ID ZN138_HUMAN Reviewed; 262 AA. AC P52744; B4DFX2; B4DP87; E9PHI7; E9PHK7; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 10-JUL-2007, sequence version 2. DT 27-MAR-2024, entry version 186. DE RecName: Full=Zinc finger protein 138; GN Name=ZNF138; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT RP GLU-62. RC TISSUE=Amygdala; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 22-260 (ISOFORM 1), AND VARIANT GLU-62. RC TISSUE=Insulinoma; RX PubMed=7557990; DOI=10.1006/geno.1995.1040; RA Tommerup N., Vissing H.; RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs RT identify putative candidate genes for developmental and malignant RT disorders."; RL Genomics 27:259-264(1995). CC -!- FUNCTION: May be involved in transcriptional regulation as a repressor. CC -!- INTERACTION: CC P52744; Q9P287: BCCIP; NbExp=3; IntAct=EBI-10746567, EBI-711154; CC P52744; P49366: DHPS; NbExp=3; IntAct=EBI-10746567, EBI-741925; CC P52744; Q8IYF1: ELOA2; NbExp=3; IntAct=EBI-10746567, EBI-741705; CC P52744; P28799: GRN; NbExp=3; IntAct=EBI-10746567, EBI-747754; CC P52744; P42858: HTT; NbExp=9; IntAct=EBI-10746567, EBI-466029; CC P52744; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10746567, EBI-12012928; CC P52744; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10746567, EBI-10172290; CC P52744; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10746567, EBI-10171774; CC P52744; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10746567, EBI-11953334; CC P52744; Q9UPM6: LHX6; NbExp=3; IntAct=EBI-10746567, EBI-10258746; CC P52744; P45984: MAPK9; NbExp=3; IntAct=EBI-10746567, EBI-713568; CC P52744; Q99750: MDFI; NbExp=3; IntAct=EBI-10746567, EBI-724076; CC P52744; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10746567, EBI-5235340; CC P52744; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10746567, EBI-725997; CC P52744; O76024: WFS1; NbExp=3; IntAct=EBI-10746567, EBI-720609; CC P52744; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-10746567, EBI-742740; CC P52744-2; P49366: DHPS; NbExp=3; IntAct=EBI-10213071, EBI-741925; CC P52744-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-10213071, EBI-10171697; CC P52744-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10213071, EBI-10171774; CC P52744-2; Q99750: MDFI; NbExp=3; IntAct=EBI-10213071, EBI-724076; CC P52744-2; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10213071, EBI-725997; CC P52744-2; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-10213071, EBI-742740; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=P52744-1; Sequence=Displayed; CC Name=2; CC IsoId=P52744-2; Sequence=VSP_044921; CC Name=3; CC IsoId=P52744-3; Sequence=VSP_044921, VSP_047446, VSP_047447; CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK055644; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK294302; BAG57583.1; -; mRNA. DR EMBL; AK298230; BAG60499.1; -; mRNA. DR EMBL; AC073349; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; U09847; AAC50263.1; -; mRNA. DR CCDS; CCDS34645.2; -. [P52744-2] DR CCDS; CCDS55115.1; -. [P52744-3] DR PIR; I38615; I38615. DR RefSeq; NP_001153655.1; NM_001160183.2. DR RefSeq; NP_001258566.1; NM_001271637.1. DR RefSeq; NP_006515.2; NM_006524.3. [P52744-2] DR AlphaFoldDB; P52744; -. DR SMR; P52744; -. DR BioGRID; 113492; 18. DR IntAct; P52744; 17. DR iPTMnet; P52744; -. DR PhosphoSitePlus; P52744; -. DR BioMuta; ZNF138; -. DR DMDM; 152031767; -. DR jPOST; P52744; -. DR MassIVE; P52744; -. DR PaxDb; 9606-ENSP00000303533; -. DR PeptideAtlas; P52744; -. DR ProteomicsDB; 20546; -. DR ProteomicsDB; 20561; -. DR ProteomicsDB; 56520; -. [P52744-1] DR Antibodypedia; 28126; 107 antibodies from 17 providers. DR DNASU; 7697; -. DR Ensembl; ENST00000440155.6; ENSP00000407262.2; ENSG00000197008.10. [P52744-2] DR GeneID; 7697; -. DR KEGG; hsa:7697; -. DR UCSC; uc011kdq.4; human. [P52744-1] DR AGR; HGNC:12922; -. DR CTD; 7697; -. DR DisGeNET; 7697; -. DR GeneCards; ZNF138; -. DR HGNC; HGNC:12922; ZNF138. DR HPA; ENSG00000197008; Low tissue specificity. DR MIM; 604080; gene. DR neXtProt; NX_P52744; -. DR OpenTargets; ENSG00000197008; -. DR PharmGKB; PA37510; -. DR VEuPathDB; HostDB:ENSG00000197008; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000162960; -. DR InParanoid; P52744; -. DR OrthoDB; 4665594at2759; -. DR PhylomeDB; P52744; -. DR TreeFam; TF342117; -. DR PathwayCommons; P52744; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; P52744; -. DR BioGRID-ORCS; 7697; 17 hits in 1107 CRISPR screens. DR ChiTaRS; ZNF138; human. DR GenomeRNAi; 7697; -. DR Pharos; P52744; Tdark. DR PRO; PR:P52744; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; P52744; Protein. DR Bgee; ENSG00000197008; Expressed in ganglionic eminence and 173 other cell types or tissues. DR ExpressionAtlas; P52744; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24399:SF69; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1. DR PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1. DR Pfam; PF00096; zf-C2H2; 3. DR Pfam; PF13912; zf-C2H2_6; 1. DR SMART; SM00355; ZnF_C2H2; 5. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Repeat; Repressor; Transcription; KW Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..262 FT /note="Zinc finger protein 138" FT /id="PRO_0000047422" FT ZN_FING 110..132 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 138..160 FT /note="C2H2-type 2; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 166..188 FT /note="C2H2-type 3; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 194..216 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 222..244 FT /note="C2H2-type 5; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 250..262 FT /note="C2H2-type 6; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT VAR_SEQ 1..12 FT /note="MKRHEMVVAKHS -> MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLEN FT YRNLVFL (in isoform 2 and isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044921" FT VAR_SEQ 13..95 FT /note="ALCSRFAQDLWLEQNIKDSFQKVTLSRYGKYGHKNLQLRKGCKSVDECKGHQ FT GGFNGLNQCLKITTSKIFQCNKYVKVMHKFS -> DLITCLEQGKEPWNMKRHEMVVAK FT HSAVAFTYDLSGLNILSFQSILPFVSALYVMGNRNQCLQKHLEARNKDLCVLVLPKTFG FT (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047446" FT VAR_SEQ 96..262 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047447" FT VARIANT 62 FT /note="G -> E (in dbSNP:rs10949946)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:7557990" FT /id="VAR_057398" FT CONFLICT 22..23 FT /note="LW -> KG (in Ref. 3; AAC50263)" FT /evidence="ECO:0000305" FT CONFLICT 67 FT /note="F -> Y (in Ref. 1; AK055644/BAG60499 and 3; FT AAC50263)" FT /evidence="ECO:0000305" FT CONFLICT P52744-2:33 FT /note="M -> V (in Ref. 1; BAG60499)" FT /evidence="ECO:0000305" SQ SEQUENCE 262 AA; 30592 MW; D2B463F0E584ACE6 CRC64; MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL RKGCKSVDEC KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH KIRHTENKHF RCKECDKSLC MLSRLTQHKK IHTRENFYKC EECGKTFNWS TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI LTKHKIIRTG EKPYKCAHCG KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH QIIYTGEEPY KCEECGKAFN LS //