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Entry version 172 (29 Sep 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

Gene

NDST2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

4 Publications

Miscellaneous

The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.7 µM for K5 polysaccharide1 Publication
  2. KM=0.76 µM for N-acetylated HS-II1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: heparan sulfate biosynthesis

This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.

Pathwayi: heparin biosynthesis

This protein is involved in the pathway heparin biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway heparin biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei613For sulfotransferase activityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei711PAPSBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi613 – 617PAPSBy similarity5
Nucleotide bindingi832 – 836PAPSBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS09410-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P52849

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022928, HS-GAG biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00756
UPA00862

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC:2.8.2.8)
Alternative name(s):
Glucosaminyl N-deacetylase/N-sulfotransferase 2
Short name:
NDST-2
N-heparan sulfate sulfotransferase 2
Short name:
N-HSST 2
Including the following 2 domains:
Heparan sulfate N-deacetylase 2 (EC:3.-.-.-)
Heparan sulfate N-sulfotransferase 2 (EC:2.8.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDST2
Synonyms:HSST2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7681, NDST2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603268, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52849

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000166507

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini40 – 883LumenalSequence analysisAdd BLAST844

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8509

Open Targets

More...
OpenTargetsi
ENSG00000166507

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31487

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P52849, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDST2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1708323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000852121 – 883Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2Add BLAST883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi802N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi817 ↔ 827By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P52849

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P52849

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P52849

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52849

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52849

PeptideAtlas

More...
PeptideAtlasi
P52849

PRoteomics IDEntifications database

More...
PRIDEi
P52849

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56545 [P52849-1]
56546 [P52849-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P52849, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52849

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52849

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166507, Expressed in spleen and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52849, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52849, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166507, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114081, 15 interactors

Protein interaction database and analysis system

More...
IntActi
P52849, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310657

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P52849, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P52849

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 597Heparan sulfate N-deacetylase 2Add BLAST557
Regioni49 – 81DisorderedSequence analysisAdd BLAST33
Regioni598 – 883Heparan sulfate N-sulfotransferase 2Add BLAST286

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 81Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3703, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011357_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52849

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMSPESR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52849

TreeFam database of animal gene trees

More...
TreeFami
TF313193

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021930, Heparan_SO4_deacetylase
IPR037359, NST/OST
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10605, PTHR10605, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12062, HSNSD, 1 hit
PF00685, Sulfotransfer_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P52849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQLWKVVRP ARQLELHRLI LLLIAFSLGS MGFLAYYVST SPKAKEPLPL
60 70 80 90 100
PLGDCSSGGA AGPGPARPPV PPRPPRPPET ARTEPVVLVF VESAYSQLGQ
110 120 130 140 150
EIVAILESSR FRYSTELAPG RGDMPTLTDN THGRYVLVIY ENLLKYVNLD
160 170 180 190 200
AWSRELLDRY CVEYGVGIIG FFRAHEHSLL SAQLKGFPLF LHSNLGLRDY
210 220 230 240 250
QVNPSAPLLH LTRPSRLEPG PLPGDDWTIF QSNHSTYEPV LLASLRPAEP
260 270 280 290 300
AVPGPVLRRA RLPTVVQDLG LHDGIQRVLF GHGLSFWLHK LIFVDAVAYL
310 320 330 340 350
TGKRLCLDLD RYILVDIDDI FVGKEGTRMK VADVEALLTT QNKLRTLVPN
360 370 380 390 400
FTFNLGFSGK FYHTGTEEED AGDDMLLKHR KEFWWFPHMW SHMQPHLFHN
410 420 430 440 450
RSVLADQMRL NKQFALEHGI PTDLGYAVAP HHSGVYPIHT QLYEAWKSVW
460 470 480 490 500
GIQVTSTEEY PHLRPARYRR GFIHNGIMVL PRQTCGLFTH TIFYNEYPGG
510 520 530 540 550
SRELDRSIRG GELFLTVLLN PISIFMTHLS NYGNDRLGLY TFESLVRFLQ
560 570 580 590 600
CWTRLRLQTL PPVPLAQKYF ELFPQERSPL WQNPCDDKRH KDIWSKEKTC
610 620 630 640 650
DRLPKFLIVG PQKTGTTAIH FFLSLHPAVT SSFPSPSTFE EIQFFNSPNY
660 670 680 690 700
HKGIDWYMDF FPVPSNASTD FLFEKSATYF DSEVVPRRGA ALLPRAKIIT
710 720 730 740 750
VLTNPADRAY SWYQHQRAHG DPVALNYTFY QVISASSQTP LALRSLQNRC
760 770 780 790 800
LVPGYYSTHL QRWLTYYPSG QLLIVDGQEL RTNPAASMES IQKFLGITPF
810 820 830 840 850
LNYTRTLRFD DDKGFWCQGL EGGKTRCLGR SKGRRYPDMD TESRLFLTDF
860 870 880
FRNHNLELSK LLSRLGQPVP SWLREELQHS SLG
Length:883
Mass (Da):100,875
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i457166F8FCB403E1
GO
Isoform 2 (identifier: P52849-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-377: TEEEDAGDDMLL → ELIPLLLWHIIV
     378-883: Missing.

Show »
Length:377
Mass (Da):42,093
Checksum:iC4831C3D2752087C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C032H7C032_HUMAN
Sulfotransferase
NDST2
149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017403366 – 377TEEED…DDMLL → ELIPLLLWHIIV in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_017404378 – 883Missing in isoform 2. 1 PublicationAdd BLAST506

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U36601 mRNA Translation: AAC27120.1
AF042084 Genomic DNA Translation: AAB97086.1
BC035711 mRNA Translation: AAH35711.1
BC110588 mRNA Translation: AAI10589.1
BC110589 mRNA Translation: AAI10590.1
AB208870 mRNA Translation: BAD92107.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7335.1 [P52849-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001317036.1, NM_001330107.1
NP_003626.1, NM_003635.3 [P52849-1]
XP_011538612.1, XM_011540310.2 [P52849-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299641; ENSP00000299641; ENSG00000166507 [P52849-1]
ENST00000309979; ENSP00000310657; ENSG00000166507 [P52849-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8509

UCSC genome browser

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UCSCi
uc001jvk.3, human [P52849-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36601 mRNA Translation: AAC27120.1
AF042084 Genomic DNA Translation: AAB97086.1
BC035711 mRNA Translation: AAH35711.1
BC110588 mRNA Translation: AAI10589.1
BC110589 mRNA Translation: AAI10590.1
AB208870 mRNA Translation: BAD92107.1
CCDSiCCDS7335.1 [P52849-1]
RefSeqiNP_001317036.1, NM_001330107.1
NP_003626.1, NM_003635.3 [P52849-1]
XP_011538612.1, XM_011540310.2 [P52849-1]

3D structure databases

SMRiP52849
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114081, 15 interactors
IntActiP52849, 11 interactors
STRINGi9606.ENSP00000310657

PTM databases

GlyGeniP52849, 6 sites
iPTMnetiP52849
PhosphoSitePlusiP52849

Genetic variation databases

BioMutaiNDST2
DMDMi1708323

Proteomic databases

EPDiP52849
jPOSTiP52849
MassIVEiP52849
MaxQBiP52849
PaxDbiP52849
PeptideAtlasiP52849
PRIDEiP52849
ProteomicsDBi56545 [P52849-1]
56546 [P52849-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55170, 87 antibodies

The DNASU plasmid repository

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DNASUi
8509

Genome annotation databases

EnsembliENST00000299641; ENSP00000299641; ENSG00000166507 [P52849-1]
ENST00000309979; ENSP00000310657; ENSG00000166507 [P52849-1]
GeneIDi8509
KEGGihsa:8509
UCSCiuc001jvk.3, human [P52849-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8509
DisGeNETi8509

GeneCards: human genes, protein and diseases

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GeneCardsi
NDST2
HGNCiHGNC:7681, NDST2
HPAiENSG00000166507, Low tissue specificity
MIMi603268, gene
neXtProtiNX_P52849
OpenTargetsiENSG00000166507
PharmGKBiPA31487
VEuPathDBiHostDB:ENSG00000166507

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3703, Eukaryota
GeneTreeiENSGT00940000156237
HOGENOMiCLU_011357_2_0_1
InParanoidiP52849
OMAiDMSPESR
PhylomeDBiP52849
TreeFamiTF313193

Enzyme and pathway databases

UniPathwayiUPA00756
UPA00862
BioCyciMetaCyc:HS09410-MONOMER
PathwayCommonsiP52849
ReactomeiR-HSA-2022928, HS-GAG biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8509, 13 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NDST2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NDST2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8509
PharosiP52849, Tbio

Protein Ontology

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PROi
PR:P52849
RNActiP52849, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166507, Expressed in spleen and 111 other tissues
ExpressionAtlasiP52849, baseline and differential
GenevisibleiP52849, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR021930, Heparan_SO4_deacetylase
IPR037359, NST/OST
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom
PANTHERiPTHR10605, PTHR10605, 1 hit
PfamiView protein in Pfam
PF12062, HSNSD, 1 hit
PF00685, Sulfotransfer_1, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDST2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52849
Secondary accession number(s): Q2TB32, Q59H89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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