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Protein

2-iminobutanoate/2-iminopropanoate deaminase

Gene

RIDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.2 Publications
May also function as an endoribonuclease, cleaving mRNA phosphodiester bonds of single-stranded RNA (By similarity). Thereby, may inhibit protein translation (PubMed:8973653).By similarity1 Publication

Catalytic activityi

2-iminobutanoate + H2O = 2-oxobutanoate + NH3.1 Publication
2-iminopropanoate + H2O = pyruvate + NH3.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-8849175 Threonine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
2-iminobutanoate/2-iminopropanoate deaminase1 Publication (EC:3.5.99.101 Publication)
Alternative name(s):
14.5 kDa translational inhibitor protein1 Publication
Short name:
hp14.51 Publication
Short name:
p14.51 Publication
Heat-responsive protein 12Imported
Reactive intermediate imine deaminase A homologImported
Translation inhibitor L-PSP ribonucleaseBy similarity (EC:3.1.-.-By similarity)
UK114 antigen homolog1 Publication
Gene namesi
Name:RIDAImported
Synonyms:HRSP12Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000132541.10
HGNCiHGNC:16897 RIDA
MIMi602487 gene
neXtProtiNX_P52758

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10247
OpenTargetsiENSG00000132541
PharmGKBiPA134890258

Chemistry databases

DrugBankiDB03793 Benzoic Acid

Polymorphism and mutation databases

BioMutaiHRSP12
DMDMi1717975

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001703082 – 1372-iminobutanoate/2-iminopropanoate deaminaseAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei13N6-succinyllysineBy similarity1
Modified residuei60N6-succinyllysineBy similarity1
Modified residuei67N6-succinyllysineBy similarity1
Modified residuei74PhosphothreonineCombined sources1
Modified residuei136PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52758
PaxDbiP52758
PeptideAtlasiP52758
PRIDEiP52758
ProteomicsDBi56530
TopDownProteomicsiP52758

2D gel databases

UCD-2DPAGEiP52758

PTM databases

iPTMnetiP52758
PhosphoSitePlusiP52758

Expressioni

Tissue specificityi

Expressed predominantly in liver and kidney. Lower levels in lung and brain.2 Publications

Developmental stagei

Up-regulated during cellular differentiation.1 Publication

Gene expression databases

BgeeiENSG00000132541 Expressed in 205 organ(s), highest expression level in right lobe of liver
CleanExiHS_HRSP12
ExpressionAtlasiP52758 baseline and differential
GenevisibleiP52758 HS

Organism-specific databases

HPAiHPA022856
HPA023489

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115541, 25 interactors
IntActiP52758, 11 interactors
STRINGi9606.ENSP00000254878

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP52758
SMRiP52758
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52758

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

eggNOGiKOG2317 Eukaryota
COG0251 LUCA
GeneTreeiENSGT00420000029792
HOGENOMiHOG000267215
HOVERGENiHBG003597
InParanoidiP52758
KOiK09022
PhylomeDBiP52758
TreeFamiTF105775

Family and domain databases

Gene3Di3.30.1330.40, 1 hit
InterProiView protein in InterPro
IPR006056 RidA
IPR019897 RidA_CS
IPR035959 RutC-like_sf
IPR006175 YjgF/YER057c/UK114
PANTHERiPTHR11803 PTHR11803, 1 hit
PfamiView protein in Pfam
PF01042 Ribonuc_L-PSP, 1 hit
SUPFAMiSSF55298 SSF55298, 1 hit
TIGRFAMsiTIGR00004 TIGR00004, 1 hit
PROSITEiView protein in PROSITE
PS01094 UPF0076, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P52758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG
60 70 80 90 100
VAEEAKQALK NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF
110 120 130
KSNFPARAAY QVAALPKGSR IEIEAVAIQG PLTTASL
Length:137
Mass (Da):14,494
Last modified:October 1, 1996 - v1
Checksum:iDD0740621E8BE6AD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBX3H0YBX3_HUMAN
2-iminobutanoate/2-iminopropanoate ...
RIDA
127Annotation score:
H0YB34H0YB34_HUMAN
2-iminobutanoate/2-iminopropanoate ...
RIDA
148Annotation score:
E5RIP8E5RIP8_HUMAN
2-iminobutanoate/2-iminopropanoate ...
RIDA
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84A → V in CAG46453 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95384 mRNA Translation: CAA64670.1
AY026764 Genomic DNA Translation: AAK01939.1
CR456844 mRNA Translation: CAG33125.1
CR541652 mRNA Translation: CAG46453.1
CH471060 Genomic DNA Translation: EAW91774.1
BC010280 mRNA Translation: AAH10280.1
BC012592 mRNA Translation: AAH12592.1
BC093059 mRNA Translation: AAH93059.1
CCDSiCCDS6276.1
RefSeqiNP_005827.1, NM_005836.2
UniGeneiHs.18426

Genome annotation databases

EnsembliENST00000254878; ENSP00000254878; ENSG00000132541
GeneIDi10247
KEGGihsa:10247
UCSCiuc003yii.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95384 mRNA Translation: CAA64670.1
AY026764 Genomic DNA Translation: AAK01939.1
CR456844 mRNA Translation: CAG33125.1
CR541652 mRNA Translation: CAG46453.1
CH471060 Genomic DNA Translation: EAW91774.1
BC010280 mRNA Translation: AAH10280.1
BC012592 mRNA Translation: AAH12592.1
BC093059 mRNA Translation: AAH93059.1
CCDSiCCDS6276.1
RefSeqiNP_005827.1, NM_005836.2
UniGeneiHs.18426

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ONIX-ray1.90A/B/C/D/E/F/G/H/I2-137[»]
ProteinModelPortaliP52758
SMRiP52758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115541, 25 interactors
IntActiP52758, 11 interactors
STRINGi9606.ENSP00000254878

Chemistry databases

DrugBankiDB03793 Benzoic Acid

PTM databases

iPTMnetiP52758
PhosphoSitePlusiP52758

Polymorphism and mutation databases

BioMutaiHRSP12
DMDMi1717975

2D gel databases

UCD-2DPAGEiP52758

Proteomic databases

EPDiP52758
PaxDbiP52758
PeptideAtlasiP52758
PRIDEiP52758
ProteomicsDBi56530
TopDownProteomicsiP52758

Protocols and materials databases

DNASUi10247
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254878; ENSP00000254878; ENSG00000132541
GeneIDi10247
KEGGihsa:10247
UCSCiuc003yii.2 human

Organism-specific databases

CTDi10247
DisGeNETi10247
EuPathDBiHostDB:ENSG00000132541.10
GeneCardsiRIDA
HGNCiHGNC:16897 RIDA
HPAiHPA022856
HPA023489
MIMi602487 gene
neXtProtiNX_P52758
OpenTargetsiENSG00000132541
PharmGKBiPA134890258
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2317 Eukaryota
COG0251 LUCA
GeneTreeiENSGT00420000029792
HOGENOMiHOG000267215
HOVERGENiHBG003597
InParanoidiP52758
KOiK09022
PhylomeDBiP52758
TreeFamiTF105775

Enzyme and pathway databases

ReactomeiR-HSA-8849175 Threonine catabolism

Miscellaneous databases

ChiTaRSiRIDA human
EvolutionaryTraceiP52758
GeneWikiiHeat-responsive_protein_12
GenomeRNAii10247
PROiPR:P52758
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132541 Expressed in 205 organ(s), highest expression level in right lobe of liver
CleanExiHS_HRSP12
ExpressionAtlasiP52758 baseline and differential
GenevisibleiP52758 HS

Family and domain databases

Gene3Di3.30.1330.40, 1 hit
InterProiView protein in InterPro
IPR006056 RidA
IPR019897 RidA_CS
IPR035959 RutC-like_sf
IPR006175 YjgF/YER057c/UK114
PANTHERiPTHR11803 PTHR11803, 1 hit
PfamiView protein in Pfam
PF01042 Ribonuc_L-PSP, 1 hit
SUPFAMiSSF55298 SSF55298, 1 hit
TIGRFAMsiTIGR00004 TIGR00004, 1 hit
PROSITEiView protein in PROSITE
PS01094 UPF0076, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIDA_HUMAN
AccessioniPrimary (citable) accession number: P52758
Secondary accession number(s): Q6FHU9, Q6IBG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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