UniProtKB - P52736 (ZN133_HUMAN)
Protein
Zinc finger protein 133
Gene
ZNF133
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation as a repressor.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 214 – 236 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 544 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 550 – 572 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 606 – 631 | C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P52736 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 133Alternative name(s): Zinc finger protein 150 |
Gene namesi | Name:ZNF133 Synonyms:ZNF150 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12917, ZNF133 |
MIMi | 604075, gene |
neXtProti | NX_P52736 |
VEuPathDBi | HostDB:ENSG00000125846.15 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7692 |
OpenTargetsi | ENSG00000125846 |
PharmGKBi | PA134900961 |
Miscellaneous databases
Pharosi | P52736, Tdark |
Genetic variation databases
BioMutai | ZNF133 |
DMDMi | 116242855 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047417 | 1 – 654 | Zinc finger protein 133Add BLAST | 654 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 310 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 338 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 506 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 576 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 604 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 618 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | P52736 |
MaxQBi | P52736 |
PaxDbi | P52736 |
PeptideAtlasi | P52736 |
PRIDEi | P52736 |
ProteomicsDBi | 25897 56508 [P52736-1] 56509 [P52736-2] |
PTM databases
iPTMneti | P52736 |
PhosphoSitePlusi | P52736 |
Expressioni
Tissue specificityi
Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Gene expression databases
Bgeei | ENSG00000125846, Expressed in right hemisphere of cerebellum and 222 other tissues |
ExpressionAtlasi | P52736, baseline and differential |
Genevisiblei | P52736, HS |
Organism-specific databases
HPAi | ENSG00000125846, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 113487, 27 interactors |
IntActi | P52736, 22 interactors |
MINTi | P52736 |
STRINGi | 9606.ENSP00000439427 |
Miscellaneous databases
RNActi | P52736, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 72 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 214 – 236 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 544 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 550 – 572 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 606 – 631 | C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162260 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | P52736 |
OMAi | EWMLLSP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P52736 |
TreeFami | TF338096 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P52736-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI
60 70 80 90 100
TQLEQGKETW REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL
110 120 130 140 150
CNHPPWIFTC LCAEGNIQPG DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG
160 170 180 190 200
AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG LRGVELEASP AQSGNPEETD
210 220 230 240 250
KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK PYVCGVCEKG
260 270 280 290 300
FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC
310 320 330 340 350
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE
360 370 380 390 400
EKTIVCSDCG LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH
410 420 430 440 450
QRTHSKEKPY VCGVCGHSFS QNSTLISHRR THTGEKPYVC GVCGRGFSLK
460 470 480 490 500
SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN LIRHQRTHSG EKPMVCGECG
510 520 530 540 550
RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH KRKHSREKPY
560 570 580 590 600
MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH
610 620 630 640 650
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS
LYSL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JXW0 | Q5JXW0_HUMAN | Zinc finger protein 133 | ZNF133 | 142 | Annotation score: | ||
Q5JXV9 | Q5JXV9_HUMAN | Zinc finger protein 133 | ZNF133 | 179 | Annotation score: | ||
Q5JXW1 | Q5JXW1_HUMAN | Zinc finger protein 133 | ZNF133 | 99 | Annotation score: | ||
A0A0A0MTH2 | A0A0A0MTH2_HUMAN | Zinc finger protein 133 | ZNF133 | 667 | Annotation score: | ||
A0A0A0MTK6 | A0A0A0MTK6_HUMAN | Zinc finger protein 133 | ZNF133 | 635 | Annotation score: | ||
A0A0D9SEV2 | A0A0D9SEV2_HUMAN | Zinc finger protein 133 | ZNF133 | 47 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 228 | N → S in BAG58259 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 363 | F → Y in BAG58430 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028228 | 193 | S → T6 PublicationsCorresponds to variant dbSNP:rs1033545Ensembl. | 1 | |
Natural variantiVAR_028229 | 194 | G → E. Corresponds to variant dbSNP:rs2228273Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055021 | 1 – 95 | Missing in isoform 3. 1 PublicationAdd BLAST | 95 | |
Alternative sequenceiVSP_055022 | 1 – 72 | MAFRD…PATCP → MCNGRKTVL in isoform 4. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_055023 | 1 | M → MAHM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_039148 | 73 | Missing in isoform 2. 3 Publications | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | P52736 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113487, 27 interactors |
IntActi | P52736, 22 interactors |
MINTi | P52736 |
STRINGi | 9606.ENSP00000439427 |
PTM databases
iPTMneti | P52736 |
PhosphoSitePlusi | P52736 |
Genetic variation databases
BioMutai | ZNF133 |
DMDMi | 116242855 |
Proteomic databases
MassIVEi | P52736 |
MaxQBi | P52736 |
PaxDbi | P52736 |
PeptideAtlasi | P52736 |
PRIDEi | P52736 |
ProteomicsDBi | 25897 56508 [P52736-1] 56509 [P52736-2] |
Protocols and materials databases
Antibodypediai | 814, 178 antibodies |
DNASUi | 7692 |
Genome annotation databases
Organism-specific databases
CTDi | 7692 |
DisGeNETi | 7692 |
GeneCardsi | ZNF133 |
HGNCi | HGNC:12917, ZNF133 |
HPAi | ENSG00000125846, Low tissue specificity |
MIMi | 604075, gene |
neXtProti | NX_P52736 |
OpenTargetsi | ENSG00000125846 |
PharmGKBi | PA134900961 |
VEuPathDBi | HostDB:ENSG00000125846.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162260 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | P52736 |
OMAi | EWMLLSP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P52736 |
TreeFami | TF338096 |
Enzyme and pathway databases
PathwayCommonsi | P52736 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7692, 58 hits in 1025 CRISPR screens |
ChiTaRSi | ZNF133, human |
GeneWikii | ZNF133 |
GenomeRNAii | 7692 |
Pharosi | P52736, Tdark |
PROi | PR:P52736 |
RNActi | P52736, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125846, Expressed in right hemisphere of cerebellum and 222 other tissues |
ExpressionAtlasi | P52736, baseline and differential |
Genevisiblei | P52736, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN133_HUMAN | |
Accessioni | P52736Primary (citable) accession number: P52736 Secondary accession number(s): A8K5S4 Q9H443 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 17, 2006 | |
Last modified: | April 7, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families