UniProtKB - P52738 (ZN140_HUMAN)

BLAST

>sp|P52738|ZN140_HUMAN Zinc finger protein 140 OS=Homo sapiens OX=9606 GN=ZNF140 PE=2 SV=2
MSQGSVTFRDVAIDFSQEEWKWLQPAQRDLYRCVMLENYGHLVSLGLSISKPDVVSLLEQ
GKEPWLGKREVKRDLFSVSESSGEIKDFSPKNVIYDDSSQYLIMERILSQGPVYSSFKGG
WKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERPYGCHECGKTFGRRFSLVLHQ
RTHTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIEHQRTHT
GEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKP
YECIECGKAFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECD
ECGKVFTWHASLIQHTKSHTGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKVCNK
SFSWSSNLAKHQRTHTLDNPYEYENSFNYHSFLTEHQ

Align

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History
Entry version 167 (07 Nov 2018)
Sequence version 2 (23 Sep 2008)
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Protein

Zinc finger protein 140

Gene

ZNF140

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be involved in transcriptional regulation as a repressor.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	161 – 183	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	189 – 211	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	217 – 239	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	245 – 267	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	273 – 295	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	301 – 323	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	329 – 351	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	357 – 379	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	385 – 407	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	413 – 435	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 7557990
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 28473536

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11470777

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 140
Gene namesⁱ	Name:ZNF140
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196387.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12925 ZNF140
MIMⁱ	604082 gene
neXtProtⁱ	NX_P52738

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7699
Open Targets More...OpenTargetsⁱ	ENSG00000196387
PharmGKBⁱ	PA37512

Polymorphism and mutation databases

BioMutaⁱ	ZNF140
DMDMⁱ	206729944

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047423	1 – 457	Zinc finger protein 140Add BLAST		457

Proteomic databases

EPDⁱ	P52738
PaxDbⁱ	P52738
PeptideAtlas More...PeptideAtlasⁱ	P52738
PRIDEⁱ	P52738
ProteomicsDBⁱ	56511

PTM databases

iPTMnetⁱ	P52738
PhosphoSitePlusⁱ	P52738

Expressionⁱ

Tissue specificityⁱ

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000196387 Expressed in 209 organ(s), highest expression level in female gonad
CleanExⁱ	HS_ZNF140
ExpressionAtlasⁱ	P52738 baseline and differential
Genevisibleⁱ	P52738 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048332

HPAⁱ

HPA048332

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	113493, 4 interactors
IntActⁱ	P52738, 2 interactors
STRINGⁱ	9606.ENSP00000347755

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52738
SMRⁱ	P52738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 77	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	161 – 183	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	189 – 211	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	217 – 239	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	245 – 267	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	273 – 295	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	301 – 323	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	329 – 351	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	357 – 379	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	385 – 407	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	413 – 435	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129704
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P52738
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	SKAFRCH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P52738
TreeFamⁱ	TF337055

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P52738-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS 
        60         70         80         90        100
KPDVVSLLEQ GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ 
       110        120        130        140        150
YLIMERILSQ GPVYSSFKGG WKCKDHTEML QENQGCIRKV TVSHQEALAQ 
       160        170        180        190        200
HMNISTVERP YGCHECGKTF GRRFSLVLHQ RTHTGEKPYA CKECGKTFSQ 
       210        220        230        240        250
ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT GEKPYECTEC 
       260        270        280        290        300
GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP 
       310        320        330        340        350
YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI 
       360        370        380        390        400
HAGEKLYECD ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL 
       410        420        430        440        450
ILHQRTHTGE KPYVCKVCNK SFSWSSNLAK HQRTHTLDNP YEYENSFNYH 

SFLTEHQ

Length:457

Mass (Da):52,996

Last modified:September 23, 2008 - v2

Checksum:ⁱF4FF0B7D85E03731

Isoform 2 (identifier: P52738-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-103: Missing.

« Hide

        10         20         30         40         50
MERILSQGPV YSSFKGGWKC KDHTEMLQEN QGCIRKVTVS HQEALAQHMN 
        60         70         80         90        100
ISTVERPYGC HECGKTFGRR FSLVLHQRTH TGEKPYACKE CGKTFSQISN 
       110        120        130        140        150
LVKHQMIHTG KKPHECKDCN KTFSYLSFLI EHQRTHTGEK PYECTECGKA 
       160        170        180        190        200
FSRASNLTRH QRIHIGKKQY ICRKCGKAFS SGSELIRHQI THTGEKPYEC 
       210        220        230        240        250
IECGKAFRRF SHLTRHQSIH TTKTPYECNE CRKAFRCHSF LIKHQRIHAG 
       260        270        280        290        300
EKLYECDECG KVFTWHASLI QHTKSHTGEK PYACAECDKA FSRSFSLILH 
       310        320        330        340        350
QRTHTGEKPY VCKVCNKSFS WSSNLAKHQR THTLDNPYEY ENSFNYHSFL 

TEHQ

Show »

Length:354

Mass (Da):41,169

Checksum:ⁱA0EEAF0E30DF4A52

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GX08	F5GX08_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	79	Annotation score:
F5H4I1	F5H4I1_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	116	Annotation score:
F5H644	F5H644_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	114	Annotation score:
I3L0I7	I3L0I7_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	161	Annotation score:
F5H3Z2	F5H3Z2_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	101	Annotation score:
I3L0D9	I3L0D9_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	87	Annotation score:
F8WAF8	F8WAF8_HUMAN	Zinc finger protein 140 Zinc finger protein 140	ZNF140	77	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	338	F → L in AAC50262 (PubMed:7649249).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046562	386	A → V. Corresponds to variant dbSNP:rs2229373Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056436	1 – 103	Missing in isoform 2. 2 PublicationsAdd BLAST		103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09368 mRNA Translation: AAC50262.1 AK122741 mRNA Translation: BAG53698.1 AK303240 mRNA Translation: BAG64326.1 AC026786 Genomic DNA No translation available. AC073911 Genomic DNA No translation available. CH471218 Genomic DNA Translation: EAW54795.1 CH471218 Genomic DNA Translation: EAW54797.1 CH471218 Genomic DNA Translation: EAW54798.1 BC022291 mRNA Translation: AAH22291.1 BC040561 mRNA Translation: AAH40561.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73550.1 [P52738-2] CCDS9282.1 [P52738-1]
PIRⁱ	C57785
NCBI Reference Sequences More...RefSeqⁱ	NP_001287705.1, NM_001300776.1 [P52738-2] NP_001287706.1, NM_001300777.1 NP_001287707.1, NM_001300778.1 [P52738-2] NP_003431.2, NM_003440.3 [P52738-1] XP_011533137.1, XM_011534835.2 [P52738-1] XP_011533142.1, XM_011534840.2 [P52738-2] XP_016875413.1, XM_017019924.1 [P52738-2] XP_016875414.1, XM_017019925.1 [P52738-2]
UniGeneⁱ	Hs.181552

Genome annotation databases

Ensemblⁱ	ENST00000355557; ENSP00000347755; ENSG00000196387 [P52738-1] ENST00000544426; ENSP00000445411; ENSG00000196387 [P52738-2]
GeneIDⁱ	7699
KEGGⁱ	hsa:7699
UCSC genome browser More...UCSCⁱ	uc001ulo.4 human [P52738-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52738	Zinc finger protein 140 (Fragment)		HUMAN		87	UniRef100_P52738
ZNF140 isoform 3 (Fragment)		PANTR		87
Zinc finger protein 140 (Fragment)		HUMAN		116
ZNF140 isoform 2 (Fragment)		PANTR		116
UPI000387B31B		HUMAN		423
P52738-2	cDNA FLJ51494, highly similar to Zinc finger protein 140		HUMAN		329	UniRef100_P52738-2
UPI0005D019B2		HUMAN		458
UPI0005D0038D		HUMAN		424

Protein	Similar proteins		Species	Score	Length	Source
P52738	Zinc finger protein 140 (Fragment)		HUMAN		87	UniRef90_P52738
ZNF140 isoform 3 (Fragment)		PANTR		87
Uncharacterized protein		NOMLE		462
Uncharacterized protein		CERAT		460
Uncharacterized protein		Cebus capucinus imitator		460
+80

Protein	Similar proteins		Species	Score	Length	Source
P52738	Zinc finger protein 565		HUMAN		539	UniRef50_P52738
Zinc finger protein 14		MOUSE		501
ZNF140 isoform 3 (Fragment)		PANTR		87
Uncharacterized protein		NOMLE		462
Uncharacterized protein		Cebus capucinus imitator		460
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09368 mRNA Translation: AAC50262.1 AK122741 mRNA Translation: BAG53698.1 AK303240 mRNA Translation: BAG64326.1 AC026786 Genomic DNA No translation available. AC073911 Genomic DNA No translation available. CH471218 Genomic DNA Translation: EAW54795.1 CH471218 Genomic DNA Translation: EAW54797.1 CH471218 Genomic DNA Translation: EAW54798.1 BC022291 mRNA Translation: AAH22291.1 BC040561 mRNA Translation: AAH40561.1
CCDSⁱ	CCDS73550.1 [P52738-2] CCDS9282.1 [P52738-1]
PIRⁱ	C57785
RefSeqⁱ	NP_001287705.1, NM_001300776.1 [P52738-2] NP_001287706.1, NM_001300777.1 NP_001287707.1, NM_001300778.1 [P52738-2] NP_003431.2, NM_003440.3 [P52738-1] XP_011533137.1, XM_011534835.2 [P52738-1] XP_011533142.1, XM_011534840.2 [P52738-2] XP_016875413.1, XM_017019924.1 [P52738-2] XP_016875414.1, XM_017019925.1 [P52738-2]
UniGeneⁱ	Hs.181552

3D structure databases

ProteinModelPortalⁱ	P52738
SMRⁱ	P52738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113493, 4 interactors
IntActⁱ	P52738, 2 interactors
STRINGⁱ	9606.ENSP00000347755

PTM databases

iPTMnetⁱ	P52738
PhosphoSitePlusⁱ	P52738

Polymorphism and mutation databases

BioMutaⁱ	ZNF140
DMDMⁱ	206729944

Proteomic databases

EPDⁱ	P52738
PaxDbⁱ	P52738
PeptideAtlasⁱ	P52738
PRIDEⁱ	P52738
ProteomicsDBⁱ	56511

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000355557; ENSP00000347755; ENSG00000196387 [P52738-1] ENST00000544426; ENSP00000445411; ENSG00000196387 [P52738-2]
GeneIDⁱ	7699
KEGGⁱ	hsa:7699
UCSCⁱ	uc001ulo.4 human [P52738-1]

Organism-specific databases

CTDⁱ	7699
DisGeNETⁱ	7699
EuPathDBⁱ	HostDB:ENSG00000196387.9
GeneCardsⁱ	ZNF140
HGNCⁱ	HGNC:12925 ZNF140
HPAⁱ	HPA048332
MIMⁱ	604082 gene
neXtProtⁱ	NX_P52738
OpenTargetsⁱ	ENSG00000196387
PharmGKBⁱ	PA37512
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00840000129704
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P52738
KOⁱ	K09228
OMAⁱ	SKAFRCH
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P52738
TreeFamⁱ	TF337055

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAiⁱ	7699
Protein Ontology More...PROⁱ	PR:P52738
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196387 Expressed in 209 organ(s), highest expression level in female gonad
CleanExⁱ	HS_ZNF140
ExpressionAtlasⁱ	P52738 baseline and differential
Genevisibleⁱ	P52738 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN140_HUMAN
Accessionⁱ	P52738Primary (citable) accession number: P52738 Secondary accession number(s): D3DXJ3, Q05CP6, Q8IV75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	September 23, 2008
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P52738 (ZN140_HUMAN)

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Zinc finger protein 140

ZNF140

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ