UniProtKB - P52722 (MT1_DANRE)
Protein
Metallothionein-1
Gene
mt
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 4 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 6 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 12 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 14 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 18 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 20 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 23 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 25 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 28 | Divalent metal cation; cluster B | 1 | |
Metal bindingi | 32 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 33 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 35 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 36 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 40 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 43 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 47 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 49 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 54 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 58 | Divalent metal cation; cluster A | 1 | |
Metal bindingi | 59 | Divalent metal cation; cluster A | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- angiogenesis Source: ZFIN
- positive regulation of cell migration involved in sprouting angiogenesis Source: ZFIN
- positive regulation of vascular endothelial growth factor production Source: ZFIN
- response to cadmium ion Source: ZFIN
- response to copper ion Source: ZFIN
- response to metal ion Source: ZFIN
- response to methylmercury Source: ZFIN
- response to zinc ion Source: ZFIN
Keywordsi
Ligand | Metal-binding, Metal-thiolate cluster |
Enzyme and pathway databases
Reactomei | R-DRE-5661231, Metallothioneins bind metals |
Names & Taxonomyi
Protein namesi | Recommended name: Metallothionein-1Short name: MT-1 |
Gene namesi | Name:mt Synonyms:mt1 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-4174, mt2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197268 | 1 – 60 | Metallothionein-1Add BLAST | 60 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | BetaAdd BLAST | 28 | |
Regioni | 29 – 60 | AlphaAdd BLAST | 32 |
Domaini
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similaritiesi
Phylogenomic databases
InParanoidi | P52722 |
Family and domain databases
Gene3Di | 4.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003019, Metalthion IPR017854, Metalthion_dom_sf IPR023587, Metalthion_dom_sf_vert IPR000006, Metalthion_vert IPR018064, Metalthion_vert_metal_BS |
PANTHERi | PTHR23299, PTHR23299, 1 hit |
Pfami | View protein in Pfam PF00131, Metallothio, 1 hit |
PRINTSi | PR00860, MTVERTEBRATE |
SUPFAMi | SSF57868, SSF57868, 1 hit |
PROSITEi | View protein in PROSITE PS00203, METALLOTHIONEIN_VRT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P52722-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPCECAKTG ACNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK
60
GNSCGTSCCQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7ZSY6 | MT2_DANRE | Metallothionein-2 | mt2 | 60 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97278 mRNA Translation: CAA65933.1 |
RefSeqi | NP_571150.1, NM_131075.1 |
Genome annotation databases
GeneIDi | 30282 |
KEGGi | dre:30282 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97278 mRNA Translation: CAA65933.1 |
RefSeqi | NP_571150.1, NM_131075.1 |
3D structure databases
SMRi | P52722 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 30282 |
KEGGi | dre:30282 |
Organism-specific databases
CTDi | 30282 |
ZFINi | ZDB-GENE-030131-4174, mt2 |
Phylogenomic databases
InParanoidi | P52722 |
Enzyme and pathway databases
Reactomei | R-DRE-5661231, Metallothioneins bind metals |
Family and domain databases
Gene3Di | 4.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003019, Metalthion IPR017854, Metalthion_dom_sf IPR023587, Metalthion_dom_sf_vert IPR000006, Metalthion_vert IPR018064, Metalthion_vert_metal_BS |
PANTHERi | PTHR23299, PTHR23299, 1 hit |
Pfami | View protein in Pfam PF00131, Metallothio, 1 hit |
PRINTSi | PR00860, MTVERTEBRATE |
SUPFAMi | SSF57868, SSF57868, 1 hit |
PROSITEi | View protein in PROSITE PS00203, METALLOTHIONEIN_VRT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MT1_DANRE | |
Accessioni | P52722Primary (citable) accession number: P52722 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Metallothioneins
Classification of metallothioneins and list of entries