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Protein

60S ribosomal protein L22

Gene

rpl-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Gene namesi
Name:rpl-22
ORF Names:C27A2.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC27A2.2a ; CE04102 ; WBGene00004434 ; rpl-22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002155082 – 13060S ribosomal protein L22Add BLAST129

Proteomic databases

EPDiP52819
PaxDbiP52819
PeptideAtlasiP52819
PRIDEiP52819

PTM databases

iPTMnetiP52819

Expressioni

Gene expression databases

BgeeiWBGene00004434

Interactioni

Protein-protein interaction databases

BioGridi39224, 1 interactor
IntActiP52819, 1 interactor
STRINGi6239.C27A2.2a.3

Structurei

3D structure databases

ProteinModelPortaliP52819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434 Eukaryota
ENOG4111UVJ LUCA
GeneTreeiENSGT00390000003719
HOGENOMiHOG000198396
InParanoidiP52819
KOiK02891
OMAiQVGRMKN
OrthoDBiEOG091G0POE
PhylomeDBiP52819

Family and domain databases

Gene3Di3.30.1360.210, 1 hit
InterProiView protein in InterPro
IPR002671 Ribosomal_L22e
IPR038526 Ribosomal_L22e_sf
PANTHERiPTHR10064 PTHR10064, 1 hit
PfamiView protein in Pfam
PF01776 Ribosomal_L22e, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P52819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPKPHAKSA KKALRKKKVH LKFNVECKNP VEDGILRIED LEAFLNEKIK
60 70 80 90 100
VNGKTGHLAA NNVKVEVAKS KVSVVSEVPF SKRYLKYLTK KYLKRNSLRD
110 120 130
WLRVVAVNKN TYEVRYFHIN DGEDAGSDHE
Length:130
Mass (Da):14,946
Last modified:January 23, 2007 - v3
Checksum:i9E2244161D88759F
GO
Isoform b (identifier: P52819-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-53: EAFLNEKIKVNG → SIEFPSLSQDQA
     54-130: Missing.

Note: No experimental confirmation available.
Show »
Length:53
Mass (Da):6,013
Checksum:i8E9F9A6316D88015
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02136542 – 53EAFLN…IKVNG → SIEFPSLSQDQA in isoform b. CuratedAdd BLAST12
Alternative sequenceiVSP_02136654 – 130Missing in isoform b. CuratedAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080349 Genomic DNA Translation: CCD63067.1
FO080349 Genomic DNA Translation: CCD63068.1
PIRiT15648
RefSeqiNP_494932.1, NM_062531.5 [P52819-1]
UniGeneiCel.8253

Genome annotation databases

EnsemblMetazoaiC27A2.2a; C27A2.2a; WBGene00004434 [P52819-1]
GeneIDi173873
KEGGicel:CELE_C27A2.2
UCSCiC27A2.2a.1 c. elegans [P52819-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL22_CAEEL
AccessioniPrimary (citable) accession number: P52819
Secondary accession number(s): P85027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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