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Protein

Transcription initiation factor IIA subunit 2

Gene

GTF2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P52657

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
TFIIA p12 subunit
Short name:
TFIIA-12
Short name:
TFIIAS
Transcription initiation factor IIA gamma chain
Short name:
TFIIA-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTF2A2
Synonyms:TF2A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140307.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4647 GTF2A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600519 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52657

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2958

Open Targets

More...
OpenTargetsi
ENSG00000140307

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29034

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GTF2A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1729806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001940421 – 109Transcription initiation factor IIA subunit 2Add BLAST109

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P52657

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52657

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52657

PeptideAtlas

More...
PeptideAtlasi
P52657

PRoteomics IDEntifications database

More...
PRIDEi
P52657

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56501

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P52657

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52657

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52657

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140307 Expressed in 234 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_GTF2A2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52657 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52657 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056239

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (By similarity). It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12) (By similarity). Interacts with NCOA6 general coactivator (PubMed:10567404). TFIIA forms a complex with TBP (PubMed:11030333). Interacts with HSF1 (via transactivation domain) (PubMed:11005381).By similarity3 Publications
(Microbial infection) Interacts with SV40 Large T antigen.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109213, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-519 Transcription factor complex TFIIA

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P52657

Database of interacting proteins

More...
DIPi
DIP-40648N

Protein interaction database and analysis system

More...
IntActi
P52657, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379372

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P52657

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52657

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P52657

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3463 Eukaryota
COG5123 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014572

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000167251

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000826

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52657

KEGG Orthology (KO)

More...
KOi
K03123

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKMESNE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0X1Z

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52657

TreeFam database of animal gene trees

More...
TreeFami
TF315131

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.190, 1 hit
2.30.18.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N

The PANTHER Classification System

More...
PANTHERi
PTHR10966 PTHR10966, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF009415 Hum_TFIIA_gamma, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD009224 TFIIA_gsu_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50784 SSF50784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P52657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINAALAQ
60 70 80 90 100
RVRNRVNFRG SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG

KNTGSNTTE
Length:109
Mass (Da):12,457
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i938E7DC8B9982AE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MYR4A8MYR4_HUMAN
Transcription initiation factor IIA...
GTF2A2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK39H0YK39_HUMAN
Transcription initiation factor IIA...
GTF2A2
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1Z5A0A0B4J1Z5_HUMAN
Transcription initiation factor IIA...
GTF2A2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X81713 mRNA Translation: CAA57357.1
U14193 mRNA Translation: AAA64951.1
U21242 mRNA Translation: AAB58247.1
BT007362 mRNA Translation: AAP36026.1
CR542192 mRNA Translation: CAG46989.1
AC092755 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77573.1
BC000287 mRNA Translation: AAH00287.1
BC001919 mRNA Translation: AAH01919.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10173.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38952

NCBI Reference Sequences

More...
RefSeqi
NP_001307858.1, NM_001320929.1
NP_001307859.1, NM_001320930.1
NP_004483.1, NM_004492.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.512934

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396060; ENSP00000379372; ENSG00000140307
ENST00000396061; ENSP00000379373; ENSG00000140307
ENST00000396063; ENSP00000379375; ENSG00000140307

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2958

UCSC genome browser

More...
UCSCi
uc002agg.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81713 mRNA Translation: CAA57357.1
U14193 mRNA Translation: AAA64951.1
U21242 mRNA Translation: AAB58247.1
BT007362 mRNA Translation: AAP36026.1
CR542192 mRNA Translation: CAG46989.1
AC092755 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77573.1
BC000287 mRNA Translation: AAH00287.1
BC001919 mRNA Translation: AAH01919.1
CCDSiCCDS10173.1
PIRiI38952
RefSeqiNP_001307858.1, NM_001320929.1
NP_001307859.1, NM_001320930.1
NP_004483.1, NM_004492.2
UniGeneiHs.512934

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NVPX-ray2.10D2-109[»]
5FURelectron microscopy8.50D3-99[»]
5IY6electron microscopy7.20O1-109[»]
5IY7electron microscopy8.60O1-109[»]
5IY8electron microscopy7.90O1-109[»]
5IY9electron microscopy6.30O1-109[»]
5IYAelectron microscopy5.40O1-109[»]
5IYBelectron microscopy3.90O1-109[»]
5IYCelectron microscopy3.90O1-109[»]
5IYDelectron microscopy3.90O1-109[»]
5M4SX-ray2.38A2-103[»]
ProteinModelPortaliP52657
SMRiP52657
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109213, 9 interactors
ComplexPortaliCPX-519 Transcription factor complex TFIIA
CORUMiP52657
DIPiDIP-40648N
IntActiP52657, 5 interactors
STRINGi9606.ENSP00000379372

PTM databases

iPTMnetiP52657
PhosphoSitePlusiP52657

Polymorphism and mutation databases

BioMutaiGTF2A2
DMDMi1729806

Proteomic databases

EPDiP52657
MaxQBiP52657
PaxDbiP52657
PeptideAtlasiP52657
PRIDEiP52657
ProteomicsDBi56501
TopDownProteomicsiP52657

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2958
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396060; ENSP00000379372; ENSG00000140307
ENST00000396061; ENSP00000379373; ENSG00000140307
ENST00000396063; ENSP00000379375; ENSG00000140307
GeneIDi2958
KEGGihsa:2958
UCSCiuc002agg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2958
DisGeNETi2958
EuPathDBiHostDB:ENSG00000140307.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GTF2A2
HGNCiHGNC:4647 GTF2A2
HPAiHPA056239
MIMi600519 gene
neXtProtiNX_P52657
OpenTargetsiENSG00000140307
PharmGKBiPA29034

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3463 Eukaryota
COG5123 LUCA
GeneTreeiENSGT00390000014572
HOGENOMiHOG000167251
HOVERGENiHBG000826
InParanoidiP52657
KOiK03123
OMAiFKMESNE
OrthoDBiEOG091G0X1Z
PhylomeDBiP52657
TreeFamiTF315131

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-9018519 Estrogen-dependent gene expression
SIGNORiP52657

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GTF2A2 human
EvolutionaryTraceiP52657

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2958

Protein Ontology

More...
PROi
PR:P52657

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140307 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_GTF2A2
ExpressionAtlasiP52657 baseline and differential
GenevisibleiP52657 HS

Family and domain databases

CDDicd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit
Gene3Di1.10.287.190, 1 hit
2.30.18.10, 1 hit
InterProiView protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N
PANTHERiPTHR10966 PTHR10966, 1 hit
PfamiView protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit
PIRSFiPIRSF009415 Hum_TFIIA_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009224 TFIIA_gsu_N, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2AG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52657
Secondary accession number(s): A8MYQ7, Q6FGB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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