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Protein

Ephrin-A2

Gene

Efna2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.2 Publications

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

GO - Biological processi

  • axon guidance Source: GO_Central
  • bone remodeling Source: UniProtKB
  • ephrin receptor signaling pathway Source: UniProtKB
  • olfactory bulb development Source: Ensembl
  • osteoclast differentiation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A2
Alternative name(s):
CEK7-ligand
Short name:
CEK7-L
ELF-1
EPH-related receptor tyrosine kinase ligand 6
Short name:
LERK-6
Gene namesi
Name:Efna2
Synonyms:Elf1, Epl6, Eplg6, Lerk6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:102707 Efna2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000836321 – 184Ephrin-A2Add BLAST164
PropeptideiPRO_0000008364185 – 209Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi69 ↔ 110PROSITE-ProRule annotation
Disulfide bondi98 ↔ 159PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi184GPI-anchor amidated asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP52801
PRIDEiP52801

PTM databases

PhosphoSitePlusiP52801

Expressioni

Tissue specificityi

Expressed in myogenic progenitor cells.1 Publication

Developmental stagei

In myogenic progenitor cells, highly expressed, at least as early as E11.5, expression decreases gradually until adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000003070
CleanExiMM_EFNA2
MM_ELF1
GenevisibleiP52801 MM

Interactioni

Subunit structurei

Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.1 Publication

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003154

Structurei

3D structure databases

ProteinModelPortaliP52801
SMRiP52801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 170Ephrin RBDPROSITE-ProRule annotationAdd BLAST141

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiP52801
KOiK05462
OMAiSDRYAVY
OrthoDBiEOG091G0LOO
PhylomeDBiP52801

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAQRPLLP LLLLLLPLRA RNEDPARANA DRYAVYWNRS NPRFQVSAVG
60 70 80 90 100
DGGGYTVEVS INDYLDIYCP HYGAPLPPAE RMERYILYMV NGEGHASCDH
110 120 130 140 150
RQRGFKRWEC NRPAAPGGPL KFSEKFQLFT PFSLGFEFRP GHEYYYISAT
160 170 180 190 200
PPNLVDRPCL RLKVYVRPTN ETLYEAPEPI FTSNSSCSGL GGCHLFLTTV

PVLWSLLGS
Length:209
Mass (Da):23,586
Last modified:October 1, 1996 - v1
Checksum:iF1997545F25B9ABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14941 mRNA Translation: AAA53636.1
U14752 mRNA Translation: AAA68520.1
BC048697 mRNA Translation: AAH48697.1
CCDSiCCDS24013.1
PIRiA54984
RefSeqiNP_031935.3, NM_007909.3
UniGeneiMm.1478

Genome annotation databases

EnsembliENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070
GeneIDi13637
KEGGimmu:13637
UCSCiuc007gcg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiEFNA2_MOUSE
AccessioniPrimary (citable) accession number: P52801
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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