UniProtKB - P52801 (EFNA2_MOUSE)
Protein
Ephrin-A2
Gene
Efna2
Organism
Mus musculus (Mouse)
Status
Functioni
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.2 Publications
GO - Molecular functioni
- ephrin receptor binding Source: UniProtKB
GO - Biological processi
- axon guidance Source: GO_Central
- bone remodeling Source: UniProtKB
- ephrin receptor signaling pathway Source: UniProtKB
- olfactory bulb development Source: Ensembl
- osteoclast differentiation Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-MMU-2682334, EPH-Ephrin signaling R-MMU-3928663, EPHA-mediated growth cone collapse R-MMU-3928665, EPH-ephrin mediated repulsion of cells |
Names & Taxonomyi
Protein namesi | Recommended name: Ephrin-A2Alternative name(s): CEK7-ligand Short name: CEK7-L ELF-1 EPH-related receptor tyrosine kinase ligand 6 Short name: LERK-6 |
Gene namesi | Name:Efna2 Synonyms:Elf1, Epl6, Eplg6, Lerk6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102707, Efna2 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; GPI-anchor Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- anchored component of membrane Source: UniProtKB-KW
- neuromuscular junction Source: MGI
- perikaryon Source: MGI
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000008363 | 21 – 184 | Ephrin-A2Add BLAST | 164 | |
PropeptideiPRO_0000008364 | 185 – 209 | Removed in mature formSequence analysisAdd BLAST | 25 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 69 ↔ 110 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 159 | PROSITE-ProRule annotation | ||
Glycosylationi | 170 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 184 | GPI-anchor amidated asparagineSequence analysis | 1 | |
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | P52801 |
PRIDEi | P52801 |
ProteomicsDBi | 277800 |
PTM databases
GlyGeni | P52801, 3 sites |
PhosphoSitePlusi | P52801 |
Expressioni
Tissue specificityi
Expressed in myogenic progenitor cells.1 Publication
Developmental stagei
In myogenic progenitor cells, highly expressed, at least as early as 11.5 dpc, expression decreases gradually until adulthood.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000003070, Expressed in midbrain and 256 other tissues |
Genevisiblei | P52801, MM |
Interactioni
Subunit structurei
Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5.
Interacts with EPHA8; activates EPHA8.
1 PublicationGO - Molecular functioni
- ephrin receptor binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000003154 |
Miscellaneous databases
RNActi | P52801, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 170 | Ephrin RBDPROSITE-ProRule annotationAdd BLAST | 141 |
Sequence similaritiesi
Belongs to the ephrin family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3858, Eukaryota |
GeneTreei | ENSGT00940000160040 |
HOGENOMi | CLU_081598_3_1_1 |
InParanoidi | P52801 |
OMAi | CCSLRVP |
OrthoDBi | 1094764at2759 |
PhylomeDBi | P52801 |
Family and domain databases
CDDi | cd10425, Ephrin-A_Ectodomain, 1 hit |
Gene3Di | 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR031328, Ephrin IPR034252, Ephrin-A_Ecto IPR019765, Ephrin_CS IPR001799, Ephrin_RBD |
PANTHERi | PTHR11304, PTHR11304, 1 hit |
Pfami | View protein in Pfam PF00812, Ephrin, 1 hit |
PRINTSi | PR01347, EPHRIN |
SUPFAMi | SSF49503, SSF49503, 1 hit |
PROSITEi | View protein in PROSITE PS01299, EPHRIN_RBD_1, 1 hit PS51551, EPHRIN_RBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P52801-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPAQRPLLP LLLLLLPLRA RNEDPARANA DRYAVYWNRS NPRFQVSAVG
60 70 80 90 100
DGGGYTVEVS INDYLDIYCP HYGAPLPPAE RMERYILYMV NGEGHASCDH
110 120 130 140 150
RQRGFKRWEC NRPAAPGGPL KFSEKFQLFT PFSLGFEFRP GHEYYYISAT
160 170 180 190 200
PPNLVDRPCL RLKVYVRPTN ETLYEAPEPI FTSNSSCSGL GGCHLFLTTV
PVLWSLLGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14941 mRNA Translation: AAA53636.1 U14752 mRNA Translation: AAA68520.1 BC048697 mRNA Translation: AAH48697.1 |
CCDSi | CCDS24013.1 |
PIRi | A54984 |
RefSeqi | NP_031935.3, NM_007909.3 |
Genome annotation databases
Ensembli | ENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070 |
GeneIDi | 13637 |
KEGGi | mmu:13637 |
UCSCi | uc007gcg.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14941 mRNA Translation: AAA53636.1 U14752 mRNA Translation: AAA68520.1 BC048697 mRNA Translation: AAH48697.1 |
CCDSi | CCDS24013.1 |
PIRi | A54984 |
RefSeqi | NP_031935.3, NM_007909.3 |
3D structure databases
SMRi | P52801 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000003154 |
PTM databases
GlyGeni | P52801, 3 sites |
PhosphoSitePlusi | P52801 |
Proteomic databases
PaxDbi | P52801 |
PRIDEi | P52801 |
ProteomicsDBi | 277800 |
Protocols and materials databases
Antibodypediai | 3919, 375 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070 |
GeneIDi | 13637 |
KEGGi | mmu:13637 |
UCSCi | uc007gcg.2, mouse |
Organism-specific databases
CTDi | 1943 |
MGIi | MGI:102707, Efna2 |
Phylogenomic databases
eggNOGi | KOG3858, Eukaryota |
GeneTreei | ENSGT00940000160040 |
HOGENOMi | CLU_081598_3_1_1 |
InParanoidi | P52801 |
OMAi | CCSLRVP |
OrthoDBi | 1094764at2759 |
PhylomeDBi | P52801 |
Enzyme and pathway databases
Reactomei | R-MMU-2682334, EPH-Ephrin signaling R-MMU-3928663, EPHA-mediated growth cone collapse R-MMU-3928665, EPH-ephrin mediated repulsion of cells |
Miscellaneous databases
BioGRID-ORCSi | 13637, 2 hits in 55 CRISPR screens |
ChiTaRSi | Efna2, mouse |
PROi | PR:P52801 |
RNActi | P52801, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000003070, Expressed in midbrain and 256 other tissues |
Genevisiblei | P52801, MM |
Family and domain databases
CDDi | cd10425, Ephrin-A_Ectodomain, 1 hit |
Gene3Di | 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR031328, Ephrin IPR034252, Ephrin-A_Ecto IPR019765, Ephrin_CS IPR001799, Ephrin_RBD |
PANTHERi | PTHR11304, PTHR11304, 1 hit |
Pfami | View protein in Pfam PF00812, Ephrin, 1 hit |
PRINTSi | PR01347, EPHRIN |
SUPFAMi | SSF49503, SSF49503, 1 hit |
PROSITEi | View protein in PROSITE PS01299, EPHRIN_RBD_1, 1 hit PS51551, EPHRIN_RBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EFNA2_MOUSE | |
Accessioni | P52801Primary (citable) accession number: P52801 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families