UniProtKB - P52789 (HXK2_HUMAN)
Protein
Hexokinase-2
Gene
HK2
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175).4 Publications
Caution
Hexokinase is known to act as a monomer in normal conditions (By similarity). It however homodimerizes at elevated protein concentrations used for crystallizations (PubMed:26985301, PubMed:29298880).By similarity2 Publications
Catalytic activityi
- EC:2.7.1.13 PublicationsThis reaction proceeds in the forward2 Publications direction.
- EC:2.7.1.1By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:2.7.1.11 PublicationThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines.1 Publication
Kineticsi
- KM=0.21 mM for D-glucose1 Publication
- KM=1.13 mM for ATP1 Publication
: hexose metabolism Pathwayi
This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.
Pathwayi: glycolysis
This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.1 PublicationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Hexokinase (HK3), Hexokinase, Hexokinase-3 (HK3), Hexokinase, Hexokinase-4 (GCK), Hexokinase, Phosphotransferase (GCK), Phosphotransferase (GCK), Phosphotransferase (HK2), Hexokinase (HK2), Phosphotransferase (GCK), Hexokinase, Phosphotransferase (GCK), Phosphotransferase, Hexokinase, Phosphotransferase, Hexokinase HKDC1 (HKDC1), Hexokinase-1 (HK1), Hexokinase-2 (HK2), Hexokinase, Phosphotransferase (HK2), Hexokinase, Hexokinase (HK1), Hexokinase, Phosphotransferase (GCK), Hexokinase, Hexokinase (DKFZp686M1669), Phosphotransferase (HK3)
- Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
- ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Liver phosphofructokinase isoform a variant, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), PFKL protein (PFKL), cDNA FLJ30173 fis, clone BRACE2000969, highly similar to 6-phosphofructokinase, liver type, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 4 (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), PFKL protein (PFKL), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 3 (PFKM), cDNA FLJ61026, highly similar to Homo sapiens phosphofructokinase, liver (PFKL), transcript variant 1, mRNA, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), Phosphofructokinase-P (PFK-P), PFKM protein (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 2 (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), cDNA FLJ56281, highly similar to 6-phosphofructokinase, muscle type, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Uncharacterized protein DKFZp686L2097 (DKFZp686L2097), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), Uncharacterized protein DKFZp686G1648 (DKFZp686G1648), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase, liver type (PFKL), Similar to phosphofructokinase, platelet, ATP-dependent 6-phosphofructokinase, platelet type (PFKP), PFKM protein (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), cDNA FLJ40373 fis, clone TESTI2035003, highly similar to 6-phosphofructokinase type C, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), PFKP protein (PFKP)
- Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 30 | ATP 1By similarity | 1 | |
Binding sitei | 209 | Glucose-6-phosphate 1Combined sources1 Publication | 1 | |
Binding sitei | 232 | Glucose-6-phosphate 1Combined sources1 Publication | 1 | |
Binding sitei | 235 | Substrate 1Combined sources1 Publication | 1 | |
Binding sitei | 260 | Substrate 1Combined sources1 Publication | 1 | |
Binding sitei | 449 | Glucose-6-phosphate 1Combined sources1 Publication | 1 | |
Binding sitei | 657 | Glucose-6-phosphate 2Combined sources2 Publications | 1 | |
Binding sitei | 680 | ATP 2By similarity | 1 | |
Binding sitei | 680 | Glucose-6-phosphate 2Combined sources2 Publications | 1 | |
Binding sitei | 708 | Substrate 2Combined sources1 Publication | 1 | |
Binding sitei | 897 | Glucose-6-phosphate 2Combined sources2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 84 – 89 | ATP 1By similarity | 6 | |
Nucleotide bindingi | 425 – 426 | ATP 1By similarity | 2 | |
Nucleotide bindingi | 532 – 537 | ATP 2By similarity | 6 | |
Nucleotide bindingi | 747 – 748 | ATP 2By similarity | 2 | |
Nucleotide bindingi | 784 – 788 | ATP 2By similarity | 5 | |
Nucleotide bindingi | 863 – 867 | ATP 2By similarity | 5 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- fructokinase activity Source: UniProtKB
- glucokinase activity Source: UniProtKB
- glucose binding Source: Ensembl
- hexokinase activity Source: UniProtKB
- mannokinase activity Source: GO_Central
GO - Biological processi
- apoptotic mitochondrial changes Source: MGI
- canonical glycolysis Source: Reactome
- cellular glucose homeostasis Source: GO_Central
- cellular response to leukemia inhibitory factor Source: Ensembl
- establishment of protein localization to mitochondrion Source: ParkinsonsUK-UCL
- fructose 6-phosphate metabolic process Source: UniProtKB
- glucose 6-phosphate metabolic process Source: UniProtKB
- glycolytic process Source: GO_Central
- lactation Source: Ensembl
- maintenance of protein location in mitochondrion Source: ParkinsonsUK-UCL
- negative regulation of mitochondrial membrane permeability Source: Ensembl
- negative regulation of reactive oxygen species metabolic process Source: Ensembl
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
- regulation of glucose import Source: Ensembl
- response to hypoxia Source: Ensembl
- response to ischemia Source: Ensembl
Keywordsi
Molecular function | Allosteric enzyme, Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08399-MONOMER |
BRENDAi | 2.7.1.1, 2681 |
PathwayCommonsi | P52789 |
Reactomei | R-HSA-70171, Glycolysis |
SABIO-RKi | P52789 |
SIGNORi | P52789 |
UniPathwayi | UPA00109;UER00180 UPA00242 |
Names & Taxonomyi
Protein namesi | Recommended name: Hexokinase-2Curated (EC:2.7.1.13 Publications)Alternative name(s): Hexokinase type II2 Publications Short name: HK II2 Publications Hexokinase-BBy similarity Muscle form hexokinase1 Publication |
Gene namesi | Name:HK2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159399.9 |
HGNCi | HGNC:4923, HK2 |
MIMi | 601125, gene |
neXtProti | NX_P52789 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication; Peripheral membrane protein Curated
Cytosol
- cytosol 1 Publication
Note: The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175).2 Publications
Cytosol
- cytosol Source: GO_Central
Endoplasmic reticulum
- sarcoplasmic reticulum Source: Ensembl
Mitochondrion
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: GO_Central
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 209 | D → A: Decreased hexokinase activity. 1 Publication | 1 | |
Mutagenesisi | 468 | R → A: Induces a rapid dissociation of D-glucose. 1 Publication | 1 | |
Mutagenesisi | 657 | D → A: Decreased hexokinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3099 |
OpenTargetsi | ENSG00000159399 |
PharmGKBi | PA29301 |
Miscellaneous databases
Pharosi | P52789, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2640 |
Polymorphism and mutation databases
BioMutai | HK2 |
DMDMi | 56405344 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197587 | 1 – 917 | Hexokinase-2Add BLAST | 917 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P52789 |
jPOSTi | P52789 |
MassIVEi | P52789 |
MaxQBi | P52789 |
PaxDbi | P52789 |
PeptideAtlasi | P52789 |
PRIDEi | P52789 |
ProteomicsDBi | 56533 |
PTM databases
iPTMneti | P52789 |
MetOSitei | P52789 |
PhosphoSitePlusi | P52789 |
SwissPalmi | P52789 |
Expressioni
Tissue specificityi
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000159399, Expressed in colon and 232 other tissues |
ExpressionAtlasi | P52789, baseline and differential |
Genevisiblei | P52789, HS |
Organism-specific databases
HPAi | ENSG00000159399, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (By similarity).
Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner (PubMed:23185017).
By similarity1 PublicationBinary interactionsi
Hide detailsP52789
Protein-protein interaction databases
BioGRIDi | 109346, 66 interactors |
DIPi | DIP-50110N |
IntActi | P52789, 33 interactors |
MINTi | P52789 |
STRINGi | 9606.ENSP00000290573 |
Chemistry databases
BindingDBi | P52789 |
Miscellaneous databases
RNActi | P52789, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P52789 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P52789 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 458 | Hexokinase 1PROSITE-ProRule annotationAdd BLAST | 443 | |
Domaini | 464 – 906 | Hexokinase 2PROSITE-ProRule annotationAdd BLAST | 443 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 16 | Mitochondrial-binding peptide (MBP)1 PublicationAdd BLAST | 16 | |
Regioni | 73 – 207 | Hexokinase small subdomain 1PROSITE-ProRule annotationAdd BLAST | 135 | |
Regioni | 84 – 88 | Glucose-6-phosphate 1 bindingCombined sources1 Publication | 5 | |
Regioni | 155 – 156 | Substrate 1 bindingCombined sources1 Publication | 2 | |
Regioni | 172 – 173 | Substrate 1 bindingCombined sources1 Publication | 2 | |
Regioni | 208 – 447 | Hexokinase large subdomain 1PROSITE-ProRule annotationAdd BLAST | 240 | |
Regioni | 208 – 209 | Substrate 1 bindingCombined sources1 Publication | 2 | |
Regioni | 291 – 294 | Substrate 1 bindingCombined sources1 Publication | 4 | |
Regioni | 413 – 415 | Glucose-6-phosphate 1 bindingCombined sources1 Publication | 3 | |
Regioni | 521 – 655 | Hexokinase small subdomain 2PROSITE-ProRule annotationAdd BLAST | 135 | |
Regioni | 532 – 536 | Glucose-6-phosphate 2 bindingCombined sources2 Publications | 5 | |
Regioni | 603 – 604 | Substrate 2 bindingCombined sources1 Publication | 2 | |
Regioni | 620 – 621 | Substrate 2 bindingCombined sources1 Publication | 2 | |
Regioni | 656 – 895 | Hexokinase large subdomain 2PROSITE-ProRule annotationAdd BLAST | 240 | |
Regioni | 656 – 657 | Substrate 2 bindingCombined sources1 Publication | 2 | |
Regioni | 682 – 683 | Substrate 2 bindingCombined sources1 Publication | 2 | |
Regioni | 739 – 742 | Substrate 2 bindingCombined sources1 Publication | 4 | |
Regioni | 861 – 863 | Glucose-6-phosphate 2 bindingCombined sources2 Publications | 3 |
Domaini
The N- and C-terminal halves of the protein contain a hexokinase domain (PubMed:29298880). In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity (PubMed:29298880). The region connecting the two hexokinase domains is required for the catalytic activity of the N-terminal hexokinase domain (PubMed:29298880). The N-terminal half regulates stability of the whole enzyme (PubMed:29298880).1 Publication
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1369, Eukaryota |
GeneTreei | ENSGT00950000182787 |
InParanoidi | P52789 |
OMAi | DHEIDMG |
OrthoDBi | 1153545at2759 |
PhylomeDBi | P52789 |
TreeFami | TF314238 |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR001312, Hexokinase IPR019807, Hexokinase_BS IPR022673, Hexokinase_C IPR022672, Hexokinase_N |
PANTHERi | PTHR19443, PTHR19443, 2 hits |
Pfami | View protein in Pfam PF00349, Hexokinase_1, 2 hits PF03727, Hexokinase_2, 2 hits |
SUPFAMi | SSF53067, SSF53067, 4 hits |
PROSITEi | View protein in PROSITE PS00378, HEXOKINASE_1, 2 hits PS51748, HEXOKINASE_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P52789-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG
60 70 80 90 100
LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN
110 120 130 140 150
GLQKVEMENQ IYAIPEDIMR GSGTQLFDHI AECLANFMDK LQIKDKKLPL
160 170 180 190 200
GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV EGRDVVALIR KAIQRRGDFD
210 220 230 240 250
IDIVAVVNDT VGTMMTCGYD DHNCEIGLIV GTGSNACYME EMRHIDMVEG
260 270 280 290 300
DEGRMCINME WGAFGDDGSL NDIRTEFDQE IDMGSLNPGK QLFEKMISGM
310 320 330 340 350
YMGELVRLIL VKMAKEELLF GGKLSPELLN TGRFETKDIS DIEGEKDGIR
360 370 380 390 400
KAREVLMRLG LDPTQEDCVA THRICQIVST RSASLCAATL AAVLQRIKEN
410 420 430 440 450
KGEERLRSTI GVDGSVYKKH PHFAKRLHKT VRRLVPGCDV RFLRSEDGSG
460 470 480 490 500
KGAAMVTAVA YRLADQHRAR QKTLEHLQLS HDQLLEVKRR MKVEMERGLS
510 520 530 540 550
KETHASAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV LLVRVRNGKW
560 570 580 590 600
GGVEMHNKIY AIPQEVMHGT GDELFDHIVQ CIADFLEYMG MKGVSLPLGF
610 620 630 640 650
TFSFPCQQNS LDESILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCGFEDP HCEVGLIVGT GSNACYMEEM RNVELVEGEE
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD FRTEFDVAVD ELSLNPGKQR FEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKRGLLFRG RISERLKTRG IFETKFLSQI ESDCLALLQV
810 820 830 840 850
RAILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA VVDRIRENRG
860 870 880 890 900
LDALKVTVGV DGTLYKLHPH FAKVMHETVK DLAPKCDVSF LQSEDGSGKG
910
AALITAVACR IREAGQR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PB90 | E9PB90_HUMAN | Hexokinase | HK2 | 889 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 803 | I → T in CAA86511 (PubMed:8250948).Curated | 1 | |
Sequence conflicti | 870 | Missing in CAA86476 (PubMed:8786021).Curated | 1 |
Polymorphismi
Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease (PubMed:7883122, PubMed:7883123).2 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003691 | 142 | Q → H Does not affect activity. 4 PublicationsCorresponds to variant dbSNP:rs2229621Ensembl. | 1 | |
Natural variantiVAR_010577 | 148 | L → F1 Publication | 1 | |
Natural variantiVAR_020504 | 274 | R → C1 PublicationCorresponds to variant dbSNP:rs28363006Ensembl. | 1 | |
Natural variantiVAR_020505 | 314 | A → P1 PublicationCorresponds to variant dbSNP:rs28363015Ensembl. | 1 | |
Natural variantiVAR_010578 | 314 | A → V1 Publication | 1 | |
Natural variantiVAR_020506 | 331 | T → I1 PublicationCorresponds to variant dbSNP:rs28363016Ensembl. | 1 | |
Natural variantiVAR_010579 | 353 | R → C1 PublicationCorresponds to variant dbSNP:rs61748096Ensembl. | 1 | |
Natural variantiVAR_020507 | 387 | A → S1 PublicationCorresponds to variant dbSNP:rs28363029Ensembl. | 1 | |
Natural variantiVAR_010580 | 497 | R → Q1 PublicationCorresponds to variant dbSNP:rs145124653Ensembl. | 1 | |
Natural variantiVAR_010581 | 775 | R → Q1 PublicationCorresponds to variant dbSNP:rs185927605Ensembl. | 1 | |
Natural variantiVAR_020508 | 801 | R → Q1 PublicationCorresponds to variant dbSNP:rs28363057Ensembl. | 1 | |
Natural variantiVAR_010582 | 844 | R → K2 PublicationsCorresponds to variant dbSNP:rs2229629Ensembl. | 1 | |
Natural variantiVAR_020509 | 881 | D → N1 PublicationCorresponds to variant dbSNP:rs28363065Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46376 mRNA Translation: CAA86511.1 Z46354 , Z46355, Z46604, Z46356, Z46357, Z46358, Z46359, Z46360, Z46361, Z46362, Z46363, Z46364, Z46365, Z46366, Z46367, Z46368, Z46369 Genomic DNA Translation: CAA86476.2 AF148513 mRNA Translation: AAD30174.1 AY623118 Genomic DNA Translation: AAT38114.1 CH471053 Genomic DNA Translation: EAW99601.1 CH471053 Genomic DNA Translation: EAW99602.1 BC021116 mRNA Translation: AAH21116.1 BC064369 mRNA Translation: AAH64369.1 D25412 Genomic DNA Translation: BAA04999.1 |
CCDSi | CCDS1956.1 |
PIRi | S48809, JC2025 |
RefSeqi | NP_000180.2, NM_000189.4 |
Genome annotation databases
Ensembli | ENST00000290573; ENSP00000290573; ENSG00000159399 |
GeneIDi | 3099 |
KEGGi | hsa:3099 |
UCSCi | uc002snd.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Hexokinase entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46376 mRNA Translation: CAA86511.1 Z46354 , Z46355, Z46604, Z46356, Z46357, Z46358, Z46359, Z46360, Z46361, Z46362, Z46363, Z46364, Z46365, Z46366, Z46367, Z46368, Z46369 Genomic DNA Translation: CAA86476.2 AF148513 mRNA Translation: AAD30174.1 AY623118 Genomic DNA Translation: AAT38114.1 CH471053 Genomic DNA Translation: EAW99601.1 CH471053 Genomic DNA Translation: EAW99602.1 BC021116 mRNA Translation: AAH21116.1 BC064369 mRNA Translation: AAH64369.1 D25412 Genomic DNA Translation: BAA04999.1 |
CCDSi | CCDS1956.1 |
PIRi | S48809, JC2025 |
RefSeqi | NP_000180.2, NM_000189.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2NZT | X-ray | 2.45 | A/B | 17-916 | [»] | |
5HEX | X-ray | 2.73 | A/B | 17-917 | [»] | |
5HFU | X-ray | 2.92 | A/B | 17-917 | [»] | |
5HG1 | X-ray | 2.76 | A | 17-916 | [»] | |
SMRi | P52789 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109346, 66 interactors |
DIPi | DIP-50110N |
IntActi | P52789, 33 interactors |
MINTi | P52789 |
STRINGi | 9606.ENSP00000290573 |
Chemistry databases
BindingDBi | P52789 |
ChEMBLi | CHEMBL2640 |
PTM databases
iPTMneti | P52789 |
MetOSitei | P52789 |
PhosphoSitePlusi | P52789 |
SwissPalmi | P52789 |
Polymorphism and mutation databases
BioMutai | HK2 |
DMDMi | 56405344 |
Proteomic databases
EPDi | P52789 |
jPOSTi | P52789 |
MassIVEi | P52789 |
MaxQBi | P52789 |
PaxDbi | P52789 |
PeptideAtlasi | P52789 |
PRIDEi | P52789 |
ProteomicsDBi | 56533 |
Protocols and materials databases
Antibodypediai | 31617, 673 antibodies |
DNASUi | 3099 |
Genome annotation databases
Ensembli | ENST00000290573; ENSP00000290573; ENSG00000159399 |
GeneIDi | 3099 |
KEGGi | hsa:3099 |
UCSCi | uc002snd.4, human |
Organism-specific databases
CTDi | 3099 |
DisGeNETi | 3099 |
EuPathDBi | HostDB:ENSG00000159399.9 |
GeneCardsi | HK2 |
HGNCi | HGNC:4923, HK2 |
HPAi | ENSG00000159399, Low tissue specificity |
MIMi | 601125, gene |
neXtProti | NX_P52789 |
OpenTargetsi | ENSG00000159399 |
PharmGKBi | PA29301 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1369, Eukaryota |
GeneTreei | ENSGT00950000182787 |
InParanoidi | P52789 |
OMAi | DHEIDMG |
OrthoDBi | 1153545at2759 |
PhylomeDBi | P52789 |
TreeFami | TF314238 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00180 UPA00242 |
BioCyci | MetaCyc:HS08399-MONOMER |
BRENDAi | 2.7.1.1, 2681 |
PathwayCommonsi | P52789 |
Reactomei | R-HSA-70171, Glycolysis |
SABIO-RKi | P52789 |
SIGNORi | P52789 |
Miscellaneous databases
BioGRID-ORCSi | 3099, 65 hits in 848 CRISPR screens |
ChiTaRSi | HK2, human |
EvolutionaryTracei | P52789 |
GeneWikii | HK2 |
GenomeRNAii | 3099 |
Pharosi | P52789, Tchem |
PROi | PR:P52789 |
RNActi | P52789, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159399, Expressed in colon and 232 other tissues |
ExpressionAtlasi | P52789, baseline and differential |
Genevisiblei | P52789, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR001312, Hexokinase IPR019807, Hexokinase_BS IPR022673, Hexokinase_C IPR022672, Hexokinase_N |
PANTHERi | PTHR19443, PTHR19443, 2 hits |
Pfami | View protein in Pfam PF00349, Hexokinase_1, 2 hits PF03727, Hexokinase_2, 2 hits |
SUPFAMi | SSF53067, SSF53067, 4 hits |
PROSITEi | View protein in PROSITE PS00378, HEXOKINASE_1, 2 hits PS51748, HEXOKINASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXK2_HUMAN | |
Accessioni | P52789Primary (citable) accession number: P52789 Secondary accession number(s): D6W5J2, Q8WU87, Q9UN82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 203 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations