UniProtKB - P52697 (6PGL_ECOLI)
Protein
6-phosphogluconolactonase
Gene
pgl
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication
Catalytic activityi
- EC:3.1.1.31
: pentose phosphate pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
- 6-phosphogluconolactonase (pgl), 6-phosphogluconolactonase (pgl)
- 6-phosphogluconate dehydrogenase, decarboxylating (gndA), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
GO - Molecular functioni
- 6-phosphogluconolactonase activity Source: EcoCyc
GO - Biological processi
- glucose metabolic process Source: UniProtKB-UniRule
- pentose-phosphate shunt Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Hydrolase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:6PGLUCONOLACT-MONOMER MetaCyc:6PGLUCONOLACT-MONOMER |
UniPathwayi | UPA00115;UER00409 |
Names & Taxonomyi
Protein namesi | Recommended name: 6-phosphogluconolactonase (EC:3.1.1.31)Short name: 6-P-gluconolactonase Short name: Pgl |
Gene namesi | Name:pgl Synonyms:ybhE Ordered Locus Names:b0767, JW0750 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171132 | 1 – 331 | 6-phosphogluconolactonaseAdd BLAST | 331 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 287 | N6-acetyllysine1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P52697 |
PaxDbi | P52697 |
PRIDEi | P52697 |
PTM databases
iPTMneti | P52697 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261151, 18 interactors |
IntActi | P52697, 5 interactors |
STRINGi | 511145.b0767 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P52697 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P52697 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cycloisomerase 2 family.Curated
Phylogenomic databases
eggNOGi | COG2706, Bacteria |
HOGENOMi | CLU_038716_2_0_6 |
InParanoidi | P52697 |
PhylomeDBi | P52697 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_01605, 6P_gluconolactonase, 1 hit |
InterProi | View protein in InterPro IPR022528, 6-phosphogluconolactonase_YbhE IPR019405, Lactonase_7-beta_prop IPR011045, N2O_reductase_N IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF10282, Lactonase, 1 hit |
SUPFAMi | SSF50974, SSF50974, 1 hit |
i Sequence
Sequence statusi: Complete.
P52697-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQTVYIASP ESQQIHVWNL NHEGALTLTQ VVDVPGQVQP MVVSPDKRYL
60 70 80 90 100
YVGVRPEFRV LAYRIAPDDG ALTFAAESAL PGSPTHISTD HQGQFVFVGS
110 120 130 140 150
YNAGNVSVTR LEDGLPVGVV DVVEGLDGCH SANISPDNRT LWVPALKQDR
160 170 180 190 200
ICLFTVSDDG HLVAQDPAEV TTVEGAGPRH MVFHPNEQYA YCVNELNSSV
210 220 230 240 250
DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG RHLYACDRTA
260 270 280 290 300
SLITVFSVSE DGSVLSKEGF QPTETQPRGF NVDHSGKYLI AAGQKSHHIS
310 320 330
VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H
Sequence cautioni
The sequence U27192 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 – 52 | QVQPM…RYLYV → RCSRWWSARTNVISML (PubMed:7665460).CuratedAdd BLAST | 16 | |
Sequence conflicti | 319 – 331 | VGQGP…VVNAH → SGRDQCGWWLTHTKR (PubMed:7665460).CuratedAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27192 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC73854.1 AP009048 Genomic DNA Translation: BAA35431.1 |
PIRi | G64812 |
RefSeqi | NP_415288.1, NC_000913.3 WP_000815435.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC73854; AAC73854; b0767 BAA35431; BAA35431; BAA35431 |
GeneIDi | 57728438 946398 |
KEGGi | ecj:JW0750 eco:b0767 |
PATRICi | fig|1411691.4.peg.1511 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27192 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC73854.1 AP009048 Genomic DNA Translation: BAA35431.1 |
PIRi | G64812 |
RefSeqi | NP_415288.1, NC_000913.3 WP_000815435.1, NZ_SSZK01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RI6 | X-ray | 2.00 | A | 2-331 | [»] | |
SMRi | P52697 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261151, 18 interactors |
IntActi | P52697, 5 interactors |
STRINGi | 511145.b0767 |
PTM databases
iPTMneti | P52697 |
Proteomic databases
jPOSTi | P52697 |
PaxDbi | P52697 |
PRIDEi | P52697 |
Genome annotation databases
EnsemblBacteriai | AAC73854; AAC73854; b0767 BAA35431; BAA35431; BAA35431 |
GeneIDi | 57728438 946398 |
KEGGi | ecj:JW0750 eco:b0767 |
PATRICi | fig|1411691.4.peg.1511 |
Organism-specific databases
EchoBASEi | EB3020 |
Phylogenomic databases
eggNOGi | COG2706, Bacteria |
HOGENOMi | CLU_038716_2_0_6 |
InParanoidi | P52697 |
PhylomeDBi | P52697 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00409 |
BioCyci | EcoCyc:6PGLUCONOLACT-MONOMER MetaCyc:6PGLUCONOLACT-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P52697 |
PROi | PR:P52697 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_01605, 6P_gluconolactonase, 1 hit |
InterProi | View protein in InterPro IPR022528, 6-phosphogluconolactonase_YbhE IPR019405, Lactonase_7-beta_prop IPR011045, N2O_reductase_N IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF10282, Lactonase, 1 hit |
SUPFAMi | SSF50974, SSF50974, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 6PGL_ECOLI | |
Accessioni | P52697Primary (citable) accession number: P52697 Secondary accession number(s): P75760 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families