pregnane-3-alpha,20-alpha-diol1 Publication
  5. KM=208 µM for 9-alpha,11-beta-prostaglandin F21 Publication
  6. KM=0.3 µM for 5-beta-androstane-3,17-dione1 Publication
  7. KM=79 µM for prostaglandin D21 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei24SubstrateBy similarity1
    Binding sitei50NADP5 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei55Proton donor1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei84Lowers pKa of active site TyrBy similarity1
    Binding sitei117Substrate1
    Binding sitei190NADP5 Publications1
    Binding sitei222SubstrateBy similarity1
    Binding sitei227Substrate1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 24NADP5 Publications5
    Nucleotide bindingi166 – 167NADP5 Publications2
    Nucleotide bindingi216 – 222NADP5 Publications7
    Nucleotide bindingi270 – 280NADP5 PublicationsAdd BLAST11

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processLipid metabolism, Steroid metabolism
    LigandNADP

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS07754-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.1.213 2681
    1.1.1.357 2681
    1.3.1.20 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P52895

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    P52895

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P52895

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000803

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aldo-keto reductase family 1 member C2 (EC:1.-.-.-)
    Alternative name(s):
    3-alpha-HSD3
    Chlordecone reductase homolog HAKRD
    Dihydrodiol dehydrogenase 2
    Short name:
    DD-2
    Short name:
    DD2
    Dihydrodiol dehydrogenase/bile acid-binding protein
    Short name:
    DD/BABP
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.201 Publication)
    Type III 3-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.3574 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AKR1C2
    Synonyms:DDH2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:385 AKR1C2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600450 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P52895

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    46,XY sex reversal 8 (SRXY8)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06663279I → V in SRXY8; partially impaired activity. 1 PublicationCorresponds to variant dbSNP:rs387906750EnsemblClinVar.1
    Natural variantiVAR_06663390H → Q in SRXY8; partially impaired activity. 1 PublicationCorresponds to variant dbSNP:rs797044460EnsemblClinVar.1
    Natural variantiVAR_066634222H → Q in SRXY8; partially impaired activity. 1 Publication1
    Natural variantiVAR_066635300N → T in SRXY8; partially impaired activity. 1 PublicationCorresponds to variant dbSNP:rs387906751EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24Y → A: Strongly decreases affinity for androstenedione. Decreases androstenedione reductase activity about 60-fold. 1 Publication1
    Mutagenesisi31K → A or M: Increases the low androstenedione reductase activity. 1 Publication1
    Mutagenesisi301R → A: Decreases 3-alpha-hydroxysteroid reductase activity about 50-fold. 1 Publication1
    Mutagenesisi304R → A: Decreases 3-alpha-hydroxysteroid reductase activity about 500-fold. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1646

    MalaCards human disease database

    More...
    MalaCardsi
    AKR1C2
    MIMi614279 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000151632

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    443087 46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24678

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P52895

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5847

    Drug and drug target database

    More...
    DrugBanki
    DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB06777 Chenodeoxycholic acid
    DB07768 Epitestosterone
    DB13751 Glycyrrhizic acid
    DB00157 NADH
    DB01586 Ursodeoxycholic acid

    DrugCentral

    More...
    DrugCentrali
    P52895

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    AKR1C2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    20532374

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246371 – 323Aldo-keto reductase family 1 member C2Add BLAST323

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P52895

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P52895

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P52895

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P52895

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P52895

    PeptideAtlas

    More...
    PeptideAtlasi
    P52895

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P52895

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    56548 [P52895-1]
    56549 [P52895-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P52895

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P52895

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P52895

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in fetal testes. Expressed in fetal and adult adrenal glands.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000151632 Expressed in 91 organ(s), highest expression level in urinary bladder

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P52895 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P52895 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB047304
    HPA068265

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    108013, 15 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P52895, 6 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000370129

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P52895

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1323
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P52895

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P52895

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1577 Eukaryota
    COG0656 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000167640

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000250272

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P52895

    KEGG Orthology (KO)

    More...
    KOi
    K00089

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ATFNALC

    Database of Orthologous Groups

    More...
    OrthoDBi
    1016440at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P52895

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106492

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06660 Aldo_ket_red, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.100, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR018170 Aldo/ket_reductase_CS
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11732 PTHR11732, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00248 Aldo_ket_red, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000097 AKR, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00069 ALDKETRDTASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51430 SSF51430, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00062 ALDOKETO_REDUCTASE_2, 1 hit
    PS00063 ALDOKETO_REDUCTASE_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P52895-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID
    60 70 80 90 100
    SAHVYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE
    110 120 130 140 150
    RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA
    160 170 180 190 200
    MEKCKDAGLA KSIGVSNFNH RLLEMILNKP GLKYKPVCNQ VECHPYFNQR
    210 220 230 240 250
    KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR
    260 270 280 290 300
    TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN
    310 320
    RNVRYLTLDI FAGPPNYPFS DEY
    Length:323
    Mass (Da):36,735
    Last modified:May 10, 2002 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D7B6F983FCE85E1
    GO
    Isoform 2 (identifier: P52895-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-139: PGEEVIPKDENGKILF → EDIGILTWKKSPKHNS
         140-323: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:139
    Mass (Da):15,748
    Checksum:i11CAE1B299B378AC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B4DK69B4DK69_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1C2
    297Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    S4R3P0S4R3P0_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1C2
    200Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76R → S AA sequence (PubMed:8486699).Curated1
    Sequence conflicti87S → C AA sequence (PubMed:8486699).Curated1
    Sequence conflicti93E → EE AA sequence (PubMed:8486699).Curated1
    Sequence conflicti111V → A in AAB38486 (PubMed:7959017).Curated1
    Sequence conflicti164G → R in BAF82993 (PubMed:14702039).Curated1
    Sequence conflicti179K → E in AAD14013 (PubMed:8274401).Curated1
    Sequence conflicti179K → E in AAB38486 (PubMed:7959017).Curated1
    Sequence conflicti185K → E in AAD14013 (PubMed:8274401).Curated1
    Sequence conflicti185K → E in AAB38486 (PubMed:7959017).Curated1
    Sequence conflicti188C → H AA sequence (PubMed:8486699).Curated1
    Sequence conflicti193C → H AA sequence (PubMed:8486699).Curated1
    Sequence conflicti319F → I in AAD14013 (PubMed:8274401).Curated1
    Sequence conflicti319F → I in AAB38486 (PubMed:7959017).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04821646F → Y1 PublicationCorresponds to variant dbSNP:rs2854482Ensembl.1
    Natural variantiVAR_06663279I → V in SRXY8; partially impaired activity. 1 PublicationCorresponds to variant dbSNP:rs387906750EnsemblClinVar.1
    Natural variantiVAR_06663390H → Q in SRXY8; partially impaired activity. 1 PublicationCorresponds to variant dbSNP:rs797044460EnsemblClinVar.1
    Natural variantiVAR_014748172L → Q. Corresponds to variant dbSNP:rs11474Ensembl.1
    Natural variantiVAR_066634222H → Q in SRXY8; partially impaired activity. 1 Publication1
    Natural variantiVAR_066635300N → T in SRXY8; partially impaired activity. 1 PublicationCorresponds to variant dbSNP:rs387906751EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043779124 – 139PGEEV…GKILF → EDIGILTWKKSPKHNS in isoform 2. 1 PublicationAdd BLAST16
    Alternative sequenceiVSP_043780140 – 323Missing in isoform 2. 1 PublicationAdd BLAST184

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    S68330 mRNA Translation: AAD14013.1
    U05598 mRNA Translation: AAA20937.1
    L32592 Genomic DNA Translation: AAB38486.1
    AB021654 mRNA Translation: BAA36169.1
    AB031084 mRNA Translation: BAA92884.1
    AB032153 Genomic DNA Translation: BAA92891.1
    AK290304 mRNA Translation: BAF82993.1
    AK296686 mRNA Translation: BAG59281.1
    BT006653 mRNA Translation: AAP35299.1
    AL391427 Genomic DNA No translation available.
    AL713867 Genomic DNA No translation available.
    BC007024 mRNA Translation: AAH07024.1
    BC063574 mRNA Translation: AAH63574.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS44350.1 [P52895-2]
    CCDS7062.1 [P52895-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I73676
    JC5240
    S61516

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001128713.1, NM_001135241.2 [P52895-2]
    NP_001345.1, NM_001354.5 [P52895-1]
    NP_995317.1, NM_205845.2 [P52895-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000380753; ENSP00000370129; ENSG00000151632 [P52895-1]
    ENST00000455190; ENSP00000408440; ENSG00000151632 [P52895-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1646

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1646

    UCSC genome browser

    More...
    UCSCi
    uc010qao.2 human [P52895-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    S68330 mRNA Translation: AAD14013.1
    U05598 mRNA Translation: AAA20937.1
    L32592 Genomic DNA Translation: AAB38486.1
    AB021654 mRNA Translation: BAA36169.1
    AB031084 mRNA Translation: BAA92884.1
    AB032153 Genomic DNA Translation: BAA92891.1
    AK290304 mRNA Translation: BAF82993.1
    AK296686 mRNA Translation: BAG59281.1
    BT006653 mRNA Translation: AAP35299.1
    AL391427 Genomic DNA No translation available.
    AL713867 Genomic DNA No translation available.
    BC007024 mRNA Translation: AAH07024.1
    BC063574 mRNA Translation: AAH63574.1
    CCDSiCCDS44350.1 [P52895-2]
    CCDS7062.1 [P52895-1]
    PIRiI73676
    JC5240
    S61516
    RefSeqiNP_001128713.1, NM_001135241.2 [P52895-2]
    NP_001345.1, NM_001354.5 [P52895-1]
    NP_995317.1, NM_205845.2 [P52895-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1IHIX-ray3.00A/B1-323[»]
    1J96X-ray1.25A/B2-323[»]
    1XJBX-ray1.90A/B2-323[»]
    2HDJX-ray2.00A/B1-323[»]
    2IPJX-ray1.80A/B3-323[»]
    4JQ1X-ray1.60A/B1-323[»]
    4JQ2X-ray1.75A/B1-323[»]
    4JQ3X-ray1.75A/B1-323[»]
    4JQ4X-ray1.52A/B1-323[»]
    4JQAX-ray1.45A/B1-323[»]
    4JTQX-ray1.60A/B1-323[»]
    4JTRX-ray1.30A/B1-323[»]
    4L1WX-ray2.20A/B2-323[»]
    4L1XX-ray2.00A/B2-323[»]
    4XO6X-ray1.20A/B2-323[»]
    4XO7X-ray1.75A/B1-323[»]
    SMRiP52895
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi108013, 15 interactors
    IntActiP52895, 6 interactors
    STRINGi9606.ENSP00000370129

    Chemistry databases

    BindingDBiP52895
    ChEMBLiCHEMBL5847
    DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB06777 Chenodeoxycholic acid
    DB07768 Epitestosterone
    DB13751 Glycyrrhizic acid
    DB00157 NADH
    DB01586 Ursodeoxycholic acid
    DrugCentraliP52895
    SwissLipidsiSLP:000000803

    PTM databases

    iPTMnetiP52895
    PhosphoSitePlusiP52895
    SwissPalmiP52895

    Polymorphism and mutation databases

    BioMutaiAKR1C2
    DMDMi20532374

    Proteomic databases

    EPDiP52895
    jPOSTiP52895
    MassIVEiP52895
    MaxQBiP52895
    PaxDbiP52895
    PeptideAtlasiP52895
    PRIDEiP52895
    ProteomicsDBi56548 [P52895-1]
    56549 [P52895-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    1646

    Genome annotation databases

    EnsembliENST00000380753; ENSP00000370129; ENSG00000151632 [P52895-1]
    ENST00000455190; ENSP00000408440; ENSG00000151632 [P52895-2]
    GeneIDi1646
    KEGGihsa:1646
    UCSCiuc010qao.2 human [P52895-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1646
    DisGeNETi1646

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    AKR1C2
    HGNCiHGNC:385 AKR1C2
    HPAiCAB047304
    HPA068265
    MalaCardsiAKR1C2
    MIMi600450 gene
    614279 phenotype
    neXtProtiNX_P52895
    OpenTargetsiENSG00000151632
    Orphaneti443087 46,XY disorder of sex development due to testicular 17,20-desmolase deficiency
    PharmGKBiPA24678

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1577 Eukaryota
    COG0656 LUCA
    GeneTreeiENSGT00940000167640
    HOGENOMiHOG000250272
    InParanoidiP52895
    KOiK00089
    OMAiATFNALC
    OrthoDBi1016440at2759
    PhylomeDBiP52895
    TreeFamiTF106492

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07754-MONOMER
    BRENDAi1.1.1.213 2681
    1.1.1.357 2681
    1.3.1.20 2681
    ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    SABIO-RKiP52895
    SignaLinkiP52895
    SIGNORiP52895

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    AKR1C2 human
    EvolutionaryTraceiP52895

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1646
    PharosiP52895

    Protein Ontology

    More...
    PROi
    PR:P52895

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000151632 Expressed in 91 organ(s), highest expression level in urinary bladder
    ExpressionAtlasiP52895 baseline and differential
    GenevisibleiP52895 HS

    Family and domain databases

    CDDicd06660 Aldo_ket_red, 1 hit
    Gene3Di3.20.20.100, 1 hit
    InterProiView protein in InterPro
    IPR018170 Aldo/ket_reductase_CS
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf
    PANTHERiPTHR11732 PTHR11732, 1 hit
    PfamiView protein in Pfam
    PF00248 Aldo_ket_red, 1 hit
    PIRSFiPIRSF000097 AKR, 1 hit
    PRINTSiPR00069 ALDKETRDTASE
    SUPFAMiSSF51430 SSF51430, 1 hit
    PROSITEiView protein in PROSITE
    PS00062 ALDOKETO_REDUCTASE_2, 1 hit
    PS00063 ALDOKETO_REDUCTASE_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1C2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52895
    Secondary accession number(s): A8K2N9
    , B4DKR9, Q14133, Q5SR16, Q7M4N1, Q96A71
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 10, 2002
    Last modified: October 16, 2019
    This is version 191 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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