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Protein

Transcriptional activator HlyU

Gene

hlyU

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 66H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: TIGR
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Virulence

Enzyme and pathway databases

BioCyciVCHO:VC0678-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator HlyU
Gene namesi
Name:hlyU
Ordered Locus Names:VC_0678
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606221 – 108Transcriptional activator HlyUAdd BLAST108

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0678

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP52695
SMRiP52695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 107HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

eggNOGiENOG41080HT Bacteria
COG0640 LUCA
KOiK22042
OMAiMQQRADH

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYLKGAPMN LQEMEKNSAK AVVLLKAMAN ERRLQILCML LDNELSVGEL
60 70 80 90 100
SSRLELSQSA LSQHLAWLRR DGLVNTRKEA QTVFYTLSST EVKAMIELLH

RLYCQANQ
Length:108
Mass (Da):12,293
Last modified:October 1, 1996 - v1
Checksum:i4FC1BE6DA960F217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66866 Genomic DNA Translation: CAA47336.1
AJ002395 Genomic DNA Translation: CAA05372.1
AE003852 Genomic DNA Translation: AAF93843.1
PIRiS37313
RefSeqiNP_230327.1, NC_002505.1
WP_001888967.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF93843; AAF93843; VC_0678
GeneIDi2615467
KEGGivch:VC0678
PATRICifig|243277.26.peg.650

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66866 Genomic DNA Translation: CAA47336.1
AJ002395 Genomic DNA Translation: CAA05372.1
AE003852 Genomic DNA Translation: AAF93843.1
PIRiS37313
RefSeqiNP_230327.1, NC_002505.1
WP_001888967.1, NC_002505.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K2EX-ray1.80A/B/C/D1-108[»]
4OOIX-ray2.20A/B/C/D1-108[»]
ProteinModelPortaliP52695
SMRiP52695
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0678

Protocols and materials databases

DNASUi2615467
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93843; AAF93843; VC_0678
GeneIDi2615467
KEGGivch:VC0678
PATRICifig|243277.26.peg.650

Phylogenomic databases

eggNOGiENOG41080HT Bacteria
COG0640 LUCA
KOiK22042
OMAiMQQRADH

Enzyme and pathway databases

BioCyciVCHO:VC0678-MONOMER

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHLYU_VIBCH
AccessioniPrimary (citable) accession number: P52695
Secondary accession number(s): Q9JMP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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