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UniProtKB - P52736 (ZN133_HUMAN)

Entry version 197 (07 Apr 2021)
Sequence version 2 (17 Oct 2006)
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Protein

Zinc finger protein 133

Gene

ZNF133

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 631C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P52736

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 133
Alternative name(s):
Zinc finger protein 150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF133
Synonyms:ZNF150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12917, ZNF133

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604075, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52736

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125846.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7692

Open Targets

More...OpenTargetsi		ENSG00000125846

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134900961

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52736, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF133

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474171 – 654Zinc finger protein 133Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki618Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52736

MaxQB - The MaxQuant DataBase

More...MaxQBi		P52736

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52736

PeptideAtlas

More...PeptideAtlasi		P52736

PRoteomics IDEntifications database

More...PRIDEi		P52736

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		25897
56508 [P52736-1]
56509 [P52736-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52736

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52736

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125846, Expressed in right hemisphere of cerebellum and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52736, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52736, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125846, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113487, 27 interactors

Protein interaction database and analysis system

More...IntActi		P52736, 22 interactors

Molecular INTeraction database

More...MINTi		P52736

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000439427

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52736, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52736

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 631C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162260

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52736

Identification of Orthologs from Complete Genome Data

More...OMAi		EWMLLSP

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52736

TreeFam database of animal gene trees

More...TreeFami		TF338096

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 14 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI 
        60         70         80         90        100
TQLEQGKETW REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL 
       110        120        130        140        150
CNHPPWIFTC LCAEGNIQPG DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG 
       160        170        180        190        200
AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG LRGVELEASP AQSGNPEETD 
       210        220        230        240        250
KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK PYVCGVCEKG 
       260        270        280        290        300
FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC 
       310        320        330        340        350
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE 
       360        370        380        390        400
EKTIVCSDCG LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH 
       410        420        430        440        450
QRTHSKEKPY VCGVCGHSFS QNSTLISHRR THTGEKPYVC GVCGRGFSLK 
       460        470        480        490        500
SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN LIRHQRTHSG EKPMVCGECG 
       510        520        530        540        550
RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH KRKHSREKPY 
       560        570        580        590        600
MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH 
       610        620        630        640        650
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS 

LYSL
Length:654
Mass (Da):73,388
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF1D47B223A6DD84
GO
Isoform 2 (identifier: P52736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Show »
Length:653
Mass (Da):73,317
Checksum:i883575A9CF6CD81D
GO
Isoform 3 (identifier: P52736-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:559
Mass (Da):62,460
Checksum:iDE76B50A05C5C9FD
GO
Isoform 4 (identifier: P52736-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MAFRDVAVDF...EKKCSPATCP → MCNGRKTVL

Show »
Length:591
Mass (Da):66,027
Checksum:i794B47D25C80881D
GO
Isoform 5 (identifier: P52736-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAHM

Show »
Length:657
Mass (Da):73,728
Checksum:iF7B081A6F912B039
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JXW0Q5JXW0_HUMAN
Zinc finger protein 133
ZNF133
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JXV9Q5JXV9_HUMAN
Zinc finger protein 133
ZNF133
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JXW1Q5JXW1_HUMAN
Zinc finger protein 133
ZNF133
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTH2A0A0A0MTH2_HUMAN
Zinc finger protein 133
ZNF133
667Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTK6A0A0A0MTK6_HUMAN
Zinc finger protein 133
ZNF133
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SEV2A0A0D9SEV2_HUMAN
Zinc finger protein 133
ZNF133
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228N → S in BAG58259 (PubMed:14702039).Curated1
Sequence conflicti363F → Y in BAG58430 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028228193S → T6 PublicationsCorresponds to variant dbSNP:rs1033545Ensembl.1
Natural variantiVAR_028229194G → E. Corresponds to variant dbSNP:rs2228273Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0550211 – 95Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0550221 – 72MAFRD…PATCP → MCNGRKTVL in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0550231M → MAHM in isoform 5. 1 Publication1
Alternative sequenceiVSP_03914873Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U09366 mRNA Translation: AAC50260.1
BT007310 mRNA Translation: AAP35974.1
AK291389 mRNA Translation: BAF84078.1
AK295273 mRNA Translation: BAG58259.1
AK295513 mRNA Translation: BAG58430.1
AK316386 mRNA Translation: BAH14757.1
AL049646 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10250.1
CH471133 Genomic DNA Translation: EAX10251.1
CH471133 Genomic DNA Translation: EAX10252.1
CH471133 Genomic DNA Translation: EAX10253.1
BC001887 mRNA Translation: AAH01887.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13134.1 [P52736-2]
CCDS63233.1 [P52736-5]
CCDS63234.1 [P52736-1]
CCDS63235.1 [P52736-4]
CCDS74703.1 [P52736-3]
CCDS74704.1 [P52736-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A57785

NCBI Reference Sequences

More...RefSeqi		NP_001076799.1, NM_001083330.2 [P52736-2]
NP_001269924.1, NM_001282995.1 [P52736-2]
NP_001269926.1, NM_001282997.1 [P52736-1]
NP_001269927.1, NM_001282998.1 [P52736-1]
NP_001269928.1, NM_001282999.1 [P52736-1]
NP_001269929.1, NM_001283000.1 [P52736-1]
NP_001269930.1, NM_001283001.1 [P52736-1]
NP_001269937.1, NM_001283008.1 [P52736-3]
NP_003425.2, NM_003434.5 [P52736-2]
XP_005260876.1, XM_005260819.1
XP_005260877.1, XM_005260820.4
XP_011527638.1, XM_011529336.1
XP_011527639.1, XM_011529337.1 [P52736-1]
XP_011527640.1, XM_011529338.2
XP_011527641.1, XM_011529339.1 [P52736-1]
XP_016883530.1, XM_017028041.1 [P52736-5]
XP_016883531.1, XM_017028042.1 [P52736-5]
XP_016883533.1, XM_017028044.1
XP_016883534.1, XM_017028045.1
XP_016883535.1, XM_017028046.1
XP_016883536.1, XM_017028047.1 [P52736-1]
XP_016883537.1, XM_017028048.1 [P52736-1]
XP_016883538.1, XM_017028049.1
XP_016883539.1, XM_017028050.1
XP_016883540.1, XM_017028051.1
XP_016883541.1, XM_017028052.1
XP_016883542.1, XM_017028053.1
XP_016883543.1, XM_017028054.1
XP_016883544.1, XM_017028055.1
XP_016883545.1, XM_017028056.1
XP_016883546.1, XM_017028057.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316358; ENSP00000346090; ENSG00000125846 [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846 [P52736-2]
ENST00000396026; ENSP00000400897; ENSG00000125846 [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846 [P52736-1]
ENST00000402618; ENSP00000385279; ENSG00000125846 [P52736-4]
ENST00000622607; ENSP00000481326; ENSG00000125846 [P52736-1]
ENST00000628216; ENSP00000487315; ENSG00000125846 [P52736-5]
ENST00000630056; ENSP00000485741; ENSG00000125846 [P52736-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7692

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7692

UCSC genome browser

More...UCSCi		uc002wql.6, human [P52736-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09366 mRNA Translation: AAC50260.1
BT007310 mRNA Translation: AAP35974.1
AK291389 mRNA Translation: BAF84078.1
AK295273 mRNA Translation: BAG58259.1
AK295513 mRNA Translation: BAG58430.1
AK316386 mRNA Translation: BAH14757.1
AL049646 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10250.1
CH471133 Genomic DNA Translation: EAX10251.1
CH471133 Genomic DNA Translation: EAX10252.1
CH471133 Genomic DNA Translation: EAX10253.1
BC001887 mRNA Translation: AAH01887.1
CCDSiCCDS13134.1 [P52736-2]
CCDS63233.1 [P52736-5]
CCDS63234.1 [P52736-1]
CCDS63235.1 [P52736-4]
CCDS74703.1 [P52736-3]
CCDS74704.1 [P52736-3]
PIRiA57785
RefSeqiNP_001076799.1, NM_001083330.2 [P52736-2]
NP_001269924.1, NM_001282995.1 [P52736-2]
NP_001269926.1, NM_001282997.1 [P52736-1]
NP_001269927.1, NM_001282998.1 [P52736-1]
NP_001269928.1, NM_001282999.1 [P52736-1]
NP_001269929.1, NM_001283000.1 [P52736-1]
NP_001269930.1, NM_001283001.1 [P52736-1]
NP_001269937.1, NM_001283008.1 [P52736-3]
NP_003425.2, NM_003434.5 [P52736-2]
XP_005260876.1, XM_005260819.1
XP_005260877.1, XM_005260820.4
XP_011527638.1, XM_011529336.1
XP_011527639.1, XM_011529337.1 [P52736-1]
XP_011527640.1, XM_011529338.2
XP_011527641.1, XM_011529339.1 [P52736-1]
XP_016883530.1, XM_017028041.1 [P52736-5]
XP_016883531.1, XM_017028042.1 [P52736-5]
XP_016883533.1, XM_017028044.1
XP_016883534.1, XM_017028045.1
XP_016883535.1, XM_017028046.1
XP_016883536.1, XM_017028047.1 [P52736-1]
XP_016883537.1, XM_017028048.1 [P52736-1]
XP_016883538.1, XM_017028049.1
XP_016883539.1, XM_017028050.1
XP_016883540.1, XM_017028051.1
XP_016883541.1, XM_017028052.1
XP_016883542.1, XM_017028053.1
XP_016883543.1, XM_017028054.1
XP_016883544.1, XM_017028055.1
XP_016883545.1, XM_017028056.1
XP_016883546.1, XM_017028057.1

3D structure databases

SMRiP52736
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113487, 27 interactors
IntActiP52736, 22 interactors
MINTiP52736
STRINGi9606.ENSP00000439427

PTM databases

iPTMnetiP52736
PhosphoSitePlusiP52736

Genetic variation databases

BioMutaiZNF133
DMDMi116242855

Proteomic databases

MassIVEiP52736
MaxQBiP52736
PaxDbiP52736
PeptideAtlasiP52736
PRIDEiP52736
ProteomicsDBi25897
56508 [P52736-1]
56509 [P52736-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		814, 178 antibodies

The DNASU plasmid repository

More...DNASUi		7692

Genome annotation databases

EnsembliENST00000316358; ENSP00000346090; ENSG00000125846 [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846 [P52736-2]
ENST00000396026; ENSP00000400897; ENSG00000125846 [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846 [P52736-1]
ENST00000402618; ENSP00000385279; ENSG00000125846 [P52736-4]
ENST00000622607; ENSP00000481326; ENSG00000125846 [P52736-1]
ENST00000628216; ENSP00000487315; ENSG00000125846 [P52736-5]
ENST00000630056; ENSP00000485741; ENSG00000125846 [P52736-3]
GeneIDi7692
KEGGihsa:7692
UCSCiuc002wql.6, human [P52736-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7692
DisGeNETi7692

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF133
HGNCiHGNC:12917, ZNF133
HPAiENSG00000125846, Low tissue specificity
MIMi604075, gene
neXtProtiNX_P52736
OpenTargetsiENSG00000125846
PharmGKBiPA134900961
VEuPathDBiHostDB:ENSG00000125846.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162260
HOGENOMiCLU_002678_44_5_1
InParanoidiP52736
OMAiEWMLLSP
OrthoDBi1318335at2759
PhylomeDBiP52736
TreeFamiTF338096

Enzyme and pathway databases

PathwayCommonsiP52736
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7692, 58 hits in 1025 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF133, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF133

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7692
PharosiP52736, Tdark

Protein Ontology

More...PROi		PR:P52736
RNActiP52736, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125846, Expressed in right hemisphere of cerebellum and 222 other tissues
ExpressionAtlasiP52736, baseline and differential
GenevisibleiP52736, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 14 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN133_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52736
Secondary accession number(s): A8K5S4
, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: April 7, 2021
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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