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Entry version 165 (08 May 2019)
Sequence version 4 (30 Nov 2010)
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Protein

Zinc finger protein 142

Gene

ZNF142

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri163 – 185C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 242C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri253 – 275C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 311C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri316 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri343 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri372 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri544 – 567C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri573 – 596C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1171 – 1194C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1228 – 1251C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1257 – 1280C2H2-type 19PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1286 – 1309C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1328 – 1351C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1354 – 1377C2H2-type 22PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1380 – 1403C2H2-type 23PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1424 – 1446C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1452 – 1474C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1480 – 1502C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1508 – 1530C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1536 – 1559C2H2-type 28PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1565 – 1587C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1593 – 1615C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1621 – 1643C2H2-type 31PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 142
Alternative name(s):
HA4654
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF142
Synonyms:KIAA0236
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12927 ZNF142

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604083 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52746

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7701

Open Targets

More...
OpenTargetsi
ENSG00000115568

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37514

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF142

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104298

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474251 – 1687Zinc finger protein 142Add BLAST1687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei154PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1591Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P52746

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52746

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52746

PeptideAtlas

More...
PeptideAtlasi
P52746

PRoteomics IDEntifications database

More...
PRIDEi
P52746

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56521

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52746

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115568 Expressed in 184 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52746 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52746 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049594

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113495, 10 interactors

Protein interaction database and analysis system

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IntActi
P52746, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398798

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52746

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri163 – 185C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 242C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri253 – 275C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 311C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri316 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri343 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri372 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri544 – 567C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri573 – 596C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1171 – 1194C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1228 – 1251C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1257 – 1280C2H2-type 19PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1286 – 1309C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1328 – 1351C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1354 – 1377C2H2-type 22PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1380 – 1403C2H2-type 23PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1424 – 1446C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1452 – 1474C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1480 – 1502C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1508 – 1530C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1536 – 1559C2H2-type 28PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1565 – 1587C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1593 – 1615C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1621 – 1643C2H2-type 31PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163074

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015350

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52746

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHENCKH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52746

TreeFam database of animal gene trees

More...
TreeFami
TF327469

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 36 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P52746-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDPLLDSQP ASSTGEMDGL CPELLLIPPP LSNRGILGPV QSPCPSRDPA
60 70 80 90 100
PIPTEPGCLL VEATATEEGP GNMEIIVETV AGTLTPGAPG ETPAPKLPPG
110 120 130 140 150
EREPSQEAGT PLPGQETAEE ENVEKEEKSD TQKDSQKAVD KGQGAQRLEG
160 170 180 190 200
DVVSGTESLF KTHMCPECKR CFKKRTHLVE HLHLHFPDPS LQCPNCQKFF
210 220 230 240 250
TSKSKLKTHL LRELGEKAHH CPLCHYSAVE RNALNRHMAS MHEDISNFYS
260 270 280 290 300
DTYACPVCRE EFRLSQALKE HLKSHTAAAA AEPLPLRCFQ EGCSYAAPDR
310 320 330 340 350
KAFIKHLKET HGVRAVECRH HSCPMLFATA EAMEAHHKSH YAFHCPHCDF
360 370 380 390 400
ACSNKHLFRK HKKQGHPGSE ELRCTFCPFA TFNPVAYQDH VGKMHAHEKI
410 420 430 440 450
HQCPECNFAT AHKRVLIRHM LLHTGEKPHK CELCDFTCRD VSYLSKHMLT
460 470 480 490 500
HSNTKDYMCT ECGYVTKWKH YLRVHMRKHA GDLRYQCNQC SYRCHRADQL
510 520 530 540 550
SSHKLRHQGK SLMCEVCAFA CKRKYELQKH MASQHHPGTP APLYPCHYCS
560 570 580 590 600
YQSRHKQAVL SHENCKHTRL REFHCALCDY RTFSNTTLLF HKRKAHGYVP
610 620 630 640 650
GDQAWQLRYA SQEPEGAMQG PTPPPDSEPS NQLSARPEGP GHEPGTVVDP
660 670 680 690 700
SLDQALPEMS EEVNTGRQEG SEAPHGGDLG GSPSPAEVEE GSCTLHLEAL
710 720 730 740 750
GVELESVTEP PLEEVTETAP MEFRPLGLEG PDGLEGPELS SFEGIGTSDL
760 770 780 790 800
SAEENPLLEK PVSEPSTNPP SLEEAPNNWV GTFKTTPPAE TAPLPPLPES
810 820 830 840 850
ESLLKALRRQ DKEQAEALVL EGRVQMVVIQ GEGRAFRCPH CPFITRREKA
860 870 880 890 900
LNLHSRTGCQ GRREPLLCPE CGASFKQQRG LSTHLLKKCP VLLRKNKGLP
910 920 930 940 950
RPDSPIPLQP VLPGTQASED TESGKPPPAS QEAELLLPKD APLELPREPE
960 970 980 990 1000
ETEEPLATVS GSPVPPAGNS LPTEAPKKHC FDPVPPAGNS SPTEAPKKHH
1010 1020 1030 1040 1050
LDPVPPAGNS SPTEALKKHR FEQGKFHCNS CPFLCSRLSS ITSHVAEGCR
1060 1070 1080 1090 1100
GGRGGGGKRG TPQTQPDVSP LSNGDSAPPK NGSTESSSGD GDTVLVQKQK
1110 1120 1130 1140 1150
GARFSCPTCP FSCQQERALR THQIRGCPLE ESGELHCSLC PFTAPAATAL
1160 1170 1180 1190 1200
RLHQKRRHPT AAPARGPRPH LQCGDCGFTC KQSRCMQQHR RLKHEGVKPH
1210 1220 1230 1240 1250
QCPFCDFSTT RRYRLEAHQS RHTGIGRIPC SSCPQTFGTN SKLRLHRLRV
1260 1270 1280 1290 1300
HDKTPTHFCP LCDYSGYLRH DITRHVNSCH QGTPAFACSQ CEAQFSSETA
1310 1320 1330 1340 1350
LKQHALRRHP EPAQPAPGSP AETTEGPLHC SRCGLLCPSP ASLRGHTRKQ
1360 1370 1380 1390 1400
HPRLECGACQ EAFPSRLALD EHRRQQHFSH RCQLCDFAAR ERVGLVKHYL
1410 1420 1430 1440 1450
EQHEETSAAV AASDGDGDAG QPPLHCPFCD FTCRHQLVLD HHVKGHGGTR
1460 1470 1480 1490 1500
LYKCTDCAYS TKNRQKITWH SRIHTGEKPY HCHLCPYACA DPSRLKYHMR
1510 1520 1530 1540 1550
IHKEERKYLC PECGYKCKWV NQLKYHMTKH TGLKPYQCPE CEYCTNRADA
1560 1570 1580 1590 1600
LRVHQETRHR EARAFMCEQC GKAFKTRFLL RTHLRKHSEA KPYVCNVCHR
1610 1620 1630 1640 1650
AFRWAAGLRH HALTHTDRHP FFCRLCNYKA KQKFQVVKHV RRHHPDQADP
1660 1670 1680
NQGVGKDPTT PTVHLHDVQL EDPSPPAPAA PHTGPEG
Length:1,687
Mass (Da):187,880
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91143EAF2481B6B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C414H7C414_HUMAN
Zinc finger protein 142
ZNF142
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2H3F2Z2H3_HUMAN
Zinc finger protein 142
ZNF142
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J055C9J055_HUMAN
Zinc finger protein 142
ZNF142
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBL7C9JBL7_HUMAN
Zinc finger protein 142
ZNF142
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13242 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti460 – 463TECG → LKGS in AAC50265 (PubMed:15815621).Curated4
Sequence conflicti541A → S in BAA13242 (PubMed:9039502).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047230751S → G1 PublicationCorresponds to variant dbSNP:rs3770214Ensembl.1
Natural variantiVAR_047231956L → H. Corresponds to variant dbSNP:rs3770213Ensembl.1
Natural variantiVAR_0472321313A → T. Corresponds to variant dbSNP:rs3821033Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D87073 mRNA Translation: BAA13242.2 Different initiation.
AC012510 Genomic DNA No translation available.
U09849 mRNA Translation: AAC50265.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42817.1

Protein sequence database of the Protein Information Resource

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PIRi
I38617

NCBI Reference Sequences

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RefSeqi
NP_001099007.1, NM_001105537.2
XP_011510091.1, XM_011511789.2
XP_016860361.1, XM_017004872.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000411696; ENSP00000398798; ENSG00000115568
ENST00000449707; ENSP00000408643; ENSG00000115568

Database of genes from NCBI RefSeq genomes

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GeneIDi
7701

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7701

UCSC genome browser

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UCSCi
uc002vin.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87073 mRNA Translation: BAA13242.2 Different initiation.
AC012510 Genomic DNA No translation available.
U09849 mRNA Translation: AAC50265.1
CCDSiCCDS42817.1
PIRiI38617
RefSeqiNP_001099007.1, NM_001105537.2
XP_011510091.1, XM_011511789.2
XP_016860361.1, XM_017004872.1

3D structure databases

SMRiP52746
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113495, 10 interactors
IntActiP52746, 3 interactors
STRINGi9606.ENSP00000398798

PTM databases

iPTMnetiP52746
PhosphoSitePlusiP52746

Polymorphism and mutation databases

BioMutaiZNF142
DMDMi313104298

Proteomic databases

jPOSTiP52746
MaxQBiP52746
PaxDbiP52746
PeptideAtlasiP52746
PRIDEiP52746
ProteomicsDBi56521

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411696; ENSP00000398798; ENSG00000115568
ENST00000449707; ENSP00000408643; ENSG00000115568
GeneIDi7701
KEGGihsa:7701
UCSCiuc002vin.6 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7701
DisGeNETi7701

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF142
HGNCiHGNC:12927 ZNF142
HPAiHPA049594
MIMi604083 gene
neXtProtiNX_P52746
OpenTargetsiENSG00000115568
PharmGKBiPA37514

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163074
HOGENOMiHOG000015350
InParanoidiP52746
OMAiNHENCKH
OrthoDBi1318335at2759
PhylomeDBiP52746
TreeFamiTF327469

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF142 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7701

Protein Ontology

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PROi
PR:P52746

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115568 Expressed in 184 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiP52746 baseline and differential
GenevisibleiP52746 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 36 hits
SUPFAMiSSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN142_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52746
Secondary accession number(s): Q92510
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 165 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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