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Protein

Protein transport protein SBH2

Gene

SBH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

  • posttranslational protein targeting to membrane, translocation Source: GO_Central
  • SRP-dependent cotranslational protein targeting to membrane Source: SGD
  • SRP-dependent cotranslational protein targeting to membrane, translocation Source: GO_Central

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30348-MONOMER

Protein family/group databases

TCDBi3.A.5.8.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SBH2
Alternative name(s):
Ssh1 complex subunit SBH2
Ssh1 complex subunit beta
Gene namesi
Name:SBH2
Synonyms:SEB2
Ordered Locus Names:YER019C-A
ORF Names:YER019BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

SGDiS000002127 SBH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001572621 – 88Protein transport protein SBH2Add BLAST88

Proteomic databases

MaxQBiP52871
PaxDbiP52871
PRIDEiP52871
TopDownProteomicsiP52871

Interactioni

Subunit structurei

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36753, 73 interactors
ComplexPortaliCPX-1834 SSH1 translocon complex
DIPiDIP-1708N
IntActiP52871, 6 interactors
MINTiP52871
STRINGi4932.YER019C-A

Structurei

3D structure databases

ProteinModelPortaliP52871
SMRiP52871
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52871

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000211109
InParanoidiP52871
KOiK09481
OMAiTKFTHII
OrthoDBiEOG092C5YZH

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit

Sequencei

Sequence statusi: Complete.

P52871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASVPPGGQ RILQKRRQAQ SIKEKQAKQT PTSTRQAGYG GSSSSILKLY
60 70 80
TDEANGFRVD SLVVLFLSVG FIFSVIALHL LTKFTHII
Length:88
Mass (Da):9,606
Last modified:October 1, 1996 - v1
Checksum:i5A4F5B9184202E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50012 mRNA Translation: CAA90305.1
L38891 mRNA Translation: AAT01101.1
U18778 Genomic DNA Translation: AAB64567.1
AY693199 Genomic DNA Translation: AAT93218.1
BK006939 Genomic DNA Translation: DAA07672.1
PIRiS68163
RefSeqiNP_010936.1, NM_001180031.1

Genome annotation databases

EnsemblFungiiYER019C-A; YER019C-A; YER019C-A
GeneIDi856740
KEGGisce:YER019C-A

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50012 mRNA Translation: CAA90305.1
L38891 mRNA Translation: AAT01101.1
U18778 Genomic DNA Translation: AAB64567.1
AY693199 Genomic DNA Translation: AAT93218.1
BK006939 Genomic DNA Translation: DAA07672.1
PIRiS68163
RefSeqiNP_010936.1, NM_001180031.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60C1-87[»]
2WWAelectron microscopy8.90C1-87[»]
ProteinModelPortaliP52871
SMRiP52871
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36753, 73 interactors
ComplexPortaliCPX-1834 SSH1 translocon complex
DIPiDIP-1708N
IntActiP52871, 6 interactors
MINTiP52871
STRINGi4932.YER019C-A

Protein family/group databases

TCDBi3.A.5.8.1 the general secretory pathway (sec) family

Proteomic databases

MaxQBiP52871
PaxDbiP52871
PRIDEiP52871
TopDownProteomicsiP52871

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER019C-A; YER019C-A; YER019C-A
GeneIDi856740
KEGGisce:YER019C-A

Organism-specific databases

SGDiS000002127 SBH2

Phylogenomic databases

HOGENOMiHOG000211109
InParanoidiP52871
KOiK09481
OMAiTKFTHII
OrthoDBiEOG092C5YZH

Enzyme and pathway databases

BioCyciYEAST:G3O-30348-MONOMER

Miscellaneous databases

EvolutionaryTraceiP52871
PROiPR:P52871

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC6B2_YEAST
AccessioniPrimary (citable) accession number: P52871
Secondary accession number(s): D3DLR8, Q53X22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
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Main funding by: National Institutes of Health

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