UniProtKB - P52874 (CLP1_CAEEL)
Protein
Protein clpf-1
Gene
clpf-1
Organism
Caenorhabditis elegans
Status
Functioni
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 16 | ATPUniRule annotation | 1 | |
Binding sitei | 56 | ATP; via carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 124 – 129 | ATPUniRule annotation | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Source: WormBase
- polynucleotide 5'-hydroxyl-kinase activity Source: GO_Central
GO - Biological processi
- mRNA polyadenylation Source: GO_Central
- nucleotide phosphorylation Source: WormBase
- RNA processing Source: GO_Central
- tRNA splicing, via endonucleolytic cleavage and ligation Source: GO_Central
Keywordsi
Biological process | mRNA processing |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-CEL-72163, mRNA Splicing - Major Pathway R-CEL-72187, mRNA 3'-end processing R-CEL-73856, RNA Polymerase II Transcription Termination R-CEL-77595, Processing of Intronless Pre-mRNAs |
Names & Taxonomyi
Protein namesi | Recommended name: Protein clpf-1UniRule annotation |
Gene namesi | Name:clpf-1UniRule annotation ORF Names:F59A2.4 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F59A2.4a ; CE17941 ; WBGene00010304 ; clpf-1 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- mRNA cleavage factor complex Source: InterPro
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065378 | 1 – 428 | Protein clpf-1Add BLAST | 428 |
Proteomic databases
EPDi | P52874 |
PaxDbi | P52874 |
PeptideAtlasi | P52874 |
Expressioni
Gene expression databases
Bgeei | WBGene00010304, Expressed in multi-cellular organism and 5 other tissues |
ExpressionAtlasi | P52874, baseline and differential |
Interactioni
Protein-protein interaction databases
BioGRIDi | 40684, 8 interactors |
DIPi | DIP-27405N |
IntActi | P52874, 3 interactors |
STRINGi | 6239.F59A2.4a |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P52874 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2749, Eukaryota |
GeneTreei | ENSGT00940000153668 |
HOGENOMi | CLU_018195_1_0_1 |
InParanoidi | P52874 |
OMAi | KVAIFTY |
OrthoDBi | 814241at2759 |
PhylomeDBi | P52874 |
Family and domain databases
Gene3Di | 2.60.120.1030, 1 hit 3.30.70.2410, 1 hit |
HAMAPi | MF_03035, Clp1, 1 hit |
InterProi | View protein in InterPro IPR028606, Clp1 IPR010655, Clp1_C IPR038238, Clp1_C_sf IPR032324, Clp1_N IPR038239, Clp1_N_sf IPR032319, CLP1_P IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF06807, Clp1, 1 hit PF16573, CLP1_N, 1 hit PF16575, CLP1_P, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P52874-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEENVQEFV LKEDCELRFA AGDDSDVCLE LVKGYAEIFG TELLLNKKYT
60 70 80 90 100
FPAKSRVAAF TWKGATIELV GTTESAYVAE STPMVIYLNI HAAMEEVRKK
110 120 130 140 150
REEQAAGNSN KAKGPRLLLV GPTDVGKTTV SRILCNYSVR QGRTPIFVEL
160 170 180 190 200
DVGQNSVSVP GTVAAVLVQK TADVIDGFER NQPIVFNFGH TSPSANLSLY
210 220 230 240 250
EALFKEMATT LNAQIQENDE AKIGGMIINT CGWVDGEGYK CIVKAASAFE
260 270 280 290 300
VDVVIVLDHE RLYSDLSKEL PEFVRLTHVP KSGGVEQRTG QIRSKMRGEN
310 320 330 340 350
VHRYFYGTRA NNLYPFTFDV SFDDVTLCKI GAEQLPDSCL PFGMEVENHE
360 370 380 390 400
TKLVIMEPSA DIKHHLFAFS RSTKADENVL KSPVFGFCLV TEVDLEKRTM
410 420
SILCPQRTIP SKVLVFSDIT HLDDQIKR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ2EEP3 | Q2EEP3_CAEEL | Clp1 domain-containing protein | clpf-1 CELE_F59A2.4, F59A2.4 | 85 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z34801 Genomic DNA Translation: CAA84329.1 |
PIRi | T22973 |
RefSeqi | NP_001040858.1, NM_001047393.2 |
Genome annotation databases
EnsemblMetazoai | F59A2.4a.1; F59A2.4a.1; WBGene00010304 |
GeneIDi | 175442 |
KEGGi | cel:CELE_F59A2.4 |
UCSCi | F59A2.4a, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z34801 Genomic DNA Translation: CAA84329.1 |
PIRi | T22973 |
RefSeqi | NP_001040858.1, NM_001047393.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4OHV | X-ray | 2.30 | A | 1-428 | [»] | |
4OHW | X-ray | 2.30 | A | 1-428 | [»] | |
4OHX | X-ray | 1.98 | A | 1-428 | [»] | |
4OHY | X-ray | 2.00 | A | 1-428 | [»] | |
4OHZ | X-ray | 2.40 | A | 1-428 | [»] | |
4OI0 | X-ray | 2.20 | A | 1-428 | [»] | |
4OI1 | X-ray | 2.30 | A | 1-428 | [»] | |
4OI2 | X-ray | 2.60 | A | 1-428 | [»] | |
SMRi | P52874 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 40684, 8 interactors |
DIPi | DIP-27405N |
IntActi | P52874, 3 interactors |
STRINGi | 6239.F59A2.4a |
Proteomic databases
EPDi | P52874 |
PaxDbi | P52874 |
PeptideAtlasi | P52874 |
Genome annotation databases
EnsemblMetazoai | F59A2.4a.1; F59A2.4a.1; WBGene00010304 |
GeneIDi | 175442 |
KEGGi | cel:CELE_F59A2.4 |
UCSCi | F59A2.4a, c. elegans |
Organism-specific databases
CTDi | 175442 |
WormBasei | F59A2.4a ; CE17941 ; WBGene00010304 ; clpf-1 |
Phylogenomic databases
eggNOGi | KOG2749, Eukaryota |
GeneTreei | ENSGT00940000153668 |
HOGENOMi | CLU_018195_1_0_1 |
InParanoidi | P52874 |
OMAi | KVAIFTY |
OrthoDBi | 814241at2759 |
PhylomeDBi | P52874 |
Enzyme and pathway databases
Reactomei | R-CEL-72163, mRNA Splicing - Major Pathway R-CEL-72187, mRNA 3'-end processing R-CEL-73856, RNA Polymerase II Transcription Termination R-CEL-77595, Processing of Intronless Pre-mRNAs |
Miscellaneous databases
PROi | PR:P52874 |
Gene expression databases
Bgeei | WBGene00010304, Expressed in multi-cellular organism and 5 other tissues |
ExpressionAtlasi | P52874, baseline and differential |
Family and domain databases
Gene3Di | 2.60.120.1030, 1 hit 3.30.70.2410, 1 hit |
HAMAPi | MF_03035, Clp1, 1 hit |
InterProi | View protein in InterPro IPR028606, Clp1 IPR010655, Clp1_C IPR038238, Clp1_C_sf IPR032324, Clp1_N IPR038239, Clp1_N_sf IPR032319, CLP1_P IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF06807, Clp1, 1 hit PF16573, CLP1_N, 1 hit PF16575, CLP1_P, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLP1_CAEEL | |
Accessioni | P52874Primary (citable) accession number: P52874 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families