ZNF133

Functionⁱ

May be involved in transcriptional regulation as a repressor.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	214 – 236	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	242 – 264	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	270 – 292	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 320	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	326 – 348	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 404	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	410 – 432	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	438 – 460	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	494 – 516	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	522 – 544	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	550 – 572	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	578 – 600	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	606 – 631	C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST	26

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 7557990
- 9278146
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 133 Alternative name(s): Zinc finger protein 150
Gene namesⁱ	Name:ZNF133 Synonyms:ZNF150
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125846.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12917 ZNF133
MIMⁱ	604075 gene
neXtProtⁱ	NX_P52736

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7692
Open Targets More...OpenTargetsⁱ	ENSG00000125846
PharmGKBⁱ	PA134900961

Polymorphism and mutation databases

DMDMⁱ	116242855

DMDMⁱ

116242855

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047417	1 – 654	Zinc finger protein 133Add BLAST		654

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	310	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	338	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	506	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	576	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	604	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	618	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P52736
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P52736
PaxDbⁱ	P52736
PeptideAtlas More...PeptideAtlasⁱ	P52736
PRIDEⁱ	P52736
ProteomicsDBⁱ	56508 56509 [P52736-2]

PTM databases

iPTMnetⁱ	P52736
PhosphoSitePlusⁱ	P52736

Expressionⁱ

Tissue specificityⁱ

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000125846 Expressed in 210 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_ZNF133
ExpressionAtlasⁱ	P52736 baseline and differential
Genevisibleⁱ	P52736 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001493

HPAⁱ

HPA001493

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FOS	P01100	4	EBI-2687350,EBI-852851
KRTAP10-7	P60409	3	EBI-2687350,EBI-10172290

Protein-protein interaction databases

BioGridⁱ	113487, 27 interactors
IntActⁱ	P52736, 7 interactors
Molecular INTeraction database More...MINTⁱ	P52736
STRINGⁱ	9606.ENSP00000366899

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52736
SMRⁱ	P52736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 72	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	214 – 236	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	242 – 264	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	270 – 292	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 320	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	326 – 348	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 404	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	410 – 432	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	438 – 460	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	494 – 516	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	522 – 544	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	550 – 572	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	578 – 600	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	606 – 631	C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST	26

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063157
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P52736
KEGG Orthology (KO) More...KOⁱ	K09228
PhylomeDBⁱ	P52736
TreeFamⁱ	TF338096

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 13 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 15 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P52736-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI 
        60         70         80         90        100
TQLEQGKETW REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL 
       110        120        130        140        150
CNHPPWIFTC LCAEGNIQPG DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG 
       160        170        180        190        200
AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG LRGVELEASP AQSGNPEETD 
       210        220        230        240        250
KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK PYVCGVCEKG 
       260        270        280        290        300
FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC 
       310        320        330        340        350
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE 
       360        370        380        390        400
EKTIVCSDCG LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH 
       410        420        430        440        450
QRTHSKEKPY VCGVCGHSFS QNSTLISHRR THTGEKPYVC GVCGRGFSLK 
       460        470        480        490        500
SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN LIRHQRTHSG EKPMVCGECG 
       510        520        530        540        550
RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH KRKHSREKPY 
       560        570        580        590        600
MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH 
       610        620        630        640        650
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS 

LYSL

Length:654

Mass (Da):73,388

Last modified:October 17, 2006 - v2

Checksum:ⁱCF1D47B223A6DD84

GO

Isoform 2 (identifier: P52736-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
73-73: Missing.

« Hide

        10         20         30         40         50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI 
        60         70         80         90        100
TQLEQGKETW REEKKCSPAT CPDPEPELYL DPFCPPGFSS QKFPMQHVLC 
       110        120        130        140        150
NHPPWIFTCL CAEGNIQPGD PGPGDQEKQQ QASEGRPWSD QAEGPEGEGA 
       160        170        180        190        200
MPLFGRTKKR TLGAFSRPPQ RQPVSSRNGL RGVELEASPA QSGNPEETDK 
       210        220        230        240        250
LLKRIEVLGF GTVNCGECGL SFSKMTNLLS HQRIHSGEKP YVCGVCEKGF 
       260        270        280        290        300
SLKKSLARHQ KAHSGEKPIV CRECGRGFNR KSTLIIHERT HSGEKPYMCS 
       310        320        330        340        350
ECGRGFSQKS NLIIHQRTHS GEKPYVCREC GKGFSQKSAV VRHQRTHLEE 
       360        370        380        390        400
KTIVCSDCGL GFSDRSNLIS HQRTHSGEKP YACKECGRCF RQRTTLVNHQ 
       410        420        430        440        450
RTHSKEKPYV CGVCGHSFSQ NSTLISHRRT HTGEKPYVCG VCGRGFSLKS 
       460        470        480        490        500
HLNRHQNIHS GEKPIVCKDC GRGFSQQSNL IRHQRTHSGE KPMVCGECGR 
       510        520        530        540        550
GFSQKSNLVA HQRTHSGERP YVCRECGRGF SHQAGLIRHK RKHSREKPYM 
       560        570        580        590        600
CRQCGLGFGN KSALITHKRA HSEEKPCVCR ECGQGFLQKS HLTLHQMTHT 
       610        620        630        640        650
GEKPYVCKTC GRGFSLKSHL SRHRKTTSVH HRLPVQPDPE PCAGQPSDSL 

YSL

Show »

Length:653

Mass (Da):73,317

Checksum:ⁱ883575A9CF6CD81D

GO

Isoform 3 (identifier: P52736-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-95: Missing.

« Hide

        10         20         30         40         50
MQHVLCNHPP WIFTCLCAEG NIQPGDPGPG DQEKQQQASE GRPWSDQAEG 
        60         70         80         90        100
PEGEGAMPLF GRTKKRTLGA FSRPPQRQPV SSRNGLRGVE LEASPAQSGN 
       110        120        130        140        150
PEETDKLLKR IEVLGFGTVN CGECGLSFSK MTNLLSHQRI HSGEKPYVCG 
       160        170        180        190        200
VCEKGFSLKK SLARHQKAHS GEKPIVCREC GRGFNRKSTL IIHERTHSGE 
       210        220        230        240        250
KPYMCSECGR GFSQKSNLII HQRTHSGEKP YVCRECGKGF SQKSAVVRHQ 
       260        270        280        290        300
RTHLEEKTIV CSDCGLGFSD RSNLISHQRT HSGEKPYACK ECGRCFRQRT 
       310        320        330        340        350
TLVNHQRTHS KEKPYVCGVC GHSFSQNSTL ISHRRTHTGE KPYVCGVCGR 
       360        370        380        390        400
GFSLKSHLNR HQNIHSGEKP IVCKDCGRGF SQQSNLIRHQ RTHSGEKPMV 
       410        420        430        440        450
CGECGRGFSQ KSNLVAHQRT HSGERPYVCR ECGRGFSHQA GLIRHKRKHS 
       460        470        480        490        500
REKPYMCRQC GLGFGNKSAL ITHKRAHSEE KPCVCRECGQ GFLQKSHLTL 
       510        520        530        540        550
HQMTHTGEKP YVCKTCGRGF SLKSHLSRHR KTTSVHHRLP VQPDPEPCAG 

QPSDSLYSL

Note: No experimental confirmation available.

Show »

Length:559

Mass (Da):62,460

Checksum:ⁱDE76B50A05C5C9FD

GO

Isoform 4 (identifier: P52736-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-72: MAFRDVAVDF...EKKCSPATCP → MCNGRKTVL

« Hide

        10         20         30         40         50
MCNGRKTVLA DPEPELYLDP FCPPGFSSQK FPMQHVLCNH PPWIFTCLCA 
        60         70         80         90        100
EGNIQPGDPG PGDQEKQQQA SEGRPWSDQA EGPEGEGAMP LFGRTKKRTL 
       110        120        130        140        150
GAFSRPPQRQ PVSSRNGLRG VELEASPAQS GNPEETDKLL KRIEVLGFGT 
       160        170        180        190        200
VNCGECGLSF SKMTNLLSHQ RIHSGEKPYV CGVCEKGFSL KKSLARHQKA 
       210        220        230        240        250
HSGEKPIVCR ECGRGFNRKS TLIIHERTHS GEKPYMCSEC GRGFSQKSNL 
       260        270        280        290        300
IIHQRTHSGE KPYVCRECGK GFSQKSAVVR HQRTHLEEKT IVCSDCGLGF 
       310        320        330        340        350
SDRSNLISHQ RTHSGEKPYA CKECGRCFRQ RTTLVNHQRT HSKEKPYVCG 
       360        370        380        390        400
VCGHSFSQNS TLISHRRTHT GEKPYVCGVC GRGFSLKSHL NRHQNIHSGE 
       410        420        430        440        450
KPIVCKDCGR GFSQQSNLIR HQRTHSGEKP MVCGECGRGF SQKSNLVAHQ 
       460        470        480        490        500
RTHSGERPYV CRECGRGFSH QAGLIRHKRK HSREKPYMCR QCGLGFGNKS 
       510        520        530        540        550
ALITHKRAHS EEKPCVCREC GQGFLQKSHL TLHQMTHTGE KPYVCKTCGR 
       560        570        580        590 
GFSLKSHLSR HRKTTSVHHR LPVQPDPEPC AGQPSDSLYS L

Note: No experimental confirmation available.

Show »

Length:591

Mass (Da):66,027

Checksum:ⁱ794B47D25C80881D

GO

Isoform 5 (identifier: P52736-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAHM

« Hide

        10         20         30         40         50
MAHMAFRDVA VDFTQDEWRL LSPAQRTLYR EVMLENYSNL VSLGISFSKP 
        60         70         80         90        100
ELITQLEQGK ETWREEKKCS PATCPADPEP ELYLDPFCPP GFSSQKFPMQ 
       110        120        130        140        150
HVLCNHPPWI FTCLCAEGNI QPGDPGPGDQ EKQQQASEGR PWSDQAEGPE 
       160        170        180        190        200
GEGAMPLFGR TKKRTLGAFS RPPQRQPVSS RNGLRGVELE ASPAQSGNPE 
       210        220        230        240        250
ETDKLLKRIE VLGFGTVNCG ECGLSFSKMT NLLSHQRIHS GEKPYVCGVC 
       260        270        280        290        300
EKGFSLKKSL ARHQKAHSGE KPIVCRECGR GFNRKSTLII HERTHSGEKP 
       310        320        330        340        350
YMCSECGRGF SQKSNLIIHQ RTHSGEKPYV CRECGKGFSQ KSAVVRHQRT 
       360        370        380        390        400
HLEEKTIVCS DCGLGFSDRS NLISHQRTHS GEKPYACKEC GRCFRQRTTL 
       410        420        430        440        450
VNHQRTHSKE KPYVCGVCGH SFSQNSTLIS HRRTHTGEKP YVCGVCGRGF 
       460        470        480        490        500
SLKSHLNRHQ NIHSGEKPIV CKDCGRGFSQ QSNLIRHQRT HSGEKPMVCG 
       510        520        530        540        550
ECGRGFSQKS NLVAHQRTHS GERPYVCREC GRGFSHQAGL IRHKRKHSRE 
       560        570        580        590        600
KPYMCRQCGL GFGNKSALIT HKRAHSEEKP CVCRECGQGF LQKSHLTLHQ 
       610        620        630        640        650
MTHTGEKPYV CKTCGRGFSL KSHLSRHRKT TSVHHRLPVQ PDPEPCAGQP 

SDSLYSL

Note: No experimental confirmation available.

Show »

Length:657

Mass (Da):73,728

Checksum:ⁱF7B081A6F912B039

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JXW0	Q5JXW0_HUMAN	Zinc finger protein 133 Zinc finger protein 133	ZNF133	142	Annotation score:
Q5JXV9	Q5JXV9_HUMAN	Zinc finger protein 133 Zinc finger protein 133	ZNF133	179	Annotation score:
Q5JXW1	Q5JXW1_HUMAN	Zinc finger protein 133 Zinc finger protein 133	ZNF133	99	Annotation score:
A0A0D9SEV2	A0A0D9SEV2_HUMAN	Zinc finger protein 133 Zinc finger protein 133	ZNF133	47	Annotation score:
A0A0A0MTH2	A0A0A0MTH2_HUMAN	Zinc finger protein 133 Zinc finger protein 133	ZNF133	667	Annotation score:
A0A0A0MTK6	A0A0A0MTK6_HUMAN	Zinc finger protein 133 Zinc finger protein 133	ZNF133	635	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	228	N → S in BAG58259 (PubMed:14702039).Curated		1
Sequence conflictⁱ	363	F → Y in BAG58430 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_028228	193	S → T6 PublicationsCorresponds to variant dbSNP:rs1033545Ensembl.		1
Natural variantⁱVAR_028229	194	G → E. Corresponds to variant dbSNP:rs2228273Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055021	1 – 95	Missing in isoform 3. 1 PublicationAdd BLAST	95
Alternative sequenceⁱVSP_055022	1 – 72	MAFRD…PATCP → MCNGRKTVL in isoform 4. 1 PublicationAdd BLAST	72
Alternative sequenceⁱVSP_055023	1	M → MAHM in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_039148	73	Missing in isoform 2. 3 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09366 mRNA Translation: AAC50260.1 BT007310 mRNA Translation: AAP35974.1 AK291389 mRNA Translation: BAF84078.1 AK295273 mRNA Translation: BAG58259.1 AK295513 mRNA Translation: BAG58430.1 AK316386 mRNA Translation: BAH14757.1 AL049646 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10250.1 CH471133 Genomic DNA Translation: EAX10251.1 CH471133 Genomic DNA Translation: EAX10252.1 CH471133 Genomic DNA Translation: EAX10253.1 BC001887 mRNA Translation: AAH01887.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13134.1 [P52736-2] CCDS63233.1 [P52736-5] CCDS63234.1 [P52736-1] CCDS63235.1 [P52736-4]
PIRⁱ	A57785
NCBI Reference Sequences More...RefSeqⁱ	NP_001076799.1, NM_001083330.2 NP_001269924.1, NM_001282995.1 NP_001269926.1, NM_001282997.1 NP_001269927.1, NM_001282998.1 NP_001269928.1, NM_001282999.1 NP_001269929.1, NM_001283000.1 NP_001269930.1, NM_001283001.1 NP_001269937.1, NM_001283008.1 NP_003425.2, NM_003434.5 XP_005260876.1, XM_005260819.1 XP_005260877.1, XM_005260820.4 XP_011527638.1, XM_011529336.1 XP_011527639.1, XM_011529337.1 [P52736-1] XP_011527640.1, XM_011529338.2 XP_011527641.1, XM_011529339.1 [P52736-1] XP_016883530.1, XM_017028041.1 [P52736-5] XP_016883531.1, XM_017028042.1 [P52736-5] XP_016883533.1, XM_017028044.1 XP_016883534.1, XM_017028045.1 XP_016883535.1, XM_017028046.1 XP_016883536.1, XM_017028047.1 [P52736-1] XP_016883537.1, XM_017028048.1 [P52736-1] XP_016883538.1, XM_017028049.1 XP_016883539.1, XM_017028050.1 XP_016883540.1, XM_017028051.1 XP_016883541.1, XM_017028052.1 XP_016883542.1, XM_017028053.1 XP_016883543.1, XM_017028054.1 XP_016883544.1, XM_017028055.1 XP_016883545.1, XM_017028056.1 XP_016883546.1, XM_017028057.1
UniGeneⁱ	Hs.472221

Genome annotation databases

Ensemblⁱ	ENST00000316358; ENSP00000346090; ENSG00000125846 [P52736-1] ENST00000377671; ENSP00000366899; ENSG00000125846 [P52736-2] ENST00000396026; ENSP00000400897; ENSG00000125846 [P52736-2] ENST00000401790; ENSP00000383945; ENSG00000125846 [P52736-1] ENST00000402618; ENSP00000385279; ENSG00000125846 [P52736-4] ENST00000622607; ENSP00000481326; ENSG00000125846 [P52736-1] ENST00000628216; ENSP00000487315; ENSG00000125846 [P52736-5] ENST00000630056; ENSP00000485741; ENSG00000125846 [P52736-3]
GeneIDⁱ	7692
KEGGⁱ	hsa:7692
UCSC genome browser More...UCSCⁱ	uc002wql.6 human [P52736-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52736-3	Zinc finger protein 133		HUMAN		667	UniRef100_A0A0A0MTH2

Protein	Similar proteins		Species	Score	Length	Source
P52736	Isoform 5 of Zinc finger protein 133		HUMAN		657	UniRef90_P52736
Zinc finger protein 133		PANTR		717
ZNF133 isoform 5		PONAB		667
Zinc finger protein 133		GORGO		667
Uncharacterized protein		CERAT		667
+144

Protein	Similar proteins		Species	Score	Length	Source
P52736	Isoform 5 of Zinc finger protein 133		HUMAN		657	UniRef50_P52736
Zinc finger protein 133		PANTR		717
Uncharacterized protein		MANLE		667
Uncharacterized protein		NOMLE		667
Uncharacterized protein		CERAT		667
+376

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09366 mRNA Translation: AAC50260.1 BT007310 mRNA Translation: AAP35974.1 AK291389 mRNA Translation: BAF84078.1 AK295273 mRNA Translation: BAG58259.1 AK295513 mRNA Translation: BAG58430.1 AK316386 mRNA Translation: BAH14757.1 AL049646 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10250.1 CH471133 Genomic DNA Translation: EAX10251.1 CH471133 Genomic DNA Translation: EAX10252.1 CH471133 Genomic DNA Translation: EAX10253.1 BC001887 mRNA Translation: AAH01887.1
CCDSⁱ	CCDS13134.1 [P52736-2] CCDS63233.1 [P52736-5] CCDS63234.1 [P52736-1] CCDS63235.1 [P52736-4]
PIRⁱ	A57785
RefSeqⁱ	NP_001076799.1, NM_001083330.2 NP_001269924.1, NM_001282995.1 NP_001269926.1, NM_001282997.1 NP_001269927.1, NM_001282998.1 NP_001269928.1, NM_001282999.1 NP_001269929.1, NM_001283000.1 NP_001269930.1, NM_001283001.1 NP_001269937.1, NM_001283008.1 NP_003425.2, NM_003434.5 XP_005260876.1, XM_005260819.1 XP_005260877.1, XM_005260820.4 XP_011527638.1, XM_011529336.1 XP_011527639.1, XM_011529337.1 [P52736-1] XP_011527640.1, XM_011529338.2 XP_011527641.1, XM_011529339.1 [P52736-1] XP_016883530.1, XM_017028041.1 [P52736-5] XP_016883531.1, XM_017028042.1 [P52736-5] XP_016883533.1, XM_017028044.1 XP_016883534.1, XM_017028045.1 XP_016883535.1, XM_017028046.1 XP_016883536.1, XM_017028047.1 [P52736-1] XP_016883537.1, XM_017028048.1 [P52736-1] XP_016883538.1, XM_017028049.1 XP_016883539.1, XM_017028050.1 XP_016883540.1, XM_017028051.1 XP_016883541.1, XM_017028052.1 XP_016883542.1, XM_017028053.1 XP_016883543.1, XM_017028054.1 XP_016883544.1, XM_017028055.1 XP_016883545.1, XM_017028056.1 XP_016883546.1, XM_017028057.1
UniGeneⁱ	Hs.472221

3D structure databases

ProteinModelPortalⁱ	P52736
SMRⁱ	P52736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113487, 27 interactors
IntActⁱ	P52736, 7 interactors
MINTⁱ	P52736
STRINGⁱ	9606.ENSP00000366899

PTM databases

iPTMnetⁱ	P52736
PhosphoSitePlusⁱ	P52736

Polymorphism and mutation databases

DMDMⁱ	116242855

DMDMⁱ

116242855

Proteomic databases

EPDⁱ	P52736
MaxQBⁱ	P52736
PaxDbⁱ	P52736
PeptideAtlasⁱ	P52736
PRIDEⁱ	P52736
ProteomicsDBⁱ	56508 56509 [P52736-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7692
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316358; ENSP00000346090; ENSG00000125846 [P52736-1] ENST00000377671; ENSP00000366899; ENSG00000125846 [P52736-2] ENST00000396026; ENSP00000400897; ENSG00000125846 [P52736-2] ENST00000401790; ENSP00000383945; ENSG00000125846 [P52736-1] ENST00000402618; ENSP00000385279; ENSG00000125846 [P52736-4] ENST00000622607; ENSP00000481326; ENSG00000125846 [P52736-1] ENST00000628216; ENSP00000487315; ENSG00000125846 [P52736-5] ENST00000630056; ENSP00000485741; ENSG00000125846 [P52736-3]
GeneIDⁱ	7692
KEGGⁱ	hsa:7692
UCSCⁱ	uc002wql.6 human [P52736-1]

Organism-specific databases

CTDⁱ	7692
DisGeNETⁱ	7692
EuPathDBⁱ	HostDB:ENSG00000125846.15
GeneCardsⁱ	ZNF133
HGNCⁱ	HGNC:12917 ZNF133
HPAⁱ	HPA001493
MIMⁱ	604075 gene
neXtProtⁱ	NX_P52736
OpenTargetsⁱ	ENSG00000125846
PharmGKBⁱ	PA134900961
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063157
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P52736
KOⁱ	K09228
PhylomeDBⁱ	P52736
TreeFamⁱ	TF338096

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZNF133 human
GeneWikiⁱ	ZNF133
GenomeRNAiⁱ	7692
Protein Ontology More...PROⁱ	PR:P52736
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125846 Expressed in 210 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_ZNF133
ExpressionAtlasⁱ	P52736 baseline and differential
Genevisibleⁱ	P52736 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 13 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 15 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN133_HUMAN
Accessionⁱ	P52736Primary (citable) accession number: P52736 Secondary accession number(s): A8K5S4 Q9H443
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - P52736 (ZN133_HUMAN)

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Zinc finger protein 133

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ