UniProtKB - P52738 (ZN140_HUMAN)
Protein
Zinc finger protein 140
Gene
ZNF140
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation as a repressor.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 161 – 183 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 189 – 211 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 217 – 239 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 245 – 267 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 273 – 295 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 301 – 323 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 329 – 351 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 357 – 379 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 385 – 407 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 413 – 435 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P52738 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 140 |
Gene namesi | Name:ZNF140 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12925, ZNF140 |
MIMi | 604082, gene |
neXtProti | NX_P52738 |
VEuPathDBi | HostDB:ENSG00000196387.9 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7699 |
OpenTargetsi | ENSG00000196387 |
PharmGKBi | PA37512 |
Miscellaneous databases
Pharosi | P52738, Tdark |
Genetic variation databases
BioMutai | ZNF140 |
DMDMi | 206729944 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047423 | 1 – 457 | Zinc finger protein 140Add BLAST | 457 |
Proteomic databases
EPDi | P52738 |
MassIVEi | P52738 |
PaxDbi | P52738 |
PeptideAtlasi | P52738 |
PRIDEi | P52738 |
ProteomicsDBi | 56511 [P52738-1] 58394 |
PTM databases
iPTMneti | P52738 |
PhosphoSitePlusi | P52738 |
Expressioni
Tissue specificityi
Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Gene expression databases
Bgeei | ENSG00000196387, Expressed in female gonad and 220 other tissues |
ExpressionAtlasi | P52738, baseline and differential |
Genevisiblei | P52738, HS |
Organism-specific databases
HPAi | ENSG00000196387, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP52738
With | #Exp. | IntAct |
---|---|---|
ARMC7 [Q9H6L4] | 3 | EBI-12069140,EBI-742909 |
CABP2 [Q9NPB3] | 3 | EBI-12069140,EBI-12011224 |
CEP70 [Q8NHQ1] | 3 | EBI-12069140,EBI-739624 |
Protein-protein interaction databases
BioGRIDi | 113493, 7 interactors |
IntActi | P52738, 5 interactors |
STRINGi | 9606.ENSP00000347755 |
Miscellaneous databases
RNActi | P52738, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 77 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 161 – 183 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 189 – 211 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 217 – 239 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 245 – 267 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 273 – 295 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 301 – 323 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 329 – 351 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 357 – 379 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 385 – 407 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 413 – 435 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163022 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | P52738 |
OMAi | NQGCIRQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P52738 |
TreeFami | TF337055 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P52738-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS
60 70 80 90 100
KPDVVSLLEQ GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ
110 120 130 140 150
YLIMERILSQ GPVYSSFKGG WKCKDHTEML QENQGCIRKV TVSHQEALAQ
160 170 180 190 200
HMNISTVERP YGCHECGKTF GRRFSLVLHQ RTHTGEKPYA CKECGKTFSQ
210 220 230 240 250
ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT GEKPYECTEC
260 270 280 290 300
GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP
310 320 330 340 350
YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI
360 370 380 390 400
HAGEKLYECD ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL
410 420 430 440 450
ILHQRTHTGE KPYVCKVCNK SFSWSSNLAK HQRTHTLDNP YEYENSFNYH
SFLTEHQ
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GX08 | F5GX08_HUMAN | Zinc finger protein 140 | ZNF140 | 79 | Annotation score: | ||
F5H3Z2 | F5H3Z2_HUMAN | Zinc finger protein 140 | ZNF140 | 101 | Annotation score: | ||
F5H4I1 | F5H4I1_HUMAN | Zinc finger protein 140 | ZNF140 | 116 | Annotation score: | ||
F5H644 | F5H644_HUMAN | Zinc finger protein 140 | ZNF140 | 114 | Annotation score: | ||
I3L0I7 | I3L0I7_HUMAN | Zinc finger protein 140 | ZNF140 | 161 | Annotation score: | ||
I3L0D9 | I3L0D9_HUMAN | Zinc finger protein 140 | ZNF140 | 87 | Annotation score: | ||
F8WAF8 | F8WAF8_HUMAN | Zinc finger protein 140 | ZNF140 | 77 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 338 | F → L in AAC50262 (PubMed:7649249).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046562 | 386 | A → V. Corresponds to variant dbSNP:rs2229373Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056436 | 1 – 103 | Missing in isoform 2. 2 PublicationsAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09368 mRNA Translation: AAC50262.1 AK122741 mRNA Translation: BAG53698.1 AK303240 mRNA Translation: BAG64326.1 AC026786 Genomic DNA No translation available. AC073911 Genomic DNA No translation available. CH471218 Genomic DNA Translation: EAW54795.1 CH471218 Genomic DNA Translation: EAW54797.1 CH471218 Genomic DNA Translation: EAW54798.1 BC022291 mRNA Translation: AAH22291.1 BC040561 mRNA Translation: AAH40561.1 |
CCDSi | CCDS73550.1 [P52738-2] CCDS9282.1 [P52738-1] |
PIRi | C57785 |
RefSeqi | NP_001287705.1, NM_001300776.1 [P52738-2] NP_001287706.1, NM_001300777.1 NP_001287707.1, NM_001300778.1 [P52738-2] NP_003431.2, NM_003440.3 [P52738-1] XP_011533137.1, XM_011534835.2 [P52738-1] XP_011533142.1, XM_011534840.2 [P52738-2] XP_016875413.1, XM_017019924.1 [P52738-2] XP_016875414.1, XM_017019925.1 [P52738-2] |
Genome annotation databases
Ensembli | ENST00000355557; ENSP00000347755; ENSG00000196387 [P52738-1] ENST00000544426; ENSP00000445411; ENSG00000196387 [P52738-2] |
GeneIDi | 7699 |
KEGGi | hsa:7699 |
UCSCi | uc001ulo.4, human [P52738-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09368 mRNA Translation: AAC50262.1 AK122741 mRNA Translation: BAG53698.1 AK303240 mRNA Translation: BAG64326.1 AC026786 Genomic DNA No translation available. AC073911 Genomic DNA No translation available. CH471218 Genomic DNA Translation: EAW54795.1 CH471218 Genomic DNA Translation: EAW54797.1 CH471218 Genomic DNA Translation: EAW54798.1 BC022291 mRNA Translation: AAH22291.1 BC040561 mRNA Translation: AAH40561.1 |
CCDSi | CCDS73550.1 [P52738-2] CCDS9282.1 [P52738-1] |
PIRi | C57785 |
RefSeqi | NP_001287705.1, NM_001300776.1 [P52738-2] NP_001287706.1, NM_001300777.1 NP_001287707.1, NM_001300778.1 [P52738-2] NP_003431.2, NM_003440.3 [P52738-1] XP_011533137.1, XM_011534835.2 [P52738-1] XP_011533142.1, XM_011534840.2 [P52738-2] XP_016875413.1, XM_017019924.1 [P52738-2] XP_016875414.1, XM_017019925.1 [P52738-2] |
3D structure databases
SMRi | P52738 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113493, 7 interactors |
IntActi | P52738, 5 interactors |
STRINGi | 9606.ENSP00000347755 |
PTM databases
iPTMneti | P52738 |
PhosphoSitePlusi | P52738 |
Genetic variation databases
BioMutai | ZNF140 |
DMDMi | 206729944 |
Proteomic databases
EPDi | P52738 |
MassIVEi | P52738 |
PaxDbi | P52738 |
PeptideAtlasi | P52738 |
PRIDEi | P52738 |
ProteomicsDBi | 56511 [P52738-1] 58394 |
Protocols and materials databases
Antibodypediai | 45872, 54 antibodies |
Genome annotation databases
Ensembli | ENST00000355557; ENSP00000347755; ENSG00000196387 [P52738-1] ENST00000544426; ENSP00000445411; ENSG00000196387 [P52738-2] |
GeneIDi | 7699 |
KEGGi | hsa:7699 |
UCSCi | uc001ulo.4, human [P52738-1] |
Organism-specific databases
CTDi | 7699 |
DisGeNETi | 7699 |
GeneCardsi | ZNF140 |
HGNCi | HGNC:12925, ZNF140 |
HPAi | ENSG00000196387, Low tissue specificity |
MIMi | 604082, gene |
neXtProti | NX_P52738 |
OpenTargetsi | ENSG00000196387 |
PharmGKBi | PA37512 |
VEuPathDBi | HostDB:ENSG00000196387.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163022 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | P52738 |
OMAi | NQGCIRQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P52738 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | P52738 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7699, 0 hits in 893 CRISPR screens |
ChiTaRSi | ZNF140, human |
GenomeRNAii | 7699 |
Pharosi | P52738, Tdark |
PROi | PR:P52738 |
RNActi | P52738, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196387, Expressed in female gonad and 220 other tissues |
ExpressionAtlasi | P52738, baseline and differential |
Genevisiblei | P52738, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN140_HUMAN | |
Accessioni | P52738Primary (citable) accession number: P52738 Secondary accession number(s): D3DXJ3, Q05CP6, Q8IV75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants