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Protein

Carnitine O-palmitoyltransferase 2, mitochondrial

Gene

Cpt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei372Proton acceptorBy similarity1
Binding sitei486CarnitineBy similarity1
Binding sitei488CarnitineBy similarity1
Binding sitei499CarnitineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • fatty acid beta-oxidation Source: GO_Central
  • positive regulation of cold-induced thermogenesis Source: YuBioLab

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial (EC:2.3.1.21)
Alternative name(s):
Carnitine palmitoyltransferase II
Short name:
CPT II
Gene namesi
Name:Cpt2
Synonyms:Cpt-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109176 Cpt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 178Mitochondrial matrixBy similarityAdd BLAST153
Intramembranei179 – 208Note=Mitochondrial inner membraneBy similarityAdd BLAST30
Topological domaini209 – 658Mitochondrial matrixBy similarityAdd BLAST450

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000000442626 – 658Carnitine O-palmitoyltransferase 2, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-succinyllysineCombined sources1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei85N6-succinyllysineCombined sources1
Modified residuei239N6-acetyllysine; alternateCombined sources1
Modified residuei239N6-succinyllysine; alternateCombined sources1
Modified residuei305N6-acetyllysineCombined sources1
Modified residuei418N6-acetyllysine; alternateCombined sources1
Modified residuei418N6-succinyllysine; alternateCombined sources1
Modified residuei424N6-succinyllysineCombined sources1
Modified residuei439N6-succinyllysineCombined sources1
Modified residuei510N6-acetyllysine; alternateCombined sources1
Modified residuei510N6-succinyllysine; alternateCombined sources1
Modified residuei544N6-acetyllysine; alternateCombined sources1
Modified residuei544N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52825
MaxQBiP52825
PaxDbiP52825
PeptideAtlasiP52825
PRIDEiP52825

PTM databases

iPTMnetiP52825
PhosphoSitePlusiP52825
SwissPalmiP52825

Expressioni

Gene expression databases

BgeeiENSMUSG00000028607 Expressed in 290 organ(s), highest expression level in brown adipose tissue
CleanExiMM_CPT2
ExpressionAtlasiP52825 baseline and differential
GenevisibleiP52825 MM

Interactioni

Protein-protein interaction databases

BioGridi198865, 2 interactors
IntActiP52825, 3 interactors
MINTiP52825
STRINGi10090.ENSMUSP00000030345

Structurei

3D structure databases

ProteinModelPortaliP52825
SMRiP52825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni452 – 464Coenzyme A bindingBy similarityAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3719 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00550000074786
HOGENOMiHOG000007446
HOVERGENiHBG098001
InParanoidiP52825
KOiK08766
OMAiNFNPFMA
OrthoDBiEOG091G0697
TreeFamiTF315202

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR039551 Cho/carn_acyl_trans
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P52825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPRLLLRDW PRCPSLVLGA PSRPLSAVSG PAEYLQHSIV PTMHYQDSLP
60 70 80 90 100
RLPIPKLEDT MKRYLSAQKP LLNDSQFRKT EVLCKDFENG IGKELHAHLL
110 120 130 140 150
AQDKQNKHTS YISGPWFDMY LTARDSVVLN FNPFMAFNPD PKSEYNDQLT
160 170 180 190 200
RATNLTVSAV RFLKTLRAGL LEPEVFHLNP ARSDTDAFKR LIRFVPSSLS
210 220 230 240 250
WYGAYLVNAY PLDMSQYFRL FNSTRIPKPS RDELFTDTKA RHLLVLRKGH
260 270 280 290 300
FYVFDVLDQD GNIVNPSEIQ AHLKYILSDS SPVPEFPLAY LTSENRDVWA
310 320 330 340 350
ELRQKLIHGG NEETLRKVDS AVFCLCLDDF PMKDLVHLSH TMLHGDGTNR
360 370 380 390 400
WFDKSFNLIV AKDGTAAVHF EHAWGDGVAV LRFFNEVFRD STQTPAIAPQ
410 420 430 440 450
SQPAATDSSV SVQKLSFKLS SALKAGVTAA KEKFDATMKT LTIDAIQFQR
460 470 480 490 500
GGKEFLKKKK LSPDAVAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE
510 520 530 540 550
TIRPASIFTK RCSEAFVREP SKHSVGELQH MMAECSKYHG QLTKEAAMGQ
560 570 580 590 600
GFDRHLFALR YLAAARGVTL PELYQDPAYQ RINHNILSTS TLSSPAVSLG
610 620 630 640 650
GFAPVVPDGF GIAYAVHDDW IGCNVSSYSG RNAREFLHCV QKCLEDMFDA

LEGKAIKT
Length:658
Mass (Da):73,981
Last modified:July 27, 2011 - v2
Checksum:i3A02DA887DF1D3A1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A8E7A2A8E7_MOUSE
Carnitine O-palmitoyltransferase 2,...
Cpt2
223Annotation score:
A2A8E8A2A8E8_MOUSE
Carnitine O-palmitoyltransferase 2,...
Cpt2
265Annotation score:
A2A8E9A2A8E9_MOUSE
Carnitine O-palmitoyltransferase 2,...
Cpt2
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503R → C in AAA18921 (PubMed:8307575).Curated1
Sequence conflicti503R → C in AAA18922 (PubMed:8307575).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01170
, U01166, U01167, U01168, U01169 Unassigned DNA Translation: AAA18922.1
U01163 mRNA Translation: AAA18921.1
AK169038 mRNA Translation: BAE40828.1
AL611936 Genomic DNA Translation: CAM23589.1
CH466527 Genomic DNA Translation: EDL30761.1
BC138514 mRNA Translation: AAI38515.1
BC145859 mRNA Translation: AAI45860.1
CCDSiCCDS18443.1
PIRiA49362
RefSeqiNP_034079.2, NM_009949.2
UniGeneiMm.307620

Genome annotation databases

EnsembliENSMUST00000030345; ENSMUSP00000030345; ENSMUSG00000028607
GeneIDi12896
KEGGimmu:12896
UCSCiuc008uan.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01170
, U01166, U01167, U01168, U01169 Unassigned DNA Translation: AAA18922.1
U01163 mRNA Translation: AAA18921.1
AK169038 mRNA Translation: BAE40828.1
AL611936 Genomic DNA Translation: CAM23589.1
CH466527 Genomic DNA Translation: EDL30761.1
BC138514 mRNA Translation: AAI38515.1
BC145859 mRNA Translation: AAI45860.1
CCDSiCCDS18443.1
PIRiA49362
RefSeqiNP_034079.2, NM_009949.2
UniGeneiMm.307620

3D structure databases

ProteinModelPortaliP52825
SMRiP52825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198865, 2 interactors
IntActiP52825, 3 interactors
MINTiP52825
STRINGi10090.ENSMUSP00000030345

PTM databases

iPTMnetiP52825
PhosphoSitePlusiP52825
SwissPalmiP52825

Proteomic databases

EPDiP52825
MaxQBiP52825
PaxDbiP52825
PeptideAtlasiP52825
PRIDEiP52825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030345; ENSMUSP00000030345; ENSMUSG00000028607
GeneIDi12896
KEGGimmu:12896
UCSCiuc008uan.2 mouse

Organism-specific databases

CTDi1376
MGIiMGI:109176 Cpt2

Phylogenomic databases

eggNOGiKOG3719 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00550000074786
HOGENOMiHOG000007446
HOVERGENiHBG098001
InParanoidiP52825
KOiK08766
OMAiNFNPFMA
OrthoDBiEOG091G0697
TreeFamiTF315202

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Miscellaneous databases

PROiPR:P52825
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028607 Expressed in 290 organ(s), highest expression level in brown adipose tissue
CleanExiMM_CPT2
ExpressionAtlasiP52825 baseline and differential
GenevisibleiP52825 MM

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR039551 Cho/carn_acyl_trans
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPT2_MOUSE
AccessioniPrimary (citable) accession number: P52825
Secondary accession number(s): Q3TFS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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