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Entry version 193 (08 May 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Kinesin-like protein KIF11

Gene

KIF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi105 – 112ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.6.4.4 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P52732

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF11
Alternative name(s):
Kinesin-like protein 1
Kinesin-like spindle protein HKSP
Kinesin-related motor protein Eg5
Thyroid receptor-interacting protein 5
Short name:
TR-interacting protein 5
Short name:
TRIP-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF11
Synonyms:EG5, KNSL1, TRIP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6388 KIF11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
148760 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52732

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067829144F → L in MCLMR. 1 Publication1
Natural variantiVAR_067830234R → C in MCLMR. 1 Publication1
Natural variantiVAR_067831235S → C in MCLMR. 1 PublicationCorresponds to variant dbSNP:rs387906643EnsemblClinVar.1
Natural variantiVAR_067832944R → C in MCLMR. 1 PublicationCorresponds to variant dbSNP:rs387906642EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi926T → A: No mitotic phosphorylation. No binding to spindle apparatus. 1 Publication1
Mutagenesisi1033S → A: Still binds to the mitotic spindle but mitotic progression is impaired. 1 Publication1
Mutagenesisi1033S → D: Still binds to the mitotic spindle but mitotic progression is impaired. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
3832

MalaCards human disease database

More...
MalaCardsi
KIF11
MIMi152950 phenotype

Open Targets

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OpenTargetsi
ENSG00000138160

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2526 Microcephaly-lymphedema-chorioretinopathy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30177

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4581

Drug and drug target database

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DrugBanki
DB04331 Monastrol

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2788

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIF11

Domain mapping of disease mutations (DMDM)

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DMDMi
116242604

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001253721 – 1056Kinesin-like protein KIF11Add BLAST1056

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146N6-acetyllysineCombined sources1
Modified residuei458PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei925PhosphothreonineCombined sources1
Modified residuei926Phosphothreonine; by CDK1Combined sources2 Publications1
Modified residuei1033Phosphoserine; by NEK6Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).2 Publications
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P52732

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P52732

MaxQB - The MaxQuant DataBase

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MaxQBi
P52732

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P52732

PeptideAtlas

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PeptideAtlasi
P52732

PRoteomics IDEntifications database

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PRIDEi
P52732

ProteomicsDB human proteome resource

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ProteomicsDBi
56504

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P52732

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P52732

SwissPalm database of S-palmitoylation events

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SwissPalmi
P52732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138160 Expressed in 143 organ(s), highest expression level in female gonad

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P52732 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB017617
HPA006916
HPA010093
HPA010568

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110030, 145 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P52732

Database of interacting proteins

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DIPi
DIP-53686N

Protein interaction database and analysis system

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IntActi
P52732, 92 interactors

Molecular INTeraction database

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MINTi
P52732

STRING: functional protein association networks

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STRINGi
9606.ENSP00000260731

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P52732

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11056
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52732

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P52732

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 359Kinesin motorPROSITE-ProRule annotationAdd BLAST342

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili364 – 480Sequence analysisAdd BLAST117
Coiled coili736 – 763Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0243 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155921

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116164

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P52732

KEGG Orthology (KO)

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KOi
K10398

Identification of Orthologs from Complete Genome Data

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OMAi
GVPFFQH

Database of Orthologous Groups

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OrthoDBi
551308at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P52732

TreeFam database of animal gene trees

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TreeFami
TF105230

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025901 Kinesin-assoc_MT-bd_dom
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24115 PTHR24115, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit
PF13931 Microtub_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P52732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQPNSSAK KKEEKGKNIQ VVVRCRPFNL AERKASAHSI VECDPVRKEV
60 70 80 90 100
SVRTGGLADK SSRKTYTFDM VFGASTKQID VYRSVVCPIL DEVIMGYNCT
110 120 130 140 150
IFAYGQTGTG KTFTMEGERS PNEEYTWEED PLAGIIPRTL HQIFEKLTDN
160 170 180 190 200
GTEFSVKVSL LEIYNEELFD LLNPSSDVSE RLQMFDDPRN KRGVIIKGLE
210 220 230 240 250
EITVHNKDEV YQILEKGAAK RTTAATLMNA YSSRSHSVFS VTIHMKETTI
260 270 280 290 300
DGEELVKIGK LNLVDLAGSE NIGRSGAVDK RAREAGNINQ SLLTLGRVIT
310 320 330 340 350
ALVERTPHVP YRESKLTRIL QDSLGGRTRT SIIATISPAS LNLEETLSTL
360 370 380 390 400
EYAHRAKNIL NKPEVNQKLT KKALIKEYTE EIERLKRDLA AAREKNGVYI
410 420 430 440 450
SEENFRVMSG KLTVQEEQIV ELIEKIGAVE EELNRVTELF MDNKNELDQC
460 470 480 490 500
KSDLQNKTQE LETTQKHLQE TKLQLVKEEY ITSALESTEE KLHDAASKLL
510 520 530 540 550
NTVEETTKDV SGLHSKLDRK KAVDQHNAEA QDIFGKNLNS LFNNMEELIK
560 570 580 590 600
DGSSKQKAML EVHKTLFGNL LSSSVSALDT ITTVALGSLT SIPENVSTHV
610 620 630 640 650
SQIFNMILKE QSLAAESKTV LQELINVLKT DLLSSLEMIL SPTVVSILKI
660 670 680 690 700
NSQLKHIFKT SLTVADKIED QKKELDGFLS ILCNNLHELQ ENTICSLVES
710 720 730 740 750
QKQCGNLTED LKTIKQTHSQ ELCKLMNLWT ERFCALEEKC ENIQKPLSSV
760 770 780 790 800
QENIQQKSKD IVNKMTFHSQ KFCADSDGFS QELRNFNQEG TKLVEESVKH
810 820 830 840 850
SDKLNGNLEK ISQETEQRCE SLNTRTVYFS EQWVSSLNER EQELHNLLEV
860 870 880 890 900
VSQCCEASSS DITEKSDGRK AAHEKQHNIF LDQMTIDEDK LIAQNLELNE
910 920 930 940 950
TIKIGLTKLN CFLEQDLKLD IPTGTTPQRK SYLYPSTLVR TEPREHLLDQ
960 970 980 990 1000
LKRKQPELLM MLNCSENNKE ETIPDVDVEE AVLGQYTEEP LSQEPSVDAG
1010 1020 1030 1040 1050
VDCSSIGGVP FFQHKKSHGK DKENRGINTL ERSKVEETTE HLVTKSRLPL

RAQINL
Length:1,056
Mass (Da):119,159
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7F2606FE68DA8EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti674 – 675EL → RNS in CAA59449 (PubMed:8548803).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067829144F → L in MCLMR. 1 Publication1
Natural variantiVAR_067830234R → C in MCLMR. 1 Publication1
Natural variantiVAR_067831235S → C in MCLMR. 1 PublicationCorresponds to variant dbSNP:rs387906643EnsemblClinVar.1
Natural variantiVAR_067832944R → C in MCLMR. 1 PublicationCorresponds to variant dbSNP:rs387906642EnsemblClinVar.1
Natural variantiVAR_0496821042L → F. Corresponds to variant dbSNP:rs34417963EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X85137 mRNA Translation: CAA59449.1
U37426 mRNA Translation: AAA86132.1
AL360222 Genomic DNA No translation available.
AL356128 Genomic DNA No translation available.
BC126211 mRNA Translation: AAI26212.1
BC136474 mRNA Translation: AAI36475.1
L40372 mRNA Translation: AAC41739.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7422.1

Protein sequence database of the Protein Information Resource

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PIRi
G02157

NCBI Reference Sequences

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RefSeqi
NP_004514.2, NM_004523.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260731; ENSP00000260731; ENSG00000138160

Database of genes from NCBI RefSeq genomes

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GeneIDi
3832

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3832

UCSC genome browser

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UCSCi
uc001kic.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85137 mRNA Translation: CAA59449.1
U37426 mRNA Translation: AAA86132.1
AL360222 Genomic DNA No translation available.
AL356128 Genomic DNA No translation available.
BC126211 mRNA Translation: AAI26212.1
BC136474 mRNA Translation: AAI36475.1
L40372 mRNA Translation: AAC41739.1
CCDSiCCDS7422.1
PIRiG02157
RefSeqiNP_004514.2, NM_004523.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1II6X-ray2.10A/B1-368[»]
1Q0BX-ray1.90A/B2-368[»]
1X88X-ray1.80A/B10-368[»]
1YRSX-ray2.50A/B1-368[»]
2FKYX-ray2.30A/B2-368[»]
2FL2X-ray2.50A/B2-368[»]
2FL6X-ray2.50A/B2-368[»]
2FMEX-ray2.10A/B1-368[»]
2G1QX-ray2.51A/B1-368[»]
2GM1X-ray2.30A/B/D/E1-368[»]
2IEHX-ray2.70A/B2-368[»]
2PG2X-ray1.85A/B1-368[»]
2Q2YX-ray2.50A/B2-368[»]
2Q2ZX-ray3.00A/B2-368[»]
2UYIX-ray2.10A/B1-368[»]
2UYMX-ray2.11A/B1-368[»]
2WOGX-ray2.00A/B/C1-368[»]
2X2RX-ray2.20A/B/C1-368[»]
2X7CX-ray1.90A/B1-368[»]
2X7DX-ray2.30A/B1-368[»]
2X7EX-ray2.40A/B1-368[»]
2XAEX-ray2.60A/B/C1-368[»]
3CJOX-ray2.28A/B2-368[»]
3HQDX-ray2.19A/B1-369[»]
3K3BX-ray2.40A/B1-368[»]
3K5EX-ray1.97A/B1-368[»]
3KENX-ray2.50A1-369[»]
3L9HX-ray2.00A/B1-368[»]
3WPNX-ray2.80A1-369[»]
3ZCWX-ray1.69A16-363[»]
4A1ZX-ray2.80A/B1-368[»]
4A28X-ray2.55A/B1-368[»]
4A50X-ray2.75A1-368[»]
4A51X-ray2.75A/B/C/D/E/F/G1-368[»]
4A5YX-ray2.45A/B/C1-368[»]
4AP0X-ray2.59A/B/C/D1-368[»]
4AQVelectron microscopy9.70C1-367[»]
4AQWelectron microscopy9.50C1-367[»]
4AS7X-ray2.40A1-368[»]
4B7BX-ray2.50A1-368[»]
4BBGX-ray2.75A1-368[»]
4BXNX-ray2.79A/B1-368[»]
4CK5electron microscopy10.00C1-367[»]
4CK6electron microscopy9.20C1-367[»]
4CK7electron microscopy9.20C1-367[»]
4ZCAX-ray2.30A/B1-369[»]
4ZHIX-ray2.30A/B1-369[»]
5JV3X-ray2.01A/B/C/D366-391[»]
5ZO7X-ray2.60A/B17-369[»]
5ZO8X-ray2.20A/B17-369[»]
5ZO9X-ray2.70A/B17-369[»]
6G6YX-ray1.80A1-368[»]
6G6ZX-ray2.80A1-368[»]
SMRiP52732
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110030, 145 interactors
CORUMiP52732
DIPiDIP-53686N
IntActiP52732, 92 interactors
MINTiP52732
STRINGi9606.ENSP00000260731

Chemistry databases

BindingDBiP52732
ChEMBLiCHEMBL4581
DrugBankiDB04331 Monastrol
GuidetoPHARMACOLOGYi2788

PTM databases

iPTMnetiP52732
PhosphoSitePlusiP52732
SwissPalmiP52732

Polymorphism and mutation databases

BioMutaiKIF11
DMDMi116242604

Proteomic databases

EPDiP52732
jPOSTiP52732
MaxQBiP52732
PaxDbiP52732
PeptideAtlasiP52732
PRIDEiP52732
ProteomicsDBi56504

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260731; ENSP00000260731; ENSG00000138160
GeneIDi3832
KEGGihsa:3832
UCSCiuc001kic.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3832
DisGeNETi3832

GeneCards: human genes, protein and diseases

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GeneCardsi
KIF11
HGNCiHGNC:6388 KIF11
HPAiCAB017617
HPA006916
HPA010093
HPA010568
MalaCardsiKIF11
MIMi148760 gene
152950 phenotype
neXtProtiNX_P52732
OpenTargetsiENSG00000138160
Orphaneti2526 Microcephaly-lymphedema-chorioretinopathy syndrome
PharmGKBiPA30177

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0243 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000155921
HOGENOMiHOG000116164
InParanoidiP52732
KOiK10398
OMAiGVPFFQH
OrthoDBi551308at2759
PhylomeDBiP52732
TreeFamiTF105230

Enzyme and pathway databases

BRENDAi3.6.4.4 2681
ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins
SIGNORiP52732

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF11 human
EvolutionaryTraceiP52732

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Kinesin_family_member_11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3832

Protein Ontology

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PROi
PR:P52732

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138160 Expressed in 143 organ(s), highest expression level in female gonad
GenevisibleiP52732 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR025901 Kinesin-assoc_MT-bd_dom
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PF13931 Microtub_bind, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52732
Secondary accession number(s): A0AV49
, B2RMV3, Q15716, Q5VWX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: May 8, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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