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Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

alh-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307NucleophilePROSITE-ProRule annotation1
Binding sitei407NADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 203NADSequence analysis5
Nucleotide bindingi251 – 256NADSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-70895 Branched-chain amino acid catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
Name:alh-8
ORF Names:F13D12.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF13D12.4a ; CE02183 ; WBGene00000114 ; alh-8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionBy similarityAdd BLAST22
ChainiPRO_000000719123 – 523Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialAdd BLAST501

Proteomic databases

EPDiP52713
PaxDbiP52713
PeptideAtlasiP52713
PRIDEiP52713

2D gel databases

World-2DPAGEi0011:P52713
0020:P52713

Expressioni

Gene expression databases

BgeeiWBGene00000114 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi40105, 1 interactor
DIPiDIP-25038N
STRINGi6239.F13D12.4a.2

Structurei

3D structure databases

ProteinModelPortaliP52713
SMRiP52713
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449 Eukaryota
ENOG410XNP1 LUCA
GeneTreeiENSGT00910000144256
HOGENOMiHOG000271507
InParanoidiP52713
KOiK00140
OMAiSQWKEED
OrthoDBiEOG091G06SO
PhylomeDBiP52713

Family and domain databases

CDDicd07085 ALDH_F6_MMSDH, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR010061 MeMal-semiAld_DH
PANTHERiPTHR43866 PTHR43866, 1 hit
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01722 MMSDH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P52713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSRLARVQP KCQQLAHFST SKSAAAAPTV KLWIDGQAVE SKTTDFVELT
60 70 80 90 100
NPATNEVIAM VPNATQAEMQ AAVDSAKNAF NTWKNTSPLT RQQCMFKLQA
110 120 130 140 150
LIKRDMKKLA ESITIEQGKT LPDAEGDVSR GLQVVEHACS VPSLMMGETL
160 170 180 190 200
PNVSRDMDTH SYRIPLGVTA GICPFNFPAM IPLWMFPVAL ATGNTMVIKP
210 220 230 240 250
SEQDPGAAQL LVELAKEAGV PDGCVNIIHG QHSAVNFICD NPDIKAISFV
260 270 280 290 300
GGDAAGKHIY ERGAKNGKRV QSNMGAKNHG VIMADANKEQ TLNQLTAAAF
310 320 330 340 350
GAAGQRCMAL TTAVLVGEAR AWLPELVEKA KNLKVNAGWK PDTDIGPLIS
360 370 380 390 400
KQSKARVLRL IESAKKEGAQ VPLDGSNITV PGFENGNFVG PTILAGVKPN
410 420 430 440 450
MTCYREEIFG PVLVVMEAEN LNEAIEIINN NPYGNGTAIF TSNGATARKF
460 470 480 490 500
TNEVDVGQIG INVPIPVPLP MFSFTGSRGS FLGDLNFYGK AGIQFYTQWK
510 520
TVTQYWNESL TELKPQMSFP QLK
Length:523
Mass (Da):56,462
Last modified:October 1, 1996 - v1
Checksum:i2871499FE3267A29
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7JMI1Q7JMI1_CAEEL
ALdehyde deHydrogenase
alh-8 CELE_F13D12.4, F13D12.4
113Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49127 Genomic DNA Translation: CAA88946.1
PIRiT20828
RefSeqiNP_001022078.1, NM_001026907.2
UniGeneiCel.17786

Genome annotation databases

EnsemblMetazoaiF13D12.4a.1; F13D12.4a.1; WBGene00000114
F13D12.4a.2; F13D12.4a.2; WBGene00000114
F13D12.4a.3; F13D12.4a.3; WBGene00000114
GeneIDi174800
KEGGicel:CELE_F13D12.4
UCSCiF13D12.4a.2 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49127 Genomic DNA Translation: CAA88946.1
PIRiT20828
RefSeqiNP_001022078.1, NM_001026907.2
UniGeneiCel.17786

3D structure databases

ProteinModelPortaliP52713
SMRiP52713
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40105, 1 interactor
DIPiDIP-25038N
STRINGi6239.F13D12.4a.2

2D gel databases

World-2DPAGEi0011:P52713
0020:P52713

Proteomic databases

EPDiP52713
PaxDbiP52713
PeptideAtlasiP52713
PRIDEiP52713

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF13D12.4a.1; F13D12.4a.1; WBGene00000114
F13D12.4a.2; F13D12.4a.2; WBGene00000114
F13D12.4a.3; F13D12.4a.3; WBGene00000114
GeneIDi174800
KEGGicel:CELE_F13D12.4
UCSCiF13D12.4a.2 c. elegans

Organism-specific databases

CTDi174800
WormBaseiF13D12.4a ; CE02183 ; WBGene00000114 ; alh-8

Phylogenomic databases

eggNOGiKOG2449 Eukaryota
ENOG410XNP1 LUCA
GeneTreeiENSGT00910000144256
HOGENOMiHOG000271507
InParanoidiP52713
KOiK00140
OMAiSQWKEED
OrthoDBiEOG091G06SO
PhylomeDBiP52713

Enzyme and pathway databases

ReactomeiR-CEL-70895 Branched-chain amino acid catabolism

Miscellaneous databases

PROiPR:P52713

Gene expression databases

BgeeiWBGene00000114 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd07085 ALDH_F6_MMSDH, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR010061 MeMal-semiAld_DH
PANTHERiPTHR43866 PTHR43866, 1 hit
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01722 MMSDH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMSA_CAEEL
AccessioniPrimary (citable) accession number: P52713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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