Efna2

Functionⁱ

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.2 Publications

GO - Molecular functionⁱ

ephrin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9053851

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance Source: GO_Central
bone remodeling
Source: UniProtKB
Inferred from direct assayⁱ
- 19299512
ephrin receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 9053851
olfactory bulb development Source: Ensembl
osteoclast differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 19299512

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2682334 EPH-Ephrin signaling R-MMU-3928663 EPHA-mediated growth cone collapse R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Reactomeⁱ

R-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ephrin-A2 Alternative name(s): CEK7-ligand Short name: CEK7-L ELF-1 EPH-related receptor tyrosine kinase ligand 6 Short name: LERK-6
Gene namesⁱ	Name:Efna2 Synonyms:Elf1, Epl6, Eplg6, Lerk6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:102707 Efna2

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
ChainⁱPRO_0000008363	21 – 184	Ephrin-A2Add BLAST	164
PropeptideⁱPRO_0000008364	185 – 209	Removed in mature formSequence analysisAdd BLAST	25

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	69 ↔ 110	PROSITE-ProRule annotation
Disulfide bondⁱ	98 ↔ 159	PROSITE-ProRule annotation
Glycosylationⁱ	170	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	184	GPI-anchor amidated asparagineSequence analysis	1
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbⁱ	P52801
PRIDEⁱ	P52801

PTM databases

PhosphoSitePlusⁱ	P52801

PhosphoSitePlusⁱ

P52801

Expressionⁱ

Tissue specificityⁱ

Expressed in myogenic progenitor cells.1 Publication

Developmental stageⁱ

In myogenic progenitor cells, highly expressed, at least as early as E11.5, expression decreases gradually until adulthood.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000003070
CleanExⁱ	MM_EFNA2 MM_ELF1
Genevisibleⁱ	P52801 MM

Interactionⁱ

Subunit structureⁱ

Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.1 Publication

GO - Molecular functionⁱ

ephrin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9053851

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000003154

STRINGⁱ

10090.ENSMUSP00000003154

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52801
SMRⁱ	P52801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	30 – 170	Ephrin RBDPROSITE-ProRule annotationAdd BLAST		141

Sequence similaritiesⁱ

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3858 Eukaryota ENOG4111FMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015107
HOGENOMⁱ	HOG000234373
HOVERGENⁱ	HBG051447
InParanoidⁱ	P52801
KEGG Orthology (KO) More...KOⁱ	K05462
OMAⁱ	SDRYAVY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LOO
PhylomeDBⁱ	P52801

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Dⁱ	2.60.40.420, 1 hit
InterProⁱ	View protein in InterPro IPR008972 Cupredoxin IPR031328 Ephrin IPR034252 Ephrin-A_Ecto IPR019765 Ephrin_CS IPR001799 Ephrin_RBD
PANTHERⁱ	PTHR11304 PTHR11304, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00812 Ephrin, 1 hit
PRINTSⁱ	PR01347 EPHRIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002533 Ephrin, 1 hit
SUPFAMⁱ	SSF49503 SSF49503, 1 hit
PROSITEⁱ	View protein in PROSITE PS01299 EPHRIN_RBD_1, 1 hit PS51551 EPHRIN_RBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P52801-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPAQRPLLP LLLLLLPLRA RNEDPARANA DRYAVYWNRS NPRFQVSAVG 
        60         70         80         90        100
DGGGYTVEVS INDYLDIYCP HYGAPLPPAE RMERYILYMV NGEGHASCDH 
       110        120        130        140        150
RQRGFKRWEC NRPAAPGGPL KFSEKFQLFT PFSLGFEFRP GHEYYYISAT 
       160        170        180        190        200
PPNLVDRPCL RLKVYVRPTN ETLYEAPEPI FTSNSSCSGL GGCHLFLTTV 

PVLWSLLGS

Length:209

Mass (Da):23,586

Last modified:October 1, 1996 - v1

Checksum:ⁱF1997545F25B9ABC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14941 mRNA Translation: AAA53636.1 U14752 mRNA Translation: AAA68520.1 BC048697 mRNA Translation: AAH48697.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24013.1
PIRⁱ	A54984
NCBI Reference Sequences More...RefSeqⁱ	NP_031935.3, NM_007909.3
UniGeneⁱ	Mm.1478

Genome annotation databases

Ensemblⁱ	ENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070
GeneIDⁱ	13637
KEGGⁱ	mmu:13637
UCSC genome browser More...UCSCⁱ	uc007gcg.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P52801	Ephrin A2		RAT		209
Uncharacterized protein		MOUSE		209
UPI000A304833		MUSPA		209
UPI0004ED6A6D		NANGA		208

Protein	Similar proteins		Species	Score	Length
P52801	Ephrin A2		RAT		209
Uncharacterized protein		MOUSE		209
UPI000A304833		MUSPA		209
UPI0004ED6A6D		NANGA		208
UPI00057B971A		CAMDR		195
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14941 mRNA Translation: AAA53636.1 U14752 mRNA Translation: AAA68520.1 BC048697 mRNA Translation: AAH48697.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24013.1
PIRⁱ	A54984
NCBI Reference Sequences More...RefSeqⁱ	NP_031935.3, NM_007909.3
UniGeneⁱ	Mm.1478

3D structure databases

ProteinModelPortalⁱ	P52801
SMRⁱ	P52801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000003154

STRINGⁱ

10090.ENSMUSP00000003154

PTM databases

PhosphoSitePlusⁱ	P52801

PhosphoSitePlusⁱ

P52801

Proteomic databases

PaxDbⁱ	P52801
PRIDEⁱ	P52801

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070
GeneIDⁱ	13637
KEGGⁱ	mmu:13637
UCSC genome browser More...UCSCⁱ	uc007gcg.2 mouse

Organism-specific databases

CTDⁱ	1943
MGIⁱ	MGI:102707 Efna2

Phylogenomic databases

eggNOGⁱ	KOG3858 Eukaryota ENOG4111FMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015107
HOGENOMⁱ	HOG000234373
HOVERGENⁱ	HBG051447
InParanoidⁱ	P52801
KEGG Orthology (KO) More...KOⁱ	K05462
OMAⁱ	SDRYAVY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LOO
PhylomeDBⁱ	P52801

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2682334 EPH-Ephrin signaling R-MMU-3928663 EPHA-mediated growth cone collapse R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Reactomeⁱ

R-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

ChiTaRSⁱ	Efna2 mouse
Protein Ontology More...PROⁱ	PR:P52801
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000003070
CleanExⁱ	MM_EFNA2 MM_ELF1
Genevisibleⁱ	P52801 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Dⁱ	2.60.40.420, 1 hit
InterProⁱ	View protein in InterPro IPR008972 Cupredoxin IPR031328 Ephrin IPR034252 Ephrin-A_Ecto IPR019765 Ephrin_CS IPR001799 Ephrin_RBD
PANTHERⁱ	PTHR11304 PTHR11304, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00812 Ephrin, 1 hit
PRINTSⁱ	PR01347 EPHRIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002533 Ephrin, 1 hit
SUPFAMⁱ	SSF49503 SSF49503, 1 hit
PROSITEⁱ	View protein in PROSITE PS01299 EPHRIN_RBD_1, 1 hit PS51551 EPHRIN_RBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EFNA2_MOUSE
Accessionⁱ	P52801Primary (citable) accession number: P52801
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	June 20, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P52801 (EFNA2_MOUSE)

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Ephrin-A2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ