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Protein

39S ribosomal protein L12, mitochondrial

Gene

MRPL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with mitochondrial RNA polymerase to activate transcription.1 Publication

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L12, mitochondrial
Short name:
L12mt
Short name:
MRP-L12
Alternative name(s):
5c5-2
Mitochondrial large ribosomal subunit protein bL12m1 Publication
Gene namesi
Name:MRPL12
Synonyms:MRPL7, RPML12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000262814.6
HGNCiHGNC:10378 MRPL12
MIMi602375 gene
neXtProtiNX_P52815

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000262814
PharmGKBiPA30941

Polymorphism and mutation databases

BioMutaiMRPL12
DMDMi20981709

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
ChainiPRO_000003045846 – 19839S ribosomal protein L12, mitochondrialAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei150N6-succinyllysineBy similarity1
Modified residuei162N6-succinyllysineBy similarity1
Modified residuei178N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52815
MaxQBiP52815
PaxDbiP52815
PeptideAtlasiP52815
PRIDEiP52815
ProteomicsDBi56540
TopDownProteomicsiP52815

2D gel databases

DOSAC-COBS-2DPAGEiP52815
SWISS-2DPAGEiP52815

PTM databases

iPTMnetiP52815
PhosphoSitePlusiP52815
SwissPalmiP52815

Expressioni

Gene expression databases

BgeeiENSG00000262814 Expressed in 110 organ(s), highest expression level in apex of heart
CleanExiHS_MRPL12
GenevisibleiP52815 HS

Organism-specific databases

HPAiHPA022853
HPA023043

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:8626705). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (Probable). bL12m interacts with NOA1 (PubMed:19103604).1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLRMTO004114EBI-358272,EBI-355145

Protein-protein interaction databases

BioGridi112097, 171 interactors
CORUMiP52815
DIPiDIP-50865N
IntActiP52815, 56 interactors
MINTiP52815
STRINGi9606.ENSP00000333837

Structurei

3D structure databases

ProteinModelPortaliP52815
SMRiP52815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1715 Eukaryota
COG0222 LUCA
GeneTreeiENSGT00390000000190
HOGENOMiHOG000248814
HOVERGENiHBG001832
InParanoidiP52815
KOiK02935
OrthoDBiEOG091G0BQ7
PhylomeDBiP52815
TreeFamiTF105997

Family and domain databases

CDDicd00387 Ribosomal_L7_L12, 1 hit
Gene3Di3.30.1390.10, 1 hit
HAMAPiMF_00368 Ribosomal_L7_L12, 1 hit
InterProiView protein in InterPro
IPR000206 Ribosomal_L7/12
IPR014719 Ribosomal_L7/12_C/ClpS-like
IPR013823 Ribosomal_L7/L12_C
IPR008932 Ribosomal_L7/L12_oligo
IPR036235 Ribosomal_L7/L12_oligo_N_sf
PfamiView protein in Pfam
PF00542 Ribosomal_L12, 1 hit
PF16320 Ribosomal_L12_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001326 Ribosomal_L7/L12_C, 1 hit
SUPFAMiSSF48300 SSF48300, 1 hit
SSF54736 SSF54736, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52815-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG
60 70 80 90 100
APLDNAPKEY PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM
110 120 130 140 150
GGVMSGAVPA AAAQEAVEED IPIAKERTHF TVRLTEAKPV DKVKLIKEIK
160 170 180 190
NYIQGINLVQ AKKLVESLPQ EIKANVAKAE AEKIKAALEA VGGTVVLE
Length:198
Mass (Da):21,348
Last modified:May 15, 2002 - v2
Checksum:i7F26BEDE9218CEF0
GO

Sequence cautioni

The sequence AAD16894 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33A → T in CAA56249 (PubMed:8626705).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052001105S → P. Corresponds to variant dbSNP:rs11546280EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79865 mRNA Translation: CAA56249.1
AF059736 Genomic DNA Translation: AAG32154.1
BC002344 mRNA Translation: AAH02344.1
BC007497 mRNA Translation: AAH07497.1
AF105278 mRNA Translation: AAD16894.1 Frameshift.
CCDSiCCDS11785.1
RefSeqiNP_002940.2, NM_002949.3
UniGeneiHs.109059

Genome annotation databases

EnsembliENST00000333676; ENSP00000333837; ENSG00000262814
GeneIDi6182
KEGGihsa:6182
UCSCiuc002kbh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79865 mRNA Translation: CAA56249.1
AF059736 Genomic DNA Translation: AAG32154.1
BC002344 mRNA Translation: AAH02344.1
BC007497 mRNA Translation: AAH07497.1
AF105278 mRNA Translation: AAD16894.1 Frameshift.
CCDSiCCDS11785.1
RefSeqiNP_002940.2, NM_002949.3
UniGeneiHs.109059

3D structure databases

ProteinModelPortaliP52815
SMRiP52815
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112097, 171 interactors
CORUMiP52815
DIPiDIP-50865N
IntActiP52815, 56 interactors
MINTiP52815
STRINGi9606.ENSP00000333837

PTM databases

iPTMnetiP52815
PhosphoSitePlusiP52815
SwissPalmiP52815

Polymorphism and mutation databases

BioMutaiMRPL12
DMDMi20981709

2D gel databases

DOSAC-COBS-2DPAGEiP52815
SWISS-2DPAGEiP52815

Proteomic databases

EPDiP52815
MaxQBiP52815
PaxDbiP52815
PeptideAtlasiP52815
PRIDEiP52815
ProteomicsDBi56540
TopDownProteomicsiP52815

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333676; ENSP00000333837; ENSG00000262814
GeneIDi6182
KEGGihsa:6182
UCSCiuc002kbh.3 human

Organism-specific databases

CTDi6182
EuPathDBiHostDB:ENSG00000262814.6
GeneCardsiMRPL12
HGNCiHGNC:10378 MRPL12
HPAiHPA022853
HPA023043
MIMi602375 gene
neXtProtiNX_P52815
OpenTargetsiENSG00000262814
PharmGKBiPA30941
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1715 Eukaryota
COG0222 LUCA
GeneTreeiENSGT00390000000190
HOGENOMiHOG000248814
HOVERGENiHBG001832
InParanoidiP52815
KOiK02935
OrthoDBiEOG091G0BQ7
PhylomeDBiP52815
TreeFamiTF105997

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL12 human
GeneWikiiMRPL12
GenomeRNAii6182
PROiPR:P52815
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000262814 Expressed in 110 organ(s), highest expression level in apex of heart
CleanExiHS_MRPL12
GenevisibleiP52815 HS

Family and domain databases

CDDicd00387 Ribosomal_L7_L12, 1 hit
Gene3Di3.30.1390.10, 1 hit
HAMAPiMF_00368 Ribosomal_L7_L12, 1 hit
InterProiView protein in InterPro
IPR000206 Ribosomal_L7/12
IPR014719 Ribosomal_L7/12_C/ClpS-like
IPR013823 Ribosomal_L7/L12_C
IPR008932 Ribosomal_L7/L12_oligo
IPR036235 Ribosomal_L7/L12_oligo_N_sf
PfamiView protein in Pfam
PF00542 Ribosomal_L12, 1 hit
PF16320 Ribosomal_L12_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001326 Ribosomal_L7/L12_C, 1 hit
SUPFAMiSSF48300 SSF48300, 1 hit
SSF54736 SSF54736, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM12_HUMAN
AccessioniPrimary (citable) accession number: P52815
Secondary accession number(s): Q969U0, Q9HCA2, Q9UQJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 15, 2002
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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