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UniProtKB - P52778 (L18A_LUPLU)
Protein
Protein LlR18A
Gene
LLR18A
Organism
Lupinus luteus (European yellow lupine)
Status
Functioni
Class II ribonuclease (RNase) (By similarity).
Binds to cytokinins (By similarity).
Interacts with melatonin (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 8 | Trans-zeatin 1Combined sources1 Publication | 1 | |
Binding sitei | 28 | Trans-zeatin 2Combined sources1 Publication | 1 | |
Metal bindingi | 32 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 38 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 54 | Trans-zeatin 2Combined sources1 Publication | 1 | |
Binding sitei | 133 | Trans-zeatin 3Combined sources1 Publication | 1 | |
Binding sitei | 136 | Trans-zeatin 3Combined sources1 Publication | 1 |
GO - Molecular functioni
- abscisic acid binding Source: InterPro
- calcium ion binding Source: UniProtKB
- cytokinin binding Source: UniProtKB
- melatonin binding Source: UniProtKB
- protein phosphatase inhibitor activity Source: InterPro
- ribonuclease activity Source: UniProtKB
- signaling receptor activity Source: InterPro
GO - Biological processi
- abscisic acid-activated signaling pathway Source: InterPro
- defense response Source: UniProtKB-KW
- response to biotic stimulus Source: UniProtKB-KW
- RNA phosphodiester bond hydrolysis Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Nuclease, Pathogenesis-related protein |
Biological process | Plant defense |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein LlR18A (EC:3.1.27.-By similarity)Alternative name(s): LlPR10.1A Allergen: Lup l 4Curated |
Gene namesi | Name:LLR18A |
Organismi | Lupinus luteus (European yellow lupine) |
Taxonomic identifieri | 3873 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › genistoids sensu lato › core genistoids › Genisteae › Lupinus |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.Curated
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 9727, Lup l 4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154192 | 1 – 156 | Protein LlR18AAdd BLAST | 156 |
Expressioni
Tissue specificityi
Expressed constitutively in roots.1 Publication
Inductioni
In leaves by pathogenic bacteria.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P52778 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P52778 |
Family & Domainsi
Sequence similaritiesi
Belongs to the BetVI family.Curated
Family and domain databases
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR000916, Bet_v_I/MLP IPR024949, Bet_v_I_allergen IPR023393, START-like_dom_sf |
Pfami | View protein in Pfam PF00407, Bet_v_1, 1 hit |
PRINTSi | PR00634, BETALLERGEN |
PROSITEi | View protein in PROSITE PS00451, PATHOGENESIS_BETVI, 1 hit |
i Sequence
Sequence statusi: Complete.
P52778-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIFAFENEQ SSTVAPAKLY KALTKDSDEI VPKVIEPIQS VEIVEGNGGP
60 70 80 90 100
GTIKKIIAIH DGHTSFVLHK LDAIDEANLT YNYSIIGGEG LDESLEKISY
110 120 130 140 150
ESKILPGPDG GSIGKINVKF HTKGDVLSET VRDQAKFKGL GLFKAIEGYV
LAHPDY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79974 mRNA Translation: CAA56298.1 AF002277 Genomic DNA Translation: AAC12790.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79974 mRNA Translation: CAA56298.1 AF002277 Genomic DNA Translation: AAC12790.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ICX | X-ray | 1.95 | A | 2-156 | [»] | |
4RYV | X-ray | 1.38 | A | 2-156 | [»] | |
4Y31 | X-ray | 1.32 | A | 2-156 | [»] | |
5C9Y | X-ray | 1.50 | A | 2-156 | [»] | |
SMRi | P52778 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
Allergomei | 9727, Lup l 4 |
Miscellaneous databases
EvolutionaryTracei | P52778 |
Family and domain databases
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR000916, Bet_v_I/MLP IPR024949, Bet_v_I_allergen IPR023393, START-like_dom_sf |
Pfami | View protein in Pfam PF00407, Bet_v_1, 1 hit |
PRINTSi | PR00634, BETALLERGEN |
PROSITEi | View protein in PROSITE PS00451, PATHOGENESIS_BETVI, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | L18A_LUPLU | |
Accessioni | P52778Primary (citable) accession number: P52778 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families