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Protein

Guanine nucleotide exchange factor VAV2

Gene

VAV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri523 – 572Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processAngiogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445144 Signal transduction by L1
R-HSA-5218920 VEGFR2 mediated vascular permeability
SignaLinkiP52735
SIGNORiP52735

Protein family/group databases

MoonDBiP52735 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor VAV2
Short name:
VAV-2
Gene namesi
Name:VAV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160293.16
HGNCiHGNC:12658 VAV2
MIMi600428 gene
neXtProtiNX_P52735

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7410
OpenTargetsiENSG00000160293
PharmGKBiPA37281

Polymorphism and mutation databases

BioMutaiVAV2
DMDMi212287930

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809841 – 878Guanine nucleotide exchange factor VAV2Add BLAST878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142Phosphotyrosine; by EGFR1 Publication1
Modified residuei159Phosphotyrosine; by EGFR1 Publication1
Modified residuei172Phosphotyrosine; by EGFR1 Publication1
Modified residuei576PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Isoform 3 (identifier: P52735-3)
Modified residuei769PhosphoserineCombined sources1
Modified residuei771PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues in response to FGR activation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP52735
MaxQBiP52735
PaxDbiP52735
PeptideAtlasiP52735
PRIDEiP52735
ProteomicsDBi56505
56506 [P52735-2]
56507 [P52735-3]
TopDownProteomicsiP52735-3 [P52735-3]

PTM databases

iPTMnetiP52735
PhosphoSitePlusiP52735

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000160293 Expressed in 192 organ(s), highest expression level in liver
GenevisibleiP52735 HS

Organism-specific databases

HPAiHPA003224

Interactioni

Subunit structurei

Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113253, 71 interactors
DIPiDIP-33088N
IntActiP52735, 68 interactors
MINTiP52735
STRINGi9606.ENSP00000360916

Structurei

Secondary structure

1878
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP52735
SMRiP52735
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52735

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 120Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST120
Domaini198 – 376DHPROSITE-ProRule annotationAdd BLAST179
Domaini405 – 512PHPROSITE-ProRule annotationAdd BLAST108
Domaini586 – 652SH3 1PROSITE-ProRule annotationAdd BLAST67
Domaini673 – 767SH2PROSITE-ProRule annotationAdd BLAST95
Domaini816 – 877SH3 2PROSITE-ProRule annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri523 – 572Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
GeneTreeiENSGT00920000148946
HOVERGENiHBG018066
InParanoidiP52735
KOiK05730
OMAiPGPKMVA
OrthoDBiEOG091G01O3
PhylomeDBiP52735
TreeFamiTF316171

Family and domain databases

CDDicd00029 C1, 1 hit
cd00014 CH, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd10406 SH2_Vav2, 1 hit
cd11980 SH3_VAV2_1, 1 hit
cd11977 SH3_VAV2_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035880 VAV2_SH2
IPR035733 VAV2_SH3_1
IPR035732 VAV2_SH3_2
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF07653 SH3_2, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P52735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL
60 70 80 90 100
SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF
110 120 130 140 150
DVRDFGKVIS AVSRLSLHSI AQNKGIRPFP SEETTENDDD VYRSLEELAD
160 170 180 190 200
EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV QQPMIRYMQK MGMTEDDKRN
210 220 230 240 250
CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV FINLEDLIKV
260 270 280 290 300
HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL
310 320 330 340 350
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS
360 370 380 390 400
AERPERQQLK EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL
410 420 430 440 450
EEFGRPKIDG ELKVRSIVNH TKQDRYLFLF DKVVIVCKRK GYSYELKEII
460 470 480 490 500
ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY LIHLQGKQGF QFFCKTEDMK
510 520 530 540 550
RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC KMFLRGTFYQ
560 570 580 590 600
GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN
610 620 630 640 650
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC
660 670 680 690 700
PVDGRPPISR PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER
710 720 730 740 750
PAEAERFAIS IKFNDEVKHI KVVEKDNWIH ITEAKKFDSL LELVEYYQCH
760 770 780 790 800
SLKESFKQLD TTLKYPYKSR ERSASRASSR SPASCASYNF SFLSPQGLSF
810 820 830 840 850
ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG DVVRIYSRIG
860 870
GDQGWWKGET NGRIGWFPST YVEEEGIQ
Length:878
Mass (Da):101,289
Last modified:July 22, 2008 - v2
Checksum:iC186911605FD5B73
GO
Isoform 2 (identifier: P52735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.

Show »
Length:868
Mass (Da):100,057
Checksum:i6C67C472825D2DFD
GO
Isoform 3 (identifier: P52735-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.
     783-811: Missing.

Show »
Length:839
Mass (Da):97,032
Checksum:i21910D516F4A211D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241F → L in CAE45861 (PubMed:17974005).Curated1
Sequence conflicti254F → L in CAE45861 (PubMed:17974005).Curated1
Sequence conflicti877I → T in CAE45861 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045690594M → V2 PublicationsCorresponds to variant dbSNP:rs602990Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034900185 – 189Missing in isoform 2 and isoform 3. 2 Publications5
Alternative sequenceiVSP_034901470 – 474Missing in isoform 2 and isoform 3. 2 Publications5
Alternative sequenceiVSP_034902783 – 811Missing in isoform 3. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76992 mRNA Translation: AAB34377.1
AL590710 Genomic DNA No translation available.
AL445931 Genomic DNA No translation available.
AL357934 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88108.1
BC033187 mRNA Translation: AAH33187.1
BC132965 mRNA Translation: AAI32966.1
BC132967 mRNA Translation: AAI32968.1
BX640754 mRNA Translation: CAE45861.1
AY563001 mRNA Translation: AAS75591.1
CCDSiCCDS48053.1 [P52735-1]
CCDS6979.1 [P52735-3]
PIRiI51940
RefSeqiNP_001127870.1, NM_001134398.1 [P52735-1]
NP_003362.2, NM_003371.3 [P52735-3]
XP_005272270.1, XM_005272213.1 [P52735-2]
UniGeneiHs.369921
Hs.689325

Genome annotation databases

EnsembliENST00000371850; ENSP00000360916; ENSG00000160293 [P52735-1]
ENST00000371851; ENSP00000360917; ENSG00000160293 [P52735-2]
ENST00000406606; ENSP00000385362; ENSG00000160293 [P52735-3]
GeneIDi7410
KEGGihsa:7410
UCSCiuc004cer.4 human [P52735-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76992 mRNA Translation: AAB34377.1
AL590710 Genomic DNA No translation available.
AL445931 Genomic DNA No translation available.
AL357934 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88108.1
BC033187 mRNA Translation: AAH33187.1
BC132965 mRNA Translation: AAI32966.1
BC132967 mRNA Translation: AAI32968.1
BX640754 mRNA Translation: CAE45861.1
AY563001 mRNA Translation: AAS75591.1
CCDSiCCDS48053.1 [P52735-1]
CCDS6979.1 [P52735-3]
PIRiI51940
RefSeqiNP_001127870.1, NM_001134398.1 [P52735-1]
NP_003362.2, NM_003371.3 [P52735-3]
XP_005272270.1, XM_005272213.1 [P52735-2]
UniGeneiHs.369921
Hs.689325

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLZNMR-A663-767[»]
2DM1NMR-A819-878[»]
2LNWNMR-A659-771[»]
2LNXNMR-A659-771[»]
4ROJX-ray1.95A/B/C667-782[»]
ProteinModelPortaliP52735
SMRiP52735
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113253, 71 interactors
DIPiDIP-33088N
IntActiP52735, 68 interactors
MINTiP52735
STRINGi9606.ENSP00000360916

Protein family/group databases

MoonDBiP52735 Predicted

PTM databases

iPTMnetiP52735
PhosphoSitePlusiP52735

Polymorphism and mutation databases

BioMutaiVAV2
DMDMi212287930

Proteomic databases

EPDiP52735
MaxQBiP52735
PaxDbiP52735
PeptideAtlasiP52735
PRIDEiP52735
ProteomicsDBi56505
56506 [P52735-2]
56507 [P52735-3]
TopDownProteomicsiP52735-3 [P52735-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371850; ENSP00000360916; ENSG00000160293 [P52735-1]
ENST00000371851; ENSP00000360917; ENSG00000160293 [P52735-2]
ENST00000406606; ENSP00000385362; ENSG00000160293 [P52735-3]
GeneIDi7410
KEGGihsa:7410
UCSCiuc004cer.4 human [P52735-1]

Organism-specific databases

CTDi7410
DisGeNETi7410
EuPathDBiHostDB:ENSG00000160293.16
GeneCardsiVAV2
HGNCiHGNC:12658 VAV2
HPAiHPA003224
MIMi600428 gene
neXtProtiNX_P52735
OpenTargetsiENSG00000160293
PharmGKBiPA37281
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
GeneTreeiENSGT00920000148946
HOVERGENiHBG018066
InParanoidiP52735
KOiK05730
OMAiPGPKMVA
OrthoDBiEOG091G01O3
PhylomeDBiP52735
TreeFamiTF316171

Enzyme and pathway databases

ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445144 Signal transduction by L1
R-HSA-5218920 VEGFR2 mediated vascular permeability
SignaLinkiP52735
SIGNORiP52735

Miscellaneous databases

ChiTaRSiVAV2 human
EvolutionaryTraceiP52735
GeneWikiiVAV2
GenomeRNAii7410
PROiPR:P52735
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160293 Expressed in 192 organ(s), highest expression level in liver
GenevisibleiP52735 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00014 CH, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd10406 SH2_Vav2, 1 hit
cd11980 SH3_VAV2_1, 1 hit
cd11977 SH3_VAV2_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035880 VAV2_SH2
IPR035733 VAV2_SH3_1
IPR035732 VAV2_SH3_2
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF07653 SH3_2, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAV2_HUMAN
AccessioniPrimary (citable) accession number: P52735
Secondary accession number(s): A2RUM4
, A8MQ12, B6ZDF5, Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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