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Protein

Hexokinase-3

Gene

HK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi95 – 100ATPSequence analysis6
Nucleotide bindingi542 – 547ATPSequence analysis6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: GO_Central
  • glucokinase activity Source: GO_Central
  • glucose binding Source: InterPro
  • hexokinase activity Source: MGI
  • mannokinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Kinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08548-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-70171 Glycolysis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P52790

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00242

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hexokinase-3 (EC:2.7.1.1)
Alternative name(s):
Hexokinase type III
Short name:
HK III
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160883.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4925 HK3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142570 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52790

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3101

Open Targets

More...
OpenTargetsi
ENSG00000160883

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29303

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2709

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HK3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206729871

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001975901 – 923Hexokinase-3Add BLAST923

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P52790

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52790

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52790

PeptideAtlas

More...
PeptideAtlasi
P52790

PRoteomics IDEntifications database

More...
PRIDEi
P52790

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56534

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52790

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52790

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P52790

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160883 Expressed in 106 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_HK3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52790 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52790 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056743

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109348, 19 interactors

Protein interaction database and analysis system

More...
IntActi
P52790, 7 interactors

Molecular INTeraction database

More...
MINTi
P52790

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1923
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P52790

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P52790

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P52790

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 471Hexokinase 1PROSITE-ProRule annotationAdd BLAST445
Domaini477 – 912Hexokinase 2PROSITE-ProRule annotationAdd BLAST436

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 488RegulatoryAdd BLAST488
Regioni84 – 220Hexokinase small subdomain 1PROSITE-ProRule annotationAdd BLAST137
Regioni162 – 188Glucose-bindingSequence analysisAdd BLAST27
Regioni221 – 460Hexokinase large subdomain 1PROSITE-ProRule annotationAdd BLAST240
Regioni489 – 923CatalyticAdd BLAST435
Regioni531 – 661Hexokinase small subdomain 2PROSITE-ProRule annotationAdd BLAST131
Regioni603 – 629Glucose-bindingSequence analysisAdd BLAST27
Regioni662 – 901Hexokinase large subdomain 2PROSITE-ProRule annotationAdd BLAST240

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1369 Eukaryota
COG5026 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153555

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162671

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005020

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52790

KEGG Orthology (KO)

More...
KOi
K00844

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDRGRVC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08MD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52790

TreeFam database of animal gene trees

More...
TreeFami
TF314238

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N

The PANTHER Classification System

More...
PANTHERi
PTHR19443 PTHR19443, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00349 Hexokinase_1, 2 hits
PF03727 Hexokinase_2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P52790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSIGSSGLR QGEETLSCSE EGLPGPSDSS ELVQECLQQF KVTRAQLQQI
60 70 80 90 100
QASLLGSMEQ ALRGQASPAP AVRMLPTYVG STPHGTEQGD FVVLELGATG
110 120 130 140 150
ASLRVLWVTL TGIEGHRVEP RSQEFVIPQE VMLGAGQQLF DFAAHCLSEF
160 170 180 190 200
LDAQPVNKQG LQLGFSFSFP CHQTGLDRST LISWTKGFRC SGVEGQDVVQ
210 220 230 240 250
LLRDAIRRQG AYNIDVVAVV NDTVGTMMGC EPGVRPCEVG LVVDTGTNAC
260 270 280 290 300
YMEEARHVAV LDEDRGRVCV SVEWGSFSDD GALGPVLTTF DHTLDHESLN
310 320 330 340 350
PGAQRFEKMI GGLYLGELVR LVLAHLARCG VLFGGCTSPA LLSQGSILLE
360 370 380 390 400
HVAEMEDPST GAARVHAILQ DLGLSPGASD VELVQHVCAA VCTRAAQLCA
410 420 430 440 450
AALAAVLSCL QHSREQQTLQ VAVATGGRVC ERHPRFCSVL QGTVMLLAPE
460 470 480 490 500
CDVSLIPSVD GGGRGVAMVT AVAARLAAHR RLLEETLAPF RLNHDQLAAV
510 520 530 540 550
QAQMRKAMAK GLRGEASSLR MLPTFVRATP DGSERGDFLA LDLGGTNFRV
560 570 580 590 600
LLVRVTTGVQ ITSEIYSIPE TVAQGSGQQL FDHIVDCIVD FQQKQGLSGQ
610 620 630 640 650
SLPLGFTFSF PCRQLGLDQG ILLNWTKGFK ASDCEGQDVV SLLREAITRR
660 670 680 690 700
QAVELNVVAI VNDTVGTMMS CGYEDPRCEI GLIVGTGTNA CYMEELRNVA
710 720 730 740 750
GVPGDSGRMC INMEWGAFGD DGSLAMLSTR FDASVDQASI NPGKQRFEKM
760 770 780 790 800
ISGMYLGEIV RHILLHLTSL GVLFRGQQIQ RLQTRDIFKT KFLSEIESDS
810 820 830 840 850
LALRQVRAIL EDLGLPLTSD DALMVLEVCQ AVSQRAAQLC GAGVAAVVEK
860 870 880 890 900
IRENRGLEEL AVSVGVDGTL YKLHPRFSSL VAATVRELAP RCVVTFLQSE
910 920
DGSGKGAALV TAVACRLAQL TRV
Length:923
Mass (Da):99,025
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA75F2A9DBB895FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8U9H0Y8U9_HUMAN
Phosphotransferase
HK3
106Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9N6H0Y9N6_HUMAN
Phosphotransferase
HK3
131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAG4H0YAG4_HUMAN
Hexokinase-3
HK3
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti277F → L in AAC50732 (PubMed:8812439).Curated1
Sequence conflicti420Q → L in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti431E → Q in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti439V → I in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti510K → R in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti512 – 513LR → SE in AAC50422 (PubMed:8717435).Curated2
Sequence conflicti516A → S in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti519L → S in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti530 – 531PD → LT in AAC50422 (PubMed:8717435).Curated2
Sequence conflicti577 – 578GQ → AE in AAC50422 (PubMed:8717435).Curated2
Sequence conflicti604L → T in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti708R → H in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti718F → L in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti728S → R in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti750M → I in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti831A → V in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti836A → P in AAC50422 (PubMed:8717435).Curated1
Sequence conflicti853E → G in AAC50732 (PubMed:8812439).Curated1
Sequence conflicti918A → T in AAC50422 (PubMed:8717435).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034004281G → R. Corresponds to variant dbSNP:rs35610191Ensembl.1
Natural variantiVAR_036186480R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376532514Ensembl.1
Natural variantiVAR_036187499A → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755546220Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51333 mRNA Translation: AAC50732.1
CH471195 Genomic DNA Translation: EAW85048.1
BC028129 mRNA Translation: AAH28129.1
U42303 mRNA Translation: AAC50422.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4407.1

NCBI Reference Sequences

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RefSeqi
NP_002106.2, NM_002115.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.411695

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292432; ENSP00000292432; ENSG00000160883

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3101

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3101

UCSC genome browser

More...
UCSCi
uc003mfa.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Hexokinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51333 mRNA Translation: AAC50732.1
CH471195 Genomic DNA Translation: EAW85048.1
BC028129 mRNA Translation: AAH28129.1
U42303 mRNA Translation: AAC50422.1
CCDSiCCDS4407.1
RefSeqiNP_002106.2, NM_002115.2
UniGeneiHs.411695

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HM8X-ray2.80A/B/C/D480-922[»]
ProteinModelPortaliP52790
SMRiP52790
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109348, 19 interactors
IntActiP52790, 7 interactors
MINTiP52790
STRINGi9606.ENSP00000292432

Chemistry databases

ChEMBLiCHEMBL2709

PTM databases

iPTMnetiP52790
PhosphoSitePlusiP52790
SwissPalmiP52790

Polymorphism and mutation databases

BioMutaiHK3
DMDMi206729871

Proteomic databases

EPDiP52790
MaxQBiP52790
PaxDbiP52790
PeptideAtlasiP52790
PRIDEiP52790
ProteomicsDBi56534

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3101
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292432; ENSP00000292432; ENSG00000160883
GeneIDi3101
KEGGihsa:3101
UCSCiuc003mfa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3101
DisGeNETi3101
EuPathDBiHostDB:ENSG00000160883.10

GeneCards: human genes, protein and diseases

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GeneCardsi
HK3
HGNCiHGNC:4925 HK3
HPAiHPA056743
MIMi142570 gene
neXtProtiNX_P52790
OpenTargetsiENSG00000160883
PharmGKBiPA29303

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00940000153555
HOGENOMiHOG000162671
HOVERGENiHBG005020
InParanoidiP52790
KOiK00844
OMAiEDRGRVC
OrthoDBiEOG091G08MD
PhylomeDBiP52790
TreeFamiTF314238

Enzyme and pathway databases

UniPathwayi
UPA00242

BioCyciMetaCyc:HS08548-MONOMER
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-70171 Glycolysis
SABIO-RKiP52790

Miscellaneous databases

EvolutionaryTraceiP52790

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HK3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3101

Protein Ontology

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PROi
PR:P52790

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160883 Expressed in 106 organ(s), highest expression level in blood
CleanExiHS_HK3
ExpressionAtlasiP52790 baseline and differential
GenevisibleiP52790 HS

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 4 hits
PfamiView protein in Pfam
PF00349 Hexokinase_1, 2 hits
PF03727 Hexokinase_2, 2 hits
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52790
Secondary accession number(s): Q8N1E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: December 5, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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