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Entry version 165 (08 May 2019)
Sequence version 3 (18 May 2010)
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Protein

Zinc finger protein 135

Gene

ZNF135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 135
Alternative name(s):
Zinc finger protein 61
Zinc finger protein 78-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF135
Synonyms:ZNF61, ZNF78L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12919 ZNF135

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604077 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P52742

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7694

Open Targets

More...
OpenTargetsi
ENSG00000176293

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37507

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF135

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453071

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474191 – 658Zinc finger protein 135Add BLAST658

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P52742

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P52742

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P52742

PeptideAtlas

More...
PeptideAtlasi
P52742

PRoteomics IDEntifications database

More...
PRIDEi
P52742

ProteomicsDB human proteome resource

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ProteomicsDBi
56518

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P52742

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P52742

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176293 Expressed in 131 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P52742 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P52742 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006961

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113489, 6 interactors

Protein interaction database and analysis system

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IntActi
P52742, 11 interactors

Molecular INTeraction database

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MINTi
P52742

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52742

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153104

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P52742

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEQWQRN

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P52742

TreeFam database of animal gene trees

More...
TreeFami
TF350822

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52742-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPGVRVSTD PEQVTFEDVV VGFSQEEWGQ LKPAQRTLYR DVMLDTFRLL
60 70 80 90 100
VSVGHWLPKP NVISLLEQEA ELWAVESRLP QGVYPDLETR PKVKLSVLKQ
110 120 130 140 150
GISEEISNSV ILVERFLWDG LWYCRGEDTE GHWEWSCESL ESLAVPVAFT
160 170 180 190 200
PVKTPVLEQW QRNGFGENIS LNPDLPHQPM TPERQSPHTW GTRGKREKPD
210 220 230 240 250
LNVLQKTCVK EKPYKCQECG KAFSHSSALI EHHRTHTGER PYECHECLKG
260 270 280 290 300
FRNSSALTKH QRIHTGEKPY KCTQCGRTFN QIAPLIQHQR THTGEKPYEC
310 320 330 340 350
SECGKSFSFR SSFSQHERTH TGEKPYECSE CGKAFRQSIH LTQHLRIHTG
360 370 380 390 400
EKPYQCGECG KAFSHSSSLT KHQRIHTGEK PYECHECGKA FTQITPLIQH
410 420 430 440 450
QRTHTGEKPY ECGECGKAFS QSTLLTEHRR IHTGEKPYGC NECGKTFSHS
460 470 480 490 500
SSLSQHERTH TGEKPYECSQ CGKAFRQSTH LTQHQRIHTG EKPYECNDCG
510 520 530 540 550
KAFSHSSSLT KHQRIHTGEK PYECNQCGRA FSQLAPLIQH QRIHTGEKPY
560 570 580 590 600
ECNQCGRAFS QSSLLIEHQR IHTKEKPYGC NECGKSFSHS SSLSQHERTH
610 620 630 640 650
TGEKPYECHD CGKSFRQSTH LTQHRRIHTG EKPYACRDCG KAFTHSSSLT

KHQRTHTG
Length:658
Mass (Da):75,261
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED6A4FB042CB3CE5
GO
Isoform 2 (identifier: P52742-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MTPGVRVSTDP → MELGSRRRSVGCRCRGLCLAVRR
     359-638: Missing.

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):44,822
Checksum:iCD54463064CF737B
GO
Isoform 3 (identifier: P52742-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-85: P → PEIKGHFQFLLLS

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:670
Mass (Da):76,675
Checksum:iE070433AD8D6C9A5
GO
Isoform 4 (identifier: P52742-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MTPGVRVSTDP → MELGSRRRSVGCRCRGLCLAVRR
     85-85: P → PEIKGHFQFLLLS

Note: Gene prediction based on EST data.
Show »
Length:682
Mass (Da):78,151
Checksum:iC4D2B1A44B70570B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N9M3Q8N9M3_HUMAN
Zinc finger protein 135
ZNF135 hCG_2039973
616Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0N7M0R0N7_HUMAN
Zinc finger protein 135
ZNF135
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50254 differs from that shown. Reason: Frameshift at positions 207, 558 and 563.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166G → R in AAC50254 (PubMed:7557990).Curated1
Sequence conflicti247C → F in BAG58141 (PubMed:14702039).Curated1
Sequence conflicti308S → C in BAG58141 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05277422G → D2 PublicationsCorresponds to variant dbSNP:rs1469087Ensembl.1
Natural variantiVAR_052775507S → L. Corresponds to variant dbSNP:rs2228277Ensembl.1
Natural variantiVAR_052776517T → A. Corresponds to variant dbSNP:rs2228278Ensembl.1
Natural variantiVAR_052777579G → R. Corresponds to variant dbSNP:rs2228279Ensembl.1
Natural variantiVAR_052778592S → L. Corresponds to variant dbSNP:rs2228275Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460731 – 11MTPGVRVSTDP → MELGSRRRSVGCRCRGLCLA VRR in isoform 2 and isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04670685P → PEIKGHFQFLLLS in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_046074359 – 638Missing in isoform 2. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK098011 mRNA Translation: BAC05214.1
AK295110 mRNA Translation: BAG58141.1
AC008751 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72553.1
BC046434 mRNA Translation: AAH46434.1
U09413 mRNA Translation: AAC50254.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12970.2 [P52742-3]
CCDS54329.1 [P52742-4]
CCDS54330.1 [P52742-2]
CCDS74471.1 [P52742-1]

Protein sequence database of the Protein Information Resource

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PIRi
I38600

NCBI Reference Sequences

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RefSeqi
NP_001158001.1, NM_001164529.1
NP_001158002.1, NM_001164530.1 [P52742-2]
NP_001276330.1, NM_001289401.1 [P52742-1]
NP_001276331.1, NM_001289402.1
NP_003427.3, NM_003436.3 [P52742-3]
NP_009065.1, NM_007134.1 [P52742-4]
XP_006723425.1, XM_006723362.3 [P52742-3]
XP_006723426.1, XM_006723363.3 [P52742-3]
XP_016882729.1, XM_017027240.1 [P52742-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313434; ENSP00000321406; ENSG00000176293 [P52742-1]
ENST00000359978; ENSP00000369437; ENSG00000176293 [P52742-2]
ENST00000401053; ENSP00000441410; ENSG00000176293 [P52742-4]
ENST00000511556; ENSP00000422074; ENSG00000176293 [P52742-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7694

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7694

UCSC genome browser

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UCSCi
uc002qrd.3 human [P52742-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098011 mRNA Translation: BAC05214.1
AK295110 mRNA Translation: BAG58141.1
AC008751 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72553.1
BC046434 mRNA Translation: AAH46434.1
U09413 mRNA Translation: AAC50254.1 Frameshift.
CCDSiCCDS12970.2 [P52742-3]
CCDS54329.1 [P52742-4]
CCDS54330.1 [P52742-2]
CCDS74471.1 [P52742-1]
PIRiI38600
RefSeqiNP_001158001.1, NM_001164529.1
NP_001158002.1, NM_001164530.1 [P52742-2]
NP_001276330.1, NM_001289401.1 [P52742-1]
NP_001276331.1, NM_001289402.1
NP_003427.3, NM_003436.3 [P52742-3]
NP_009065.1, NM_007134.1 [P52742-4]
XP_006723425.1, XM_006723362.3 [P52742-3]
XP_006723426.1, XM_006723363.3 [P52742-3]
XP_016882729.1, XM_017027240.1 [P52742-1]

3D structure databases

SMRiP52742
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113489, 6 interactors
IntActiP52742, 11 interactors
MINTiP52742
STRINGi9606.ENSP00000441410

PTM databases

iPTMnetiP52742
PhosphoSitePlusiP52742

Polymorphism and mutation databases

BioMutaiZNF135
DMDMi296453071

Proteomic databases

EPDiP52742
jPOSTiP52742
PaxDbiP52742
PeptideAtlasiP52742
PRIDEiP52742
ProteomicsDBi56518

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313434; ENSP00000321406; ENSG00000176293 [P52742-1]
ENST00000359978; ENSP00000369437; ENSG00000176293 [P52742-2]
ENST00000401053; ENSP00000441410; ENSG00000176293 [P52742-4]
ENST00000511556; ENSP00000422074; ENSG00000176293 [P52742-3]
GeneIDi7694
KEGGihsa:7694
UCSCiuc002qrd.3 human [P52742-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7694
DisGeNETi7694

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF135
HGNCiHGNC:12919 ZNF135
HPAiHPA006961
MIMi604077 gene
neXtProtiNX_P52742
OpenTargetsiENSG00000176293
PharmGKBiPA37507

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153104
HOGENOMiHOG000234617
InParanoidiP52742
KOiK09228
OMAiQEQWQRN
OrthoDBi1318335at2759
PhylomeDBiP52742
TreeFamiTF350822

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7694

Protein Ontology

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PROi
PR:P52742

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000176293 Expressed in 131 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP52742 baseline and differential
GenevisibleiP52742 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN135_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52742
Secondary accession number(s): B4DHH9
, E9PEV2, F5GYY9, I3L0B3, Q5U5L3, Q8N1I7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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