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Entry version 157 (22 Apr 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Retinal guanylyl cyclase 1

Gene

Gucy2e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21598940). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (PubMed:17255100).2 Publications

Miscellaneous

The gene name nomenclature of retinal guanylyl cyclase 1 is confusing; for mouse the gene name is GUCY2E whereas the gene name is GUCY2D for human and rat orthologs.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (PubMed:21598940). Negatively regulated by RD3; RD3 inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (By similarity).By similarity1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.64 mM for GTP (in presence of GUCA1A)1 Publication
  2. KM=0.7 mM for GTP (in presence of GUCA1B)1 Publication
  3. KM=1.55 nM for GTP1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processcGMP biosynthesis, Sensory transduction, Vision
    LigandGTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Retinal guanylyl cyclase 1
    Alternative name(s):
    Guanylate cyclase 2E
    Guanylyl cyclase GC-E (EC:4.6.1.21 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Gucy2e
    Synonyms:Guc2e
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:105123 Gucy2e

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini55 – 465ExtracellularSequence analysisAdd BLAST411
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei466 – 490HelicalSequence analysisAdd BLAST25
    Topological domaini491 – 1108CytoplasmicSequence analysisAdd BLAST618

    Keywords - Cellular componenti

    Cell projection, Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Deficient mice exhibit abnormal retinal cone cell morphology, impaired cone and rod electrophysiology, and severe retinal cone cell degeneration. GUCY2E and GUCY2F double knockout mice does not show any photoresponse, their rods and cones degenerate and the intracellular transport of some phototransduction proteins is impaired.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 54By similarityAdd BLAST54
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001238355 – 1108Retinal guanylyl cyclase 1Add BLAST1054

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 136By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi452InterchainBy similarity
    Disulfide bondi460InterchainBy similarity

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P52785

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P52785

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P52785

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P52785

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P52785

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000020890 Expressed in secondary oocyte and 16 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P52785 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer; requires homodimerization for guanylyl cyclase activity (By similarity).

    Interacts (via C-terminus) with RD3 (via C-terminus); promotes the exit of GUCY2E from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity). Interaction with RD3 negatively regulates GUCY2E guanylate cyclase activity (By similarity).

    By similarity

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    200127, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    P52785, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000021259

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P52785 protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini491 – 811Protein kinasePROSITE-ProRule annotationAdd BLAST321
    Domaini883 – 1013Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1023 Eukaryota
    COG2114 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161326

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_001072_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P52785

    KEGG Orthology (KO)

    More...
    KOi
    K12321

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GPDPSCW

    Database of Orthologous Groups

    More...
    OrthoDBi
    229634at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106338

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.1230, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001054 A/G_cyclase
    IPR018297 A/G_cyclase_CS
    IPR001828 ANF_lig-bd_rcpt
    IPR011645 HNOB_dom_associated
    IPR011009 Kinase-like_dom_sf
    IPR029787 Nucleotide_cyclase
    IPR028082 Peripla_BP_I
    IPR000719 Prot_kinase_dom
    IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01094 ANF_receptor, 1 hit
    PF00211 Guanylate_cyc, 1 hit
    PF07701 HNOBA, 1 hit
    PF07714 Pkinase_Tyr, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00044 CYCc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53822 SSF53822, 1 hit
    SSF55073 SSF55073, 1 hit
    SSF56112 SSF56112, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00452 GUANYLATE_CYCLASE_1, 1 hit
    PS50125 GUANYLATE_CYCLASE_2, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P52785-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSAWLLPAGG LPGAGFCVPA RQSPSSFSRV LRWPRPGLPG LLLLLLLPSP
    60 70 80 90 100
    SALSAVFKVG VLGPWACDPI FARARPDLAA RLAANRLNRD FALDGGPRFE
    110 120 130 140 150
    VALLPEPCLT PGSLGAVSSA LSRVSGLVGP VNPAACRPAE LLAQEAGVAL
    160 170 180 190 200
    VPWGCPGTRA AGTTAPAVTP AADALYVLLR AFRWARVALI TAPQDLWVEA
    210 220 230 240 250
    GRALSTALRA RGLPVALVTS METSDRSGAR EALGRIRDGP RVRVVIMVMH
    260 270 280 290 300
    SVLLGGEEQR YLLEAAEELA LTDGSLVFLP FDTLHYALSP GPEALAAFVN
    310 320 330 340 350
    SSQLRRAHDA VLTLTRRCPP GGSVQDSLRR AQEHQELPLD LNLKQVSPLF
    360 370 380 390 400
    GTIYDAVFLL AGGVKRARTA VGGGWVSGAS VARQVREAQV SGFCGVLGRT
    410 420 430 440 450
    EEPSFVLLDT DASGEQLFAT HLLDPVLGSL RSAGTPMHFP RGGPAPGPDP
    460 470 480 490 500
    SCWFDPDVIC NGGVEPGLVF VGFLLVIGMG LTGAFLAHYL RHRLLHMQMA
    510 520 530 540 550
    SGPNKIILTL EDVTFLHPPG GSSRKVVQGS RSSLATRSAS DIRSVPSQPQ
    560 570 580 590 600
    ESTNVGLYEG DWVWLKKFPG EHHMAIRPAT KTAFSKLREL RHENVALYLG
    610 620 630 640 650
    LFLAGTADSP ATPGEGILAV VSEHCARGSL HDLLAQREIK LDWMFKSSLL
    660 670 680 690 700
    LDLIKGMRYL HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL
    710 720 730 740 750
    PEPPSAEDQL WTAPELLRDP SLERRGTLAG DVFSLAIIMQ EVVCRSTPYA
    760 770 780 790 800
    MLELTPEEVI QRVRSPPPLC RPLVSMDQAP MECIQLMTQC WAEHPELRPS
    810 820 830 840 850
    MDLTFDLFKS INKGRKTNII DSMLRMLEQY SSNLEDLIRE RTEELEQEKQ
    860 870 880 890 900
    KTDRLLTQML PPSVAEALKM GTSVEPEYFE EVTLYFSDIV GFTTISAMSE
    910 920 930 940 950
    PIEVVDLLND LYTLFDAIIG AHDVYKVETI GDAYMVASGL PQRNGQRHAA
    960 970 980 990 1000
    EIANMSLDIL SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC
    1010 1020 1030 1040 1050
    LFGDTVNTAS RMESTGLPYR IHVNMSTVRI LRALDQGFQM ECRGRTELKG
    1060 1070 1080 1090 1100
    KGIEDTYWLV GRLGFNKPIP KPPDLQPGAS NHGISLQEIP PERRKKLEKA

    RPGQFTGK
    Length:1,108
    Mass (Da):120,638
    Last modified:July 27, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3F4FE69D38EB1C8
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15G → R in AAC42081 (PubMed:8838319).Curated1
    Sequence conflicti92A → G in AAC42081 (PubMed:8838319).Curated1
    Sequence conflicti135A → G in AAC42081 (PubMed:8838319).Curated1
    Sequence conflicti1033A → S in AAC42081 (PubMed:8838319).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L41933 Genomic DNA Translation: AAC42081.1
    AL645527 Genomic DNA No translation available.
    CH466601 Genomic DNA Translation: EDL10484.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS24887.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_032218.2, NM_008192.3
    XP_006532307.1, XM_006532244.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000021259; ENSMUSP00000021259; ENSMUSG00000020890
    ENSMUST00000108664; ENSMUSP00000104304; ENSMUSG00000020890
    ENSMUST00000108665; ENSMUSP00000104305; ENSMUSG00000020890

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    14919

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:14919

    UCSC genome browser

    More...
    UCSCi
    uc007jpn.2 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L41933 Genomic DNA Translation: AAC42081.1
    AL645527 Genomic DNA No translation available.
    CH466601 Genomic DNA Translation: EDL10484.1
    CCDSiCCDS24887.1
    RefSeqiNP_032218.2, NM_008192.3
    XP_006532307.1, XM_006532244.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi200127, 1 interactor
    IntActiP52785, 1 interactor
    STRINGi10090.ENSMUSP00000021259

    PTM databases

    iPTMnetiP52785
    PhosphoSitePlusiP52785

    Proteomic databases

    MaxQBiP52785
    PaxDbiP52785
    PRIDEiP52785

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    12365 242 antibodies

    Genome annotation databases

    EnsembliENSMUST00000021259; ENSMUSP00000021259; ENSMUSG00000020890
    ENSMUST00000108664; ENSMUSP00000104304; ENSMUSG00000020890
    ENSMUST00000108665; ENSMUSP00000104305; ENSMUSG00000020890
    GeneIDi14919
    KEGGimmu:14919
    UCSCiuc007jpn.2 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    14919
    MGIiMGI:105123 Gucy2e

    Phylogenomic databases

    eggNOGiKOG1023 Eukaryota
    COG2114 LUCA
    GeneTreeiENSGT00940000161326
    HOGENOMiCLU_001072_1_0_1
    InParanoidiP52785
    KOiK12321
    OMAiGPDPSCW
    OrthoDBi229634at2759
    TreeFamiTF106338

    Enzyme and pathway databases

    ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    Gucy2e mouse

    Protein Ontology

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    PROi
    PR:P52785
    RNActiP52785 protein

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000020890 Expressed in secondary oocyte and 16 other tissues
    GenevisibleiP52785 MM

    Family and domain databases

    Gene3Di3.30.70.1230, 1 hit
    InterProiView protein in InterPro
    IPR001054 A/G_cyclase
    IPR018297 A/G_cyclase_CS
    IPR001828 ANF_lig-bd_rcpt
    IPR011645 HNOB_dom_associated
    IPR011009 Kinase-like_dom_sf
    IPR029787 Nucleotide_cyclase
    IPR028082 Peripla_BP_I
    IPR000719 Prot_kinase_dom
    IPR001245 Ser-Thr/Tyr_kinase_cat_dom
    PfamiView protein in Pfam
    PF01094 ANF_receptor, 1 hit
    PF00211 Guanylate_cyc, 1 hit
    PF07701 HNOBA, 1 hit
    PF07714 Pkinase_Tyr, 1 hit
    SMARTiView protein in SMART
    SM00044 CYCc, 1 hit
    SUPFAMiSSF53822 SSF53822, 1 hit
    SSF55073 SSF55073, 1 hit
    SSF56112 SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00452 GUANYLATE_CYCLASE_1, 1 hit
    PS50125 GUANYLATE_CYCLASE_2, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUC2E_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52785
    Secondary accession number(s): B1ASX7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: April 22, 2020
    This is version 157 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    2. SIMILARITY comments
      Index of protein domains and families
    3. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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