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UniProtKB - P52736 (ZN133_HUMAN)

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Protein

Zinc finger protein 133

Gene

ZNF133

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 631C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 133
Alternative name(s):
Zinc finger protein 150
Gene namesi
Name:ZNF133
Synonyms:ZNF150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125846.15
HGNCiHGNC:12917 ZNF133
MIMi604075 gene
neXtProtiNX_P52736

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7692
OpenTargetsiENSG00000125846
PharmGKBiPA134900961

Polymorphism and mutation databases

DMDMi116242855

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474171 – 654Zinc finger protein 133Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki618Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP52736
MaxQBiP52736
PaxDbiP52736
PeptideAtlasiP52736
PRIDEiP52736
ProteomicsDBi56508
56509 [P52736-2]

PTM databases

iPTMnetiP52736
PhosphoSitePlusiP52736

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000125846
CleanExiHS_ZNF133
ExpressionAtlasiP52736 baseline and differential
GenevisibleiP52736 HS

Organism-specific databases

HPAiHPA001493

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113487, 27 interactors
IntActiP52736, 7 interactors
MINTiP52736
STRINGi9606.ENSP00000366899

Structurei

3D structure databases

ProteinModelPortaliP52736
SMRiP52736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 631C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063157
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP52736
KOiK09228
PhylomeDBiP52736
TreeFamiTF338096

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI 
        60         70         80         90        100
TQLEQGKETW REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL 
       110        120        130        140        150
CNHPPWIFTC LCAEGNIQPG DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG 
       160        170        180        190        200
AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG LRGVELEASP AQSGNPEETD 
       210        220        230        240        250
KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK PYVCGVCEKG 
       260        270        280        290        300
FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC 
       310        320        330        340        350
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE 
       360        370        380        390        400
EKTIVCSDCG LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH 
       410        420        430        440        450
QRTHSKEKPY VCGVCGHSFS QNSTLISHRR THTGEKPYVC GVCGRGFSLK 
       460        470        480        490        500
SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN LIRHQRTHSG EKPMVCGECG 
       510        520        530        540        550
RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH KRKHSREKPY 
       560        570        580        590        600
MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH 
       610        620        630        640        650
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS 

LYSL
Length:654
Mass (Da):73,388
Last modified:October 17, 2006 - v2
Checksum:iCF1D47B223A6DD84
GO
Isoform 2 (identifier: P52736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Show »
Length:653
Mass (Da):73,317
Checksum:i883575A9CF6CD81D
GO
Isoform 3 (identifier: P52736-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):62,460
Checksum:iDE76B50A05C5C9FD
GO
Isoform 4 (identifier: P52736-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MAFRDVAVDF...EKKCSPATCP → MCNGRKTVL

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):66,027
Checksum:i794B47D25C80881D
GO
Isoform 5 (identifier: P52736-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAHM

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):73,728
Checksum:iF7B081A6F912B039
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228N → S in BAG58259 (PubMed:14702039).Curated1
Sequence conflicti363F → Y in BAG58430 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028228193S → T6 PublicationsCorresponds to variant dbSNP:rs1033545Ensembl.1
Natural variantiVAR_028229194G → E. Corresponds to variant dbSNP:rs2228273Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550211 – 95Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0550221 – 72MAFRD…PATCP → MCNGRKTVL in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0550231M → MAHM in isoform 5. 1 Publication1
Alternative sequenceiVSP_03914873Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09366 mRNA Translation: AAC50260.1
BT007310 mRNA Translation: AAP35974.1
AK291389 mRNA Translation: BAF84078.1
AK295273 mRNA Translation: BAG58259.1
AK295513 mRNA Translation: BAG58430.1
AK316386 mRNA Translation: BAH14757.1
AL049646 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10250.1
CH471133 Genomic DNA Translation: EAX10251.1
CH471133 Genomic DNA Translation: EAX10252.1
CH471133 Genomic DNA Translation: EAX10253.1
BC001887 mRNA Translation: AAH01887.1
CCDSiCCDS13134.1 [P52736-2]
CCDS63233.1 [P52736-5]
CCDS63234.1 [P52736-1]
CCDS63235.1 [P52736-4]
PIRiA57785
RefSeqiNP_001076799.1, NM_001083330.2
NP_001269924.1, NM_001282995.1
NP_001269926.1, NM_001282997.1
NP_001269927.1, NM_001282998.1
NP_001269928.1, NM_001282999.1
NP_001269929.1, NM_001283000.1
NP_001269930.1, NM_001283001.1
NP_001269937.1, NM_001283008.1
NP_003425.2, NM_003434.5
XP_005260876.1, XM_005260819.1 [P52736-1]
XP_005260877.1, XM_005260820.4 [P52736-1]
XP_011527638.1, XM_011529336.1 [P52736-1]
XP_011527639.1, XM_011529337.1 [P52736-1]
XP_011527640.1, XM_011529338.2 [P52736-1]
XP_011527641.1, XM_011529339.1 [P52736-1]
XP_016883530.1, XM_017028041.1 [P52736-5]
XP_016883531.1, XM_017028042.1 [P52736-5]
XP_016883533.1, XM_017028044.1 [P52736-1]
XP_016883534.1, XM_017028045.1 [P52736-1]
XP_016883535.1, XM_017028046.1 [P52736-1]
XP_016883536.1, XM_017028047.1 [P52736-1]
XP_016883537.1, XM_017028048.1 [P52736-1]
XP_016883538.1, XM_017028049.1 [P52736-2]
XP_016883539.1, XM_017028050.1 [P52736-2]
XP_016883540.1, XM_017028051.1 [P52736-2]
XP_016883541.1, XM_017028052.1 [P52736-2]
XP_016883542.1, XM_017028053.1 [P52736-2]
XP_016883543.1, XM_017028054.1 [P52736-2]
XP_016883544.1, XM_017028055.1 [P52736-4]
XP_016883545.1, XM_017028056.1 [P52736-4]
XP_016883546.1, XM_017028057.1 [P52736-4]
UniGeneiHs.472221

Genome annotation databases

EnsembliENST00000316358; ENSP00000346090; ENSG00000125846 [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846 [P52736-2]
ENST00000396026; ENSP00000400897; ENSG00000125846 [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846 [P52736-1]
ENST00000402618; ENSP00000385279; ENSG00000125846 [P52736-4]
ENST00000622607; ENSP00000481326; ENSG00000125846 [P52736-1]
ENST00000628216; ENSP00000487315; ENSG00000125846 [P52736-5]
ENST00000630056; ENSP00000485741; ENSG00000125846 [P52736-3]
GeneIDi7692
KEGGihsa:7692
UCSCiuc002wql.6 human [P52736-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN133_HUMAN
AccessioniPrimary (citable) accession number: P52736
Secondary accession number(s): A8K5S4
, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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